{"id":"https://openalex.org/W2041301976","doi":"https://doi.org/10.1016/0014-5793(92)80506-c","title":"The amino acid composition is different between the cytoplasmic and extracellular sides in membrane proteins","display_name":"The amino acid composition is different between the cytoplasmic and extracellular sides in membrane proteins","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2041301976","doi":"https://doi.org/10.1016/0014-5793(92)80506-c","mag":"2041301976","pmid":"https://pubmed.ncbi.nlm.nih.gov/1607012"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(92)80506-c","doi":"https://doi.org/10.1016/0014-5793(92)80506-c","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(92)80506-c","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054093764","display_name":"Hiroshi Nakashima","orcid":"https://orcid.org/0000-0001-9678-9234","observed_orcids":["https://orcid.org/0000-0001-9678-9234"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Nakashima","raw_affiliation_strings":["School of Allied Medical Professions, Kanazawa University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Allied Medical Professions, Kanazawa University, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045866467","display_name":"Kazuya Nishikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nishikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.1905,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.78016733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"303","issue":"2-3","first_page":"141","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transmembrane-proteins","display_name":"transmembrane proteins","score":0.8100000023841858},{"id":"https://openalex.org/keywords/amino-acid-composition","display_name":"amino acid composition","score":0.9769999980926514},{"id":"https://openalex.org/keywords/membrane-orientation","display_name":"membrane orientation","score":0.42500001192092896},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.6600000262260437},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/threonine","display_name":"threonine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cystine","display_name":"cystine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sequence-based-prediction","display_name":"sequence-based prediction","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.9094105958938599},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.7393505573272705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6351820230484009},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6304800510406494},{"id":"https://openalex.org/C2777608289","wikidata":"https://www.wikidata.org/wiki/Q408626","display_name":"Cystine","level":4,"score":0.5882625579833984},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5460444092750549},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5373502969741821},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.534859299659729},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.490501344203949},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4544837474822998},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.44076380133628845},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.42905062437057495},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.419522762298584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4174423813819885},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.41535478830337524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40660884976387024},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.39330604672431946},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.15862029790878296},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07567957043647766},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(92)80506-c","doi":"https://doi.org/10.1016/0014-5793(92)80506-c","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(92)80506-c","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:1607012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1607012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W262216995","https://openalex.org/W1246794412","https://openalex.org/W1498772725","https://openalex.org/W1498819321","https://openalex.org/W1522605200","https://openalex.org/W1572826595","https://openalex.org/W1579580511","https://openalex.org/W1600754228","https://openalex.org/W1780090776","https://openalex.org/W1820648369","https://openalex.org/W1821507858","https://openalex.org/W1947481567","https://openalex.org/W1964822816","https://openalex.org/W1966350980","https://openalex.org/W1966964245","https://openalex.org/W1971896762","https://openalex.org/W1977903514","https://openalex.org/W1985899857","https://openalex.org/W1995445964","https://openalex.org/W1995713763","https://openalex.org/W2002085601","https://openalex.org/W2003513113","https://openalex.org/W2007088607","https://openalex.org/W2010874987","https://openalex.org/W2012249011","https://openalex.org/W2013067874","https://openalex.org/W2013127377","https://openalex.org/W2017498808","https://openalex.org/W2019494212","https://openalex.org/W2024302638","https://openalex.org/W2027407556","https://openalex.org/W2028372889","https://openalex.org/W2029766804","https://openalex.org/W2037048489","https://openalex.org/W2038286066","https://openalex.org/W2048602049","https://openalex.org/W2052896363","https://openalex.org/W2054731523","https://openalex.org/W2060311116","https://openalex.org/W2063266718","https://openalex.org/W2065510140","https://openalex.org/W2068760238","https://openalex.org/W2069274271","https://openalex.org/W2070107457","https://openalex.org/W2073421608","https://openalex.org/W2074783201","https://openalex.org/W2076378327","https://openalex.org/W2077136636","https://openalex.org/W2081254674","https://openalex.org/W2084872132","https://openalex.org/W2089728262","https://openalex.org/W2096746841","https://openalex.org/W2098108069","https://openalex.org/W2108631075","https://openalex.org/W2122408798","https://openalex.org/W2126719129","https://openalex.org/W2153712534","https://openalex.org/W2226529940","https://openalex.org/W2346237422","https://openalex.org/W2436075400","https://openalex.org/W2505028576","https://openalex.org/W2600349519","https://openalex.org/W4236697171","https://openalex.org/W4245490409"],"related_works":["https://openalex.org/W7096637328","https://openalex.org/W2169702528","https://openalex.org/W1983464528","https://openalex.org/W2059846299","https://openalex.org/W1251243258","https://openalex.org/W2103102425","https://openalex.org/W1585514291","https://openalex.org/W2013127377","https://openalex.org/W2039587858","https://openalex.org/W3192764854"],"abstract_inverted_index":{"The":[0,21,53],"amino":[1],"acid":[2],"composition":[3,22,54,78],"of":[4,55,60,66,71,81,103],"transmembrane":[5,15],"proteins":[6,62,109,118],"was":[7,23,79,113,120],"analyzed":[8],"for":[9,116],"their":[10],"three":[11],"separate":[12],"portions:":[13],"the":[14,38,42,50,82,86,110],"apolar,":[16],"cytoplasmic":[17,26,39,56,96],"and":[18,27,31,44,57,68],"extracellular":[19,28,51,58,69],"regions.":[20],"different":[24],"between":[25],"peptides:":[29],"alanine":[30],"arginine":[32],"residues":[33],"were":[34,46],"preferentially":[35,47],"sited":[36,48],"on":[37,49],"side,":[40],"while":[41],"threonine":[43],"cysteine/cystine":[45],"side.":[52],"peptides":[59],"membrane":[61,108],"corresponded":[63],"to":[64],"those":[65],"intracellular":[67],"types":[70],"soluble":[72],"proteins,":[73],"respectively.":[74],"This":[75],"difference":[76],"in":[77],"independent":[80],"peptide":[83],"orientation":[84],"against":[85],"membrane.":[87],"Peptide":[88],"chains":[89],"could":[90],"be":[91],"correctly":[92],"assigned":[93],"as":[94],"either":[95],"or":[97],"extracellular,":[98],"solely":[99],"from":[100],"an":[101],"analysis":[102],"sequence":[104],"composition.":[105],"For":[106],"single-spanning":[107],"predictive":[111],"accuracy":[112],"90%,":[114],"whereas":[115],"multi-spanning":[117],"this":[119],"85%.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}