{"id":"https://openalex.org/W2041422804","doi":"https://doi.org/10.1042/bst0360357","title":"TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic \u03b2-cells","display_name":"TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic \u03b2-cells","publication_year":2008,"publication_date":"2008-05-21","ids":{"openalex":"https://openalex.org/W2041422804","doi":"https://doi.org/10.1042/bst0360357","mag":"2041422804","pmid":"https://pubmed.ncbi.nlm.nih.gov/18481957"},"language":"en","primary_location":{"id":"doi:10.1042/bst0360357","doi":"https://doi.org/10.1042/bst0360357","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst0360357","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041957858","display_name":"Merewyn K. Loder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Merewyn\u00a0K. Loder","raw_affiliation_strings":["Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089992606","display_name":"Gabriela da Silva Xavier","orcid":"https://orcid.org/0000-0002-0678-012X","observed_orcids":["https://orcid.org/0000-0002-0678-012X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gabriela\u00a0da\u00a0Silva Xavier","raw_affiliation_strings":["Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027499712","display_name":"Angela McDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Angela McDonald","raw_affiliation_strings":["Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guy\u00a0A. Rutter","raw_affiliation_strings":["Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College, Faculty of Medicine, Department of Cell Biology, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, U.K","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":4.7014,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.9531938,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"36","issue":"3","first_page":"357","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tcf7l2","display_name":"TCF7L2","score":1.0},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/insulin-expression","display_name":"insulin gene expression","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7559999823570251},{"id":"https://openalex.org/keywords/rs7903146","display_name":"rs7903146","score":0.9620000123977661},{"id":"https://openalex.org/keywords/rna-silencing","display_name":"RNA silencing","score":0.597000002861023},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6510000228881836},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C39263347","wikidata":"https://www.wikidata.org/wiki/Q14913892","display_name":"TCF7L2","level":5,"score":0.8794569969177246},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7113750576972961},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6200099587440491},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6158927083015442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6152262687683105},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5781728029251099},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.5455765724182129},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48044368624687195},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4527187943458557},{"id":"https://openalex.org/C98335778","wikidata":"https://www.wikidata.org/wiki/Q425185","display_name":"Glucokinase","level":3,"score":0.4189961552619934},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.39246758818626404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3635687828063965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15454986691474915},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12044000625610352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10035437345504761}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051820","descriptor_name":"TCF Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051820","descriptor_name":"TCF Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bst0360357","doi":"https://doi.org/10.1042/bst0360357","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst0360357","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},{"id":"pmid:18481957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18481957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/2430b1f9-a8f0-43df-964b-504bb01b2f12","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/2430b1f9-a8f0-43df-964b-504bb01b2f12","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Loder, M K, da Silva Xavier, G, McDonald, A & Rutter, G A 2008, 'TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells', Biochemical Society Transactions, vol. 36, no. Pt 3, pp. 357-9. https://doi.org/10.1042/BST0360357","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4407712938","display_name":"Molecular mechanisms of glucose sensing by pancreatic islet B-cells.","funder_award_id":"067081","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6129361817","display_name":"The role of PAS domain containing protein kinase in pancreatic ?-cell function","funder_award_id":"13/0004672","funder_id":"https://openalex.org/F4320320065","funder_display_name":"Diabetes UK"},{"id":"https://openalex.org/G6611224400","display_name":"Molecular mechanisms of glucose sending by pancreatic islet b-cells and hypothalamic neurons.","funder_award_id":"081958/Z/07/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320065","display_name":"Diabetes UK","ror":"https://ror.org/050rgn017"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1959438396","https://openalex.org/W1965929705","https://openalex.org/W1966650637","https://openalex.org/W1985620791","https://openalex.org/W2025143098","https://openalex.org/W2028458054","https://openalex.org/W2075387442","https://openalex.org/W2078591745","https://openalex.org/W2091664732","https://openalex.org/W2118543841","https://openalex.org/W2132717133","https://openalex.org/W2134635889","https://openalex.org/W2138638445","https://openalex.org/W2150447119","https://openalex.org/W2165353287","https://openalex.org/W6640998155"],"related_works":["https://openalex.org/W7098548227","https://openalex.org/W2111824788","https://openalex.org/W2086087017","https://openalex.org/W2124655787","https://openalex.org/W2732196290","https://openalex.org/W1962785595","https://openalex.org/W7096424123","https://openalex.org/W1966650637","https://openalex.org/W2010876773","https://openalex.org/W2132717133"],"abstract_inverted_index":{"Genetic":[0],"studies":[1],"have":[2,32],"linked":[3],"the":[4,16,19,52,61,70,86,91,98],"risk":[5,30],"of":[6,51,63,93,100],"Type":[7],"2":[8],"diabetes":[9],"with":[10,35],"SNPs":[11],"(single":[12],"nucleotide":[13],"polymorphisms)":[14],"in":[15,65,76,108,131],"gene":[17,106,123],"encoding":[18],"Wnt":[20],"signalling-associated":[21],"transcription":[22],"factor,":[23],"TCF7L2":[24,64,77,101,115],"(T-cell":[25],"factor":[26],"7-like":[27],"2).":[28],"The":[29],"alleles":[31],"been":[33],"associated":[34],"reduced":[36,114],"glucose":[37,128],"and":[38,105,121],"GLP-1":[39],"(glucagon-like":[40],"peptide":[41],"1)-stimulated":[42],"insulin":[43,81,103,119,122],"secretion.":[44],"Recent":[45],"evidence":[46],"has":[47],"suggested":[48],"that":[49,113],"inheritance":[50],"at-risk":[53],"T":[54],"allele":[55],"at":[56],"SNP":[57],"rs7903146":[58],"may":[59,79],"increase":[60],"expression":[62,107,116,124],"adult":[66],"human":[67],"islets.":[68,110],"However,":[69],"cellular":[71],"mechanisms":[72],"by":[73],"which":[74],"changes":[75,130],"levels":[78],"affect":[80],"secretion":[82,104,120],"are":[83],"unclear.":[84],"In":[85],"present":[87],"paper,":[88],"we":[89],"describe":[90],"use":[92],"RNA":[94],"silencing":[95],"to":[96],"investigate":[97],"role":[99],"on":[102],"rodent":[109],"We":[111],"find":[112],"reduces":[117],"glucose-simulated":[118],"while":[125],"slightly":[126],"potentiating":[127],"stimulated":[129],"intracellular":[132],"free":[133],"Ca(2+)":[134],"concentrations.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
