{"id":"https://openalex.org/W2041298534","doi":"https://doi.org/10.1038/nrmicro1816","title":"Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis","display_name":"Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis","publication_year":2007,"publication_date":"2007-12-14","ids":{"openalex":"https://openalex.org/W2041298534","doi":"https://doi.org/10.1038/nrmicro1816","mag":"2041298534","pmid":"https://pubmed.ncbi.nlm.nih.gov/18079742"},"language":"en","primary_location":{"id":"doi:10.1038/nrmicro1816","doi":"https://doi.org/10.1038/nrmicro1816","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrmicro1816","pdf_url":null,"source":{"id":"https://openalex.org/S56802129","display_name":"Nature Reviews Microbiology","issn_l":"1740-1526","issn":["1740-1526","1740-1534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103456216","display_name":"James C. Sacchettini","orcid":"https://orcid.org/0000-0001-5767-2367","observed_orcids":["https://orcid.org/0000-0001-5767-2367"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James C. Sacchettini","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, USA. sacchett@tamu.edu","Department of Biochemistry and Biophysics, Texas A&M University,College Station,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, USA. sacchett@tamu.edu","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University,College Station,USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018392937","display_name":"Eric J. Rubin","orcid":"https://orcid.org/0000-0001-5120-962X","observed_orcids":["https://orcid.org/0000-0001-5120-962X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Rubin","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, 02115, Massachusetts, USA","Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, 02115, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044700909","display_name":"Joel S. Freundlich","orcid":"https://orcid.org/0000-0002-3411-3455","observed_orcids":["https://orcid.org/0000-0002-3411-3455"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel S. Freundlich","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A&M University, College Station, 77843, Texas, USA","Department of Biochemistry and Biophysics, Texas A&M University,College Station,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, 77843, Texas, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University,College Station,USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103456216"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":2.5447,"has_fulltext":false,"cited_by_count":252,"citation_normalized_percentile":{"value":0.92251462,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"41","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tuberculosis-drug-discovery","display_name":"tuberculosis drug discovery","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8690000176429749},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.578000009059906},{"id":"https://openalex.org/keywords/hiv-1-coinfection","display_name":"HIV-1 coinfection","score":0.7919999957084656},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.699999988079071},{"id":"https://openalex.org/keywords/tuberculosis-mortality","display_name":"tuberculosis mortality","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2778059882","wikidata":"https://www.wikidata.org/wiki/Q133780","display_name":"Plague (disease)","level":2,"score":0.7412707209587097},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6894409656524658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6343749761581421},{"id":"https://openalex.org/C2780903317","wikidata":"https://www.wikidata.org/wiki/Q3625599","display_name":"Complicity","level":2,"score":0.6067019104957581},{"id":"https://openalex.org/C2778627824","wikidata":"https://www.wikidata.org/wiki/Q178561","display_name":"Battle","level":2,"score":0.5423027873039246},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5339037179946899},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49528899788856506},{"id":"https://openalex.org/C2780544761","wikidata":"https://www.wikidata.org/wiki/Q1257318","display_name":"Bedaquiline","level":4,"score":0.4400220513343811},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.4309016466140747},{"id":"https://openalex.org/C189326681","wikidata":"https://www.wikidata.org/wiki/Q10294","display_name":"Poverty","level":2,"score":0.4308604896068573},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4284832775592804},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3448466658592224},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.18359479308128357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16855335235595703},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.14575549960136414},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.11007913947105408},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10899412631988525},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrmicro1816","doi":"https://doi.org/10.1038/nrmicro1816","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrmicro1816","pdf_url":null,"source":{"id":"https://openalex.org/S56802129","display_name":"Nature Reviews Microbiology","issn_l":"1740-1526","issn":["1740-1526","1740-1534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Microbiology","raw_type":"journal-article"},{"id":"pmid:18079742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18079742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1402524010","display_name":null,"funder_award_id":"P01A1068135","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W1483135106","https://openalex.org/W1538374398","https://openalex.org/W1540126244","https://openalex.org/W1579095159","https://openalex.org/W1614868353","https://openalex.org/W1643004344","https://openalex.org/W1742005759","https://openalex.org/W1794035661","https://openalex.org/W1964141703","https://openalex.org/W1966642070","https://openalex.org/W1968064650","https://openalex.org/W1968397983","https://openalex.org/W1969586092","https://openalex.org/W1970651561","https://openalex.org/W1973368143","https://openalex.org/W1973789730","https://openalex.org/W1976575734","https://openalex.org/W1976593378","https://openalex.org/W1977086272","https://openalex.org/W1978582732","https://openalex.org/W1979877807","https://openalex.org/W1986111503","https://openalex.org/W1987635163","https://openalex.org/W1987672867","https://openalex.org/W1987864694","https://openalex.org/W1992311897","https://openalex.org/W1998301640","https://openalex.org/W2000287398","https://openalex.org/W2002908181","https://openalex.org/W2004361822","https://openalex.org/W2008541744","https://openalex.org/W2010320265","https://openalex.org/W2012092858","https://openalex.org/W2012171112","https://openalex.org/W2015231189","https://openalex.org/W2017501157","https://openalex.org/W2018408116","https://openalex.org/W2022472102","https://openalex.org/W2024321664","https://openalex.org/W2027887879","https://openalex.org/W2029149752","https://openalex.org/W2031784829","https://openalex.org/W2040624813","https://openalex.org/W2050866306","https://openalex.org/W2051795596","https://openalex.org/W2053229417","https://openalex.org/W2053867514","https://openalex.org/W2058925610","https://openalex.org/W2061843861","https://openalex.org/W2063618543","https://openalex.org/W2065376976","https://openalex.org/W2066958748","https://openalex.org/W2070854001","https://openalex.org/W2072290149","https://openalex.org/W2073691834","https://openalex.org/W2074370114","https://openalex.org/W2074978477","https://openalex.org/W2076822926","https://openalex.org/W2077343916","https://openalex.org/W2082573007","https://openalex.org/W2083217931","https://openalex.org/W2085079876","https://openalex.org/W2085619760","https://openalex.org/W2085684476","https://openalex.org/W2089663335","https://openalex.org/W2093364655","https://openalex.org/W2093431262","https://openalex.org/W2093712250","https://openalex.org/W2093975175","https://openalex.org/W2094761728","https://openalex.org/W2096442566","https://openalex.org/W2096759796","https://openalex.org/W2097233276","https://openalex.org/W2100613152","https://openalex.org/W2102545353","https://openalex.org/W2105716423","https://openalex.org/W2105853963","https://openalex.org/W2107851387","https://openalex.org/W2109725458","https://openalex.org/W2112214408","https://openalex.org/W2114818630","https://openalex.org/W2115619985","https://openalex.org/W2116247422","https://openalex.org/W2117610468","https://openalex.org/W2117800058","https://openalex.org/W2122171540","https://openalex.org/W2123974374","https://openalex.org/W2125249259","https://openalex.org/W2130503164","https://openalex.org/W2131731929","https://openalex.org/W2132514017","https://openalex.org/W2132629607","https://openalex.org/W2132876702","https://openalex.org/W2133587820","https://openalex.org/W2134575107","https://openalex.org/W2135193803","https://openalex.org/W2135271770","https://openalex.org/W2135732933","https://openalex.org/W2137478946","https://openalex.org/W2138250809","https://openalex.org/W2139531099","https://openalex.org/W2140862820","https://openalex.org/W2142907906","https://openalex.org/W2147045968","https://openalex.org/W2147990227","https://openalex.org/W2148523428","https://openalex.org/W2151859311","https://openalex.org/W2152510108","https://openalex.org/W2152562731","https://openalex.org/W2153513099","https://openalex.org/W2155457558","https://openalex.org/W2158023121","https://openalex.org/W2158658436","https://openalex.org/W2159303922","https://openalex.org/W2162246740","https://openalex.org/W2163748812","https://openalex.org/W2164429494","https://openalex.org/W2165705465","https://openalex.org/W2167158113","https://openalex.org/W2168635615","https://openalex.org/W2169800706","https://openalex.org/W2172137232","https://openalex.org/W2233997915","https://openalex.org/W2286754504","https://openalex.org/W2313508918","https://openalex.org/W2327368473","https://openalex.org/W2335208177","https://openalex.org/W2402914344","https://openalex.org/W2406329707","https://openalex.org/W2407788342","https://openalex.org/W4235854857","https://openalex.org/W4248107770","https://openalex.org/W4302369202"],"related_works":["https://openalex.org/W2105290158","https://openalex.org/W3109345941","https://openalex.org/W3007750071","https://openalex.org/W2394426037","https://openalex.org/W4290960184","https://openalex.org/W2806721450","https://openalex.org/W4406974789","https://openalex.org/W2140716928","https://openalex.org/W4283581930","https://openalex.org/W2341435914"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
