{"id":"https://openalex.org/W2042020448","doi":"https://doi.org/10.1016/0304-3959(89)90108-5","title":"Central post-stroke pain \u2014 a controlled trial of amitriptyline and carbamazepine","display_name":"Central post-stroke pain \u2014 a controlled trial of amitriptyline and carbamazepine","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2042020448","doi":"https://doi.org/10.1016/0304-3959(89)90108-5","mag":"2042020448","pmid":"https://pubmed.ncbi.nlm.nih.gov/2465530"},"language":"en","primary_location":{"id":"doi:10.1016/0304-3959(89)90108-5","doi":"https://doi.org/10.1016/0304-3959(89)90108-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3959(89)90108-5","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2042020448"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057561485","display_name":"G\u00f6ran Leijon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"G. Leijon","raw_affiliation_strings":["Department of Neurology, University Hospital, S-581 85 Link\u00f6pingSweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital, S-581 85 Link\u00f6pingSweden","institution_ids":["https://openalex.org/I4210151885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108536032","display_name":"J. Boivie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. Boivie","raw_affiliation_strings":["Department of Neurology, University Hospital, S-581 85 Link\u00f6pingSweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital, S-581 85 Link\u00f6pingSweden","institution_ids":["https://openalex.org/I4210151885"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057561485"],"corresponding_institution_ids":["https://openalex.org/I4210151885"],"apc_list":null,"apc_paid":null,"fwci":6.5898,"has_fulltext":false,"cited_by_count":395,"citation_normalized_percentile":{"value":0.97111064,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"36","issue":"1","first_page":"27","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-post-stroke-pain","display_name":"central post-stroke pain","score":1.0},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":0.9819999933242798},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":1.0},{"id":"https://openalex.org/keywords/analgesic-effect","display_name":"analgesic effect","score":0.5960000157356262},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7039999961853027},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.6840000152587891},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.671999990940094},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.37400001287460327},{"id":"https://openalex.org/keywords/nortriptyline","display_name":"nortriptyline","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.9347748756408691},{"id":"https://openalex.org/C2780779033","wikidata":"https://www.wikidata.org/wiki/Q61387","display_name":"Nortriptyline","level":3,"score":0.8024678826332092},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.7803069353103638},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7605834007263184},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6226916909217834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6130610108375549},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5795486569404602},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.546235203742981},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4333125352859497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3146604299545288},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27670809626579285},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15995436906814575},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.1424350142478943},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010166","descriptor_name":"Palliative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0304-3959(89)90108-5","doi":"https://doi.org/10.1016/0304-3959(89)90108-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3959(89)90108-5","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:2465530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2465530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W16441074","https://openalex.org/W203403257","https://openalex.org/W274723353","https://openalex.org/W1535791249","https://openalex.org/W1548958780","https://openalex.org/W1970538956","https://openalex.org/W1970805063","https://openalex.org/W1982071890","https://openalex.org/W1983572531","https://openalex.org/W1984936684","https://openalex.org/W1985623640","https://openalex.org/W1988702243","https://openalex.org/W1990810755","https://openalex.org/W1991353203","https://openalex.org/W1992457684","https://openalex.org/W1992830749","https://openalex.org/W2004035928","https://openalex.org/W2007894957","https://openalex.org/W2017878166","https://openalex.org/W2031713503","https://openalex.org/W2032297248","https://openalex.org/W2036474149","https://openalex.org/W2037340753","https://openalex.org/W2038947420","https://openalex.org/W2050954917","https://openalex.org/W2055939488","https://openalex.org/W2056187152","https://openalex.org/W2070675681","https://openalex.org/W2076586987","https://openalex.org/W2080979995","https://openalex.org/W2092165377","https://openalex.org/W2095044060","https://openalex.org/W2101075026","https://openalex.org/W2114524185","https://openalex.org/W2122817475","https://openalex.org/W2131823335","https://openalex.org/W2144065017","https://openalex.org/W2150883260","https://openalex.org/W2330636348","https://openalex.org/W2396322917","https://openalex.org/W2400368340","https://openalex.org/W2418134951","https://openalex.org/W2462255665","https://openalex.org/W2470818232","https://openalex.org/W2596171374","https://openalex.org/W2765747422","https://openalex.org/W4249108345","https://openalex.org/W4301719247","https://openalex.org/W4317731556","https://openalex.org/W6843735053"],"related_works":["https://openalex.org/W2003555425","https://openalex.org/W2063961643","https://openalex.org/W4390774029","https://openalex.org/W235639563","https://openalex.org/W1975015993","https://openalex.org/W2365450991","https://openalex.org/W1998257102","https://openalex.org/W2350883951","https://openalex.org/W1991211549","https://openalex.org/W2018331747"],"abstract_inverted_index":{"A":[0],"double-blind,":[1],"3-phase,":[2],"cross-over,":[3],"placebo-controlled":[4],"trial":[5],"of":[6,10,28,38,67,79,87,99,115,127,196,219,260],"the":[7,77,88,97,101,123,128,143,154,158,180,183,205,208,220,231,253,256,275],"pain-relieving":[8],"effect":[9,90,137,232,247],"amitriptyline":[11,56,261],"and":[12,51,57,75,147,162,167,173,199,248,274],"carbamazepine":[13,225],"was":[14,31,107,211,244,267],"carried":[15],"out":[16],"in":[17,33,282],"15":[18,129],"patients":[19,130,184,222,254],"with":[20,179,224],"central":[21],"post-stroke":[22],"pain":[23,68,116,209,228],"(CPSP)":[24],"but":[25,230],"without":[26],"signs":[27],"depression.":[29],"Treatment":[30],"given,":[32],"randomized":[34],"order,":[35],"for":[36,55,171,204],"periods":[37],"4":[39,283],"weeks,":[40],"separated":[41],"by":[42,64,83,214],"1":[43,287],"week":[44,146],"wash-out.":[45],"The":[46,59,136,175],"final":[47,258,264,276],"doses":[48],"were":[49,62,131,165,185],"75":[50],"800":[52],"mg/day,":[53],"respectively,":[54,170],"carbamazepine.":[58],"treatment":[60,81,145],"effects":[61,273],"assessed":[63],"daily":[65],"ratings":[66,195],"intensity":[69],"on":[70,91,194,295],"a":[71,84,92,111],"10-step":[72],"verbal":[73,94],"scale":[74],"at":[76],"end":[78],"each":[80],"period":[82],"global":[85,124],"rating":[86],"analgesic":[89],"5-step":[93],"scale.":[95],"For":[96],"assessment":[98],"depression":[100],"Comprehensive":[102],"Psychopathological":[103],"Rating":[104],"Scale":[105],"(CPRS)":[106],"used.":[108],"Amitriptyline":[109],"produced":[110],"statistically":[112],"significant":[113],"reduction":[114,266],"when":[117,238],"compared":[118,239],"to":[119,122,133,150,153,240,279,290,299],"placebo.":[120,241],"According":[121],"rating,":[125],"10":[126],"responders":[132,172],"this":[134],"drug.":[135],"could":[138],"already":[139],"be":[140,151,280,291],"noticed":[141],"during":[142],"second":[144],"it":[148],"appeared":[149],"correlated":[152],"plasma":[155,249],"concentration,":[156],"since":[157],"median":[159],"total":[160],"ami-":[161],"nortriptyline":[163],"concentrations":[164],"497":[166],"247":[168],"nmol/l,":[169],"non-responders.":[174],"early":[176],"onset,":[177],"together":[178],"fact":[181],"that":[182,207],"not":[186,212,234],"depressed,":[187],"nor":[188],"did":[189,233],"they":[190],"obtain":[191],"reduced":[192,281],"scores":[193],"depressive":[197],"symptoms":[198],"signs,":[200],"provides":[201],"strong":[202],"support":[203],"conclusion":[206],"relief":[210],"caused":[213,270],"an":[215],"antidepressive":[216],"effect.":[217],"Five":[218],"14":[221],"treated":[223],"reported":[226],"some":[227],"relief,":[229],"reach":[235],"statistical":[236],"significance":[237],"No":[242,263],"correlation":[243],"found":[245],"between":[246],"concentration.":[250],"In":[251],"general,":[252],"tolerated":[255],"planned":[257],"dose":[259,265,277],"well.":[262],"necessary.":[268],"Carbamazepine":[269],"more":[271],"side":[272],"had":[278,289],"patients.":[284],"However,":[285],"only":[286],"patient":[288],"taken":[292],"off":[293],"medication,":[294],"day":[296],"25,":[297],"due":[298],"drug":[300],"interaction.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}