{"id":"https://openalex.org/W2041551978","doi":"https://doi.org/10.1185/0300799009117013","title":"Efficacy and Tolerability of a Low-dose of Oesclim \u00ae (25 mcg Daily) in the Management of Symptomatic Menopausal Women: A French Open-label Study","display_name":"Efficacy and Tolerability of a Low-dose of Oesclim \u00ae (25 mcg Daily) in the Management of Symptomatic Menopausal Women: A French Open-label Study","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2041551978","doi":"https://doi.org/10.1185/0300799009117013","mag":"2041551978","pmid":"https://pubmed.ncbi.nlm.nih.gov/10893653"},"language":"en","primary_location":{"id":"doi:10.1185/0300799009117013","doi":"https://doi.org/10.1185/0300799009117013","is_oa":false,"landing_page_url":"https://doi.org/10.1185/0300799009117013","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108825048","display_name":"D. Elia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Elia","raw_affiliation_strings":["Director of Menopause Centres, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Director of Menopause Centres, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002893009","display_name":"Alain Tamborini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166892","display_name":"H\u00f4pital Boucicaut","ror":"https://ror.org/04j0szy54","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235","https://openalex.org/I4210166892"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Tamborini","raw_affiliation_strings":["H\u00f4pital Boucicaut, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Boucicaut, Paris, France","institution_ids":["https://openalex.org/I4210166892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006386005","display_name":"Yann L\u00e9ocmach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Leocmach","raw_affiliation_strings":["Laboratoires Fournier, Daix, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Fournier, Daix, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060889352","display_name":"Harbajan Chadha\u2010Boreham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Chadha-Boreham","raw_affiliation_strings":["Laboratoires Fournier, Daix, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Fournier, Daix, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4213,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62186426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"16","issue":"2","first_page":"94","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-dose-hormone-replacement-therapy","display_name":"low-dose hormone replacement therapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9100000262260437},{"id":"https://openalex.org/keywords/menopausal-symptoms","display_name":"menopausal symptoms","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/treatment-tolerability","display_name":"treatment tolerability","score":0.8429999947547913},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5350000262260437},{"id":"https://openalex.org/keywords/progestogens","display_name":"progestogens","score":0.5019999742507935},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.8140000104904175},{"id":"https://openalex.org/keywords/risk-benefit-ratio","display_name":"risk-benefit ratio","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9770668745040894},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.9284261465072632},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.49944067001342773},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.46793124079704285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42615413665771484},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3903566896915436},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019584","descriptor_name":"Hot Flashes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1185/0300799009117013","doi":"https://doi.org/10.1185/0300799009117013","is_oa":false,"landing_page_url":"https://doi.org/10.1185/0300799009117013","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"doi:10.1185/030079900542894","doi":"https://doi.org/10.1185/030079900542894","is_oa":false,"landing_page_url":"https://doi.org/10.1185/030079900542894","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:10893653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10893653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1964646109","https://openalex.org/W1964770647","https://openalex.org/W1991043147","https://openalex.org/W1995128734","https://openalex.org/W1996599354","https://openalex.org/W1997728756","https://openalex.org/W2000339436","https://openalex.org/W2003292227","https://openalex.org/W2005769596","https://openalex.org/W2035358354","https://openalex.org/W2047001294","https://openalex.org/W2048617987","https://openalex.org/W2053530432","https://openalex.org/W2077919450","https://openalex.org/W2078921288","https://openalex.org/W2081278964","https://openalex.org/W2113371921","https://openalex.org/W2146272590","https://openalex.org/W2316785482","https://openalex.org/W2338482410","https://openalex.org/W3022017015"],"related_works":["https://openalex.org/W2117788428","https://openalex.org/W1991177028","https://openalex.org/W1980832622","https://openalex.org/W2005769596","https://openalex.org/W2314858614","https://openalex.org/W1989023295","https://openalex.org/W2053490973","https://openalex.org/W2110755366","https://openalex.org/W2030433763","https://openalex.org/W2417580015"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"establish":[2],"the":[3,97,110,130,143,156,172,177,180,184,200],"proportion":[4],"of":[5,91,103,116,171,176,183,234],"symptomatic":[6],"postmenopausal":[7,227],"women,":[8],"whose":[9],"HRT":[10],"treatment":[11,40,71,185,190],"is":[12,240],"initiated":[13,44,191],"on":[14,22,106],"Oesclim":[15,46,59,107,131,135,164,206,213,216],"25,":[16],"who":[17],"can":[18,221],"be":[19,56],"satisfactorily":[20],"maintained":[21],"this":[23],"low":[24,194,217],"dose":[25,157,195,218],"after":[26,63],"two":[27,64],"months.":[28],"STUDY":[29],"DESIGN":[30],"AND":[31],"PATIENTS:":[32],"This":[33],"was":[34,43,76,119,152,158,196],"an":[35,73],"open-label,":[36],"multicentre,":[37],"non-comparative,":[38],"four-month":[39],"study.":[41,98,112],"Treatment":[42],"with":[45,72,202,229],"25":[47,52,108,132,207],"(17":[48],"beta-oestradiol":[49],"transdermal":[50],"patch,":[51],"mcg/day).":[53],"Dosage":[54],"could":[55],"increased":[57],"to":[58,67,163],"50":[60,136],"if":[61],"required":[62],"months,":[65],"according":[66],"clinical":[68],"evaluation.":[69],"Sequential":[70],"oral":[74],"progestagen":[75],"also":[77],"given":[78],"for":[79,245],">":[80],"or":[81],"=":[82],"12":[83],"days/month":[84],"in":[85,96,129,145,160,225],"all":[86],"non-hysterectomised":[87],"women.":[88],"A":[89],"total":[90],"1465":[92],"women":[93,228],"were":[94],"included":[95],"RESULTS:":[99],"82.3%":[100],"(CI:":[101],"80.1-84.4)":[102],"patients":[104,161,178],"remained":[105],"across":[109],"whole":[111],"The":[113,236],"mean":[114],"number":[115],"hot":[117,146],"flushes":[118,147],"reduced":[120],"similarly":[121],"by":[122],"93%":[123],"and":[124,134,148,174],"94%":[125],"at":[126,140,192],"month":[127,141],"4":[128],"group":[133],"group,":[137],"respectively.":[138],"However,":[139],"2":[142],"decrease":[144],"other":[149],"menopausal":[150],"symptoms":[151,224],"less":[153],"marked":[154],"until":[155],"adjusted,":[159],"switching":[162],"50.":[165,214],"In":[166],"a":[167,193,203,230],"global":[168],"evaluation,":[169],"97.5%":[170],"investigators":[173],"95.7%":[175],"rated":[179],"overall":[181],"efficacy":[182],"as":[186,208],"good/very":[187],"good.":[188],"Overall,":[189],"well":[197],"tolerated":[198,211],"throughout":[199],"study,":[201],"trend":[204],"showing":[205],"being":[209],"better":[210],"than":[212],"CONCLUSION:":[215],"(25":[219],"mcg)":[220],"effectively":[222],"reduce":[223],"most":[226],"very":[231],"satisfactory":[232],"level":[233],"tolerability.":[235],"risk/benefit":[237],"ratio":[238],"observed":[239],"probably":[241],"one":[242],"key":[243],"reason":[244],"good":[246],"patient":[247],"compliance.":[248]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
