{"id":"https://openalex.org/W2040860320","doi":"https://doi.org/10.1126/science.185.4147.267","title":"Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain","display_name":"Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain","publication_year":1974,"publication_date":"1974-07-19","ids":{"openalex":"https://openalex.org/W2040860320","doi":"https://doi.org/10.1126/science.185.4147.267","mag":"2040860320","pmid":"https://pubmed.ncbi.nlm.nih.gov/4209272"},"language":"en","primary_location":{"id":"doi:10.1126/science.185.4147.267","doi":"https://doi.org/10.1126/science.185.4147.267","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.185.4147.267","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108912848","display_name":"Michael Brownstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Brownstein","raw_affiliation_strings":["Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084703314","display_name":"Mikl\u00f3s Palkovits","orcid":"https://orcid.org/0000-0003-0578-0387","observed_orcids":["https://orcid.org/0000-0003-0578-0387"]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miklos Palkovits","raw_affiliation_strings":["Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083608744","display_name":"Juan M. Saavedra","orcid":"https://orcid.org/0000-0002-7238-9647","observed_orcids":["https://orcid.org/0000-0002-7238-9647"]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan M. Saavedra","raw_affiliation_strings":["Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004601850","display_name":"Rabim M. Bassiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rabim M. Bassiri","raw_affiliation_strings":["Endocrine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111812447","display_name":"Robert D. Utiger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Utiger","raw_affiliation_strings":["Endocrine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":28.5502,"has_fulltext":false,"cited_by_count":375,"citation_normalized_percentile":{"value":0.99948678,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"185","issue":"4147","first_page":"267","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":1.0},{"id":"https://openalex.org/keywords/regional-brain-distribution","display_name":"brain regional distribution","score":0.6880000233650208},{"id":"https://openalex.org/keywords/median-eminence","display_name":"median eminence","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypothalamic-nuclei","display_name":"hypothalamic nuclei","score":0.984000027179718},{"id":"https://openalex.org/keywords/septal-area","display_name":"septal area","score":0.9129999876022339},{"id":"https://openalex.org/keywords/preoptic-area","display_name":"preoptic area","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C2779067335","wikidata":"https://www.wikidata.org/wiki/Q1337712","display_name":"Median eminence","level":3,"score":0.9382429122924805},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.8336594700813293},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.78029465675354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6954851150512695},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6808754801750183},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6582460999488831},{"id":"https://openalex.org/C2776451244","wikidata":"https://www.wikidata.org/wiki/Q7240592","display_name":"Preoptic area","level":3,"score":0.5488501191139221},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.45780181884765625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43297651410102844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41434332728385925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15409111976623535},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008326","descriptor_name":"Mammillary Bodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.185.4147.267","doi":"https://doi.org/10.1126/science.185.4147.267","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.185.4147.267","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:4209272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4209272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W32727128","https://openalex.org/W1696451936","https://openalex.org/W1775749144","https://openalex.org/W1968578062","https://openalex.org/W1971626169","https://openalex.org/W1985293173","https://openalex.org/W1985876897","https://openalex.org/W1987289944","https://openalex.org/W1989316195","https://openalex.org/W1990793009","https://openalex.org/W1995071066","https://openalex.org/W2007130139","https://openalex.org/W2007802362","https://openalex.org/W2010403450","https://openalex.org/W2014741978","https://openalex.org/W2022424526","https://openalex.org/W2029368407","https://openalex.org/W2039327795","https://openalex.org/W2047244957","https://openalex.org/W2051267207","https://openalex.org/W2051656979","https://openalex.org/W2055903829","https://openalex.org/W2066922718","https://openalex.org/W2072448451","https://openalex.org/W2072521941","https://openalex.org/W2072649922","https://openalex.org/W2087477534","https://openalex.org/W2093965562","https://openalex.org/W2130799585","https://openalex.org/W2132936307","https://openalex.org/W2151368240","https://openalex.org/W2194582951","https://openalex.org/W2418868949","https://openalex.org/W2473357736","https://openalex.org/W2987283907","https://openalex.org/W3025742634"],"related_works":["https://openalex.org/W56313780","https://openalex.org/W2036707383","https://openalex.org/W2014741978","https://openalex.org/W2020867161","https://openalex.org/W1547399881","https://openalex.org/W2045796847","https://openalex.org/W1976382189","https://openalex.org/W1991621920","https://openalex.org/W2033505880","https://openalex.org/W2101020710"],"abstract_inverted_index":{"The":[0,12],"regional":[1],"distribution":[2],"of":[3,15,38],"thyrotropin-releasing":[4],"hormone":[5],"(TRH)":[6],"in":[7,19,28,42],"rat":[8],"brain":[9],"was":[10,17],"studied.":[11],"greatest":[13],"concentration":[14],"TRH":[16,39],"found":[18,27,41],"the":[20,33,43],"median":[21],"eminence.":[22],"High":[23],"concentrations":[24],"were":[25,40],"also":[26],"several":[29],"hypothalamic":[30],"nuclei.":[31],"Outside":[32],"hypothalamus,":[34],"relatively":[35],"large":[36],"amounts":[37],"septal":[44],"and":[45],"preoptic":[46],"areas.":[47]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
