{"id":"https://openalex.org/W2040980668","doi":"https://doi.org/10.1083/jcb.140.6.1383","title":"Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion","display_name":"Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion","publication_year":1998,"publication_date":"1998-03-23","ids":{"openalex":"https://openalex.org/W2040980668","doi":"https://doi.org/10.1083/jcb.140.6.1383","mag":"2040980668","pmid":"https://pubmed.ncbi.nlm.nih.gov/9508771","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2132673"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.140.6.1383","doi":"https://doi.org/10.1083/jcb.140.6.1383","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.140.6.1383","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2132673","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026500116","display_name":"Kazufumi Honda","orcid":"https://orcid.org/0000-0003-1321-5345","observed_orcids":["https://orcid.org/0000-0003-1321-5345"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazufumi Honda","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049388697","display_name":"Tesshi Yamada","orcid":"https://orcid.org/0000-0002-6843-7482","observed_orcids":["https://orcid.org/0000-0002-6843-7482"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tesshi Yamada","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077738802","display_name":"Ritsuko Endo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ritsuko Endo","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078011405","display_name":"Yoshinori Ino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Ino","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103514813","display_name":"Masahiro Gotoh","orcid":"https://orcid.org/0009-0005-6808-3900","observed_orcids":["https://orcid.org/0009-0005-6808-3900"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Gotoh","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063851467","display_name":"Hitoshi Tsuda","orcid":"https://orcid.org/0000-0003-3457-4224","observed_orcids":["https://orcid.org/0000-0003-3457-4224"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Tsuda","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111368382","display_name":"Yozo Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yozo Yamada","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110181680","display_name":"Hiroshige Chiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshige Chiba","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113959874","display_name":"Setsuo Hirohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Setsuo Hirohashi","raw_affiliation_strings":["*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan; \u2021Department of Oral and Maxillofacial Surgery, Tokyo Medical College, Tokyo 160, Japan; and \u00a7Hirohashi Cell Configuration Project, ERATO, Japan Scientific and Technology Corporation (JST), Tsukuba 300-26, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4405287541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9102,"has_fulltext":false,"cited_by_count":487,"citation_normalized_percentile":{"value":0.9070258,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"140","issue":"6","first_page":"1383","last_page":"1393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actinin-4","display_name":"actinin-4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/actin-cytoskeleton-regulation","display_name":"actin cytoskeleton regulation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9539999961853027},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7210000157356262},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8550000190734863},{"id":"https://openalex.org/keywords/actin-depolymerization","display_name":"actin depolymerization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7419999837875366},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8180801868438721},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.7390532493591309},{"id":"https://openalex.org/C133702464","wikidata":"https://www.wikidata.org/wiki/Q3487083","display_name":"Actinin","level":4,"score":0.6935487985610962},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6263482570648193},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.608461856842041},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5990172624588013},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5518341064453125},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5449872612953186},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.4721683859825134},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4559607207775116},{"id":"https://openalex.org/C20563397","wikidata":"https://www.wikidata.org/wiki/Q410803","display_name":"Filamin","level":4,"score":0.43420636653900146},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.42415109276771545},{"id":"https://openalex.org/C130861313","wikidata":"https://www.wikidata.org/wiki/Q3775363","display_name":"Actin-binding protein","level":5,"score":0.4203084111213684},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3517995774745941},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.20149469375610352},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18462693691253662},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10979369282722473},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05603596568107605}],"mesh":[{"descriptor_ui":"D000185","descriptor_name":"Actinin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.140.6.1383","doi":"https://doi.org/10.1083/jcb.140.6.1383","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.140.6.1383","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:915908","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2132673","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2132673","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2132673","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:9508771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9508771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:915908","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2132673","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W28084666","https://openalex.org/W126840171","https://openalex.org/W591375881","https://openalex.org/W1448147067","https://openalex.org/W1501702588","https://openalex.org/W1919166337","https://openalex.org/W1962628502","https://openalex.org/W1967265143","https://openalex.org/W1979300931","https://openalex.org/W1983764003","https://openalex.org/W1991590323","https://openalex.org/W1992449776","https://openalex.org/W1992896717","https://openalex.org/W1993944415","https://openalex.org/W1997470922","https://openalex.org/W2006924926","https://openalex.org/W2012301000","https://openalex.org/W2012553828","https://openalex.org/W2012847227","https://openalex.org/W2018235962","https://openalex.org/W2018289835","https://openalex.org/W2030213176","https://openalex.org/W2030388894","https://openalex.org/W2030463167","https://openalex.org/W2036919653","https://openalex.org/W2040617316","https://openalex.org/W2042265187","https://openalex.org/W2043682382","https://openalex.org/W2044869434","https://openalex.org/W2046303437","https://openalex.org/W2048381117","https://openalex.org/W2051109754","https://openalex.org/W2056104802","https://openalex.org/W2062099855","https://openalex.org/W2073452143","https://openalex.org/W2074284759","https://openalex.org/W2080647760","https://openalex.org/W2086441678","https://openalex.org/W2091587708","https://openalex.org/W2094121810","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2102838769","https://openalex.org/W2110478336","https://openalex.org/W2130837149","https://openalex.org/W2135096442","https://openalex.org/W2138766779","https://openalex.org/W2145310996","https://openalex.org/W2231645346","https://openalex.org/W2400040322","https://openalex.org/W2408690689","https://openalex.org/W2409556525","https://openalex.org/W2411007334","https://openalex.org/W2418241691","https://openalex.org/W3041047318","https://openalex.org/W6662667592"],"related_works":["https://openalex.org/W2163298355","https://openalex.org/W3210454758","https://openalex.org/W1985497018","https://openalex.org/W1981026270","https://openalex.org/W1966985735","https://openalex.org/W7010565472","https://openalex.org/W139596789","https://openalex.org/W1558122031","https://openalex.org/W2020308375","https://openalex.org/W2060710580"],"abstract_inverted_index":{"Regulation":[0],"of":[1,51,77,108,118,138,168],"the":[2,41,61,75,91,101,104,148,162,165],"actin":[3,113,149],"cytoskeleton":[4,150],"may":[5],"play":[6],"a":[7,19,48,132],"crucial":[8],"role":[9],"in":[10,60,69,135],"cell":[11,36,78],"motility":[12,154],"and":[13,68,72,128,151,155],"cancer":[14],"invasion.":[15],"We":[16],"have":[17],"produced":[18],"monoclonal":[20],"antibody":[21],"(NCC-":[22],"Lu-632,":[23],"IgM,":[24],"k)":[25],"reactive":[26],"with":[27,123,131],"an":[28,124],"antigenic":[29],"protein":[30],"that":[31,144,156],"is":[32],"upregulated":[33],"upon":[34,106],"enhanced":[35],"movement.":[37],"The":[38,115],"cDNA":[39],"for":[40],"antigen":[42],"molecule":[43],"was":[44,58,81,95,120],"found":[45],"to":[46,103,161],"encode":[47],"novel":[49],"isoform":[50,55,93],"nonmuscle":[52],"alpha-actinin.":[53],"This":[54],"(designated":[56],"actinin-4)":[57],"concentrated":[59],"cytoplasm":[62,102],"where":[63,90],"cells":[64,70],"were":[65],"sharply":[66],"extended":[67],"migrating":[71],"located":[73],"at":[74],"edge":[76],"clusters,":[79],"but":[80],"absent":[82],"from":[83,100],"focal":[84],"adhesion":[85],"plaques":[86],"or":[87,112],"adherens":[88],"junctions,":[89],"classic":[92],"(actinin-1)":[94],"concentrated.":[96],"Actinin-4":[97],"shifted":[98],"steadily":[99],"nucleus":[105,163],"inhibition":[107],"phosphatidylinositol":[109],"3":[110],"kinase":[111],"depolymerization.":[114],"cytoplasmic":[116,145],"localization":[117],"actinin-4":[119,146],"closely":[121],"associated":[122],"infiltrative":[125],"histological":[126],"phenotype":[127],"correlated":[129],"significantly":[130],"poorer":[133],"prognosis":[134],"61":[136],"cases":[137],"breast":[139],"cancer.":[140],"These":[141],"findings":[142],"suggest":[143],"regulates":[147],"increases":[152],"cellular":[153],"its":[157],"inactivation":[158],"by":[159],"transfer":[160],"abolishes":[164],"metastatic":[166],"potential":[167],"human":[169],"cancers.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
