{"id":"https://openalex.org/W2040975751","doi":"https://doi.org/10.1185/03007995.2015.1005835","title":"An open-label extension study to evaluate the safety of ropinirole prolonged release in Chinese patients with advanced Parkinson\u2019s disease","display_name":"An open-label extension study to evaluate the safety of ropinirole prolonged release in Chinese patients with advanced Parkinson\u2019s disease","publication_year":2015,"publication_date":"2015-01-14","ids":{"openalex":"https://openalex.org/W2040975751","doi":"https://doi.org/10.1185/03007995.2015.1005835","mag":"2040975751","pmid":"https://pubmed.ncbi.nlm.nih.gov/25586298"},"language":"en","primary_location":{"id":"doi:10.1185/03007995.2015.1005835","doi":"https://doi.org/10.1185/03007995.2015.1005835","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007995.2015.1005835","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101584425","display_name":"Zhenxin Zhang","orcid":"https://orcid.org/0000-0003-1659-8951","observed_orcids":["https://orcid.org/0000-0003-1659-8951"]},"institutions":[{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenxin Zhang","raw_affiliation_strings":["Department of Neurology, Peking Union Medical College Hospital , Beijing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Peking Union Medical College Hospital , Beijing , China","institution_ids":["https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["Department of Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449440","display_name":"Xiaoying Zhang","orcid":"https://orcid.org/0000-0002-8130-1889","observed_orcids":["https://orcid.org/0000-0002-8130-1889","https://orcid.org/0009-0008-6114-9091"]},"institutions":[{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Zhang","raw_affiliation_strings":["Department of Neurology, Beijing Tiantan Hospital Affiliated to Capital MU, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Beijing Tiantan Hospital Affiliated to Capital MU, Beijing, China","institution_ids":["https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029257310","display_name":"Shengdi Chen","orcid":"https://orcid.org/0000-0002-6242-1025","observed_orcids":["https://orcid.org/0000-0002-6242-1025"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengdi Chen","raw_affiliation_strings":["Department of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028161507","display_name":"Zhenfu Wang","orcid":"https://orcid.org/0000-0001-8783-0338","observed_orcids":["https://orcid.org/0000-0001-8783-0338"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenfu Wang","raw_affiliation_strings":["Department of Neurology, The Chinese PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005215105","display_name":"Baorong Zhang","orcid":"https://orcid.org/0000-0002-8099-7407","observed_orcids":["https://orcid.org/0000-0002-8099-7407"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baorong Zhang","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital Zhejiang University College Of Medicine, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital Zhejiang University College Of Medicine, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631266","display_name":"Chun\u2010Feng Liu","orcid":"https://orcid.org/0000-0002-8364-0219","observed_orcids":["https://orcid.org/0000-0002-8364-0219"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunfeng Liu","raw_affiliation_strings":["Department of Neurology, The 2nd Affiliated Hospital of Soochow University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The 2nd Affiliated Hospital of Soochow University, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100786666","display_name":"Qiumin Qu","orcid":"https://orcid.org/0000-0002-5634-6209","observed_orcids":["https://orcid.org/0000-0002-5634-6209","https://orcid.org/0000-0002-6416-6961"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiumin Qu","raw_affiliation_strings":["Department of Neurology, The 1st Affiliated Hospital of Xi\u2019an Jiaotong Univ, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The 1st Affiliated Hospital of Xi\u2019an Jiaotong Univ, Shanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613012","display_name":"Yan Cheng","orcid":"https://orcid.org/0000-0003-0639-6117","observed_orcids":["https://orcid.org/0000-0003-0639-6117","https://orcid.org/0000-0001-5813-4691"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Cheng","raw_affiliation_strings":["Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rongxuan Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137016","display_name":"GlaxoSmithKline (China)","ror":"https://ror.org/03jrn4k58","country_code":"CN","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210137016"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongxuan Zhu","raw_affiliation_strings":["GlaxoSmithKline (China) R&D Company Limited, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline (China) R&D Company Limited, Shanghai, China","institution_ids":["https://openalex.org/I4210137016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080670840","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-2977-8559","observed_orcids":["https://orcid.org/0000-0002-2977-8559","https://orcid.org/0000-0002-6791-104X"]},"institutions":[{"id":"https://openalex.org/I4210137016","display_name":"GlaxoSmithKline (China)","ror":"https://ror.org/03jrn4k58","country_code":"CN","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210137016"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":["GlaxoSmithKline (China) R&D Company Limited, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline (China) R&D Company Limited, Shanghai, China","institution_ids":["https://openalex.org/I4210137016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005302281","display_name":"Jingqiu Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137016","display_name":"GlaxoSmithKline (China)","ror":"https://ror.org/03jrn4k58","country_code":"CN","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210137016"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingqiu Hu","raw_affiliation_strings":["GlaxoSmithKline (China) R&D Company Limited, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline (China) R&D Company Limited, Shanghai, China","institution_ids":["https://openalex.org/I4210137016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078480555","display_name":"Meng Cai","orcid":"https://orcid.org/0000-0001-7539-6925","observed_orcids":["https://orcid.org/0000-0001-7539-6925"]},"institutions":[{"id":"https://openalex.org/I4210137016","display_name":"GlaxoSmithKline (China)","ror":"https://ror.org/03jrn4k58","country_code":"CN","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210137016"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Cai","raw_affiliation_strings":["GlaxoSmithKline (China) Investment Co. Ltd, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline (China) Investment Co. Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210137016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5101584425"],"corresponding_institution_ids":["https://openalex.org/I2801228662"],"apc_list":null,"apc_paid":null,"fwci":0.7023,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.71545987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"31","issue":"4","first_page":"723","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-parkinson-s-disease","display_name":"advanced Parkinson's disease","score":0.8669999837875366},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8019999861717224},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dyskinesia","display_name":"dyskinesia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hallucinations","display_name":"hallucinations","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.6809999942779541},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2777453868","wikidata":"https://www.wikidata.org/wiki/Q420590","display_name":"Ropinirole","level":5,"score":0.9919404983520508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9115241765975952},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.70096755027771},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6782591342926025},{"id":"https://openalex.org/C2779034229","wikidata":"https://www.wikidata.org/wiki/Q1077823","display_name":"Somnolence","level":3,"score":0.6115099787712097},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.5277037024497986},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5224360823631287},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.4942338764667511},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36930108070373535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36223965883255005},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22594395279884338}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1185/03007995.2015.1005835","doi":"https://doi.org/10.1185/03007995.2015.1005835","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007995.2015.1005835","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:25586298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25586298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Controlled Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320313903","display_name":"Tata Consultancy Services","ror":"https://ror.org/01b9n8m42"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1967609142","https://openalex.org/W1983336654","https://openalex.org/W1984432498","https://openalex.org/W2016280858","https://openalex.org/W2026533497","https://openalex.org/W2031470249","https://openalex.org/W2036560280","https://openalex.org/W2037835920","https://openalex.org/W2047991174","https://openalex.org/W2064996887","https://openalex.org/W2074868798"],"related_works":["https://openalex.org/W1967609142","https://openalex.org/W2136326362","https://openalex.org/W2074868798","https://openalex.org/W2207343128","https://openalex.org/W2581331349","https://openalex.org/W1568248219","https://openalex.org/W2582202299","https://openalex.org/W2025250048","https://openalex.org/W2606464692","https://openalex.org/W3030227530"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1,32],"open-label":[2],"extension":[3],"(OLE)":[4],"study":[5,39,61,69,76,276],"evaluated":[6],"the":[7,55,74,78,82,109,153,159,204,273,280,288],"safety":[8,254,258,266,282],"profile":[9,267,283],"of":[10,189,239,268,291],"ropinirole":[11,52,87,177,190,261,269,292],"prolonged":[12],"release":[13],"(PR)":[14],"administered":[15],"for":[16,165,260,284],"24":[17,35,48,121],"weeks":[18],"as":[19,294],"adjunctive":[20,296],"to":[21,77,98,120,124,176,244,297],"levodopa":[22,298],"in":[23,40,54,67,115,299],"Chinese":[24,41,300],"patients":[25,42,85,200,228,234,301],"with":[26,43,51,92,272,279,302],"advanced":[27,44,303],"Parkinson's":[28],"disease":[29],"(PD).":[30],"METHODS:":[31],"was":[33,167,180,191,242,270],"a":[34,246],"week,":[36],"flexible-dose,":[37],"OLE":[38,79,83],"PD":[45],"who":[46],"received":[47,86],"week":[49,102],"treatment":[50,70,179],"PR":[53,88,178,293],"preceding":[56,274],"double-blind":[57],"(DB),":[58],"phase":[59],"III":[60],"(NCT01154166)":[62],"and":[63,95,148,183,223,277],"had":[64],"no":[65,129,251],"break":[66],"receiving":[68],"while":[71],"switching":[72],"from":[73],"DB":[75,275],"study.":[80,160],"In":[81],"study,":[84],"once":[89],"daily,":[90],"starting":[91],"2":[93],"mg/d":[94,100,122],"increasing":[96],"up":[97,119],"8":[99,192],"at":[101],"4":[103,116],"(2":[104],"mg":[105,117,193],"increment/week);":[106],"if":[107],"tolerable,":[108],"dose":[110,188],"could":[111],"be":[112,245],"further":[113],"increased":[114],"increments":[118],"according":[123],"clinical":[125],"judgment.":[126],"There":[127,249],"were":[128,212,250,262],"efficacy":[130],"assessments.":[131],"Safety":[132],"assessments":[133],"included":[134],"monitoring":[135],"adverse":[136],"events":[137],"(AEs),":[138],"neurological":[139],"examination,":[140],"Gambling":[141],"Symptom":[142],"Assessment":[143],"Scale":[144],"questionnaire,":[145],"liver":[146],"chemistry,":[147],"laboratory":[149],"tests.":[150],"RESULTS:":[151],"Of":[152],"295":[154],"enrolled":[155],"patients,":[156],"282":[157],"completed":[158],"The":[161,173,265],"most":[162,205],"common":[163],"reason":[164],"withdrawal":[166],"AEs":[168,208,237],"(n":[169],"=":[170],"9,":[171],"3.1%).":[172],"mean":[174],"duration":[175],"173.1":[181],"days":[182],"an":[184,295],"overall":[185],"median":[186],"daily":[187],"(range:":[194],"2-24":[195],"mg).":[196],"Overall,":[197],"114":[198],"(38.6%)":[199],"experienced":[201,230,235],"on-treatment":[202],"AEs;":[203],"frequent":[206],"reported":[207],"(":[209],"\u2265":[210],"2%)":[211],"dyskinesia":[213],"(6.1%),":[214],"dizziness":[215],"(4.1%),":[216],"nausea":[217],"(3.4%),":[218,220],"hallucinations":[219],"somnolence":[221],"(2.7%)":[222],"decreased":[224],"weight":[225],"(2.4%).":[226],"Sixty-eight":[227],"(23.1%)":[229],"treatment-related":[231,247],"AEs.":[232],"Six":[233],"serious":[236],"(SAEs),":[238],"which":[240],"hallucination":[241],"determined":[243],"SAE.":[248],"other":[252],"significant":[253],"findings.":[255],"No":[256],"new":[257],"signals":[259],"identified.":[263],"CONCLUSION:":[264],"consistent":[271],"also":[278],"established":[281],"ropinirole.":[285],"Results":[286],"support":[287],"long-term":[289],"use":[290],"PD.":[304],"ClinicalTrials.gov":[305],"identifier:":[306],"NCT":[307],"1536574.":[308]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
