{"id":"https://openalex.org/W2040576293","doi":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","title":"Integration of epithelial patterning and morphogenesis inDrosophila ovarian follicle cells","display_name":"Integration of epithelial patterning and morphogenesis inDrosophila ovarian follicle cells","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2040576293","doi":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","mag":"2040576293","pmid":"https://pubmed.ncbi.nlm.nih.gov/10822261"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0177%28200005%29218%3A1%3C80%3A%3AAID-DVDY7%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0177%28200005%29218%3A1%3C80%3A%3AAID-DVDY7%3E3.0.CO%3B2-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047805720","display_name":"Leonard L. Dobens","orcid":"https://orcid.org/0000-0003-1239-066X","observed_orcids":["https://orcid.org/0000-0003-1239-066X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard L. Dobens","raw_affiliation_strings":["Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA","Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081634838","display_name":"Laurel A. Raftery","orcid":"https://orcid.org/0000-0003-4797-4163","observed_orcids":["https://orcid.org/0000-0003-4797-4163"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laurel A. Raftery","raw_affiliation_strings":["Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081634838"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.6902,"has_fulltext":true,"cited_by_count":176,"citation_normalized_percentile":{"value":0.57142857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"218","issue":"1","first_page":"80","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicle-cells","display_name":"follicle cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/drosophila-oogenesis","display_name":"Drosophila oogenesis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/epithelial-patterning","display_name":"epithelial patterning","score":0.925000011920929},{"id":"https://openalex.org/keywords/morphogenesis","display_name":"morphogenesis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7559999823570251},{"id":"https://openalex.org/keywords/de-cadherin","display_name":"DE-cadherin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/egf-signaling","display_name":"EGF signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/eggshell-formation","display_name":"eggshell formation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/terminal-differentiation","display_name":"terminal differentiation","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8422943353652954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7969213724136353},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.7529764771461487},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5021581649780273},{"id":"https://openalex.org/C2780536345","wikidata":"https://www.wikidata.org/wiki/Q953556","display_name":"Ovarian follicle","level":3,"score":0.47713375091552734},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.4637700915336609},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4593539237976074},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3393021523952484},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.27570050954818726},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.13601762056350708},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10585200786590576},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0177%28200005%29218%3A1%3C80%3A%3AAID-DVDY7%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:10822261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10822261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0177(200005)218:1<80::aid-dvdy7>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0177%28200005%29218%3A1%3C80%3A%3AAID-DVDY7%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.4699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1914822747","display_name":null,"funder_award_id":"GM60501","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8006669049","display_name":"TGF-beta family regulation of epithelial morphogenesis ","funder_award_id":"R01GM060501","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040576293.pdf","grobid_xml":"https://content.openalex.org/works/W2040576293.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W122846848","https://openalex.org/W209304007","https://openalex.org/W1545962441","https://openalex.org/W1555563809","https://openalex.org/W1825701914","https://openalex.org/W1826103719","https://openalex.org/W1832760132","https://openalex.org/W1858629934","https://openalex.org/W1870044696","https://openalex.org/W1923868955","https://openalex.org/W1928474359","https://openalex.org/W1947528035","https://openalex.org/W1948644152","https://openalex.org/W1964090237","https://openalex.org/W1980992536","https://openalex.org/W1983096415","https://openalex.org/W1984689602","https://openalex.org/W1990891647","https://openalex.org/W1991758769","https://openalex.org/W1992854237","https://openalex.org/W1999751317","https://openalex.org/W2003460583","https://openalex.org/W2006666611","https://openalex.org/W2008297562","https://openalex.org/W2013791364","https://openalex.org/W2015114060","https://openalex.org/W2015877043","https://openalex.org/W2017995506","https://openalex.org/W2019788425","https://openalex.org/W2021974175","https://openalex.org/W2024481695","https://openalex.org/W2035595923","https://openalex.org/W2048281901","https://openalex.org/W2049663474","https://openalex.org/W2050880525","https://openalex.org/W2052746404","https://openalex.org/W2057989418","https://openalex.org/W2064729120","https://openalex.org/W2066818389","https://openalex.org/W2069613957","https://openalex.org/W2074861203","https://openalex.org/W2091638660","https://openalex.org/W2096658690","https://openalex.org/W2096791952","https://openalex.org/W2097276658","https://openalex.org/W2100730392","https://openalex.org/W2101172608","https://openalex.org/W2101273266","https://openalex.org/W2101806268","https://openalex.org/W2104262655","https://openalex.org/W2108450183","https://openalex.org/W2108489580","https://openalex.org/W2110767317","https://openalex.org/W2112258991","https://openalex.org/W2112310659","https://openalex.org/W2113538446","https://openalex.org/W2114692975","https://openalex.org/W2115724679","https://openalex.org/W2119339052","https://openalex.org/W2127303546","https://openalex.org/W2132332604","https://openalex.org/W2135482336","https://openalex.org/W2139985100","https://openalex.org/W2147655622","https://openalex.org/W2151677871","https://openalex.org/W2157417376","https://openalex.org/W2159494508","https://openalex.org/W2165780130","https://openalex.org/W2167179274","https://openalex.org/W2167644662","https://openalex.org/W2171483658","https://openalex.org/W2171887312","https://openalex.org/W2184627692","https://openalex.org/W2185119839","https://openalex.org/W2185403194","https://openalex.org/W2187952665","https://openalex.org/W2189187333","https://openalex.org/W2337710835","https://openalex.org/W2427832542","https://openalex.org/W3217797670","https://openalex.org/W4297673475","https://openalex.org/W4300723053"],"related_works":["https://openalex.org/W1975613609","https://openalex.org/W1979351753","https://openalex.org/W2125938051","https://openalex.org/W2801873416","https://openalex.org/W127293479","https://openalex.org/W7100557577","https://openalex.org/W2032333371","https://openalex.org/W3086748855","https://openalex.org/W2039196196","https://openalex.org/W2376034899"],"abstract_inverted_index":{"Drosophila":[0],"oogenesis":[1],"involves":[2],"the":[3,24,56,61,70,86,89,100,150,154],"coordinated":[4],"development":[5],"of":[6,27,41,60,72,133,138,153],"germ":[7],"cells":[8,16,32,43,52,74,91],"and":[9,29,44,65,108,121,135,143],"an":[10],"overlying":[11],"follicular":[12],"epithelium.":[13],"The":[14],"follicle":[15,73,90,105,122],"provide":[17],"a":[18,35,39],"genetically":[19],"tractable":[20],"system":[21],"to":[22,54,84],"investigate":[23],"cell":[25,106,123],"biology":[26],"patterning":[28,107,134],"morphogenesis.":[30],"Follicle":[31],"initially":[33],"form":[34],"cuboidal":[36],"epithelium":[37],"surrounding":[38],"syncytium":[40],"nurse":[42],"oocyte.":[45],"Epithelial":[46],"structure":[47],"is":[48,112,127],"maintained":[49],"as":[50],"these":[51],"reorganize":[53],"create":[55,77],"three":[57],"dimensional":[58],"architecture":[59],"eggshell.":[62,156],"Both":[63],"long-range":[64],"short-range":[66],"cell-cell":[67,101],"communications":[68],"pattern":[69],"domains":[71],"that":[75,103],"will":[76],"specific":[78],"eggshell":[79,87],"structures.":[80],"After":[81],"terminal":[82],"differentiation":[83],"deposit":[85],"proteins,":[88],"die.":[92],"This":[93],"review":[94],"summarizes":[95],"recent":[96],"progress":[97],"in":[98,117],"understanding":[99],"communication":[102],"orchestrates":[104],"migrations.":[109],"DE-cadherin-mediated":[110],"adhesion":[111],"important":[113],"at":[114],"several":[115],"steps":[116],"egg":[118],"chamber":[119],"formation":[120],"migration.":[124,136],"Notch":[125],"signaling":[126],"critical":[128],"during":[129],"each":[130],"successive":[131],"round":[132],"Integration":[137],"bone":[139],"morphogenetic":[140],"protein":[141],"(BMP)":[142],"epidermal":[144],"growth":[145],"factor":[146],"(EGF)":[147],"signals":[148],"patterns":[149],"elaborate":[151],"structures":[152],"dorsal-anterior":[155]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}