{"id":"https://openalex.org/W2040940293","doi":"https://doi.org/10.1111/exd.12203","title":"Keratinocyte cell lines derived from severe generalized recessive E pidermolysis B ullosa patients carrying a highly recurrent COL 7A1 homozygous mutation: models to assess cell and gene therapies in vitro and in vivo","display_name":"Keratinocyte cell lines derived from severe generalized recessive E pidermolysis B ullosa patients carrying a highly recurrent COL 7A1 homozygous mutation: models to assess cell and gene therapies in vitro and in vivo","publication_year":2013,"publication_date":"2013-06-28","ids":{"openalex":"https://openalex.org/W2040940293","doi":"https://doi.org/10.1111/exd.12203","mag":"2040940293","pmid":"https://pubmed.ncbi.nlm.nih.gov/23947675"},"language":"en","primary_location":{"id":"doi:10.1111/exd.12203","doi":"https://doi.org/10.1111/exd.12203","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.12203","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Cristina Chamorro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Chamorro","raw_affiliation_strings":["Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005333098","display_name":"David Almarza","orcid":"https://orcid.org/0000-0002-3290-3656","observed_orcids":["https://orcid.org/0000-0002-3290-3656"]},"institutions":[{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Almarza","raw_affiliation_strings":["Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101447095","display_name":"Blanca Duarte","orcid":"https://orcid.org/0000-0002-2850-5348","observed_orcids":["https://orcid.org/0000-0002-2850-5348"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Blanca Duarte","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015398294","display_name":"Sara G\u00f3mez Llames","orcid":"https://orcid.org/0000-0001-5456-1389","observed_orcids":["https://orcid.org/0000-0001-5456-1389"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sara G. Llames","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073885936","display_name":"Rodolfo Murillas","orcid":"https://orcid.org/0000-0001-9813-1006","observed_orcids":["https://orcid.org/0000-0001-9813-1006"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rodolfo Murillas","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101561680","display_name":"Marta Garc\u00eda","orcid":"https://orcid.org/0000-0001-8598-8537","observed_orcids":["https://orcid.org/0000-0001-8598-8537"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Garc\u00eda","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain","institution_ids":["https://openalex.org/I50357001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010765538","display_name":"Juan C. Cigudosa","orcid":"https://orcid.org/0000-0002-5100-4568","observed_orcids":["https://orcid.org/0000-0002-5100-4568"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan C. Cigudosa","raw_affiliation_strings":["Centro de Investigaciones Oncol\u00f3gicas Molecular Cytogenetics Group Human Cancer Genetics Program Spanish National Cancer Research Centre (CNIO\u2010CIBERER) Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Oncol\u00f3gicas Molecular Cytogenetics Group Human Cancer Genetics Program Spanish National Cancer Research Centre (CNIO\u2010CIBERER) Madrid Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040912403","display_name":"Luis Espinosa\u2010Hevia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Espinosa\u2010Hevia","raw_affiliation_strings":["Centro de Investigaciones Oncol\u00f3gicas Molecular Cytogenetics Group Human Cancer Genetics Program Spanish National Cancer Research Centre (CNIO\u2010CIBERER) Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Oncol\u00f3gicas Molecular Cytogenetics Group Human Cancer Genetics Program Spanish National Cancer Research Centre (CNIO\u2010CIBERER) Madrid Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066296080","display_name":"Maria Jose Escamez","orcid":"https://orcid.org/0000-0002-5434-1885","observed_orcids":["https://orcid.org/0000-0002-5434-1885"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]},{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Jos\u00e9 Esc\u00e1mez","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain","Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088050328","display_name":"\u00c1ngeles Menc\u00eda","orcid":"https://orcid.org/0000-0002-9977-9514","observed_orcids":["https://orcid.org/0000-0002-9977-9514"]},"institutions":[{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1ngeles Menc\u00eda","raw_affiliation_strings":["Department of Bioengineering, Universidad Carlos III de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Universidad Carlos III de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I50357001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003481552","display_name":"\u00c1lvaro Meana","orcid":"https://orcid.org/0000-0001-9434-6042","observed_orcids":["https://orcid.org/0000-0001-9434-6042"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1lvaro Meana","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046963843","display_name":"Ram\u00f3n Garc\u00eda\u2010Escudero","orcid":"https://orcid.org/0000-0001-5640-6542","observed_orcids":["https://orcid.org/0000-0001-5640-6542"]},"institutions":[{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ram\u00f3n Garc\u00eda\u2010Escudero","raw_affiliation_strings":["Molecular Oncology Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088756937","display_name":"Rosa Moro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa Moro","raw_affiliation_strings":["Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020635870","display_name":"Claudio Jorge Conti","orcid":"https://orcid.org/0000-0003-4753-0722","observed_orcids":["https://orcid.org/0000-0003-4753-0722"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Claudio J. Conti","raw_affiliation_strings":["Department of Bioengineering, Universidad Carlos III de Madrid, Madrid, Spain","Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Universidad Carlos III de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX, USA","institution_ids":["https://openalex.org/I125029298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019012569","display_name":"Marcela Del R\u00edo","orcid":"https://orcid.org/0000-0003-2910-7189","observed_orcids":["https://orcid.org/0000-0003-2910-7189"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]},{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Marcela Del R\u00edo","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain","Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026078221","display_name":"Fernando Larcher","orcid":"https://orcid.org/0000-0002-6771-3561","observed_orcids":["https://orcid.org/0000-0002-6771-3561"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]},{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Fernando Larcher","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain","Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER\u2010 U714) Madrid Spain","institution_ids":["https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Department of Bioengineering Universidad Carlos III de Madrid Madrid Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Epithelial Biomedicine Division, Cutaneous Disease Modelling Unit, CIEMAT, Madrid, Spain","institution_ids":["https://openalex.org/I4210165411"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019012569","https://openalex.org/A5026078221"],"corresponding_institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165411","https://openalex.org/I50357001"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.8773,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.66069559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"22","issue":"9","first_page":"601","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recessive-dystrophic-epidermolysis-bullosa","display_name":"recessive dystrophic epidermolysis bullosa","score":1.0},{"id":"https://openalex.org/keywords/keratinocyte-cell-lines","display_name":"keratinocyte cell lines","score":0.843999981880188},{"id":"https://openalex.org/keywords/col7a1-mutations","display_name":"COL7A1 mutations","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.7160000205039978},{"id":"https://openalex.org/keywords/sv40-large-t-antigen","display_name":"SV40 large T antigen","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6000000238418579},{"id":"https://openalex.org/keywords/epidermal-regeneration","display_name":"epidermal regeneration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6032710075378418},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.554814875125885},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5351722240447998},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5347496867179871},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5214342474937439},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5100129842758179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4617379605770111},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4509789049625397},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4202902913093567},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4046395421028137},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4045485854148865},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3196524977684021},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20702394843101501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15183097124099731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11689445376396179},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D016108","descriptor_name":"Epidermolysis Bullosa Dystrophica","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016108","descriptor_name":"Epidermolysis Bullosa Dystrophica","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016108","descriptor_name":"Epidermolysis Bullosa Dystrophica","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D024143","descriptor_name":"Collagen Type VII","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/exd.12203","doi":"https://doi.org/10.1111/exd.12203","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.12203","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:23947675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23947675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Letter"},{"id":"pmh:oai:digital.csic.es:10261/111643","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/111643","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W22520275","https://openalex.org/W1602244317","https://openalex.org/W1632349675","https://openalex.org/W1966829529","https://openalex.org/W1972368443","https://openalex.org/W1984396652","https://openalex.org/W1995787970","https://openalex.org/W1996310802","https://openalex.org/W2000482931","https://openalex.org/W2003336954","https://openalex.org/W2011862370","https://openalex.org/W2016463554","https://openalex.org/W2017965318","https://openalex.org/W2021320569","https://openalex.org/W2021951190","https://openalex.org/W2027960997","https://openalex.org/W2035985390","https://openalex.org/W2038085058","https://openalex.org/W2046163943","https://openalex.org/W2054569402","https://openalex.org/W2060155650","https://openalex.org/W2074343656","https://openalex.org/W2077430978","https://openalex.org/W2085362638","https://openalex.org/W2092633851","https://openalex.org/W2114924142","https://openalex.org/W2122190480","https://openalex.org/W2126253425","https://openalex.org/W2147762577","https://openalex.org/W2409475925"],"related_works":["https://openalex.org/W4380877247","https://openalex.org/W3150652490","https://openalex.org/W2338965223","https://openalex.org/W4285984814","https://openalex.org/W4386040736","https://openalex.org/W2978135166","https://openalex.org/W2936345706","https://openalex.org/W1990983046","https://openalex.org/W2126016558","https://openalex.org/W4366191331"],"abstract_inverted_index":{"Recessive":[0],"dystrophic":[1],"epidermolysis":[2],"bullosa":[3],"(RDEB)":[4],"is":[5],"caused":[6],"by":[7],"deficiency":[8],"of":[9,28,38,44,113],"type":[10],"VII":[11],"collagen":[12],"due":[13],"to":[14,102,127],"COL7A1":[15],"mutations":[16],"such":[17],"as":[18],"c.6527insC,":[19],"recurrently":[20],"found":[21],"in":[22,118],"the":[23,41,61,78,114],"Spanish":[24],"RDEB":[25,34,50,75,116],"population.":[26],"Assessment":[27],"clonal":[29],"correction-based":[30],"therapeutic":[31,130],"approaches":[32,131],"for":[33,108],"requires":[35],"large":[36,63],"expansions":[37],"cells,":[39],"exceeding":[40],"replication":[42],"capacity":[43],"human":[45],"primary":[46],"keratinocytes.":[47],"Thus,":[48],"immortalized":[49,72],"cells":[51,100],"with":[52],"enhanced":[53],"proliferative":[54,84],"abilities":[55],"would":[56],"be":[57],"valuable.":[58],"Using":[59],"either":[60],"SV40":[62],"T":[64,94],"antigen":[65],"or":[66],"papillomavirus":[67],"HPV16-derived":[68],"E6-E7":[69],"proteins,":[70],"we":[71],"and":[73,85,96,105,111],"cloned":[74],"keratinocytes":[76],"carrying":[77],"c.6527insC":[79],"mutation.":[80],"Clones":[81],"exhibited":[82],"high":[83],"colony-forming":[86],"features.":[87],"Cytogenetic":[88],"analysis":[89],"revealed":[90],"important":[91],"differences":[92],"between":[93],"antigen-driven":[95],"E6-E7-driven":[97],"immortalization.":[98],"Immortalized":[99],"responded":[101],"differentiation":[103],"stimuli":[104],"were":[106],"competent":[107],"epidermal":[109],"regeneration":[110],"recapitulation":[112],"blistering":[115],"phenotype":[117],"vivo.":[119],"These":[120],"features":[121],"make":[122],"these":[123],"cell":[124],"lines":[125],"useful":[126],"test":[128],"novel":[129],"including":[132],"those":[133],"aimed":[134],"at":[135],"editing":[136],"mutant":[137],"COL7A1.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}