{"id":"https://openalex.org/W2041821145","doi":"https://doi.org/10.1590/s0004-27302006000200023","title":"Orlistat and cardiovascular risk profile in hypertensive patients with metabolic syndrome: the ARCOS study","display_name":"Orlistat and cardiovascular risk profile in hypertensive patients with metabolic syndrome: the ARCOS study","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2041821145","doi":"https://doi.org/10.1590/s0004-27302006000200023","mag":"2041821145","pmid":"https://pubmed.ncbi.nlm.nih.gov/16767303"},"language":"en","primary_location":{"id":"doi:10.1590/s0004-27302006000200023","doi":"https://doi.org/10.1590/s0004-27302006000200023","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302006000200023","pdf_url":"https://www.scielo.br/j/abem/a/6hRDrtq4rzykxSqL64MSjBv/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/abem/a/6hRDrtq4rzykxSqL64MSjBv/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086288331","display_name":"Maria Teresa Zanella","orcid":"https://orcid.org/0000-0002-8451-8522","observed_orcids":["https://orcid.org/0000-0002-8451-8522"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Teresa Zanella","raw_affiliation_strings":["Federal University of S\u00e3o Paulo","Federal University of Sao Paulo#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Federal University of Sao Paulo#TAB#","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041811700","display_name":"Marcelo Hiroshi Uehara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Hiroshi Uehara","raw_affiliation_strings":["Federal University of S\u00e3o Paulo","Federal University of Sao Paulo#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Federal University of Sao Paulo#TAB#","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045970850","display_name":"Artur Beltrame Ribeiro","orcid":"https://orcid.org/0000-0002-8624-5302","observed_orcids":["https://orcid.org/0000-0002-8624-5302"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Artur Beltrame Ribeiro","raw_affiliation_strings":["Federal University of S\u00e3o Paulo","Federal University of Sao Paulo#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Federal University of Sao Paulo#TAB#","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000936383","display_name":"Marcelo Chiara Bertolami","orcid":"https://orcid.org/0000-0003-0801-9729","observed_orcids":["https://orcid.org/0000-0003-0801-9729"]},"institutions":[{"id":"https://openalex.org/I4210152499","display_name":"Instituto Dante Pazzanese de Cardiologia","ror":"https://ror.org/04spxqa35","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210152499"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Bertolami","raw_affiliation_strings":["Instituto Dante Pazzaneze de Cardiologia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Dante Pazzaneze de Cardiologia","institution_ids":["https://openalex.org/I4210152499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082942532","display_name":"Ana Claudia Falsetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Claudia Falsetti","raw_affiliation_strings":["Roche Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Laboratories","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029516416","display_name":"Mirela A. Yunes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirela A. Yunes","raw_affiliation_strings":["Roche Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Laboratories","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7619,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7148445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"50","issue":"2","first_page":"368","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orlistat","display_name":"orlistat","score":1.0},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9879999756813049},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7429999709129333},{"id":"https://openalex.org/keywords/coronary-heart-disease-risk","display_name":"coronary heart disease risk","score":0.871999979019165},{"id":"https://openalex.org/keywords/framingham-risk-score","display_name":"Framingham risk score","score":0.972000002861023},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7039999961853027},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6290000081062317},{"id":"https://openalex.org/keywords/type-2-diabetes-prevention","display_name":"type 2 diabetes prevention","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.5350000262260437},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9100069403648376},{"id":"https://openalex.org/C2780780548","wikidata":"https://www.wikidata.org/wiki/Q424163","display_name":"Orlistat","level":4,"score":0.7493470311164856},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7155332565307617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7086740732192993},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6071515083312988},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5673938393592834},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5269713401794434},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5253716707229614},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48658978939056396},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.47710639238357544},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4740447998046875},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.45786741375923157},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4352490305900574},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4335668683052063},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25693485140800476}],"mesh":[{"descriptor_ui":"D000077403","descriptor_name":"Orlistat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D049629","descriptor_name":"Waist-Hip Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1590/s0004-27302006000200023","doi":"https://doi.org/10.1590/s0004-27302006000200023","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302006000200023","pdf_url":"https://www.scielo.br/j/abem/a/6hRDrtq4rzykxSqL64MSjBv/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},{"id":"pmid:16767303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16767303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos brasileiros de endocrinologia e metabologia","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:2788255","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/3047","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:scielo:S0004-27302006000200023","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0004-27302006000200023","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp;amp; Metabologia v.50 n.2 2006","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2630502","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000200023","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp;amp; Metabologia v.50 n.2 2006","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/3047","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/3047","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2154811707","doi":null,"is_oa":false,"landing_page_url":"https://scielo.br/pdf/abem/v50n2/29320.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1590/s0004-27302006000200023","doi":"https://doi.org/10.1590/s0004-27302006000200023","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302006000200023","pdf_url":"https://www.scielo.br/j/abem/a/6hRDrtq4rzykxSqL64MSjBv/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2041821145.pdf","grobid_xml":"https://content.openalex.org/works/W2041821145.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1582605484","https://openalex.org/W1961815438","https://openalex.org/W1963734433","https://openalex.org/W1964227153","https://openalex.org/W1973098415","https://openalex.org/W1980641839","https://openalex.org/W1988913139","https://openalex.org/W2008736090","https://openalex.org/W2015605491","https://openalex.org/W2015918699","https://openalex.org/W2029664864","https://openalex.org/W2053054105","https://openalex.org/W2064584917","https://openalex.org/W2066051121","https://openalex.org/W2069680000","https://openalex.org/W2090824142","https://openalex.org/W2096190290","https://openalex.org/W2108606500","https://openalex.org/W2116891025","https://openalex.org/W2134860420","https://openalex.org/W2147098206","https://openalex.org/W2157135485","https://openalex.org/W2158822657","https://openalex.org/W2165884492","https://openalex.org/W2168615474","https://openalex.org/W2241709104","https://openalex.org/W2303071711","https://openalex.org/W2324163371","https://openalex.org/W2332951586","https://openalex.org/W2400714626","https://openalex.org/W2409215037","https://openalex.org/W2416966076","https://openalex.org/W4243187460","https://openalex.org/W4246683151"],"related_works":["https://openalex.org/W2154811707","https://openalex.org/W2109800077","https://openalex.org/W2069680000","https://openalex.org/W2001589173","https://openalex.org/W1987922225","https://openalex.org/W2419572901","https://openalex.org/W2384300889","https://openalex.org/W2065732781","https://openalex.org/W2040009966","https://openalex.org/W2092486561"],"abstract_inverted_index":{"Weight":[0],"loss":[1,21,161],"improves":[2],"metabolic":[3,29],"abnormalities":[4],"and":[5,76,100,201,212],"reduces":[6],"cardiovascular":[7],"risk":[8,46,57,157,208],"in":[9,58,127,144,165,173],"obese":[10],"hypertensive":[11,26],"patients.":[12],"To":[13],"evaluate":[14],"the":[15,91,94,107,116,119,125,133,136],"impact":[16],"of":[17,53,93,118,135,167,209],"a":[18,142,155,203],"sustained":[19],"weight":[20,160],"on":[22],"coronary":[23,54,145,210],"risk,":[24,151],"181":[25],"patients":[27,149,185],"with":[28,171,178],"syndrome":[30],"underwent":[31],"to":[32,69,83,115,124,139,154,199],"orlistat":[33,196],"therapy,":[34,44],"120":[35],"mg,":[36],"t.i.d.,":[37],"plus":[38],"diet":[39],"for":[40,51],"36":[41],"weeks.":[42],"During":[43],"Framingham":[45],"scores":[47],"(FRS)":[48],"were":[49,112],"calculated":[50],"determination":[52],"heart":[55],"disease":[56,211],"ten":[59],"years.":[60],"Body":[61],"mass":[62],"index":[63],"decreased":[64],"from":[65,79],"35.0":[66],"+/-":[67,71,81,85],"4.2":[68],"32.6":[70],"4.5":[72],"kg/m(2)":[73],"(p<":[74,88,191],"0.0001)":[75],"waist":[77],"circumference":[78],"108.1":[80],"10.1":[82],"100.5":[84],"11.1":[86],"cm":[87],"0.0001),":[89],"at":[90,132,150],"end":[92,117,134],"study":[95],"period":[96],"(week":[97],"36).":[98],"Systolic":[99],"diastolic":[101],"blood":[102],"pressure":[103],"showed":[104],"reductions":[105],"after":[106],"two":[108],"first":[109],"weeks,":[110],"which":[111],"maintained":[113],"up":[114],"study.":[120],"A":[121,159],"clear":[122],"shift":[123],"left":[126],"FRS":[128],"distribution":[129],"curve":[130],"occurred":[131,164],"study,":[137],"compared":[138],"baseline,":[140],"indicating":[141],"reduction":[143],"risk.":[146],"Over":[147],"all":[148,168],"49.2%":[152],"moved":[153],"lower":[156,204],"category.":[158],">":[162],"5%":[163],"64.6%":[166],"patients,":[169],"associated":[170],"improvement":[172],"glucose":[174,180,189,214],"metabolism.":[175],"Among":[176],"those":[177],"abnormal":[179],"metabolism,":[181,215],"38":[182],"out":[183],"53":[184],"(71.7%)":[186],"improved":[187],"their":[188],"tolerance":[190],"0.0005).":[192],"In":[193],"conclusion,":[194],"long-term":[195],"therapy":[197],"helps":[198],"reduce":[200],"maintain":[202],"body":[205],"weight,":[206],"decreasing":[207],"improving":[213],"thus":[216],"protecting":[217],"against":[218],"type":[219],"2":[220],"diabetes.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}