{"id":"https://openalex.org/W2041796574","doi":"https://doi.org/10.4088/jcp.v67n1118","title":"Alzheimer's Disease A Century Later","display_name":"Alzheimer's Disease A Century Later","publication_year":2006,"publication_date":"2006-11-15","ids":{"openalex":"https://openalex.org/W2041796574","doi":"https://doi.org/10.4088/jcp.v67n1118","mag":"2041796574","pmid":"https://pubmed.ncbi.nlm.nih.gov/17196061"},"language":"en","primary_location":{"id":"doi:10.4088/jcp.v67n1118","doi":"https://doi.org/10.4088/jcp.v67n1118","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.v67n1118","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074086871","display_name":"Richard J. Caselli","orcid":"https://orcid.org/0000-0001-5784-2987","observed_orcids":["https://orcid.org/0000-0001-5784-2987"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Caselli","raw_affiliation_strings":["Department of Neurology, Mayo Clinic and Arizona Alzheimer's Disease Consortium, Scottsdale 85259, USA. Caselli.Richard@Mayo.edu","Department of Neurology, Mayo Clinic and Arizona Alzheimer's Disease Consortium, Scottsdale 85259, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic and Arizona Alzheimer's Disease Consortium, Scottsdale 85259, USA. Caselli.Richard@Mayo.edu","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Department of Neurology, Mayo Clinic and Arizona Alzheimer's Disease Consortium, Scottsdale 85259, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072613176","display_name":"Thomas G. Beach","orcid":"https://orcid.org/0000-0003-3296-6128","observed_orcids":["https://orcid.org/0000-0003-3296-6128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas G. Beach","raw_affiliation_strings":["W. H. Civin Laboratory for Neuropathology, Sun Health Research Institute and Arizona Alzheimer's Disease Consortium, Sun City, AZ, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. H. Civin Laboratory for Neuropathology, Sun Health Research Institute and Arizona Alzheimer's Disease Consortium, Sun City, AZ, US","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roy Yaari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152203","display_name":"Banner Alzheimer\u2019s Institute","ror":"https://ror.org/023jwkg52","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4387152203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy Yaari","raw_affiliation_strings":["Banner Alzheimer's Institute and Arizona Alzheimer's Disease Consortium, Phoenix, AZ, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Alzheimer's Institute and Arizona Alzheimer's Disease Consortium, Phoenix, AZ, US","institution_ids":["https://openalex.org/I4387152203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047768726","display_name":"Eric M. Reiman","orcid":"https://orcid.org/0000-0002-0705-3696","observed_orcids":["https://orcid.org/0000-0002-0705-3696"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4387152203","display_name":"Banner Alzheimer\u2019s Institute","ror":"https://ror.org/023jwkg52","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4387152203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Reiman","raw_affiliation_strings":["Banner Alzheimer's Institute, Neurogenomics Division, Translational Genomics Research Institute, the Department of Psychiatry, University of Arizona, and Arizona Alzheimer's Disease Consortium, Phoenix, AZ, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Alzheimer's Institute, Neurogenomics Division, Translational Genomics Research Institute, the Department of Psychiatry, University of Arizona, and Arizona Alzheimer's Disease Consortium, Phoenix, AZ, US","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I138006243","https://openalex.org/I4387152203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.5172,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.97647837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"67","issue":"11","first_page":"1784","last_page":"1800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.6909999847412109},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.972000002861023},{"id":"https://openalex.org/keywords/neuritic-plaques","display_name":"neuritic plaques","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":1.0},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.5899999737739563},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.4359999895095825},{"id":"https://openalex.org/keywords/treatment","display_name":"treatment","score":0.6359999775886536},{"id":"https://openalex.org/keywords/behavioral-symptoms","display_name":"behavioral symptoms","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.593999981880188},{"id":"https://openalex.org/keywords/prevention","display_name":"prevention","score":0.38199999928474426},{"id":"https://openalex.org/keywords/primary-and-secondary-prevention","display_name":"primary and secondary prevention","score":0.5139999985694885},{"id":"https://openalex.org/keywords/driving-cessation","display_name":"driving cessation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/residential-care","display_name":"residential care","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5536500215530396},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.531862199306488},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4417315721511841},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3510492146015167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3316273093223572},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08680638670921326}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012598","descriptor_name":"Sclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4088/jcp.v67n1118","doi":"https://doi.org/10.4088/jcp.v67n1118","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.v67n1118","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},{"id":"pmid:17196061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17196061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1312448696","display_name":null,"funder_award_id":"MH057899-06","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G513408367","display_name":null,"funder_award_id":"P30 AG-19610-01","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5789671569","display_name":"PET, APOE & The Preclinical Course of Alzheimer Disease","funder_award_id":"R01MH057899","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G704822541","display_name":"Arizona Alzheimer's Disease Core Center","funder_award_id":"P30AG019610","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":192,"referenced_works":["https://openalex.org/W81352527","https://openalex.org/W92525294","https://openalex.org/W114781849","https://openalex.org/W126151141","https://openalex.org/W1526863987","https://openalex.org/W1545450610","https://openalex.org/W1589418222","https://openalex.org/W1603244154","https://openalex.org/W1693283493","https://openalex.org/W1837896746","https://openalex.org/W1883948802","https://openalex.org/W1895538680","https://openalex.org/W1963905681","https://openalex.org/W1964203272","https://openalex.org/W1965793399","https://openalex.org/W1966607391","https://openalex.org/W1968942251","https://openalex.org/W1971310777","https://openalex.org/W1972477405","https://openalex.org/W1974439414","https://openalex.org/W1974574717","https://openalex.org/W1974701449","https://openalex.org/W1979065513","https://openalex.org/W1979477211","https://openalex.org/W1980001884","https://openalex.org/W1980774978","https://openalex.org/W1980786936","https://openalex.org/W1981220714","https://openalex.org/W1982556153","https://openalex.org/W1985528178","https://openalex.org/W1986144956","https://openalex.org/W1986748953","https://openalex.org/W1987925748","https://openalex.org/W1988211686","https://openalex.org/W1989146486","https://openalex.org/W1989451265","https://openalex.org/W1989538668","https://openalex.org/W1990582551","https://openalex.org/W1991952617","https://openalex.org/W1991993391","https://openalex.org/W1992007228","https://openalex.org/W1992681087","https://openalex.org/W1992959071","https://openalex.org/W1994685984","https://openalex.org/W1995006422","https://openalex.org/W1996372359","https://openalex.org/W1997226034","https://openalex.org/W1999631936","https://openalex.org/W2000733339","https://openalex.org/W2002894477","https://openalex.org/W2004209268","https://openalex.org/W2005206672","https://openalex.org/W2011364876","https://openalex.org/W2011617651","https://openalex.org/W2012168902","https://openalex.org/W2014670147","https://openalex.org/W2015001118","https://openalex.org/W2016698723","https://openalex.org/W2017231145","https://openalex.org/W2017294885","https://openalex.org/W2020471014","https://openalex.org/W2023121717","https://openalex.org/W2028494426","https://openalex.org/W2028545299","https://openalex.org/W2028937059","https://openalex.org/W2030269791","https://openalex.org/W2031709382","https://openalex.org/W2032070606","https://openalex.org/W2034963833","https://openalex.org/W2036362108","https://openalex.org/W2037968780","https://openalex.org/W2039664444","https://openalex.org/W2041789591","https://openalex.org/W2042266730","https://openalex.org/W2042665602","https://openalex.org/W2042885626","https://openalex.org/W2044914106","https://openalex.org/W2046209489","https://openalex.org/W2047660069","https://openalex.org/W2048532208","https://openalex.org/W2050784521","https://openalex.org/W2051530804","https://openalex.org/W2051788298","https://openalex.org/W2052725315","https://openalex.org/W2054089714","https://openalex.org/W2054519576","https://openalex.org/W2055649795","https://openalex.org/W2057679568","https://openalex.org/W2058034919","https://openalex.org/W2058059121","https://openalex.org/W2058513135","https://openalex.org/W2060352042","https://openalex.org/W2065052203","https://openalex.org/W2068201336","https://openalex.org/W2068401546","https://openalex.org/W2068817417","https://openalex.org/W2072691846","https://openalex.org/W2075478727","https://openalex.org/W2077533946","https://openalex.org/W2078718001","https://openalex.org/W2081331575","https://openalex.org/W2082324417","https://openalex.org/W2083633251","https://openalex.org/W2084957666","https://openalex.org/W2086357634","https://openalex.org/W2086363884","https://openalex.org/W2086793697","https://openalex.org/W2087840791","https://openalex.org/W2088410896","https://openalex.org/W2089292460","https://openalex.org/W2090496922","https://openalex.org/W2091159443","https://openalex.org/W2091635052","https://openalex.org/W2092171180","https://openalex.org/W2093290371","https://openalex.org/W2096410114","https://openalex.org/W2097524879","https://openalex.org/W2099489910","https://openalex.org/W2099614709","https://openalex.org/W2101265858","https://openalex.org/W2102319322","https://openalex.org/W2102572922","https://openalex.org/W2102716324","https://openalex.org/W2103440561","https://openalex.org/W2103705156","https://openalex.org/W2103807862","https://openalex.org/W2104893553","https://openalex.org/W2105755033","https://openalex.org/W2106900897","https://openalex.org/W2108563688","https://openalex.org/W2108851081","https://openalex.org/W2112150247","https://openalex.org/W2112436745","https://openalex.org/W2113708991","https://openalex.org/W2114624908","https://openalex.org/W2114953476","https://openalex.org/W2116145543","https://openalex.org/W2116424646","https://openalex.org/W2117618489","https://openalex.org/W2118592618","https://openalex.org/W2119682588","https://openalex.org/W2121732554","https://openalex.org/W2122692162","https://openalex.org/W2125471430","https://openalex.org/W2126346838","https://openalex.org/W2126974689","https://openalex.org/W2129029307","https://openalex.org/W2129269087","https://openalex.org/W2130035294","https://openalex.org/W2131266318","https://openalex.org/W2131851314","https://openalex.org/W2133324295","https://openalex.org/W2138878035","https://openalex.org/W2142803335","https://openalex.org/W2143746808","https://openalex.org/W2146729934","https://openalex.org/W2149614271","https://openalex.org/W2152681246","https://openalex.org/W2153402143","https://openalex.org/W2153631628","https://openalex.org/W2154170073","https://openalex.org/W2154463941","https://openalex.org/W2154882333","https://openalex.org/W2155406256","https://openalex.org/W2155513557","https://openalex.org/W2156220037","https://openalex.org/W2156998090","https://openalex.org/W2157067671","https://openalex.org/W2157359173","https://openalex.org/W2159122349","https://openalex.org/W2159789463","https://openalex.org/W2160810023","https://openalex.org/W2161695527","https://openalex.org/W2162298355","https://openalex.org/W2163784847","https://openalex.org/W2167720733","https://openalex.org/W2168558795","https://openalex.org/W2169096667","https://openalex.org/W2169119607","https://openalex.org/W2169758229","https://openalex.org/W2171264766","https://openalex.org/W2171405125","https://openalex.org/W2171960085","https://openalex.org/W2172183046","https://openalex.org/W2188679450","https://openalex.org/W2192576612","https://openalex.org/W2295393683","https://openalex.org/W2398208871","https://openalex.org/W2464308055","https://openalex.org/W2590411450","https://openalex.org/W4244977113","https://openalex.org/W4254525260"],"related_works":["https://openalex.org/W7151855831","https://openalex.org/W3082714046","https://openalex.org/W7222228887","https://openalex.org/W4247353609","https://openalex.org/W3207170903","https://openalex.org/W2236987351","https://openalex.org/W2084172837","https://openalex.org/W118275422","https://openalex.org/W2038129982","https://openalex.org/W4211036635"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"provide":[2],"a":[3,98,141,265],"current":[4],"survey":[5],"of":[6,21,28,73,113,121,131,138,157,162,178,194,215,218,237,243],"the":[7,41,46,61,69,93,110,118,129,216,219,230,241],"clinical":[8,136,160],"and":[9,14,19,25,52,55,80,105,109,128,133,143,148,166,173,189,206,235,239,257],"pathologic":[10],"features,":[11],"known":[12],"genetic":[13],"suggested":[15],"pathogenic":[16],"contributions,":[17],"diagnosis,":[18],"treatment":[20],"Alzheimer's":[22,62,196,208],"disease":[23,63,197,209],"(AD)":[24],"related":[26],"forms":[27,156],"dementia.":[29,158],"DATA":[30,65],"SOURCES:":[31],"PubMed":[32],"was":[33],"searched":[34],"for":[35,169],"specific":[36],"indexing":[37],"terms":[38],"identified":[39],"by":[40,97],"authors":[42],"as":[43,86,180,182,186,198,200],"relevant":[44],"to":[45,89,152,204,212,253,263],"topic.":[47],"Also":[48],"included":[49],"were":[50],"diagnostic":[51],"consensus":[53],"criteria":[54],"classic":[56],"references":[57],"long":[58],"standing":[59],"in":[60,77,103,229,240,261],"literature.":[64],"SYNTHESIS:":[66],"AD":[67,122,139,163,238],"is":[68,83,95],"most":[70],"common":[71,155],"form":[72],"disabling":[74],"cognitive":[75,107],"impairment":[76],"older":[78,90],"persons,":[79],"its":[81],"prevalence":[82],"rapidly":[84],"growing":[85],"people":[87],"live":[88],"ages.":[91],"Clinically,":[92],"disorder":[94],"characterized":[96],"gradual":[99],"but":[100],"progressive":[101],"decline":[102],"memory":[104],"other":[106,174],"domains":[108],"frequent":[111],"occurrence":[112],"noncognitive":[114],"behavioral":[115],"symptoms.":[116],"Neuropathologically,":[117],"cardinal":[119],"features":[120],"include":[123],"neuritic":[124],"plaques,":[125],"neuro-fibrillary":[126],"tangles,":[127],"loss":[130],"synapses":[132],"neurons.":[134],"The":[135,159],"evaluation":[137],"includes":[140,164],"history":[142],"physical":[144],"examination,":[145],"laboratory":[146],"tests,":[147],"structural":[149],"brain":[150],"imaging":[151],"exclude":[153],"less":[154],"management":[161],"medication":[165],"nonmedication":[167],"strategies":[168],"addressing":[170],"cognitive,":[171],"behavioral,":[172],"commonly":[175],"associated":[176],"symptoms":[177],"patients":[179],"well":[181,199],"lifestyle":[183],"changes":[184],"such":[185],"driving":[187],"cessation":[188],"residential":[190],"care.":[191],"Genetic":[192],"causes":[193],"familial":[195],"genes":[201],"that":[202],"predispose":[203],"late-onset":[205],"sporadic":[207],"have":[210],"led":[211],"greater":[213],"understanding":[214],"pathophysiology":[217],"neurodegenerative":[220],"process.":[221],"CONCLUSIONS:":[222],"While":[223],"there":[224,247],"has":[225],"been":[226],"great":[227],"promise":[228],"scientific":[231],"understanding,":[232],"early":[233],"detection,":[234],"tracking":[236],"discovery":[242],"promising":[244],"disease-slowing":[245],"treatments,":[246],"remains":[248],"an":[249],"unmet":[250],"urgent":[251],"need":[252],"identify":[254],"effective":[255],"primary":[256],"secondary":[258],"prevention":[259],"therapies":[260],"order":[262],"avert":[264],"financially":[266],"overwhelming":[267],"public":[268],"health":[269],"problem.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}