{"id":"https://openalex.org/W204082185","doi":null,"title":"Investigating the role of the JAK/STAT and MAPK pathways in ischaemia/reperfusion injury and inflammation","display_name":"Investigating the role of the JAK/STAT and MAPK pathways in ischaemia/reperfusion injury and inflammation","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W204082185","mag":"204082185"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18505","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18505/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080763334","display_name":"Se\u00e1n P. Barry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sean Barry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080763334"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9390000104904175},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tempol","display_name":"tempol","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.824999988079071},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.777999997138977},{"id":"https://openalex.org/keywords/mkp-1","display_name":"MKP-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/endotoxic-shock","display_name":"endotoxic shock","score":0.7170000076293945},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.949999988079071},{"id":"https://openalex.org/keywords/trif","display_name":"TRIF","score":0.8090000152587891},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7080000042915344},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.8406215906143188},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.7908300161361694},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.6906108260154724},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5769896507263184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5394817590713501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47937896847724915},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.4669417440891266},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43275225162506104},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41537168622016907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3546332120895386},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3364189863204956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3286253809928894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1805976927280426}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18505","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18505/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:204082185","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18505/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":235,"referenced_works":["https://openalex.org/W133647476","https://openalex.org/W1482408448","https://openalex.org/W1493556752","https://openalex.org/W1511779378","https://openalex.org/W1514064771","https://openalex.org/W1515615230","https://openalex.org/W1527404918","https://openalex.org/W1547005412","https://openalex.org/W1557686543","https://openalex.org/W1566992315","https://openalex.org/W1616121322","https://openalex.org/W1644953918","https://openalex.org/W1650996792","https://openalex.org/W1755667520","https://openalex.org/W1821858011","https://openalex.org/W1845459216","https://openalex.org/W1869577220","https://openalex.org/W1892781835","https://openalex.org/W1909777320","https://openalex.org/W1934994215","https://openalex.org/W1963677189","https://openalex.org/W1964162519","https://openalex.org/W1964879817","https://openalex.org/W1964982794","https://openalex.org/W1965808713","https://openalex.org/W1966798559","https://openalex.org/W1968754277","https://openalex.org/W1968918322","https://openalex.org/W1970436087","https://openalex.org/W1971641482","https://openalex.org/W1971819575","https://openalex.org/W1972377673","https://openalex.org/W1976129366","https://openalex.org/W1976134000","https://openalex.org/W1976148098","https://openalex.org/W1977601515","https://openalex.org/W1979036898","https://openalex.org/W1979785616","https://openalex.org/W1980017984","https://openalex.org/W1984235771","https://openalex.org/W1985186821","https://openalex.org/W1985723042","https://openalex.org/W1986956003","https://openalex.org/W1987790381","https://openalex.org/W1987806865","https://openalex.org/W1988827270","https://openalex.org/W1988981784","https://openalex.org/W1989144661","https://openalex.org/W1991601985","https://openalex.org/W1992239409","https://openalex.org/W1992423562","https://openalex.org/W1993278853","https://openalex.org/W1993961434","https://openalex.org/W1994851993","https://openalex.org/W1996635086","https://openalex.org/W1997202195","https://openalex.org/W1997951257","https://openalex.org/W1998036349","https://openalex.org/W1998244317","https://openalex.org/W1999197294","https://openalex.org/W2001751920","https://openalex.org/W2004143904","https://openalex.org/W2004175299","https://openalex.org/W2004266769","https://openalex.org/W2004751481","https://openalex.org/W2005296060","https://openalex.org/W2007555056","https://openalex.org/W2008359430","https://openalex.org/W2008686279","https://openalex.org/W2009183764","https://openalex.org/W2009316212","https://openalex.org/W2010526388","https://openalex.org/W2010711320","https://openalex.org/W2010764593","https://openalex.org/W2014255348","https://openalex.org/W2014999693","https://openalex.org/W2016292931","https://openalex.org/W2017834876","https://openalex.org/W2018824998","https://openalex.org/W2019276374","https://openalex.org/W2020428280","https://openalex.org/W2021253052","https://openalex.org/W2021860656","https://openalex.org/W2022400785","https://openalex.org/W2022539205","https://openalex.org/W2024996523","https://openalex.org/W2025850537","https://openalex.org/W2026525843","https://openalex.org/W2026873116","https://openalex.org/W2028402416","https://openalex.org/W2028503280","https://openalex.org/W2028526507","https://openalex.org/W2031717064","https://openalex.org/W2034270241","https://openalex.org/W2034831207","https://openalex.org/W2038599271","https://openalex.org/W2038657561","https://openalex.org/W2039077632","https://openalex.org/W2041043528","https://openalex.org/W2041204531","https://openalex.org/W2041792559","https://openalex.org/W2042409437","https://openalex.org/W2044335855","https://openalex.org/W2044578153","https://openalex.org/W2044860026","https://openalex.org/W2045526190","https://openalex.org/W2045575961","https://openalex.org/W2048547503","https://openalex.org/W2048706932","https://openalex.org/W2048748125","https://openalex.org/W2050252881","https://openalex.org/W2051638902","https://openalex.org/W2051732586","https://openalex.org/W2052397527","https://openalex.org/W2052660678","https://openalex.org/W2052982889","https://openalex.org/W2054714441","https://openalex.org/W2055946816","https://openalex.org/W2056469110","https://openalex.org/W2057138015","https://openalex.org/W2059177966","https://openalex.org/W2059289792","https://openalex.org/W2061023870","https://openalex.org/W2061968489","https://openalex.org/W2062447787","https://openalex.org/W2062892166","https://openalex.org/W2063099262","https://openalex.org/W2064123540","https://openalex.org/W2065568194","https://openalex.org/W2065601509","https://openalex.org/W2066436387","https://openalex.org/W2066675672","https://openalex.org/W2067244501","https://openalex.org/W2067791475","https://openalex.org/W2067801492","https://openalex.org/W2067894718","https://openalex.org/W2068833403","https://openalex.org/W2070330987","https://openalex.org/W2070886703","https://openalex.org/W2074067501","https://openalex.org/W2074356752","https://openalex.org/W2074396028","https://openalex.org/W2074800090","https://openalex.org/W2077709632","https://openalex.org/W2082620866","https://openalex.org/W2083446462","https://openalex.org/W2085188839","https://openalex.org/W2085935547","https://openalex.org/W2086823604","https://openalex.org/W2087765738","https://openalex.org/W2087814657","https://openalex.org/W2091128689","https://openalex.org/W2092172066","https://openalex.org/W2092289677","https://openalex.org/W2092808670","https://openalex.org/W2093524014","https://openalex.org/W2094052642","https://openalex.org/W2094061196","https://openalex.org/W2094433621","https://openalex.org/W2096147746","https://openalex.org/W2098437309","https://openalex.org/W2099132542","https://openalex.org/W2099733017","https://openalex.org/W2102131116","https://openalex.org/W2103666037","https://openalex.org/W2103933335","https://openalex.org/W2105507544","https://openalex.org/W2105808377","https://openalex.org/W2109171783","https://openalex.org/W2109821965","https://openalex.org/W2110076038","https://openalex.org/W2113345769","https://openalex.org/W2114445658","https://openalex.org/W2114542500","https://openalex.org/W2114705189","https://openalex.org/W2115185894","https://openalex.org/W2115701574","https://openalex.org/W2116401711","https://openalex.org/W2116815871","https://openalex.org/W2118310862","https://openalex.org/W2119683782","https://openalex.org/W2122093149","https://openalex.org/W2123444403","https://openalex.org/W2124159333","https://openalex.org/W2126012511","https://openalex.org/W2127170482","https://openalex.org/W2127551467","https://openalex.org/W2127921520","https://openalex.org/W2128209215","https://openalex.org/W2129019771","https://openalex.org/W2129231604","https://openalex.org/W2129274801","https://openalex.org/W2130271956","https://openalex.org/W2131371764","https://openalex.org/W2134155110","https://openalex.org/W2134739644","https://openalex.org/W2136530061","https://openalex.org/W2137649057","https://openalex.org/W2138049320","https://openalex.org/W2139198003","https://openalex.org/W2143812692","https://openalex.org/W2145577370","https://openalex.org/W2146150621","https://openalex.org/W2146477767","https://openalex.org/W2147110503","https://openalex.org/W2147511779","https://openalex.org/W2149122929","https://openalex.org/W2149396086","https://openalex.org/W2150004300","https://openalex.org/W2150164439","https://openalex.org/W2152532651","https://openalex.org/W2152685704","https://openalex.org/W2153111398","https://openalex.org/W2153496521","https://openalex.org/W2155706758","https://openalex.org/W2156320225","https://openalex.org/W2158666748","https://openalex.org/W2158969445","https://openalex.org/W2159168998","https://openalex.org/W2160242859","https://openalex.org/W2162653594","https://openalex.org/W2164228620","https://openalex.org/W2164516260","https://openalex.org/W2165528446","https://openalex.org/W2167978531","https://openalex.org/W2169350835","https://openalex.org/W2170852425","https://openalex.org/W2172281246","https://openalex.org/W2235239233","https://openalex.org/W2336925175","https://openalex.org/W2336976573","https://openalex.org/W2403653384","https://openalex.org/W2416074078","https://openalex.org/W4313331748","https://openalex.org/W4313377128"],"related_works":["https://openalex.org/W2160505865","https://openalex.org/W7097246218","https://openalex.org/W1994363226","https://openalex.org/W1982605537","https://openalex.org/W2791828004","https://openalex.org/W2275291877","https://openalex.org/W4405267398","https://openalex.org/W2379597742","https://openalex.org/W4297025133","https://openalex.org/W2377720299"],"abstract_inverted_index":{"The":[0,368],"signal":[1],"transducer":[2],"and":[3,23,33,90,98,124,137,164,173,220,233,250,267,274,287,309,327,336,348,353,363,371],"activator":[4],"of":[5,12,68,107,111,142,148,161,186,191,200,206,227,244,290,313,345,357,373,386,421],"transcription":[6,13],"(STAT)":[7],"proteins":[8],"are":[9],"a":[10,53,100,158,169,196,401],"family":[11,260],"factors":[14,22],"which":[15],"transduce":[16],"extracellular":[17],"signals":[18],"from":[19,208,417],"cytokines,":[20],"growth":[21],"G-proteins":[24],"to":[25,35,42,51,95,116,130,306,319,378,392,394,403,415],"the":[26,36,37,59,66,105,149,183,209,251,288,294,332,358,364,406],"nucleus.":[27],"STATs":[28],"become":[29],"activated":[30,256],"by":[31,103,168,248,280],"phosphorylation":[32,178,193,344],"translocate":[34],"nucleus":[38],"where":[39],"they":[40],"bind":[41],"specific":[43],"target":[44],"promoters.":[45],"STAT1":[46,172,177,192],"has":[47],"previously":[48],"been":[49],"shown":[50,79],"have":[52,400],"role":[54,67,102,289,402],"in":[55,58,70,84,88,91,93,133,152,157,171,210,224,230,263,271,292,301,340,376,405],"inducing":[56],"apoptosis":[57,72],"myocardium":[60],"following":[61,119,322,350],"ischaemia/reperfusion":[62],"injury":[63,97,163,273],"(I/R),":[64],"however":[65],"STAT3":[69,81,112,126,174],"myocardial":[71],"is":[73,78,82,261,278],"less":[74],"clear.":[75],"Here":[76],"it":[77],"that":[80,189],"phosphorylated":[83],"cardiac":[85,245],"cells":[86],"both":[87],"vito":[89],"vivo":[92,211],"response":[94,145,296,377,409],"I/R":[96,162,212,272],"plays":[99],"protective":[101,184,198],"reducing":[104],"levels":[106,312],"apoptosis.":[108],"Several":[109],"modulators":[110],"activity":[113,141,277],"were":[114,303],"found":[115,129,318,391],"be":[117,131,195,320],"upregulated":[118,321],"I/R,":[120],"including":[121],"JAK2,":[122],"SOCS3":[123],"GRIM-19.":[125],"was":[127,166,297,317,329,381,389],"also":[128],"important":[132],"regulating":[134],"DNA":[135,143],"damage":[136,144],"repair":[138],"through":[139],"altered":[140],"proteins.":[146],"Administration":[147],"antioxidant":[150],"tempol":[151,201,249],"vivo,":[153],"reduced":[154],"infarct":[155],"size":[156],"rat":[159],"model":[160,213,420],"this":[165,237,328],"accompanied":[167],"reduction":[170,223],"phosphorylation.":[175],"Increasing":[176],"with":[179],"IFN-\u2022":[180],"treatment":[181],"abolished":[182],"effect":[185,199],"tempol,":[187],"suggesting":[188],"inhibition":[190,385],"may":[194],"key":[197,269],"infusion.":[202],"Affymetrix":[203],"microarray":[204],"analysis":[205],"hearts":[207],"identified":[214,239],"several":[215,240],"novel":[216],"gene":[217],"expression":[218],"changes":[219],"uncovered":[221],"transcriptional":[222],"large":[225],"numbers":[226],"genes":[228],"involved":[229,262],"mitochondrial":[231],"respiration":[232],"transport.":[234],"In":[235],"addition,":[236],"approach":[238],"possible":[241],"new":[242],"regulators":[243],"protection":[246],"mediated":[247],"urocortin":[252],"hormones.":[253],"\\nThe":[254],"mitogen":[255],"protein":[257],"kinase":[258],"(MAPK)":[259],"sensing":[264],"cellular":[265],"stress":[266],"play":[268,404],"roles":[270],"inflammation.":[275],"MAPK":[276,281,347],"balanced":[279],"phosphatases":[282],"(MKPs)":[283],"such":[284],"as":[285,410],"MKP-1":[286,291,302,316,341,388],"modulating":[293],"immune":[295,408],"investigated.":[298],"Mice":[299],"deficient":[300,339,412],"more":[304],"susceptible":[305],"endotoxic":[307],"shock":[308],"had":[310,342],"elevated":[311,355],"serum":[314],"cytokines.":[315],"toll-like":[323],"recptor":[324],"(TLR)":[325],"stimulation":[326,352,380],"dependent":[330],"on":[331],"signaling":[333],"adaptors":[334],"MyD88":[335],"Trif.":[337],"Macrophages":[338],"increased":[343],"p38":[346],"JNK":[349],"TLR":[351,379],"secreted":[354],"amounts":[356],"pro-inflammatory":[359],"cytokines":[360],"TNF-\u03b1,":[361],"IL-12":[362],"anti-inflammatory":[365],"cytokine":[366,374],"IL-10.":[367],"temporal":[369],"control":[370],"regulation":[372],"production":[375],"dissected":[382],"using":[383],"pharmacological":[384],"MAPKs.":[387],"not":[390],"contribute":[393],"T":[395],"cell":[396],"differentiation":[397],"but":[398],"did":[399],"adaptive":[407],"MKP-1-":[411],"mice":[413],"failed":[414],"recover":[416],"an":[418],"experimental":[419],"multiple":[422],"sclerosis.":[423]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}