{"id":"https://openalex.org/W2041124145","doi":"https://doi.org/10.1364/ao.40.003784","title":"Absolute autofluorescence spectra of human healthy, metaplastic, and early cancerous bronchial tissue in vivo","display_name":"Absolute autofluorescence spectra of human healthy, metaplastic, and early cancerous bronchial tissue in vivo","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2041124145","doi":"https://doi.org/10.1364/ao.40.003784","mag":"2041124145","pmid":"https://pubmed.ncbi.nlm.nih.gov/18360412"},"language":"en","primary_location":{"id":"doi:10.1364/ao.40.003784","doi":"https://doi.org/10.1364/ao.40.003784","is_oa":false,"landing_page_url":"https://doi.org/10.1364/ao.40.003784","pdf_url":null,"source":{"id":"https://openalex.org/S4210211917","display_name":"Applied Optics","issn_l":"0003-6935","issn":["0003-6935","1539-4522","1540-8981","1559-128X","2155-3165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Optics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/109607","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025987389","display_name":"Matthieu Zellweger","orcid":"https://orcid.org/0000-0002-0590-3175","observed_orcids":["https://orcid.org/0000-0002-0590-3175","https://orcid.org/0000-0003-1893-0903"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthieu Zellweger","raw_affiliation_strings":["The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056023007","display_name":"Didier Goujon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Didier Goujon","raw_affiliation_strings":["The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110079184","display_name":"Ramiro Conde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ramiro Conde","raw_affiliation_strings":["The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113557583","display_name":"Martin Forrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin Forrer","raw_affiliation_strings":["The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111547057","display_name":"Hubert van den Bergh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hubert van den Bergh","raw_affiliation_strings":["The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010493249","display_name":"Georges Wagni\u00e8res","orcid":"https://orcid.org/0000-0002-9082-3099","observed_orcids":["https://orcid.org/0000-0002-9082-3099"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Georges Wagni\u00e8res","raw_affiliation_strings":["The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are with Laboratoire de la Pollution Atmosph\u00e9rique et Sol, D\u00e9partement de G\u00e9nie Rural, Institute of Environmental Engineering, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":null,"apc_paid":null,"fwci":2.128,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.85998278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"40","issue":"22","first_page":"3784","last_page":"3784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-autofluorescence","display_name":"tissue autofluorescence","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bronchial-tissue","display_name":"bronchial tissue","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bronchial-metaplasia","display_name":"bronchial metaplasia","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bronchial-dysplasia","display_name":"bronchial dysplasia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/early-detection-of-lung-cancer","display_name":"early detection of lung cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/excitation-wavelength-dependence","display_name":"excitation wavelength dependence","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.9723624587059021},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.6445557475090027},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5988144874572754},{"id":"https://openalex.org/C125245961","wikidata":"https://www.wikidata.org/wiki/Q221656","display_name":"Brightness","level":2,"score":0.5903210043907166},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.5885642170906067},{"id":"https://openalex.org/C6260449","wikidata":"https://www.wikidata.org/wiki/Q41364","display_name":"Wavelength","level":2,"score":0.4882626533508301},{"id":"https://openalex.org/C3232514","wikidata":"https://www.wikidata.org/wiki/Q7575196","display_name":"Spectral imaging","level":2,"score":0.459824800491333},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.42999985814094543},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42284417152404785},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.39367157220840454},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22699090838432312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.062154412269592285},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1364/ao.40.003784","doi":"https://doi.org/10.1364/ao.40.003784","is_oa":false,"landing_page_url":"https://doi.org/10.1364/ao.40.003784","pdf_url":null,"source":{"id":"https://openalex.org/S4210211917","display_name":"Applied Optics","issn_l":"0003-6935","issn":["0003-6935","1539-4522","1540-8981","1559-128X","2155-3165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Optics","raw_type":"journal-article"},{"id":"pmid:18360412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18360412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied optics","raw_type":"Journal Article"},{"id":"pmh:oai:infoscience.epfl.ch:109607","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/109607","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:109607","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/109607","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:109607","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/109607","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1963661495","https://openalex.org/W1967832079","https://openalex.org/W1971795140","https://openalex.org/W1979098622","https://openalex.org/W1991492580","https://openalex.org/W2006119091","https://openalex.org/W2007549293","https://openalex.org/W2008718363","https://openalex.org/W2009990588","https://openalex.org/W2021011001","https://openalex.org/W2021186660","https://openalex.org/W2021468491","https://openalex.org/W2022664743","https://openalex.org/W2025804847","https://openalex.org/W2040218279","https://openalex.org/W2040708168","https://openalex.org/W2047576691","https://openalex.org/W2047639210","https://openalex.org/W2051151920","https://openalex.org/W2059825996","https://openalex.org/W2077458464","https://openalex.org/W2083466906","https://openalex.org/W2089859889","https://openalex.org/W2090601131","https://openalex.org/W2104996384","https://openalex.org/W2108192515","https://openalex.org/W2118963481","https://openalex.org/W2124572395","https://openalex.org/W2124793399","https://openalex.org/W2137304940","https://openalex.org/W2137392373","https://openalex.org/W2142449420","https://openalex.org/W2154216590","https://openalex.org/W2156099567","https://openalex.org/W2157622553","https://openalex.org/W2160721212","https://openalex.org/W2164480795","https://openalex.org/W2168680454","https://openalex.org/W4247503184","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1682414128","https://openalex.org/W1967832079","https://openalex.org/W2168680454","https://openalex.org/W2002765211","https://openalex.org/W1679160976","https://openalex.org/W7135751268","https://openalex.org/W2335778074","https://openalex.org/W1767945747","https://openalex.org/W1993664776","https://openalex.org/W1970878698"],"abstract_inverted_index":{"Autofluorescence":[0],"is":[1,57],"emerging":[2],"as":[3,155],"a":[4,42,58,75,117],"useful":[5],"tool":[6],"for":[7],"the":[8,14,34,37,63,82,87,121,124,131,137,145,150,156,161,169,172],"detection":[9],"of":[10,36,39,45,65,86,130,140,147,149,163,171],"early":[11],"cancers":[12],"in":[13,26,53,61,90],"bronchi.":[15],"It":[16],"has":[17],"already":[18],"produced":[19],"interesting":[20],"results,":[21],"which":[22],"have":[23,50],"been":[24,51],"implemented":[25],"commercial":[27],"imaging":[28,66],"devices.":[29],"Their":[30],"design":[31],"relies":[32],"on":[33,69,96],"spectroscopy":[35,48],"tissues":[38,102],"interest.":[40],"However,":[41],"large":[43],"majority":[44],"these":[46],"autofluorescence":[47,89,151],"studies":[49],"presented":[52],"arbitrary":[54],"units.":[55],"This":[56],"drawback":[59],"for,":[60],"particular,":[62],"designing":[64],"devices":[67],"based":[68],"autofluorescence.":[70],"Using":[71],"correction":[72,78],"factors":[73],"and":[74,99,123],"spectral":[76,84],"sensitivity":[77],"curve,":[79],"we":[80,114],"determined":[81],"absolute":[83],"distribution":[85],"tissue":[88,122],"vivo.":[91],"These":[92],"measurements":[93],"were":[94],"performed":[95],"healthy,":[97],"metaplastic,":[98],"dysplastic":[100],"bronchial":[101],"at":[103,116,168],"several":[104],"excitation":[105,157],"wavelengths":[106,158],"ranging":[107],"from":[108],"350":[109],"to":[110,126,136],"495":[111],"nm.":[112],"Moreover,":[113],"measured":[115],"fixed":[118],"distance":[119],"between":[120],"probe":[125],"avoid":[127],"geometric":[128],"distortions":[129],"spectra":[132],"that":[133,144],"are":[134],"due":[135],"optical":[138],"characteristics":[139],"tissue.":[141],"We":[142],"found":[143],"order":[146,162],"magnitude":[148],"brightness":[152],"was":[153],"stable":[154],"varied":[159],"(on":[160],"5":[164],"pW/muW":[165],"x":[166],"nm":[167],"maximum":[170],"fluorescence":[173],"emission":[174],"spectra).":[175]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
