{"id":"https://openalex.org/W2041620107","doi":"https://doi.org/10.1016/0165-5728(94)90113-9","title":"Immunopharmacological profile of SR 31747: In vitro and in vivo studies on humoral and cellular responses","display_name":"Immunopharmacological profile of SR 31747: In vitro and in vivo studies on humoral and cellular responses","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2041620107","doi":"https://doi.org/10.1016/0165-5728(94)90113-9","mag":"2041620107","pmid":"https://pubmed.ncbi.nlm.nih.gov/8034758"},"language":"en","primary_location":{"id":"doi:10.1016/0165-5728(94)90113-9","doi":"https://doi.org/10.1016/0165-5728(94)90113-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-5728(94)90113-9","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110276611","display_name":"Pierre Casellas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Casellas","raw_affiliation_strings":["Department of Immunopharmacology, Sanofi Recherche, Montpellier, France","Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, Montpellier, France","institution_ids":["https://openalex.org/I3018075036"]},{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109881655","display_name":"Bernard Bourri\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Bourri\u00e9","raw_affiliation_strings":["Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013170200","display_name":"Xavier Canat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Canat","raw_affiliation_strings":["Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pierre Carayon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Carayon","raw_affiliation_strings":["Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Isabelle Buisson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Buisson","raw_affiliation_strings":["Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033184991","display_name":"Raymond Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raymond Paul","raw_affiliation_strings":["Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111621439","display_name":"Jean-Claude Breli\u00e8re","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Claude Breli\u00e8re","raw_affiliation_strings":["Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopharmacology, Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111932689","display_name":"G\u00e9rard Le Fur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G\u00e9rard Le Fur","raw_affiliation_strings":["Sanofi Recherche, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi Recherche, Paris, France","institution_ids":["https://openalex.org/I3018075036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3018075036"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":4.5606,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.95655783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"52","issue":"2","first_page":"193","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sigma-receptor-ligands","display_name":"sigma receptor ligands","score":0.7300000190734863},{"id":"https://openalex.org/keywords/sigma-receptors","display_name":"sigma receptors","score":0.6830000281333923},{"id":"https://openalex.org/keywords/lymphocyte-proliferation-inhibition","display_name":"lymphocyte proliferation inhibition","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.6830000281333923},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.6790000200271606},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8080000281333923},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/granuloma-formation","display_name":"granuloma formation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7672833204269409},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.744889497756958},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6871293187141418},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.592636227607727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5207971930503845},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46276986598968506},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.460682213306427},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44316476583480835},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4274406135082245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4044948220252991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3613775372505188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1997905671596527},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006087","descriptor_name":"Graft vs Host Reaction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006824","descriptor_name":"Hybridization, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013163","descriptor_name":"Splenomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-5728(94)90113-9","doi":"https://doi.org/10.1016/0165-5728(94)90113-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-5728(94)90113-9","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},{"id":"pmid:8034758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8034758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroimmunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W72396953","https://openalex.org/W197781038","https://openalex.org/W1506157243","https://openalex.org/W1523175658","https://openalex.org/W1526963379","https://openalex.org/W1533596330","https://openalex.org/W1886668162","https://openalex.org/W1980181546","https://openalex.org/W1982912920","https://openalex.org/W1985027818","https://openalex.org/W1992364117","https://openalex.org/W1999048700","https://openalex.org/W2003532781","https://openalex.org/W2012204136","https://openalex.org/W2020920014","https://openalex.org/W2021718755","https://openalex.org/W2038651264","https://openalex.org/W2053872497","https://openalex.org/W2069055948","https://openalex.org/W2074900847","https://openalex.org/W2077467843","https://openalex.org/W2131812998","https://openalex.org/W2142616095","https://openalex.org/W2172937773","https://openalex.org/W2256829083","https://openalex.org/W2782175582","https://openalex.org/W2915222326"],"related_works":["https://openalex.org/W1982571745","https://openalex.org/W2039594774","https://openalex.org/W4256210712","https://openalex.org/W1947910184","https://openalex.org/W2418490482","https://openalex.org/W2097346383","https://openalex.org/W2110332742","https://openalex.org/W2068675983","https://openalex.org/W1977075261","https://openalex.org/W1993196185"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}