{"id":"https://openalex.org/W2041963256","doi":"https://doi.org/10.1073/pnas.0608127103","title":"A Ras-induced conformational switch in the Ras activator Son of sevenless","display_name":"A Ras-induced conformational switch in the Ras activator Son of sevenless","publication_year":2006,"publication_date":"2006-10-30","ids":{"openalex":"https://openalex.org/W2041963256","doi":"https://doi.org/10.1073/pnas.0608127103","mag":"2041963256","pmid":"https://pubmed.ncbi.nlm.nih.gov/17075039","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1629002"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0608127103","doi":"https://doi.org/10.1073/pnas.0608127103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0608127103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1629002/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076175732","display_name":"Tanya S. Freedman","orcid":"https://orcid.org/0000-0001-5168-5829","observed_orcids":["https://orcid.org/0000-0001-5168-5829"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya S. Freedman","raw_affiliation_strings":["*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research, University of California, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028476200","display_name":"Holger Sondermann","orcid":"https://orcid.org/0000-0003-2211-6234","observed_orcids":["https://orcid.org/0000-0003-2211-6234"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holger Sondermann","raw_affiliation_strings":["*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","institution_ids":[]},{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058884796","display_name":"Gregory D. Friedland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D. Friedland","raw_affiliation_strings":["Graduate Group in Biophysics,","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Group in Biophysics,","institution_ids":[]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000906927","display_name":"Tanja Kortemme","orcid":"https://orcid.org/0000-0002-8494-680X","observed_orcids":["https://orcid.org/0000-0002-8494-680X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanja Kortemme","raw_affiliation_strings":["Department of Biopharmaceutical Sciences, and California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94143; and","Graduate Group in Biophysics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutical Sciences, and California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94143; and","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Graduate Group in Biophysics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056698491","display_name":"Dafna Bar\u2010Sagi","orcid":"https://orcid.org/0000-0003-2597-8948","observed_orcids":["https://orcid.org/0000-0003-2597-8948"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dafna Bar-Sagi","raw_affiliation_strings":["Department of Biochemistry, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043858304","display_name":"Susan Marqusee","orcid":"https://orcid.org/0000-0001-7648-2163","observed_orcids":["https://orcid.org/0000-0001-7648-2163"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Marqusee","raw_affiliation_strings":["*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","institution_ids":[]},{"raw_affiliation_string":"Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038330393","display_name":"John Kuriyan","orcid":"https://orcid.org/0000-0002-4414-5477","observed_orcids":["https://orcid.org/0000-0002-4414-5477"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kuriyan","raw_affiliation_strings":["**Department of Chemistry, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720;","*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Department of Chemistry, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I95457486"]},{"raw_affiliation_string":"*Department of Molecular and Cell Biology, California Institute for Quantitative Biomedical Research,","institution_ids":[]},{"raw_affiliation_string":"Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;","institution_ids":["https://openalex.org/I148283060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3217,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.87647975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"103","issue":"45","first_page":"16692","last_page":"16697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/son-of-sevenless","display_name":"Son of Sevenless","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rasgrf1","display_name":"RASGRF1","score":0.824999988079071},{"id":"https://openalex.org/keywords/ras-activation","display_name":"Ras activation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange","display_name":"guanine nucleotide exchange","score":0.8190000057220459},{"id":"https://openalex.org/keywords/allosteric-activation","display_name":"allosteric activation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/conformational-switch","display_name":"conformational switching","score":0.8199999928474426},{"id":"https://openalex.org/keywords/helical-hairpin","display_name":"helical hairpin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/steric-occlusion","display_name":"steric occlusion","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.9072463512420654},{"id":"https://openalex.org/C2778583388","wikidata":"https://www.wikidata.org/wiki/Q3775177","display_name":"Cdc25","level":5,"score":0.8723534345626831},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.7766702175140381},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4923659563064575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4752975404262543},{"id":"https://openalex.org/C2775889303","wikidata":"https://www.wikidata.org/wiki/Q17146891","display_name":"Dictyostelium","level":3,"score":0.4197961390018463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41071265935897827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39166972041130066},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3551117777824402},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3324441909790039},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3018847703933716},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.2484111189842224},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.07073920965194702},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020666","descriptor_name":"ras-GRF1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020666","descriptor_name":"ras-GRF1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020837","descriptor_name":"SOS1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020837","descriptor_name":"SOS1 Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0608127103","doi":"https://doi.org/10.1073/pnas.0608127103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0608127103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:17075039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17075039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1629002","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1629002/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1629002","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1629002/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1808841604","display_name":null,"funder_award_id":"GM50945","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2181398155","display_name":"Tumor Virus Host Interactions","funder_award_id":"P01CA028146","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4234251209","display_name":"CHILDRENS CANCER GROUP","funder_award_id":"U10CA055362","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5334013676","display_name":"Sequence and Environmental Determinants of the Protein Energy Landscape","funder_award_id":"R01GM050945","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5592985994","display_name":"Engineered Antibody EGFR Antagonist Cancer Therapeutics","funder_award_id":"R01CA096504","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000142712","display_name":null,"funder_award_id":"GM50945","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W154635582","https://openalex.org/W243303449","https://openalex.org/W1539796472","https://openalex.org/W1612570252","https://openalex.org/W1824220821","https://openalex.org/W1849458801","https://openalex.org/W1966360216","https://openalex.org/W1971475788","https://openalex.org/W1995017064","https://openalex.org/W1995682111","https://openalex.org/W2004638925","https://openalex.org/W2009484032","https://openalex.org/W2016765195","https://openalex.org/W2022840517","https://openalex.org/W2026370952","https://openalex.org/W2029443323","https://openalex.org/W2041223728","https://openalex.org/W2043820536","https://openalex.org/W2052845309","https://openalex.org/W2053632669","https://openalex.org/W2057193041","https://openalex.org/W2058083313","https://openalex.org/W2058691244","https://openalex.org/W2068064315","https://openalex.org/W2078163944","https://openalex.org/W2095724872","https://openalex.org/W2106993162","https://openalex.org/W2110863368","https://openalex.org/W2134059200","https://openalex.org/W2135815512","https://openalex.org/W2156470803","https://openalex.org/W2156571424","https://openalex.org/W2183571846","https://openalex.org/W2333205235","https://openalex.org/W4244736178"],"related_works":["https://openalex.org/W2007064403","https://openalex.org/W2885398742","https://openalex.org/W1824220821","https://openalex.org/W2106993162","https://openalex.org/W2057193041","https://openalex.org/W2067772577","https://openalex.org/W2156470803","https://openalex.org/W4389510026","https://openalex.org/W2295122842","https://openalex.org/W2079233342"],"abstract_inverted_index":{"The":[0],"Ras-specific":[1],"guanine":[2,11],"nucleotide-exchange":[3],"factors":[4],"Son":[5],"of":[6,26,34,55,112,118,127,135,146,154,164,178,191,210],"sevenless":[7],"(Sos)":[8],"and":[9,78,115,133,186],"Ras":[10,20,47,68,81,88,140,149,184],"nucleotide-releasing":[12],"factor":[13],"1":[14],"(RasGRF1)":[15],"transduce":[16],"extracellular":[17],"stimuli":[18],"into":[19],"activation":[21,145,241],"by":[22,93,98,148],"catalyzing":[23],"the":[24,38,51,64,75,96,113,125,155,169,179,192,207,222,229,239],"exchange":[25,92],"Ras-bound":[27],"GDP":[28],"for":[29,45,246],"GTP.":[30],"A":[31,189],"truncated":[32],"form":[33],"RasGRF1":[35,194,211,237],"containing":[36],"only":[37],"core":[39],"catalytic":[40,65,171,180],"Cdc25":[41,53,76,116,195,208,230],"domain":[42,54,77,157,196,209,231],"is":[43,57,159,212,244],"sufficient":[44],"stimulating":[46],"nucleotide":[48,91,187],"exchange,":[49],"whereas":[50],"isolated":[52,193],"Sos":[56,119,136,147,170,247],"inactive.":[58],"At":[59],"a":[60,80,109,152,162,165],"site":[61],"distal":[62],"to":[63,70,138,161,214],"site,":[66,181],"nucleotide-bound":[67],"binds":[69],"Sos,":[71,94],"making":[72],"contacts":[73],"with":[74,79,202,228],"exchanger":[82],"motif":[83],"(Rem)":[84],"domain.":[85],"This":[86,173],"allosteric":[87,144,240],"binding":[89,185],"stimulates":[90],"but":[95],"mechanism":[97],"which":[99],"this":[100,131],"stimulation":[101],"occurs":[102,150],"has":[103,225],"not":[104],"been":[105],"defined.":[106],"We":[107],"present":[108],"crystal":[110],"structure":[111,132,190],"Rem":[114,156],"domains":[117],"determined":[120,197],"at":[121,168,198],"2.0-A":[122],"resolution":[123],"in":[124,219],"absence":[126],"Ras.":[128],"Differences":[129],"between":[130],"that":[134,143,158,206,236,243],"bound":[137],"two":[139],"molecules":[141],"show":[142],"through":[151],"rotation":[153,163],"coupled":[160],"helical":[166,223],"hairpin":[167,224],"site.":[172],"motion":[174],"relieves":[175],"steric":[176],"occlusion":[177],"allowing":[182],"substrate":[183],"exchange.":[188],"2.2-A":[199],"resolution,":[200],"combined":[201],"computational":[203],"analyses,":[204],"suggests":[205],"able":[213],"maintain":[215],"an":[216],"active":[217],"conformation":[218],"isolation":[220],"because":[221],"strengthened":[226],"interactions":[227],"core.":[232],"These":[233],"results":[234],"indicate":[235],"lacks":[238],"switch":[242],"crucial":[245],"activity.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
