{"id":"https://openalex.org/W2040977154","doi":"https://doi.org/10.1097/01.ccm.0000054907.33928.48","title":"Enrolling the uninsured in clinical trials: An ethical perspective","display_name":"Enrolling the uninsured in clinical trials: An ethical perspective","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2040977154","doi":"https://doi.org/10.1097/01.ccm.0000054907.33928.48","mag":"2040977154","pmid":"https://pubmed.ncbi.nlm.nih.gov/12626956"},"language":"en","primary_location":{"id":"doi:10.1097/01.ccm.0000054907.33928.48","doi":"https://doi.org/10.1097/01.ccm.0000054907.33928.48","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000054907.33928.48","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109125776","display_name":"Christine A. Pace","orcid":"https://orcid.org/0000-0003-4937-7602","observed_orcids":["https://orcid.org/0000-0003-4937-7602"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Pace","raw_affiliation_strings":["Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA. cpace@cc.nih.gov","Christine Pace, Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892-1156. E-mail: [email\u00a0protected]","Not only should investigators seek to enroll and recruit all research participants, including the uninsured, in as fair a way as possible, but investigators and their institutions should take responsibility for their role in defining what research pursuits and scientific advances are medically and socially valuable","The opinions expressed herein are the authors' and do not necessarily represent the views of the National Institutes of Health or the U.S. Department of Health and Human Services","the Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA. cpace@cc.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"Christine Pace, Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892-1156. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"Not only should investigators seek to enroll and recruit all research participants, including the uninsured, in as fair a way as possible, but investigators and their institutions should take responsibility for their role in defining what research pursuits and scientific advances are medically and socially valuable","institution_ids":[]},{"raw_affiliation_string":"The opinions expressed herein are the authors' and do not necessarily represent the views of the National Institutes of Health or the U.S. Department of Health and Human Services","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"the Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080727811","display_name":"Franklin G. Miller","orcid":"https://orcid.org/0000-0001-5942-1991","observed_orcids":["https://orcid.org/0000-0001-5942-1991"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franklin G. Miller","raw_affiliation_strings":["Not only should investigators seek to enroll and recruit all research participants, including the uninsured, in as fair a way as possible, but investigators and their institutions should take responsibility for their role in defining what research pursuits and scientific advances are medically and socially valuable","The opinions expressed herein are the authors\u2019 and do not necessarily represent the views of the National Institutes of Health or the U.S. Department of Health and Human Services","the Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Not only should investigators seek to enroll and recruit all research participants, including the uninsured, in as fair a way as possible, but investigators and their institutions should take responsibility for their role in defining what research pursuits and scientific advances are medically and socially valuable","institution_ids":[]},{"raw_affiliation_string":"The opinions expressed herein are the authors\u2019 and do not necessarily represent the views of the National Institutes of Health or the U.S. Department of Health and Human Services","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"the Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008883559","display_name":"Marion Danis","orcid":"https://orcid.org/0000-0002-4749-4568","observed_orcids":["https://orcid.org/0000-0002-4749-4568"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marion Danis","raw_affiliation_strings":["Not only should investigators seek to enroll and recruit all research participants, including the uninsured, in as fair a way as possible, but investigators and their institutions should take responsibility for their role in defining what research pursuits and scientific advances are medically and socially valuable","The opinions expressed herein are the authors\u2019 and do not necessarily represent the views of the National Institutes of Health or the U.S. Department of Health and Human Services","the Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Not only should investigators seek to enroll and recruit all research participants, including the uninsured, in as fair a way as possible, but investigators and their institutions should take responsibility for their role in defining what research pursuits and scientific advances are medically and socially valuable","institution_ids":[]},{"raw_affiliation_string":"The opinions expressed herein are the authors\u2019 and do not necessarily represent the views of the National Institutes of Health or the U.S. Department of Health and Human Services","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"the Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0594,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.93177975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"Supplement","first_page":"S121","last_page":"S125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13147","display_name":"Ethics and bioethics in healthcare","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uninsured-patients","display_name":"uninsured patients","score":0.7699999809265137},{"id":"https://openalex.org/keywords/clinical-trial-enrollment","display_name":"clinical trial recruitment","score":0.8889999985694885},{"id":"https://openalex.org/keywords/research-ethics","display_name":"research ethics","score":0.925000011920929},{"id":"https://openalex.org/keywords/research-participation","display_name":"research participation","score":0.527999997138977},{"id":"https://openalex.org/keywords/undue-inducement","display_name":"undue inducement","score":0.7129999995231628},{"id":"https://openalex.org/keywords/participant-recruitment","display_name":"participant recruitment","score":0.4449999928474426},{"id":"https://openalex.org/keywords/health-insurance","display_name":"health insurance","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7653336524963379},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6835781335830688},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6435565948486328},{"id":"https://openalex.org/C2986663376","wikidata":"https://www.wikidata.org/wiki/Q9465","display_name":"Ethical issues","level":2,"score":0.47152265906333923},{"id":"https://openalex.org/C153997805","wikidata":"https://www.wikidata.org/wiki/Q42240","display_name":"Research ethics","level":2,"score":0.45018258690834045},{"id":"https://openalex.org/C2775832928","wikidata":"https://www.wikidata.org/wiki/Q407954","display_name":"Expanded access","level":2,"score":0.4399658739566803},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.42407095432281494},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3843083381652832},{"id":"https://openalex.org/C39549134","wikidata":"https://www.wikidata.org/wiki/Q133080","display_name":"Public relations","level":1,"score":0.35942915081977844},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.35209888219833374},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.18317446112632751},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11657741665840149},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.107185959815979},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D006297","descriptor_name":"Health Services Accessibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006805","descriptor_name":"Human Experimentation","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017057","descriptor_name":"Medically Uninsured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D032984","descriptor_name":"Ethics, Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035862","descriptor_name":"Vulnerable Populations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.ccm.0000054907.33928.48","doi":"https://doi.org/10.1097/01.ccm.0000054907.33928.48","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000054907.33928.48","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:12626956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12626956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7578999996185303},{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1969704932","https://openalex.org/W2044418793","https://openalex.org/W2045206297","https://openalex.org/W2047259127","https://openalex.org/W2084892974","https://openalex.org/W2091768883","https://openalex.org/W2105940636","https://openalex.org/W2108019843","https://openalex.org/W2150060517","https://openalex.org/W2235691012"],"related_works":["https://openalex.org/W2886337392","https://openalex.org/W4415782356","https://openalex.org/W4224299691","https://openalex.org/W2055532322","https://openalex.org/W2479157491","https://openalex.org/W7099826987","https://openalex.org/W4410177912","https://openalex.org/W2522841748","https://openalex.org/W2333155758","https://openalex.org/W2578435204"],"abstract_inverted_index":{"Research":[0],"participation":[1],"by":[2],"individuals":[3],"who":[4],"lack":[5,25],"health":[6],"insurance":[7],"raises":[8],"significant":[9],"but":[10],"seldom-discussed":[11],"ethical":[12],"issues":[13,84],"for":[14,28,77,88],"clinical":[15],"investigators.":[16],"Of":[17],"particular":[18],"concern":[19],"are":[20],"the":[21,32,37,47,69,72,99],"possibility":[22,48],"that":[23,49],"their":[24,50,60,107],"of":[26,34,71],"options":[27],"getting":[29],"care":[30],"at":[31],"time":[33],"enrollment":[35,110],"makes":[36],"uninsured":[38,73,94,100],"susceptible":[39],"to":[40,43,52,59,74,104],"undue":[41],"inducement":[42],"join":[44],"trials":[45,57],"and":[46,85,97,109],"inability":[51],"access":[53,103],"research":[54,78,95,105],"products":[55],"after":[56],"leads":[58],"exploitation.":[61],"In":[62],"tension":[63],"with":[64,101],"these":[65,82],"concerns,":[66],"however,":[67],"is":[68],"right":[70],"fair":[75,102],"consideration":[76],"participation.":[79],"We":[80],"discuss":[81],"competing":[83],"make":[86],"recommendations":[87],"how":[89],"investigators":[90],"can":[91],"both":[92],"protect":[93],"participants":[96],"provide":[98],"in":[106],"recruitment":[108],"strategies.":[111]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
