{"id":"https://openalex.org/W2040816352","doi":"https://doi.org/10.7554/elife.00190","title":"AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis","display_name":"AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis","publication_year":2013,"publication_date":"2013-03-05","ids":{"openalex":"https://openalex.org/W2040816352","doi":"https://doi.org/10.7554/elife.00190","mag":"2040816352","pmid":"https://pubmed.ncbi.nlm.nih.gov/23482940","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3591783"},"language":"en","primary_location":{"id":"doi:10.7554/elife.00190","doi":"https://doi.org/10.7554/elife.00190","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.00190","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.00190","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043908379","display_name":"Mingyu Gu","orcid":"https://orcid.org/0009-0006-9085-8749","observed_orcids":["https://orcid.org/0009-0006-9085-8749"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyu Gu","raw_affiliation_strings":["Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075372349","display_name":"Qiang Liu","orcid":"https://orcid.org/0000-0002-9232-1420","observed_orcids":["https://orcid.org/0000-0002-9232-1420"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Liu","raw_affiliation_strings":["Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081919864","display_name":"Shigeki Watanabe","orcid":"https://orcid.org/0000-0001-7580-8141","observed_orcids":["https://orcid.org/0000-0001-7580-8141"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shigeki Watanabe","raw_affiliation_strings":["Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101913611","display_name":"Lin Sun","orcid":"https://orcid.org/0000-0003-0286-3822","observed_orcids":["https://orcid.org/0000-0003-0286-3822"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Sun","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, United States","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027595235","display_name":"Gunther Hollopeter","orcid":"https://orcid.org/0000-0002-6409-0530","observed_orcids":["https://orcid.org/0000-0002-6409-0530"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunther Hollopeter","raw_affiliation_strings":["Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012414482","display_name":"Barth D. Grant","orcid":"https://orcid.org/0000-0002-5943-8336","observed_orcids":["https://orcid.org/0000-0002-5943-8336"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barth D Grant","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, United States","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026863162","display_name":"Erik M. J\u00f8rgensen","orcid":"https://orcid.org/0000-0002-2978-8028","observed_orcids":["https://orcid.org/0000-0002-2978-8028"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erik M Jorgensen","raw_affiliation_strings":["Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States","Department of Biology, University of Utah, Salt Lake City, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Biology, University of Utah, Salt Lake City, United States","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026863162"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":4.3019,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.94830525,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"2","issue":null,"first_page":"e00190","last_page":"e00190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptic-vesicle-endocytosis","display_name":"synaptic vesicle endocytosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/alpha-adaptin","display_name":"alpha-adaptin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8629999756813049},{"id":"https://openalex.org/keywords/null-mutations","display_name":"null mutations","score":0.7400000095367432},{"id":"https://openalex.org/keywords/vacuoles","display_name":"vacuoles","score":0.765999972820282},{"id":"https://openalex.org/keywords/synaptic-vesicle-recycling","display_name":"synaptic vesicle recycling","score":0.3930000066757202},{"id":"https://openalex.org/keywords/heterotetramer","display_name":"heterotetramer","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7908166646957397},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.7436884045600891},{"id":"https://openalex.org/C191597335","wikidata":"https://www.wikidata.org/wiki/Q4996475","display_name":"Bulk endocytosis","level":5,"score":0.6696634292602539},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5889849066734314},{"id":"https://openalex.org/C2908668639","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle recycling","level":5,"score":0.5040920972824097},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.4894072115421295},{"id":"https://openalex.org/C165254790","wikidata":"https://www.wikidata.org/wiki/Q6416872","display_name":"Kiss-and-run fusion","level":5,"score":0.45550182461738586},{"id":"https://openalex.org/C196330066","wikidata":"https://www.wikidata.org/wiki/Q7923216","display_name":"Vesicle fusion","level":5,"score":0.4488700032234192},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.43815380334854126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42832493782043457},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.4194616973400116},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3851754367351532},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.3844529986381531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3391563296318054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1075986921787262},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09816789627075195},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.06585800647735596}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033962","descriptor_name":"Adaptor Protein Complex 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033962","descriptor_name":"Adaptor Protein Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033965","descriptor_name":"Adaptor Protein Complex alpha Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033965","descriptor_name":"Adaptor Protein Complex alpha Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033966","descriptor_name":"Adaptor Protein Complex beta Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033966","descriptor_name":"Adaptor Protein Complex beta Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033983","descriptor_name":"Adaptor Protein Complex mu Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033983","descriptor_name":"Adaptor Protein Complex mu Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7554/elife.00190","doi":"https://doi.org/10.7554/elife.00190","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.00190","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2591800","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3591783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3591783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3591783","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:23482940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23482940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7dbb98ede5df41b7b5de629133bdcd94","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7dbb98ede5df41b7b5de629133bdcd94","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 2 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.00190","doi":"https://doi.org/10.7554/elife.00190","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.00190","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2594523866","display_name":"Membrane Traffic in C. elegans and Mammals","funder_award_id":"R01GM067237","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2630808466","display_name":null,"funder_award_id":"GM067237","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4719161599","display_name":null,"funder_award_id":"NS034307","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4788154053","display_name":"Synaptic Function in the Nematode C. Elegans","funder_award_id":"R01NS034307","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000185413","display_name":null,"funder_award_id":"NS034307","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W306302075","https://openalex.org/W1515946344","https://openalex.org/W1605667399","https://openalex.org/W1673406285","https://openalex.org/W1840564118","https://openalex.org/W1973988284","https://openalex.org/W1975658980","https://openalex.org/W1988155076","https://openalex.org/W1996761102","https://openalex.org/W1996862455","https://openalex.org/W2006189175","https://openalex.org/W2008315205","https://openalex.org/W2011625746","https://openalex.org/W2013903929","https://openalex.org/W2020223488","https://openalex.org/W2026590190","https://openalex.org/W2029873308","https://openalex.org/W2032444338","https://openalex.org/W2037386165","https://openalex.org/W2048451267","https://openalex.org/W2049484730","https://openalex.org/W2056086918","https://openalex.org/W2076645585","https://openalex.org/W2079458003","https://openalex.org/W2085605757","https://openalex.org/W2089157578","https://openalex.org/W2089554293","https://openalex.org/W2089866954","https://openalex.org/W2090999244","https://openalex.org/W2097856882","https://openalex.org/W2101200615","https://openalex.org/W2101235918","https://openalex.org/W2104927620","https://openalex.org/W2108812454","https://openalex.org/W2108836535","https://openalex.org/W2114410573","https://openalex.org/W2115977533","https://openalex.org/W2117679566","https://openalex.org/W2118858388","https://openalex.org/W2119260049","https://openalex.org/W2122310374","https://openalex.org/W2130790725","https://openalex.org/W2135614292","https://openalex.org/W2137351340","https://openalex.org/W2137802705","https://openalex.org/W2141686549","https://openalex.org/W2144230507","https://openalex.org/W2145410464","https://openalex.org/W2146282045","https://openalex.org/W2147556035","https://openalex.org/W2147762902","https://openalex.org/W2153371646","https://openalex.org/W2153685501","https://openalex.org/W2155657795","https://openalex.org/W2156569107","https://openalex.org/W2159803165","https://openalex.org/W2163046615","https://openalex.org/W2166783571","https://openalex.org/W2167118899","https://openalex.org/W2172095199"],"related_works":["https://openalex.org/W2135614292","https://openalex.org/W2008315205","https://openalex.org/W1966345964","https://openalex.org/W2118973203","https://openalex.org/W2968939215","https://openalex.org/W4283742499","https://openalex.org/W2291025283","https://openalex.org/W1975528012","https://openalex.org/W2144230507","https://openalex.org/W2768155891"],"abstract_inverted_index":{"The":[0,64],"clathrin":[1],"adaptor":[2],"complex":[3,60],"AP2":[4,21,72,85,133],"is":[5,46,49],"thought":[6],"to":[7,80,116],"be":[8,67],"an":[9],"obligate":[10],"heterotetramer.":[11],"We":[12],"identify":[13],"null":[14],"mutations":[15],"in":[16,22,40,74,90,120],"the":[17,23,32,43,59,75,82,98,124],"\u03b1":[18,92,111],"subunit":[19],"of":[20,58,71,100,109,126],"nematode":[24],"Caenorhabditis":[25],"elegans.":[26],"\u03b1-adaptin":[27],"mutants":[28,54],"are":[29,62],"viable":[30],"and":[31,48,61,112,123],"remaining":[33],"\u03bc2/\u03b2":[34],"hemicomplex":[35,45],"retains":[36],"some":[37],"function.":[38],"Conversely,":[39],"\u03bc2":[41,94,113],"mutants,":[42],"alpha/sigma2":[44],"localized":[47],"partially":[50,138],"functional.":[51],"\u03b1-\u03bc2":[52],"double":[53],"disrupt":[55],"both":[56,110],"halves":[57],"lethal.":[63],"lethality":[65],"can":[66],"rescued":[68],"by":[69,103],"expression":[70],"components":[73],"skin,":[76],"which":[77],"allowed":[78],"us":[79],"evaluate":[81],"requirement":[83],"for":[84],"subunits":[86,95,114],"at":[87],"synapses.":[88],"Mutations":[89],"either":[91],"or":[93],"alone":[96],"reduce":[97],"number":[99],"synaptic":[101,121],"vesicles":[102,122],"about":[104],"30%;":[105],"however,":[106],"simultaneous":[107],"loss":[108],"leads":[115],"a":[117],"70%":[118],"reduction":[119],"presence":[125],"large":[127],"vacuoles.":[128],"These":[129],"data":[130],"suggest":[131],"that":[132],"may":[134],"function":[135],"as":[136],"two":[137],"independent":[139],"hemicomplexes.":[140],"DOI:http://dx.doi.org/10.7554/eLife.00190.001.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}