{"id":"https://openalex.org/W2041647799","doi":"https://doi.org/10.1530/jrf.0.0450437","title":"EMBRYONIC MORTALITY DURING THE PRE- AND POST-IMPLANTATION PERIODS OF PREGNANCY IN MATURE MICE AFTER SUPEROVULATION","display_name":"EMBRYONIC MORTALITY DURING THE PRE- AND POST-IMPLANTATION PERIODS OF PREGNANCY IN MATURE MICE AFTER SUPEROVULATION","publication_year":1975,"publication_date":"1975-12-01","ids":{"openalex":"https://openalex.org/W2041647799","doi":"https://doi.org/10.1530/jrf.0.0450437","mag":"2041647799","pmid":"https://pubmed.ncbi.nlm.nih.gov/1206643"},"language":"en","primary_location":{"id":"doi:10.1530/jrf.0.0450437","doi":"https://doi.org/10.1530/jrf.0.0450437","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0450437","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/45/3/jrf_45_3_004.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/45/3/jrf_45_3_004.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000890226","display_name":"Heather M. Beaumont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"HEATHER M. BEAUMONT","raw_affiliation_strings":["Department of Anatomy ,","Medical School , University of Birmingham , Birmingham 15","Department of Anatomy, Medical School, University of Birmingham, Birmingham 15","Department of Pathology, St Paul's Hospital, 24 Endell Street, London WC2H 9AE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy ,","institution_ids":[]},{"raw_affiliation_string":"Medical School , University of Birmingham , Birmingham 15","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Anatomy, Medical School, University of Birmingham, Birmingham 15","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Pathology, St Paul's Hospital, 24 Endell Street, London WC2H 9AE","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"AGNES F. SMITH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"AGNES F. SMITH","raw_affiliation_strings":["Department of Anatomy ,","Medical School , University of Birmingham , Birmingham 15","Department of Anatomy, Medical School, University of Birmingham, Birmingham 15","Department of Pathology, St Paul's Hospital, 24 Endell Street, London WC2H 9AE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy ,","institution_ids":[]},{"raw_affiliation_string":"Medical School , University of Birmingham , Birmingham 15","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Anatomy, Medical School, University of Birmingham, Birmingham 15","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Pathology, St Paul's Hospital, 24 Endell Street, London WC2H 9AE","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79619799"],"apc_list":null,"apc_paid":null,"fwci":0.9096,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.65881624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"3","first_page":"437","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryonic-mortality","display_name":"embryonic mortality","score":0.9620000123977661},{"id":"https://openalex.org/keywords/superovulation","display_name":"superovulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.6729999780654907},{"id":"https://openalex.org/keywords/oocyte-loss","display_name":"oocyte loss","score":0.5519999861717224},{"id":"https://openalex.org/keywords/implantation","display_name":"implantation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.6669999957084656},{"id":"https://openalex.org/keywords/developmental-delay","display_name":"developmental delay","score":0.6909999847412109},{"id":"https://openalex.org/keywords/conceptus","display_name":"conceptus","score":0.47099998593330383},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7741044759750366},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7154719829559326},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6414932012557983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.626266598701477},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.6084007024765015},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.5708841681480408},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.546394944190979},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5082342028617859},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4835505187511444},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34187039732933044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27227503061294556},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0742926299571991},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005313","descriptor_name":"Fetal Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010060","descriptor_name":"Ovulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013480","descriptor_name":"Superovulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D020964","descriptor_name":"Embryo Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/jrf.0.0450437","doi":"https://doi.org/10.1530/jrf.0.0450437","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0450437","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/45/3/jrf_45_3_004.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:1206643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1206643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of reproduction and fertility","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1530/jrf.0.0450437","doi":"https://doi.org/10.1530/jrf.0.0450437","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0450437","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/45/3/jrf_45_3_004.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2041647799.pdf","grobid_xml":"https://content.openalex.org/works/W2041647799.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W139509657","https://openalex.org/W199869775","https://openalex.org/W270916537","https://openalex.org/W1515059751","https://openalex.org/W1520498118","https://openalex.org/W1586947583","https://openalex.org/W1945781875","https://openalex.org/W1990245754","https://openalex.org/W2008230904","https://openalex.org/W2011468645","https://openalex.org/W2035582388","https://openalex.org/W2048840540","https://openalex.org/W2053245344","https://openalex.org/W2061351785","https://openalex.org/W2085099340","https://openalex.org/W2110310104","https://openalex.org/W2123947187","https://openalex.org/W2124819812","https://openalex.org/W2128526399","https://openalex.org/W2342468466","https://openalex.org/W2491859759","https://openalex.org/W2750291023"],"related_works":["https://openalex.org/W2409481415","https://openalex.org/W2256629103","https://openalex.org/W1965230064","https://openalex.org/W7169937917","https://openalex.org/W2099401496","https://openalex.org/W2067064741","https://openalex.org/W2131644540","https://openalex.org/W2090797760","https://openalex.org/W2057043485","https://openalex.org/W2138609171"],"abstract_inverted_index":{"Sexually":[0],"mature":[1],"mice":[2,106],"were":[3,114],"stimulated":[4],"to":[5,156],"superovulate":[6],"by":[7,31,95,159],"giving":[8],"exogenous":[9],"gonadotrophins":[10],"at":[11,71,82,134,153],"known":[12],"stages":[13,56],"of":[14,28,38,41,43,48,57,64,79,92,111,131,140],"the":[15,39,46,52,62,68,112,123,129,138,147],"oestrous":[16],"cycle.":[17],"Untreated":[18],"animals":[19,97],"which":[20,107],"ovulated":[21,30,94],"spontaneously":[22],"served":[23],"as":[24,143],"controls.":[25,124,151],"The":[26,89,162],"number":[27,40,63,91,139],"oocytes":[29,93],"each":[32],"female":[33],"was":[34,59,98],"estimated":[35],"from":[36,61,67],"counts":[37],"CL":[42],"pregnancy,":[44],"and":[45,54,73,78,84,133,136,166],"incidence":[47],"embryonic":[49,173],"mortality":[50],"during":[51],"pre-":[53],"post-implantation":[55],"pregnancy":[58],"assessed":[60],"zygotes":[65],"recovered":[66],"reproductive":[69],"tract":[70],"2-0":[72],"4-0":[74],"days":[75,86],"post":[76,87],"coitum":[77],"conceptuses":[80],"examined":[81],"7-5":[83],"11-5":[85],"coitum.":[88],"mean":[90],"treated":[96],"39-54,":[99],"compared":[100,118],"with":[101,119],"12-80":[102],"in":[103,105,122,150,172],"controls:":[104],"had":[108],"superovulated,":[109],"44%":[110],"ova":[113],"lost":[115],"before":[116],"implantation":[117,132],"about":[120,128],"10%":[121],"Further":[125],"losses":[126],"occurred":[127],"time":[130],"mid-pregnancy":[135,154],"thus":[137],"embryos":[141],"classified":[142],"normal":[144],"rarely":[145],"exceeded":[146],"maximum":[148],"found":[149],"Death":[152],"seemed":[155],"be":[157],"preceded":[158],"developmental":[160],"retardation.":[161],"possibility":[163],"that":[164],"genetic":[165],"environmental":[167],"factors":[168],"play":[169],"a":[170],"role":[171],"loss":[174],"after":[175],"superovulation":[176],"is":[177],"discussed.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
