{"id":"https://openalex.org/W2041098552","doi":"https://doi.org/10.1007/s10637-006-9011-x","title":"A Phase II study of SU5416 in patients with advanced or recurrent head and neck cancers","display_name":"A Phase II study of SU5416 in patients with advanced or recurrent head and neck cancers","publication_year":2006,"publication_date":"2006-09-15","ids":{"openalex":"https://openalex.org/W2041098552","doi":"https://doi.org/10.1007/s10637-006-9011-x","mag":"2041098552","pmid":"https://pubmed.ncbi.nlm.nih.gov/16983506"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-006-9011-x","doi":"https://doi.org/10.1007/s10637-006-9011-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-006-9011-x","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072271778","display_name":"Matthew G. Fury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew G. Fury","raw_affiliation_strings":["Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073682761","display_name":"Andrew J. Zahalsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Zahalsky","raw_affiliation_strings":["Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078178893","display_name":"Richard J. Wong","orcid":"https://orcid.org/0000-0001-6259-7314","observed_orcids":["https://orcid.org/0000-0001-6259-7314"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Wong","raw_affiliation_strings":["Head and Neck Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035446911","display_name":"Ennapadam S. Venkatraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ennapadam Venkatraman","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017686334","display_name":"Eric Lis","orcid":"https://orcid.org/0000-0002-4138-3867","observed_orcids":["https://orcid.org/0000-0002-4138-3867"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Lis","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000790856","display_name":"Lucy E. Hann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy Hann","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018127054","display_name":"Timothy B. Aliff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Aliff","raw_affiliation_strings":["Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109979531","display_name":"William L. Gerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Gerald","raw_affiliation_strings":["Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012521956","display_name":"Martin Fleisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Fleisher","raw_affiliation_strings":["Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005775817","display_name":"David G. Pfister","orcid":"https://orcid.org/0000-0002-2109-3221","observed_orcids":["https://orcid.org/0000-0002-2109-3221"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David G. Pfister","raw_affiliation_strings":["Department of Medicine, 1275 First Avenue, Box 188, New York, NY, 10021, USA","Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, 1275 First Avenue, Box 188, New York, NY, 10021, USA","institution_ids":[]},{"raw_affiliation_string":"Head and Neck Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005775817"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":2.3638,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.88206028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"2","first_page":"165","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.1996999979019165,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/su5416","display_name":"SU5416","score":0.9319999814033508},{"id":"https://openalex.org/keywords/vegfr-2-inhibitors","display_name":"VEGFR-2 inhibitors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/recurrent-or-metastatic-cancer","display_name":"recurrent or metastatic cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-vascularity","display_name":"tumor vascularity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/power-doppler-ultrasound","display_name":"power Doppler","score":0.9440000057220459},{"id":"https://openalex.org/keywords/serum-vegf","display_name":"serum VEGF","score":0.9259999990463257},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.36000001430511475},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5149999856948853},{"id":"https://openalex.org/keywords/carotid-artery-hemorrhage","display_name":"carotid artery hemorrhage","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.7187451720237732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6590340733528137},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5576596856117249},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3819635808467865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33786314725875854},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3308390974998474},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17635291814804077}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10637-006-9011-x","doi":"https://doi.org/10.1007/s10637-006-9011-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-006-9011-x","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:16983506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16983506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1480076252","https://openalex.org/W1555764667","https://openalex.org/W1819301164","https://openalex.org/W1951359666","https://openalex.org/W1952422131","https://openalex.org/W1982595551","https://openalex.org/W2074542185","https://openalex.org/W2101808949","https://openalex.org/W2101886636","https://openalex.org/W2109261874","https://openalex.org/W2117909405","https://openalex.org/W2121713339","https://openalex.org/W2123097882","https://openalex.org/W2149923229","https://openalex.org/W2151079442","https://openalex.org/W2157769714","https://openalex.org/W2160202883","https://openalex.org/W2162117731","https://openalex.org/W2163124389","https://openalex.org/W2163564441","https://openalex.org/W2166573361","https://openalex.org/W2166825418","https://openalex.org/W2167805334","https://openalex.org/W2169475385","https://openalex.org/W2189197096","https://openalex.org/W2247923872","https://openalex.org/W2280283394"],"related_works":["https://openalex.org/W2074542185","https://openalex.org/W1983940745","https://openalex.org/W2155424478","https://openalex.org/W2151079442","https://openalex.org/W7096875110","https://openalex.org/W1785986158","https://openalex.org/W2137841367","https://openalex.org/W2108427446","https://openalex.org/W2166825418","https://openalex.org/W2004264900"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}