{"id":"https://openalex.org/W2042328552","doi":"https://doi.org/10.1016/j.sbi.2014.08.011","title":"Structural mechanisms in NLR inflammasome signaling","display_name":"Structural mechanisms in NLR inflammasome signaling","publication_year":2014,"publication_date":"2014-09-15","ids":{"openalex":"https://openalex.org/W2042328552","doi":"https://doi.org/10.1016/j.sbi.2014.08.011","mag":"2042328552","pmid":"https://pubmed.ncbi.nlm.nih.gov/25201319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4268015"},"language":"en","primary_location":{"id":"doi:10.1016/j.sbi.2014.08.011","doi":"https://doi.org/10.1016/j.sbi.2014.08.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sbi.2014.08.011","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4268015/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072282453","display_name":"Bernhard C. Lechtenberg","orcid":"https://orcid.org/0000-0002-5674-6894","observed_orcids":["https://orcid.org/0000-0002-5674-6894"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernhard C Lechtenberg","raw_affiliation_strings":["Programs on Cell Death and Survival Networks, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programs on Cell Death and Survival Networks, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026934240","display_name":"Peter D. Mace","orcid":"https://orcid.org/0000-0003-2175-9537","observed_orcids":["https://orcid.org/0000-0003-2175-9537"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Peter D Mace","raw_affiliation_strings":["Biochemistry Department, Otago School of Medical Sciences, University of Otago, P.O. Box 56, 710 Cumberland St., Dunedin 9054, New Zealand. Electronic address: peter.mace@otago.ac.nz","Biochemistry Department, Otago School of Medical Sciences, University of Otago, P.O. Box 56, 710 Cumberland St., Dunedin 9054, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Otago School of Medical Sciences, University of Otago, P.O. Box 56, 710 Cumberland St., Dunedin 9054, New Zealand. Electronic address: peter.mace@otago.ac.nz","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"Biochemistry Department, Otago School of Medical Sciences, University of Otago, P.O. Box 56, 710 Cumberland St., Dunedin 9054, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032790946","display_name":"Stefan J. Riedl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stefan J Riedl","raw_affiliation_strings":["Programs on Cell Death and Survival Networks, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: sriedl@sanfordburnham.org","Programs on Cell Death and Survival Networks, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programs on Cell Death and Survival Networks, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: sriedl@sanfordburnham.org","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Programs on Cell Death and Survival Networks, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026934240","https://openalex.org/A5032790946"],"corresponding_institution_ids":["https://openalex.org/I188891513","https://openalex.org/I80281795"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":1.1693,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.7613335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"29","issue":null,"first_page":"17","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nod-like-receptors","display_name":"NOD-like receptors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nlrp3","display_name":"NLRP3","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nlrc4","display_name":"NLRC4","score":1.0},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.5370000004768372},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.6890000104904175},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5460000038146973},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8259999752044678},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9760000109672546},{"id":"https://openalex.org/keywords/aim2","display_name":"AIM2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/protein-complexes","display_name":"protein complexes","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9220144748687744},{"id":"https://openalex.org/C56432331","wikidata":"https://www.wikidata.org/wiki/Q18044860","display_name":"NLRC4","level":5,"score":0.8823129534721375},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.7532564401626587},{"id":"https://openalex.org/C187831198","wikidata":"https://www.wikidata.org/wiki/Q18034187","display_name":"AIM2","level":4,"score":0.7374483346939087},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6270073652267456},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5969529747962952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5109905004501343},{"id":"https://openalex.org/C139964883","wikidata":"https://www.wikidata.org/wiki/Q14901964","display_name":"Caspase 1","level":4,"score":0.498765230178833},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.46082010865211487},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4242277145385742},{"id":"https://openalex.org/C139174496","wikidata":"https://www.wikidata.org/wiki/Q24725912","display_name":"Pyrin domain","level":4,"score":0.4226286709308624},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36740946769714355},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26593172550201416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20198732614517212}],"mesh":[{"descriptor_ui":"D000071198","descriptor_name":"Pyrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053455","descriptor_name":"Caspase 10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053468","descriptor_name":"CARD Signaling Adaptor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053477","descriptor_name":"Apoptotic Protease-Activating Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053478","descriptor_name":"Apoptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.sbi.2014.08.011","doi":"https://doi.org/10.1016/j.sbi.2014.08.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sbi.2014.08.011","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},{"id":"pmid:25201319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25201319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in structural biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4268015","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4268015/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Struct Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4268015","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4268015/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Struct Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3304167615","display_name":"The Mechanism of DISC Formation","funder_award_id":"R01AA017238","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000864383","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA030199","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1576718627","https://openalex.org/W1878755986","https://openalex.org/W1968423671","https://openalex.org/W1974070734","https://openalex.org/W1975014158","https://openalex.org/W1975032025","https://openalex.org/W1984046437","https://openalex.org/W1988654439","https://openalex.org/W1992014522","https://openalex.org/W1992089548","https://openalex.org/W1994362040","https://openalex.org/W1998639445","https://openalex.org/W2000023984","https://openalex.org/W2001946532","https://openalex.org/W2005282780","https://openalex.org/W2005482741","https://openalex.org/W2012046458","https://openalex.org/W2015449243","https://openalex.org/W2019407752","https://openalex.org/W2034230597","https://openalex.org/W2036007039","https://openalex.org/W2041074318","https://openalex.org/W2042433863","https://openalex.org/W2042851093","https://openalex.org/W2043380097","https://openalex.org/W2045953344","https://openalex.org/W2048224251","https://openalex.org/W2050778896","https://openalex.org/W2052509313","https://openalex.org/W2053352311","https://openalex.org/W2053530884","https://openalex.org/W2061042417","https://openalex.org/W2062223459","https://openalex.org/W2067230454","https://openalex.org/W2068772341","https://openalex.org/W2073743133","https://openalex.org/W2078819049","https://openalex.org/W2078850432","https://openalex.org/W2085006185","https://openalex.org/W2087128996","https://openalex.org/W2088164523","https://openalex.org/W2089250915","https://openalex.org/W2089503694","https://openalex.org/W2092126110","https://openalex.org/W2118084489","https://openalex.org/W2127108097","https://openalex.org/W2127906781","https://openalex.org/W2133287612","https://openalex.org/W2142805130","https://openalex.org/W2162295519","https://openalex.org/W2172155557","https://openalex.org/W2883076715","https://openalex.org/W4211217520"],"related_works":["https://openalex.org/W2502778518","https://openalex.org/W7222975256","https://openalex.org/W1927502256","https://openalex.org/W2404951803","https://openalex.org/W2913004193","https://openalex.org/W4310366847","https://openalex.org/W4319335680","https://openalex.org/W2791761634","https://openalex.org/W7165646124","https://openalex.org/W2980784106"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}