{"id":"https://openalex.org/W2040960639","doi":"https://doi.org/10.1097/00125480-200201000-00004","title":"Genetic and Biologic Progression in Astrocytomas and Their Relation to Angiogenic Dysregulation","display_name":"Genetic and Biologic Progression in Astrocytomas and Their Relation to Angiogenic Dysregulation","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2040960639","doi":"https://doi.org/10.1097/00125480-200201000-00004","mag":"2040960639","pmid":"https://pubmed.ncbi.nlm.nih.gov/11756757"},"language":"en","primary_location":{"id":"doi:10.1097/00125480-200201000-00004","doi":"https://doi.org/10.1097/00125480-200201000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00125480-200201000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S3815926","display_name":"Advances in Anatomic Pathology","issn_l":"1072-4109","issn":["1072-4109","1533-4031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Anatomic Pathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078484855","display_name":"Daniel Jay Brat","orcid":"https://orcid.org/0000-0002-0633-6563","observed_orcids":["https://orcid.org/0000-0002-0633-6563"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel J. Brat","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. dbrat@emory.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. dbrat@emory.edu","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036596528","display_name":"Amilcar Antonio Castellano-Sanchez","orcid":"https://orcid.org/0000-0002-6429-8294","observed_orcids":["https://orcid.org/0000-0002-6429-8294"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amilcar Castellano-Sanchez","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine and \u2020Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, U.S.A","Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine and \u2020Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, U.S.A","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041131555","display_name":"Balveen Kaur","orcid":"https://orcid.org/0000-0001-7738-0804","observed_orcids":["https://orcid.org/0000-0001-7738-0804"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balveen Kaur","raw_affiliation_strings":["Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078040311","display_name":"Erwin G. Van Meir","orcid":"https://orcid.org/0000-0003-2444-7707","observed_orcids":["https://orcid.org/0000-0003-2444-7707"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erwin G. Van Meir","raw_affiliation_strings":["Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036596528","https://openalex.org/A5078484855"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"],"apc_list":null,"apc_paid":null,"fwci":0.835,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.68330309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"24","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pseudopalisading-necrosis","display_name":"pseudopalisading necrosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9150000214576721},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/retinoblastoma-pathway","display_name":"retinoblastoma pathway","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pten-mutation","display_name":"PTEN mutation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.7270432114601135},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6529123187065125},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5762820839881897},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5648428797721863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5139083862304688},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4985535144805908},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4969082176685333},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.475538969039917},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4561433792114258},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40369221568107605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31807941198349},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2823546230792999},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18877527117729187},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.15918853878974915},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15853354334831238},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13701030611991882}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00125480-200201000-00004","doi":"https://doi.org/10.1097/00125480-200201000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00125480-200201000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S3815926","display_name":"Advances in Anatomic Pathology","issn_l":"1072-4109","issn":["1072-4109","1533-4031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Anatomic Pathology","raw_type":"journal-article"},{"id":"pmid:11756757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11756757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in anatomic pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G487879621","display_name":null,"funder_award_id":"CA/HL-86335","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G573246761","display_name":"Comparative DNA Microarray Analysis of Brain Tumors","funder_award_id":"K08NS042934","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8060586949","display_name":null,"funder_award_id":"NS-HD-41403","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W32167704","https://openalex.org/W64759109","https://openalex.org/W81665236","https://openalex.org/W149403254","https://openalex.org/W189480869","https://openalex.org/W1497143324","https://openalex.org/W1498486272","https://openalex.org/W1498586399","https://openalex.org/W1503005497","https://openalex.org/W1519412172","https://openalex.org/W1522549867","https://openalex.org/W1526030166","https://openalex.org/W1543662618","https://openalex.org/W1573363574","https://openalex.org/W1579423154","https://openalex.org/W1592582459","https://openalex.org/W1721183049","https://openalex.org/W1783580437","https://openalex.org/W1970174108","https://openalex.org/W1973071934","https://openalex.org/W1978139448","https://openalex.org/W1985712533","https://openalex.org/W1985804036","https://openalex.org/W1986559037","https://openalex.org/W1989873520","https://openalex.org/W1991958278","https://openalex.org/W1994810553","https://openalex.org/W1996430165","https://openalex.org/W2000892993","https://openalex.org/W2001493754","https://openalex.org/W2004258072","https://openalex.org/W2005981206","https://openalex.org/W2006676866","https://openalex.org/W2007332721","https://openalex.org/W2012255417","https://openalex.org/W2015344488","https://openalex.org/W2018069344","https://openalex.org/W2024685798","https://openalex.org/W2027131105","https://openalex.org/W2032294682","https://openalex.org/W2034194437","https://openalex.org/W2034651365","https://openalex.org/W2034850749","https://openalex.org/W2043247007","https://openalex.org/W2045164193","https://openalex.org/W2046516822","https://openalex.org/W2048306047","https://openalex.org/W2048897188","https://openalex.org/W2052804176","https://openalex.org/W2053375897","https://openalex.org/W2054331246","https://openalex.org/W2054728198","https://openalex.org/W2055453170","https://openalex.org/W2056574134","https://openalex.org/W2058355285","https://openalex.org/W2059614508","https://openalex.org/W2061754224","https://openalex.org/W2063445389","https://openalex.org/W2068345721","https://openalex.org/W2069294039","https://openalex.org/W2077919252","https://openalex.org/W2085277801","https://openalex.org/W2089088316","https://openalex.org/W2093062161","https://openalex.org/W2093736433","https://openalex.org/W2094447223","https://openalex.org/W2096425504","https://openalex.org/W2099791897","https://openalex.org/W2110425570","https://openalex.org/W2112319045","https://openalex.org/W2114098415","https://openalex.org/W2114292508","https://openalex.org/W2116889376","https://openalex.org/W2119308535","https://openalex.org/W2122068837","https://openalex.org/W2124052729","https://openalex.org/W2129866793","https://openalex.org/W2131976264","https://openalex.org/W2132482143","https://openalex.org/W2144550336","https://openalex.org/W2150048971","https://openalex.org/W2155140015","https://openalex.org/W2155870124","https://openalex.org/W2160365879","https://openalex.org/W2161810908","https://openalex.org/W2162264777","https://openalex.org/W2172908331","https://openalex.org/W2316486738","https://openalex.org/W2399827755","https://openalex.org/W2402633379","https://openalex.org/W4294718043","https://openalex.org/W4323966355"],"related_works":["https://openalex.org/W2030964553","https://openalex.org/W2305075010","https://openalex.org/W1964839309","https://openalex.org/W1998068337","https://openalex.org/W2063445389","https://openalex.org/W119992939","https://openalex.org/W184915947","https://openalex.org/W23866876","https://openalex.org/W2146587188","https://openalex.org/W2427968612"],"abstract_inverted_index":{"Infiltrative":[0],"astrocytic":[1,248],"neoplasms":[2,249],"are":[3,163,201,256],"the":[4,9,62,76,147,158,222],"most":[5,63],"common":[6],"malignancies":[7],"of":[8,18,21,51,66,107,150,187,230,235,263],"central":[10],"nervous":[11],"system.":[12],"They":[13],"remain":[14],"clinically":[15],"problematic":[16],"because":[17],"their":[19,32,44,242],"involvement":[20],"brain":[22],"structures":[23],"critical":[24],"to":[25,40,117,156,181,203,208,244,253],"proper":[26],"cognitive,":[27],"behavioral,":[28],"and":[29,43,119,139,170,178,214,241],"motor":[30],"function;":[31],"widely":[33],"invasive":[34],"properties,":[35],"which":[36],"make":[37],"them":[38],"difficult":[39],"resect":[41],"totally;":[42],"nearly":[45],"inevitable":[46],"biologic":[47],"progression":[48,116],"in":[49,176,199,247],"spite":[50],"adjuvant":[52],"therapy.":[53],"Glioblastoma":[54],"multiforme":[55],"(GBM,":[56],"World":[57],"Health":[58],"Organization":[59],"grade":[60,88],"IV),":[61],"malignant":[64],"form":[65],"infiltrating":[67],"astrocytoma,":[68],"can":[69,83],"present":[70],"as":[71,102],"a":[72,86,103],"high-grade":[73],"lesion":[74,90],"from":[75,85],"outset":[77],"(so-called":[78],"de":[79],"novo":[80],"GBM)":[81],"or":[82,206],"evolve":[84,162],"lower":[87],"precursor":[89],"(secondary":[91],"GBM).":[92],"Molecular":[93,112],"genetic":[94,110,122,151,197,215,239],"investigations":[95],"suggest":[96],"that":[97,120,153,161,255],"GBM":[98,118,177,200],"is":[99,168,179],"best":[100],"regarded":[101],"clinicopathologic":[104],"entity":[105],"composed":[106],"multiple":[108],"molecular":[109],"subsets.":[111],"alterations":[113,134,198],"associated":[114,172],"with":[115,173],"define":[121],"subsets":[123,262],"include":[124],"epidermal":[125],"growth":[126,193],"factor":[127],"receptor":[128],"amplifications,":[129],"p53":[130,212],"mutations,":[131],"retinoblastoma":[132],"pathway":[133],"[most":[135],"commonly,":[136],"p16(CDKN2A)":[137],"losses],":[138],"chromosome":[140,218],"10":[141,219],"alterations,":[142],"including":[143],"PTEN":[144],"mutations.":[145],"Despite":[146],"wide":[148],"range":[149],"events":[152,240],"ultimately":[154],"lead":[155,252],"GBM,":[157],"vascular":[159,191],"changes":[160],"remarkably":[164],"similar.":[165],"Microvascular":[166],"hyperplasia":[167],"spatially":[169],"temporally":[171],"pseudopalisading":[174],"necrosis":[175],"believed":[180],"be":[182],"driven":[183],"by":[184],"hypoxia-induced":[185],"expression":[186],"proangiogenic":[188,231],"cytokines":[189],"such":[190],"endothelial":[192],"factor.":[194],"In":[195],"addition,":[196],"thought":[202],"contribute":[204],"directly":[205],"indirectly":[207],"angiogenic":[209,226,245],"dysregulation.":[210],"Both":[211],"mutations":[213],"losses":[216],"on":[217],"may":[220,250],"tip":[221],"balance":[223],"toward":[224],"an":[225],"phenotype":[227],"through":[228],"upregulation":[229],"factors":[232],"and/or":[233],"downregulation":[234],"angiogenesis":[236],"inhibitors.":[237],"Understanding":[238],"relation":[243],"regulation":[246],"eventually":[251],"therapies":[254],"specifically":[257],"directed":[258],"at":[259],"molecularly":[260],"defined":[261],"these":[264],"diseases.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}