{"id":"https://openalex.org/W2040740591","doi":"https://doi.org/10.1111/j.1532-5415.1981.tb02388.x","title":"Serum Concentrations of the Iodothyronines in Elderly Subjects: Decreased Triiodothyronine (T 3 ) and Free T 3 Index","display_name":"Serum Concentrations of the Iodothyronines in Elderly Subjects: Decreased Triiodothyronine (T 3 ) and Free T 3 Index","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2040740591","doi":"https://doi.org/10.1111/j.1532-5415.1981.tb02388.x","mag":"2040740591","pmid":"https://pubmed.ncbi.nlm.nih.gov/7005294"},"language":"en","primary_location":{"id":"doi:10.1111/j.1532-5415.1981.tb02388.x","doi":"https://doi.org/10.1111/j.1532-5415.1981.tb02388.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.1981.tb02388.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028052828","display_name":"Robert H. Caplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127659","display_name":"Gundersen Lutheran Hospital","ror":"https://ror.org/03tmy2526","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1284541357","https://openalex.org/I4210127659"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert H. Caplan","raw_affiliation_strings":["The Department of Internal Medicine, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin","institution_ids":["https://openalex.org/I4210127659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060565747","display_name":"Gary G. Wickus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127659","display_name":"Gundersen Lutheran Hospital","ror":"https://ror.org/03tmy2526","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1284541357","https://openalex.org/I4210127659"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Wickus","raw_affiliation_strings":["The Department of Clinical Laboratories, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Clinical Laboratories, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin","institution_ids":["https://openalex.org/I4210127659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088248034","display_name":"James E. Glasser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127659","display_name":"Gundersen Lutheran Hospital","ror":"https://ror.org/03tmy2526","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1284541357","https://openalex.org/I4210127659"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Glasser","raw_affiliation_strings":["The Department of Internal Medicine, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin","institution_ids":["https://openalex.org/I4210127659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090478245","display_name":"Kent D. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127659","display_name":"Gundersen Lutheran Hospital","ror":"https://ror.org/03tmy2526","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1284541357","https://openalex.org/I4210127659"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent Davis","raw_affiliation_strings":["The Department of Clinical Laboratories, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Clinical Laboratories, Gundersen Clinic, Ltd. La Crosse Lutheran Hospital La Crosse Wisconsin","institution_ids":["https://openalex.org/I4210127659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111874079","display_name":"Heinz W. Wahner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heinz W. Wahner","raw_affiliation_strings":["Section of Nuclear Medicine, Mayo Clinic Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Nuclear Medicine, Mayo Clinic Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028052828"],"corresponding_institution_ids":["https://openalex.org/I4210127659"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":0.7186,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.68998844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"1","first_page":"19","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iodothyronines","display_name":"iodothyronines","score":0.9100000262260437},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.8360000252723694},{"id":"https://openalex.org/keywords/reverse-t3","display_name":"reverse T3","score":0.9800000190734863},{"id":"https://openalex.org/keywords/diiodothyronine","display_name":"diiodothyronine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7870000004768372},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.906000018119812},{"id":"https://openalex.org/keywords/nursing-home-residents","display_name":"nursing home residents","score":0.9419999718666077},{"id":"https://openalex.org/keywords/thyroid-function-tests","display_name":"thyroid function tests","score":0.875}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.919117271900177},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.7948702573776245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6778950095176697},{"id":"https://openalex.org/C2993737852","wikidata":"https://www.wikidata.org/wiki/Q712838","display_name":"Free thyroxine","level":4,"score":0.6711094379425049},{"id":"https://openalex.org/C2780486670","wikidata":"https://www.wikidata.org/wiki/Q7318276","display_name":"Reverse triiodothyronine","level":4,"score":0.5902940034866333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5380985140800476},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.514195442199707},{"id":"https://openalex.org/C2780176905","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid disease","level":3,"score":0.4154147505760193},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.41534388065338135}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004104","descriptor_name":"Diiodothyronines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007158","descriptor_name":"Immunologic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013960","descriptor_name":"Thyroid Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014285","descriptor_name":"Triiodothyronine, Reverse","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1532-5415.1981.tb02388.x","doi":"https://doi.org/10.1111/j.1532-5415.1981.tb02388.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.1981.tb02388.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},{"id":"pmid:7005294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7005294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320314207","display_name":"Gundersen Medical Foundation","ror":"https://ror.org/043wc0k64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1971368771","https://openalex.org/W1971706497","https://openalex.org/W1989506240","https://openalex.org/W1993507789","https://openalex.org/W1996041827","https://openalex.org/W2010099907","https://openalex.org/W2012220540","https://openalex.org/W2027330439","https://openalex.org/W2031062498","https://openalex.org/W2033590313","https://openalex.org/W2040659434","https://openalex.org/W2044741666","https://openalex.org/W2045123614","https://openalex.org/W2045192722","https://openalex.org/W2046057388","https://openalex.org/W2047845212","https://openalex.org/W2051768504","https://openalex.org/W2053980214","https://openalex.org/W2055401411","https://openalex.org/W2069450746","https://openalex.org/W2073239574","https://openalex.org/W2073964652","https://openalex.org/W2075428644","https://openalex.org/W2077139770","https://openalex.org/W2095960211","https://openalex.org/W2102207024","https://openalex.org/W2108612944","https://openalex.org/W2120681566","https://openalex.org/W2129571971","https://openalex.org/W2130428409","https://openalex.org/W2148642592","https://openalex.org/W2160893704","https://openalex.org/W2171477401","https://openalex.org/W2312316296","https://openalex.org/W3025186250","https://openalex.org/W7129576051"],"related_works":["https://openalex.org/W2073239574","https://openalex.org/W2026246371","https://openalex.org/W2055401411","https://openalex.org/W2051768504","https://openalex.org/W3089042684","https://openalex.org/W2001026479","https://openalex.org/W1562310838","https://openalex.org/W2416305335","https://openalex.org/W4387080077","https://openalex.org/W2037334304"],"abstract_inverted_index":{"In":[0],"four":[1],"groups":[2,107],"of":[3,6,16,29,108,140],"subjects":[4,41,49,110],"free":[5,30,34],"thyroid":[7,165],"disease,":[8],"the":[9,78,86,137,143,155],"following":[10],"determinations":[11],"were":[12,81,116],"made:":[13],"serum":[14,138],"concentrations":[15,76],"thyroxine":[17,31],"(T4),":[18],"triiodothyronine":[19,35],"(T3),":[20],"reverse":[21],"T3(rT3)":[22],"and":[23,26,33,74,77,111,142,160],"diiodothyronine":[24],"(T2),":[25],"calculated":[27],"indices":[28],"(FT4)":[32],"(FT3).":[36],"Group":[37,44,52,64,96],"A":[38],"comprised":[39],"healthy":[40,47],"aged":[42,50,62,70],"16-64;":[43],"B,":[45],"24":[46],"elderly":[48,55,109],"68-95;":[51],"C,":[53],"23":[54],"patients":[56],"with":[57],"mild":[58],"well-controlled":[59],"chronic":[60],"illnesses,":[61],"70-85;":[63],"D,":[65],"40":[66],"nursing":[67],"home":[68],"residents":[69],"66-100.":[71],"Serum":[72,99],"T4":[73],"T2":[75],"FT4":[79],"index":[80,114],"not":[82],"affected":[83],"by":[84,133],"age;":[85],"rT3":[87],"concentration":[88,101],"was":[89,102,122],"slightly":[90],"but":[91],"significantly":[92,103],"elevated":[93],"only":[94,132],"in":[95,105,136,158],"D":[97],"patients.":[98],"T3":[100,141,159],"lower":[104],"all":[106],"decreased":[112],"FT3":[113,144,161],"measurements":[115],"detected":[117],"after":[118],"age":[119],"75.":[120],"It":[121],"concluded":[123],"that":[124],"old":[125],"age,":[126],"without":[127],"complicating":[128],"illness,":[129],"is":[130],"accompanied":[131],"a":[134],"decrease":[135],"level":[139],"index;":[145],"values":[146,162],"for":[147],"other":[148],"iodothyronines":[149],"are":[150],"unchanged.":[151],"Clinicians":[152],"should":[153],"consider":[154],"age-related":[156],"changes":[157],"when":[163],"interpreting":[164],"function":[166],"tests.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}