{"id":"https://openalex.org/W2042019934","doi":"https://doi.org/10.1002/path.2148","title":"Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms","display_name":"Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms","publication_year":2007,"publication_date":"2007-03-13","ids":{"openalex":"https://openalex.org/W2042019934","doi":"https://doi.org/10.1002/path.2148","mag":"2042019934","pmid":"https://pubmed.ncbi.nlm.nih.gov/17352452"},"language":"en","primary_location":{"id":"doi:10.1002/path.2148","doi":"https://doi.org/10.1002/path.2148","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.2148","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037058812","display_name":"Xavier Houard","orcid":"https://orcid.org/0000-0002-3920-7821","observed_orcids":["https://orcid.org/0000-0002-3920-7821"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"X Houard","raw_affiliation_strings":["INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001462379","display_name":"Fran\u00e7ois Rouzet","orcid":"https://orcid.org/0000-0001-6109-0087","observed_orcids":["https://orcid.org/0000-0001-6109-0087"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Rouzet","raw_affiliation_strings":["Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210145170","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106729868","display_name":"Ziad Touat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Z Touat","raw_affiliation_strings":["INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112885535","display_name":"M. Philippe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Philippe","raw_affiliation_strings":["INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111816193","display_name":"Miguel Dom\u00ednguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Dominguez","raw_affiliation_strings":["INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033189496","display_name":"Vincent Fontaine","orcid":"https://orcid.org/0009-0001-7228-2743","observed_orcids":["https://orcid.org/0009-0001-7228-2743"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V Fontaine","raw_affiliation_strings":["INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051883204","display_name":"Laure Sarda\u2010Mantel","orcid":"https://orcid.org/0000-0003-2926-1717","observed_orcids":["https://orcid.org/0000-0003-2926-1717"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Sarda\u2010Mantel","raw_affiliation_strings":["Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210145170","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066853452","display_name":"Alain Meulemans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Meulemans","raw_affiliation_strings":["Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210145170","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042887533","display_name":"Dominique Le Guludec","orcid":"https://orcid.org/0000-0001-6434-4716","observed_orcids":["https://orcid.org/0000-0001-6434-4716"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Le Guludec","raw_affiliation_strings":["Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Bichat Hospital, AP-HP, INSERM U773 and University Denis Diderot-Paris 7 UMR5773, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210145170","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047460685","display_name":"Olivier Meilhac","orcid":"https://orcid.org/0000-0002-3740-7539","observed_orcids":["https://orcid.org/0000-0002-3740-7539"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O Meilhac","raw_affiliation_strings":["INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109106535","display_name":"Michel Jb","orcid":"https://orcid.org/0000-0002-1282-3835","observed_orcids":["https://orcid.org/0000-0002-1282-3835"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J\u2010B Michel","raw_affiliation_strings":["INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109106535"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":8.7525,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.98035445,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"212","issue":"1","first_page":"20","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mural-thrombus","display_name":"mural thrombus","score":0.9359999895095825},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.996999979019165},{"id":"https://openalex.org/keywords/plasminogen-activator","display_name":"plasminogen activator","score":0.9430000185966492},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/plasmin-antiplasmin-complex","display_name":"plasmin-antiplasmin complex","score":0.8930000066757202},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.796999990940094},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.7129999995231628},{"id":"https://openalex.org/keywords/upa","display_name":"uPA","score":0.9869999885559082},{"id":"https://openalex.org/keywords/aneurysm-progression","display_name":"aneurysm progression","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.684086799621582},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.6798864603042603},{"id":"https://openalex.org/C2776716733","wikidata":"https://www.wikidata.org/wiki/Q1890226","display_name":"Adventitia","level":2,"score":0.6128214001655579},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.586194634437561},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.5795644521713257},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5489599108695984},{"id":"https://openalex.org/C2780799893","wikidata":"https://www.wikidata.org/wiki/Q418625","display_name":"Aprotinin","level":2,"score":0.5203961133956909},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4256994426250458},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41568413376808167},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37275826930999756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31934067606925964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.315523624420166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2086869776248932},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.19560307264328003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14843419194221497},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000979","descriptor_name":"alpha-2-Antiplasmin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000979","descriptor_name":"alpha-2-Antiplasmin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/path.2148","doi":"https://doi.org/10.1002/path.2148","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.2148","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},{"id":"pmid:17352452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17352452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309713","display_name":"Fondation Lefoulon Delalande","ror":"https://ror.org/00h5ca650"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W141217221","https://openalex.org/W1968368894","https://openalex.org/W1969765250","https://openalex.org/W1969887141","https://openalex.org/W1970612660","https://openalex.org/W1973635961","https://openalex.org/W1978537045","https://openalex.org/W1987050508","https://openalex.org/W1993718274","https://openalex.org/W2001930593","https://openalex.org/W2002658097","https://openalex.org/W2008304528","https://openalex.org/W2010523072","https://openalex.org/W2015156312","https://openalex.org/W2021145842","https://openalex.org/W2022639462","https://openalex.org/W2031989194","https://openalex.org/W2036097309","https://openalex.org/W2038855255","https://openalex.org/W2041645234","https://openalex.org/W2050556701","https://openalex.org/W2052980795","https://openalex.org/W2057663146","https://openalex.org/W2083271521","https://openalex.org/W2092952849","https://openalex.org/W2094743529","https://openalex.org/W2095094849","https://openalex.org/W2111228702","https://openalex.org/W2122028809","https://openalex.org/W2133138662","https://openalex.org/W2133913480","https://openalex.org/W2152938302","https://openalex.org/W2166201554","https://openalex.org/W2226290316","https://openalex.org/W2405416714","https://openalex.org/W2418881620","https://openalex.org/W2419113933","https://openalex.org/W2462810404","https://openalex.org/W4210984075","https://openalex.org/W6689010356"],"related_works":["https://openalex.org/W2036097309","https://openalex.org/W1969887141","https://openalex.org/W2092952849","https://openalex.org/W2332079088","https://openalex.org/W2073123057","https://openalex.org/W1970612660","https://openalex.org/W2126496641","https://openalex.org/W2791260013","https://openalex.org/W1968368894","https://openalex.org/W2057663146"],"abstract_inverted_index":{"Development":[0],"and":[1,33,43,47,49,76,82,112,116,154,163,165,189,215],"progression":[2],"of":[3,20,27,98,114,138,146,152,161,175,187,213,237,249],"acquired":[4],"abdominal":[5],"aortic":[6],"aneurysms":[7],"(AAAs)":[8],"involve":[9],"proteolytic":[10,226],"activity.":[11],"In":[12,79,178],"the":[13,18,34,131,135,143,147,158,166,172,176,192,201,209,238],"present":[14,125],"study,":[15],"we":[16],"investigate":[17],"distribution":[19],"fibrinolytic":[21,121,239],"system":[22,122,240],"components":[23,100,123],"within":[24,191,200],"mural":[25,31,132,224],"thrombi":[26,32],"human":[28],"AAAs.":[29],"20":[30],"remaining":[35],"AAA":[36,219,234],"walls":[37],"were":[38,51,60,124],"dissected.":[39],"The":[40,91],"luminal,":[41],"intermediate":[42],"abluminal":[44],"thrombus":[45,133,148,225,250],"layers,":[46],"media":[48,59],"adventitia":[50],"separately":[52],"incubated":[53],"in":[54,101,126,171,218,252],"cell":[55],"culture":[56],"medium.":[57],"Conditioned":[58],"then":[61],"analysed":[62],"for":[63,246],"plasminogen":[64,67,162],"activators":[65],"(PAs),":[66],"activator":[68],"inhibitor-1":[69],"(PAI-1),":[70],"free-plasmin,":[71],"plasmin":[72],"alpha(2)-antiplasmin":[73],"complexes":[74],"(PAPs)":[75],"D-dimers":[77,216],"release.":[78,141],"parallel,":[80],"PA":[81],"PAI-1":[83,190],"mRNA":[84,180,196],"expression":[85,181],"analysis":[86,182],"was":[87,93,134,197],"performed":[88],"by":[89,95],"RT-PCR.":[90],"study":[92],"completed":[94],"immunohistochemical":[96],"localization":[97],"these":[99,205],"AAA,":[102],"ex":[103],"vivo":[104],"functional":[105,247],"imaging":[106,248],"using":[107],"(99m)Tc-aprotinin":[108,167],"as":[109],"a":[110,244],"ligand":[111],"measurement":[113],"PAP":[115],"D-dimer":[117],"plasma":[118,211],"levels.":[119],"All":[120],"each":[127],"aneurysmal":[128],"layer.":[129],"However,":[130],"main":[136],"source":[137],"active":[139],"serine-protease":[140],"Interestingly,":[142],"luminal":[144,173],"layer":[145],"released":[149],"greater":[150],"amounts":[151],"PAPs":[153,214],"D-dimers.":[155],"This":[156],"paralleled":[157],"preferential":[159],"immunolocalization":[160],"PAs,":[164],"scintigraphic":[168],"signal":[169],"observed":[170],"pole":[174],"thrombus.":[177,202],"contrast,":[179],"showed":[183],"an":[184],"exclusive":[185],"synthesis":[186],"tPA":[188],"wall,":[193],"whereas":[194],"uPA":[195],"also":[198,242],"expressed":[199],"Taken":[203],"together,":[204],"results":[206],"suggest":[207],"that":[208],"increased":[210],"concentrations":[212],"found":[217],"patients":[220],"are":[221],"related":[222],"to":[223],"activity,":[227],"thus":[228],"explaining":[229],"their":[230],"known":[231],"link":[232],"with":[233],"progression.":[235],"Components":[236],"could":[241],"represent":[243],"target":[245],"activities":[251],"AAA.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}