{"id":"https://openalex.org/W2040600256","doi":"https://doi.org/10.1016/0024-3205(74)90228-8","title":"Analogs of cyclic AMP and cyclic GMP: General methods of synthesis and the relationship of structure to enzymic activity","display_name":"Analogs of cyclic AMP and cyclic GMP: General methods of synthesis and the relationship of structure to enzymic activity","publication_year":1974,"publication_date":"1974-03-01","ids":{"openalex":"https://openalex.org/W2040600256","doi":"https://doi.org/10.1016/0024-3205(74)90228-8","mag":"2040600256","pmid":"https://pubmed.ncbi.nlm.nih.gov/4362776"},"language":"en","primary_location":{"id":"doi:10.1016/0024-3205(74)90228-8","doi":"https://doi.org/10.1016/0024-3205(74)90228-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(74)90228-8","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110665893","display_name":"RICH B. JUN. MEYER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rich B. Meyer","raw_affiliation_strings":["ICN Pharmaceuticals, Inc. Nucleic Acid Research Institute 2727 Campus Drive Irvine, California 92664, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc. Nucleic Acid Research Institute 2727 Campus Drive Irvine, California 92664, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000365980","display_name":"Jon P. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon P. Miller","raw_affiliation_strings":["ICN Pharmaceuticals, Inc. Nucleic Acid Research Institute 2727 Campus Drive Irvine, California 92664, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc. Nucleic Acid Research Institute 2727 Campus Drive Irvine, California 92664, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.1722,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.70408163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"6","first_page":"1019","last_page":"1040"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-amp-analogues","display_name":"cyclic AMP analogs","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cyclic-nucleotide-synthesis","display_name":"cyclic nucleotide synthesis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cyclic-nucleotide-dependent-protein-kinases","display_name":"cyclic nucleotide-dependent protein kinases","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cyclic-nucleotide-phosphodiesterase","display_name":"cyclic nucleotide phosphodiesterase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.7704070806503296},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7548242807388306},{"id":"https://openalex.org/C2778524494","wikidata":"https://www.wikidata.org/wiki/Q967433","display_name":"Cyclic nucleotide","level":4,"score":0.7457265853881836},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.6104708909988403},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6089569926261902},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5894705653190613},{"id":"https://openalex.org/C2780215583","wikidata":"https://www.wikidata.org/wiki/Q946700","display_name":"Cyclic nucleotide phosphodiesterase","level":4,"score":0.5854349732398987},{"id":"https://openalex.org/C3020139451","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic gmp","level":3,"score":0.5716208815574646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5428301692008972},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.46783649921417236},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4610663056373596},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4152100384235382},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3311575651168823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0024-3205(74)90228-8","doi":"https://doi.org/10.1016/0024-3205(74)90228-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(74)90228-8","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:4362776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4362776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1594497161","https://openalex.org/W1973288764","https://openalex.org/W1976712157","https://openalex.org/W1983270056","https://openalex.org/W1990801533","https://openalex.org/W1991665104","https://openalex.org/W1998264645","https://openalex.org/W2025447842","https://openalex.org/W2029881034","https://openalex.org/W2047929650","https://openalex.org/W2060891368","https://openalex.org/W2070848386","https://openalex.org/W2074090122","https://openalex.org/W2076217345","https://openalex.org/W2080452204","https://openalex.org/W2084967649","https://openalex.org/W2128588426","https://openalex.org/W2135299196","https://openalex.org/W2157507751","https://openalex.org/W2312440692","https://openalex.org/W2313409955","https://openalex.org/W2315911157","https://openalex.org/W2318367225","https://openalex.org/W4296843051","https://openalex.org/W4406985008"],"related_works":["https://openalex.org/W1996310804","https://openalex.org/W2011370114","https://openalex.org/W2070732778","https://openalex.org/W1543080609","https://openalex.org/W2048113963","https://openalex.org/W2308424682","https://openalex.org/W200077918","https://openalex.org/W2148485786","https://openalex.org/W189529612","https://openalex.org/W1992529146"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
