{"id":"https://openalex.org/W2041850264","doi":"https://doi.org/10.2741/3502","title":"Clonal expansion of HTLV-1 infected cells depends on the CD4 versus CD8 phenotype","display_name":"Clonal expansion of HTLV-1 infected cells depends on the CD4 versus CD8 phenotype","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2041850264","doi":"https://doi.org/10.2741/3502","mag":"2041850264","pmid":"https://pubmed.ncbi.nlm.nih.gov/19273324"},"language":"en","primary_location":{"id":"doi:10.2741/3502","doi":"https://doi.org/10.2741/3502","is_oa":true,"landing_page_url":"https://doi.org/10.2741/3502","pdf_url":"https://www.fbscience.com/Landmark/articles/pdf/Landmark3502.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.fbscience.com/Landmark/articles/pdf/Landmark3502.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054016628","display_name":"Linda K. Zane","orcid":"https://orcid.org/0000-0002-1097-8075","observed_orcids":["https://orcid.org/0000-0002-1097-8075"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Linda Zane","raw_affiliation_strings":["Oncovirology and Biotherapy, FRE CNRS 3011 Lyon I University, Leon Berard Center, Lyon France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncovirology and Biotherapy, FRE CNRS 3011 Lyon I University, Leon Berard Center, Lyon France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210105738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054016628"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210105738"],"apc_list":null,"apc_paid":null,"fwci":1.7915,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84448184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"Volume","issue":"14","first_page":"3935","last_page":"3935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/adult-t-cell-leukemia-lymphoma","display_name":"adult T-cell leukemia/lymphoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4560000002384186},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.7699999809265137},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7590000033378601},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9380000233650208},{"id":"https://openalex.org/keywords/deltaretrovirus","display_name":"deltaretrovirus","score":0.847000002861023},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7251501679420471},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6577664613723755},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5991363525390625},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47263309359550476},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4487548768520355},{"id":"https://openalex.org/C2776913467","wikidata":"https://www.wikidata.org/wiki/Q7667895","display_name":"T-cell leukemia","level":3,"score":0.4454341232776642},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4292992353439331},{"id":"https://openalex.org/C2777868816","wikidata":"https://www.wikidata.org/wiki/Q5134952","display_name":"Clonal deletion","level":5,"score":0.42246881127357483},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3899936079978943},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.34158724546432495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32408958673477173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.256134569644928},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24516692757606506},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2341553270816803},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16418060660362244},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.0832013189792633}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015493","descriptor_name":"Paraparesis, Tropical Spastic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015493","descriptor_name":"Paraparesis, Tropical Spastic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2741/3502","doi":"https://doi.org/10.2741/3502","is_oa":true,"landing_page_url":"https://doi.org/10.2741/3502","pdf_url":"https://www.fbscience.com/Landmark/articles/pdf/Landmark3502.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},{"id":"pmid:19273324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19273324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioscience (Landmark edition)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05795563v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05795563","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioscience, 2009, Volume (14), pp.3935. &#x27E8;10.2741/3502&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2741/3502","doi":"https://doi.org/10.2741/3502","is_oa":true,"landing_page_url":"https://doi.org/10.2741/3502","pdf_url":"https://www.fbscience.com/Landmark/articles/pdf/Landmark3502.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2041850264.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2127719142","https://openalex.org/W7134615220","https://openalex.org/W166472954","https://openalex.org/W7143526630","https://openalex.org/W2117217972","https://openalex.org/W2148445464","https://openalex.org/W2580951476","https://openalex.org/W2160927245","https://openalex.org/W7138125798","https://openalex.org/W3126941418"],"abstract_inverted_index":{"As":[0],"other":[1],"deltaretroviruses":[2],"HTLV-1":[3,85,124,162],"replication":[4],"in":[5,63,100,147],"vivo":[6,27],"includes":[7],"a":[8,60,127],"first":[9],"short":[10],"step":[11],"of":[12,23,48,76,84,120,161],"reverse":[13],"transcription":[14],"that":[15,45,130],"is":[16,46,131],"followed":[17],"by":[18],"the":[19,31,37,49,74,81,101,105,108,138,158],"persistent":[20],"clonal":[21,82],"expansion":[22,83],"infected":[24,53,112,135,152],"cells.":[25],"In":[26,79],"these":[28],"cells":[29,54,149],"include":[30],"CD4+":[32,50,89,114,134],"and":[33,71,88,144],"CD8+":[34,69,87],"lymphocytes":[35,70,90,115],"yet":[36],"virus":[38],"induces":[39],"adult":[40],"T":[41],"cell":[42,98,109,142],"leukemia/lymphoma":[43],"(ATLL)":[44],"regularly":[47],"phenotype.":[51],"Cloned":[52],"from":[55,150],"individuals":[56,153],"without":[57],"malignancy":[58],"possess":[59],"dramatic":[61],"increase":[62],"spontaneous":[64],"proliferation,":[65],"which":[66],"predominated":[67],"with":[68],"depends":[72],"on":[73,92],"amount":[75],"tax":[77],"mRNA.":[78],"fact,":[80],"positive":[86],"relies":[91],"two":[93],"distinct":[94],"mechanisms:":[95],"infection":[96,125],"prevented":[97],"death":[99],"former":[102],"whereas":[103],"recruiting":[104],"latter":[106],"into":[107],"cycle.":[110],"Furthermore":[111],"tax-expressing":[113],"cumulate":[116],"cellular":[117],"defects":[118],"characteristic":[119],"genetic":[121],"instability.":[122],"Therefore,":[123],"establishes":[126],"preleukemic":[128],"phenotype":[129],"restricted":[132],"to":[133,156],"clones.":[136],"Investigating":[137],"mechanisms":[139],"underlying":[140],"apoptosis,":[141],"cycling":[143],"DNA":[145],"repair":[146],"cloned":[148],"naturally":[151],"will":[154],"permit":[155],"deciphering":[157],"molecular":[159],"pathogenesis":[160],"infection.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
