{"id":"https://openalex.org/W2042017410","doi":"https://doi.org/10.1536/ihj.4.426","title":"Pathological Studies on the Endocrine Organs of the Spontaneously Hypertensive Rats","display_name":"Pathological Studies on the Endocrine Organs of the Spontaneously Hypertensive Rats","publication_year":1963,"publication_date":"1963-01-01","ids":{"openalex":"https://openalex.org/W2042017410","doi":"https://doi.org/10.1536/ihj.4.426","mag":"2042017410","pmid":"https://pubmed.ncbi.nlm.nih.gov/14065369"},"language":"en","primary_location":{"id":"doi:10.1536/ihj.4.426","doi":"https://doi.org/10.1536/ihj.4.426","is_oa":true,"landing_page_url":"https://doi.org/10.1536/ihj.4.426","pdf_url":"https://www.jstage.jst.go.jp/article/ihj1960/4/5/4_5_426/_pdf","source":{"id":"https://openalex.org/S120602568","display_name":"Japanese Heart Journal","issn_l":"0021-4868","issn":["0021-4868","1348-673X","1573-8612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313504","host_organization_name":"Japanese Heart Journal Assoc","host_organization_lineage":["https://openalex.org/P4310313504"],"host_organization_lineage_names":["Japanese Heart Journal Assoc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/ihj1960/4/5/4_5_426/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111369990","display_name":"Kyuzo Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyuzo AOKI","raw_affiliation_strings":["Department of Pathology Kyoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Kyoto University School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021136815","display_name":"Hidemitsu Tankawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidemitsu TANKAWA","raw_affiliation_strings":["Department of Pathology Kyoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Kyoto University School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112509764","display_name":"Takao Fujinami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao FUJINAMI","raw_affiliation_strings":["Department of Pathology Kyoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Kyoto University School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akio MIYAZAKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio MIYAZAKI","raw_affiliation_strings":["Department of Pathology Kyoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Kyoto University School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yoshiteru HASHIMOTO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiteru HASHIMOTO","raw_affiliation_strings":["Department of Pathology Kyoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Kyoto University School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":4.6708,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.9633905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"5","first_page":"426","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.14149999618530273,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8479999899864197},{"id":"https://openalex.org/keywords/endocrine-organs","display_name":"endocrine organs","score":0.902999997138977},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.8690000176429749},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.9810000061988831},{"id":"https://openalex.org/keywords/zona-glomerulosa","display_name":"zona glomerulosa","score":0.7300000190734863},{"id":"https://openalex.org/keywords/reticular-zone","display_name":"reticular zone","score":0.953000009059906},{"id":"https://openalex.org/keywords/thyroid","display_name":"thyroid gland","score":0.7059999704360962},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.6389999985694885},{"id":"https://openalex.org/keywords/histomorphometry","display_name":"histomorphometry","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7550986409187317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7067805528640747},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6797681450843811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6095847487449646},{"id":"https://openalex.org/C118190526","wikidata":"https://www.wikidata.org/wiki/Q7239981","display_name":"Prehypertension","level":3,"score":0.5443716049194336},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5286398530006409},{"id":"https://openalex.org/C95190701","wikidata":"https://www.wikidata.org/wiki/Q3268002","display_name":"Reticular connective tissue","level":2,"score":0.4374425709247589},{"id":"https://openalex.org/C2911077047","wikidata":"https://www.wikidata.org/wiki/Q1434446","display_name":"Nephrosclerosis","level":3,"score":0.43673044443130493},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4193367660045624},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.24903005361557007},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2248947024345398},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12218114733695984}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004702","descriptor_name":"Endocrine Glands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004704","descriptor_name":"Endocrinology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010336","descriptor_name":"Pathology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1536/ihj.4.426","doi":"https://doi.org/10.1536/ihj.4.426","is_oa":true,"landing_page_url":"https://doi.org/10.1536/ihj.4.426","pdf_url":"https://www.jstage.jst.go.jp/article/ihj1960/4/5/4_5_426/_pdf","source":{"id":"https://openalex.org/S120602568","display_name":"Japanese Heart Journal","issn_l":"0021-4868","issn":["0021-4868","1348-673X","1573-8612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313504","host_organization_name":"Japanese Heart Journal Assoc","host_organization_lineage":["https://openalex.org/P4310313504"],"host_organization_lineage_names":["Japanese Heart Journal Assoc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Heart Journal","raw_type":"journal-article"},{"id":"pmid:14065369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14065369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese heart journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1536/ihj.4.426","doi":"https://doi.org/10.1536/ihj.4.426","is_oa":true,"landing_page_url":"https://doi.org/10.1536/ihj.4.426","pdf_url":"https://www.jstage.jst.go.jp/article/ihj1960/4/5/4_5_426/_pdf","source":{"id":"https://openalex.org/S120602568","display_name":"Japanese Heart Journal","issn_l":"0021-4868","issn":["0021-4868","1348-673X","1573-8612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313504","host_organization_name":"Japanese Heart Journal Assoc","host_organization_lineage":["https://openalex.org/P4310313504"],"host_organization_lineage_names":["Japanese Heart Journal Assoc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2042017410.pdf","grobid_xml":"https://content.openalex.org/works/W2042017410.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2026310571","https://openalex.org/W2032059733","https://openalex.org/W2102839147","https://openalex.org/W2914387350"],"related_works":["https://openalex.org/W2058201986","https://openalex.org/W2055853215","https://openalex.org/W4255564083","https://openalex.org/W7151583017","https://openalex.org/W172004455","https://openalex.org/W2002962592","https://openalex.org/W2115924456","https://openalex.org/W1988644677","https://openalex.org/W1972059659","https://openalex.org/W2042618906"],"abstract_inverted_index":{"Body":[0],"weight":[1,77,170],"and":[2,19,25,46,61,64,81,106,126,133,140,148,167,201,231,233,258,277,287,302,310],"blood":[3,15],"pressure":[4,16],"were":[5,31,59,71,91,99,113,136,151,188,213,239,266],"measured":[6],"in":[7,67,76,82,87,115,142,169,182,192,197,203,210,225,235,307,314],"the":[8,13,68,79,83,88,94,107,118,120,123,127,131,146,155,178,185,198,204,221,223,242,255,259,275,285,296,308,315],"normotensive":[9,288],"Wistar":[10],"rats":[11,22],"with":[12,268],"systolic":[14],"below":[17],"149mm.Hg":[18],"spontaneously":[20,316],"hypertensive":[21,69,286,317],"by":[23,215],"Okamoto":[24],"Aoki.":[26],"Animals,":[27],"from":[28],"both":[29],"groups,":[30],"killed":[32],"at":[33,93,154,241],"40-50":[34],"days":[35],"(prehypertensive":[36],"stage),":[37],"4-5":[38],"months":[39,48],"(after":[40,51],"a":[41,52],"moderate":[42,202],"duration":[43,54],"of":[44,49,55,78,85,122,130,145,160,171,174,177,184,227,237,254,270,312],"hypertension),":[45],"12-14":[47],"ages":[50],"long":[53],"hypertension).":[56],"Endocrine":[57],"organs":[58],"weighed":[60],"studied":[62],"histometrically":[63],"histopathologically.The":[65],"results":[66],"animals":[70],"as":[72,101],"follows.(1)":[73],"Some":[74],"increases":[75],"pituitary":[80,297],"percentage":[84],"basophils":[86],"anterior":[89,298],"lobe":[90],"noted":[92],"prehypertensive":[95,243],"stage.":[96,157,244],"These":[97],"changes":[98,163,249,265],"exaggerated":[100],"hypertension":[102,161,246,313],"persisted.":[103],"The":[104,138,190,263,290],"hypertrophy":[105,139],"change":[108,112],"similar":[109],"to":[110],"hyaline":[111],"observed":[114],"basophils.(2)":[116],"In":[117,220,274],"adrenals,":[119,172],"area":[121,129,226],"glomerular":[124,147,199],"zone":[125,187,200,206],"summed":[128],"fascicular":[132,149,179,205],"reticular":[134,186],"zones":[135,150],"increased.":[137],"increase":[141,168,191,224],"lipid":[143,193],"content":[144,194,261],"detected":[152],"even":[153],"prehypertensi.ve":[156],"With":[158],"persistence":[159],"these":[162,248],"became":[164,250],"more":[165,208,251],"marked,":[166],"irregularity":[173,234],"cell":[175],"cords":[176],"zone,":[180],"decrease":[181],"width":[183],"demonstrated.":[189],"was":[195,280],"remarkable":[196,209],"but":[207],"groups":[211],"which":[212],"complicated":[214],"periarteritis":[216],"nodosa":[217],"or":[218],"nephrosclerosis.(3)":[219],"thyroid,":[222],"follicle":[228,230],"cells,":[229],"lumen,":[232],"shape":[236],"follicles":[238],"found":[240],"As":[245],"persisted":[247],"remarkable.":[252],"Weight":[253],"thyroid":[256,303],"increased":[257],"colloid":[260],"decreased.":[262],"histological":[264],"compatible":[267],"that":[269,295],"struma":[271],"parenchymatosa":[272],"macrofollicularis.(4)":[273],"pancreas":[276],"gonads,":[278],"there":[279],"no":[281],"significant":[282,305],"difference":[283],"between":[284],"groups.(5)":[289],"present":[291],"study":[292],"has":[293],"demonstrated":[294],"lobe,":[299],"adrenal":[300],"cortex":[301],"have":[304],"roles":[306],"development":[309],"maintenance":[311],"rats.":[318]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}