{"id":"https://openalex.org/W2041817396","doi":"https://doi.org/10.3346/jkms.1996.11.3.250","title":"Effects of calcium antagonists on contractions of chorionic arteries in normal and preeclampsia placenta","display_name":"Effects of calcium antagonists on contractions of chorionic arteries in normal and preeclampsia placenta","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2041817396","doi":"https://doi.org/10.3346/jkms.1996.11.3.250","mag":"2041817396","pmid":"https://pubmed.ncbi.nlm.nih.gov/8843008","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3054054"},"language":"en","primary_location":{"id":"doi:10.3346/jkms.1996.11.3.250","doi":"https://doi.org/10.3346/jkms.1996.11.3.250","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.1996.11.3.250","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-11-250.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-11-250.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034313842","display_name":"Hyun Yi Kook","orcid":"https://orcid.org/0000-0002-0740-1806","observed_orcids":["https://orcid.org/0000-0002-0740-1806"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Kook","raw_affiliation_strings":["Department of Pharmacology, Chonnam University Medical School, Kwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Chonnam University Medical School, Kwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102310036","display_name":"Young Don Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Don Yoon","raw_affiliation_strings":["Department of Pharmacology, Chonnam University Medical School, Kwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Chonnam University Medical School, Kwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111642372","display_name":"Yung Hong Baik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yung Hong Baik","raw_affiliation_strings":["Department of Pharmacology, Chonnam University Medical School, Kwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Chonnam University Medical School, Kwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111277659"],"apc_list":{"value":900000,"currency":"KRW","value_usd":690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.18759558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"3","first_page":"250","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.7990000247955322},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":1.0},{"id":"https://openalex.org/keywords/diltiazem","display_name":"diltiazem","score":1.0},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.6499999761581421},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.878000020980835},{"id":"https://openalex.org/keywords/potassium-induced-contraction","display_name":"potassium-induced contraction","score":0.6579999923706055},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.9210000038146973},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9909999966621399},{"id":"https://openalex.org/keywords/endothelium","display_name":"endothelium","score":0.7509999871253967},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.7555931806564331},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7126651406288147},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.7084243297576904},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6733823418617249},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6575914621353149},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.6498953104019165},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.5965208411216736},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5662040710449219},{"id":"https://openalex.org/C2776741139","wikidata":"https://www.wikidata.org/wiki/Q422229","display_name":"Diltiazem","level":3,"score":0.510837972164154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4935187101364136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4222852289676666},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.4153786301612854},{"id":"https://openalex.org/C2778524494","wikidata":"https://www.wikidata.org/wiki/Q967433","display_name":"Cyclic nucleotide","level":4,"score":0.41284823417663574},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.24848538637161255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19102269411087036},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.13697537779808044},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12066042423248291},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.10456669330596924},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.10447704792022705},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3346/jkms.1996.11.3.250","doi":"https://doi.org/10.3346/jkms.1996.11.3.250","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.1996.11.3.250","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-11-250.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3054054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3054054","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Korean Med Sci","raw_type":"Text"},{"id":"pmid:8843008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8843008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean medical science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3346/jkms.1996.11.3.250","doi":"https://doi.org/10.3346/jkms.1996.11.3.250","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.1996.11.3.250","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-11-250.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2041817396.pdf"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1996542720","https://openalex.org/W2016976308","https://openalex.org/W2039458448","https://openalex.org/W2044806678","https://openalex.org/W2051578385","https://openalex.org/W2057668671","https://openalex.org/W2168996754","https://openalex.org/W2406337914"],"related_works":["https://openalex.org/W2030883406","https://openalex.org/W2035992288","https://openalex.org/W2060660587","https://openalex.org/W2067157599","https://openalex.org/W2012673054","https://openalex.org/W2414680874","https://openalex.org/W2033245156","https://openalex.org/W2078438994","https://openalex.org/W2016378113","https://openalex.org/W2892836454"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,91,141,148,182],"undertaken":[3],"to":[4,15,219],"observe":[5],"the":[6,17,24,28,65,84,88,101,124,136,205,215,220],"effects":[7],"of":[8,19,51,87,103,208,214,223],"organic":[9],"or":[10,33,188],"inorganic":[11],"calcium":[12,224],"antagonists":[13],"and":[14,37,44,54,61,73,83,108,120,129,211],"investigate":[16],"involvement":[18],"cyclic":[20,155,171,176,179,196,199],"nucleotides":[21],"in":[22,27,47,76,80,115,158,203,217,231],"regulating":[23,204],"vascular":[25,206],"tone":[26,207],"chorionic":[29,48,117,134,209],"artery":[30,210,216],"from":[31,229],"normal":[32,53,116,232],"preeclamptic":[34,55,98,133],"placenta.":[35,233],"KCI":[36,72,128],"prostaglandin":[38],"(PG)":[39],"F2":[40],"alpha":[41,75],"produced":[42,70],"marked":[43],"constant":[45],"contractions":[46],"arterial":[49],"preparations":[50,163],"both":[52,81,159,162],"placentas.":[56],"Nifedipine":[57],"(NIF),":[58],"verapamil":[59],"(VER)":[60],"diltiazem":[62],"(DIL)":[63],"reduced":[64],"tension":[66,125],"that":[67,145,194,212,230],"had":[68],"been":[69],"by":[71,106,127,139,146,165,184],"PGF2":[74,130,166],"a":[77],"concentration-dependent":[78],"fashion":[79],"preparations,":[82],"potency":[85],"order":[86],"three":[89],"agents":[90],"NIF":[92,107],">":[93,95],"VER":[94],"DIL.":[96],"In":[97,132,161],"arteries,":[99],"however,":[100],"magnitudes":[102],"vasodilatation":[104,137],"induced":[105,126,138],"DIL":[109],"were":[110],"much":[111],"smaller":[112],"than":[113],"those":[114],"arteries.":[118],"Mg2+":[119,140],"Cd2+":[121,147],"also":[122],"relaxed":[123],"alpha.":[131],"artery,":[135],"significantly":[142],"potentiated,":[143],"while":[144],"not.":[149],"Removing":[150],"endothelium":[151],"did":[152],"not":[153],"alter":[154],"GMP":[156,172,177,200],"content":[157,181],"preparations.":[160],"contracted":[164],"alpha,":[167],"nitroprusside":[168],"markedly":[169],"increased":[170],"content,":[173],"but":[174],"neither":[175,195],"nor":[178,198],"AMP":[180,197],"affected":[183],"acetylcholine,":[185],"NIF,":[186],"isopro-terenol,":[187],"Mg2+.":[189],"The":[190],"above":[191],"results":[192],"suggest":[193],"is":[201],"involved":[202],"sensitivity":[213],"preeclampsia":[218],"inhibitory":[221],"action":[222],"antagonist":[225],"might":[226],"be":[227],"different":[228]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}