{"id":"https://openalex.org/W2040478366","doi":"https://doi.org/10.1113/jphysiol.2008.162784","title":"Anchors aweigh: NMDA receptors set sail from their presynaptic port","display_name":"Anchors aweigh: NMDA receptors set sail from their presynaptic port","publication_year":2008,"publication_date":"2008-10-14","ids":{"openalex":"https://openalex.org/W2040478366","doi":"https://doi.org/10.1113/jphysiol.2008.162784","mag":"2040478366","pmid":"https://pubmed.ncbi.nlm.nih.gov/18854432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614065"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2008.162784","doi":"https://doi.org/10.1113/jphysiol.2008.162784","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2008.162784","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614065","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021870639","display_name":"Annalisa Scimemi","orcid":"https://orcid.org/0000-0003-4975-093X","observed_orcids":["https://orcid.org/0000-0003-4975-093X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annalisa Scimemi","raw_affiliation_strings":["Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3701, USA. scimemia@ninds.nih.gov","Synaptic Physiology Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Building 35, Room 3C\u20101006, Bethesda, MD 20892\u20103701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3701, USA. scimemia@ninds.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Synaptic Physiology Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Building 35, Room 3C\u20101006, Bethesda, MD 20892\u20103701, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021870639"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14270652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"586","issue":"20","first_page":"4787","last_page":"4787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/presynaptic-nmda-receptors","display_name":"presynaptic NMDA receptors","score":0.921999990940094},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.871999979019165},{"id":"https://openalex.org/keywords/receptor-lateral-diffusion","display_name":"receptor lateral diffusion","score":0.4950000047683716},{"id":"https://openalex.org/keywords/extrasynaptic-receptors","display_name":"extrasynaptic receptors","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nr1-subunit","display_name":"NR1 subunit","score":0.7239999771118164},{"id":"https://openalex.org/keywords/psd-95","display_name":"PSD-95","score":0.8690000176429749},{"id":"https://openalex.org/keywords/sap102","display_name":"SAP102","score":0.972000002861023},{"id":"https://openalex.org/keywords/cytoplasmic-tail","display_name":"cytoplasmic tail","score":0.722000002861023},{"id":"https://openalex.org/keywords/reelin","display_name":"reelin","score":0.6499999761581421},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.5419999957084656},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.6710000038146973},{"id":"https://openalex.org/keywords/synaptic-vesicle-release","display_name":"synaptic vesicle release","score":0.3089999854564667},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.7251507043838501},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6199785470962524},{"id":"https://openalex.org/C32802771","wikidata":"https://www.wikidata.org/wiki/Q2443617","display_name":"Port (circuit theory)","level":2,"score":0.5295758247375488},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5023059844970703},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.48464876413345337},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30890583992004395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3003193736076355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29179906845092773},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15656423568725586},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.08596685528755188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06775647401809692},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.2008.162784","doi":"https://doi.org/10.1113/jphysiol.2008.162784","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2008.162784","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2614065","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614065","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:18854432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18854432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Comment"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2614065","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614065","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1563422430","https://openalex.org/W1800504601","https://openalex.org/W2000779549","https://openalex.org/W2011875417","https://openalex.org/W2025653075","https://openalex.org/W2080550406","https://openalex.org/W2101151644"],"related_works":["https://openalex.org/W2966607646","https://openalex.org/W1669304660","https://openalex.org/W2065460329","https://openalex.org/W4301037431","https://openalex.org/W2037038958","https://openalex.org/W1972884505","https://openalex.org/W2071854079","https://openalex.org/W1751156075","https://openalex.org/W2080357850","https://openalex.org/W2132101657"],"abstract_inverted_index":{"NMDA":[0,38,82,100,165,198,212,270,289,303,311,336,373,404,426,469,488,510,537,578,625,657,698,712,772],"receptors":[1,39,83,101,166,199,213,271,312,337,374,405,470,489,538,579,603,626,707,713,750,773],"are":[2,92,395,490,530,571],"unevenly":[3],"expressed":[4],"in":[5,13,18,96,191,262,320,343,379,388,440,446,525,546,667],"neuronal":[6],"cell":[7,283,569],"membranes,":[8],"reaching":[9],"their":[10,105,141,543,727],"highest":[11],"concentration":[12],"the":[14,33,50,59,88,110,120,156,194,219,227,263,266,282,288,295,333,347,380,430,450,473,483,504,509,547,560,568,598,606,638,653,668,704,746,768,785],"postsynaptic":[15,111,310,487],"density":[16],"(PSD),":[17],"register":[19],"with":[20,45,200,250,259,377,532,562,597,683,781],"presynaptic":[21,330,335,476,536,551,599,624],"active":[22,591,741],"zones.":[23],"This":[24,361],"confined":[25],"distribution":[26],"partly":[27],"arises":[28],"from":[29,84,87,366,443,503,740],"biochemical":[30,228],"interactions":[31,77,91,268,561],"that":[32,160,174,422,485,585],"large":[34],"cytosolic":[35],"tail":[36],"of":[37,49,140,152,163,175,193,197,210,236,253,265,294,346,372,383,400,411,415,432,449,459,462,468,475,494,499,516,542,549,608,623,641,656,706,749,755,763,771,784],"(>":[40],"600":[41],"amino":[42],"acids)":[43],"establishes":[44],"subsynaptic":[46],"scaffold":[47],"proteins":[48,70,293,564],"PSD":[51],"(PSD-95,":[52],"SAP102),":[53],"which":[54,526,721],"ultimately":[55],"anchor":[56],"them":[57],"to":[58,68,135,242,245,286,301,341,398,409,575,635,646,672,687,695,716,725,778],"intracellular":[60],"cytoskeleton.":[61],"In":[62,143,332,676],"part,":[63],"it":[64,679],"is":[65,167,214,315,375,480],"also":[66,240,744],"due":[67,408],"neighbouring":[69,132,273,563],"and":[71,78,94,98,122,256,272,350,497,539,566,605,662],"lipids":[72],"that,":[73],"through":[74,403,711],"weak":[75],"molecular":[76,267],"steric":[79],"hindrance,":[80],"prevent":[81],"drifting":[85],"away":[86],"PSD.\r\n\r\nAll":[89],"these":[90,393],"transient":[93],"reversible":[95],"nature,":[97],"most":[99],"do":[102,326,420],"not":[103,325,572],"spend":[104,136],"entire":[106],"lifetime":[107],"docked":[108],"at":[109,147,318,329,423,751],"harbour":[112,133],"(Choquet":[113],"&":[114,358],"Triller,":[115],"2003).":[116],"Occasionally,":[117],"they":[118,129,323,419],"remove":[119],"mooring":[121],"start":[123],"sailing":[124,276],"across":[125],"extrasynaptic":[126,176],"seas":[127],"until":[128],"reach":[130],"a":[131,137,234,278,412,437,522,556,620,632,663],"where":[134,369,593,610],"few":[138],"seconds":[139],"life.":[142],"cultured":[144],"hippocampal":[145],"neurons,":[146],"room":[148],"temperature,":[149],"optical":[150],"tracking":[151],"Cy3-conjugated":[153],"antibodies":[154],"against":[155],"NR1":[157],"subunit":[158,195,221],"shows":[159],"lateral":[161,586,648],"diffusion":[162,587,649],"synaptic":[164,616,689,764],"around":[168],"0.021":[169],"\u03bcm2":[170,179],"s\u22121,":[171],"slower":[172],"than":[173],"ones":[177],"(0.037":[178],"s\u22121)":[180],"(Groc":[181,204,222,306,730],"et":[182,205,223,307,354,454,731],"al.":[183,206,224,308,355,455,732],"2004).":[184,733],"These":[185],"estimates":[186],"have":[187,338,464],"recently":[188,465],"been":[189,339,363,723],"re-evaluated":[190],"view":[192],"composition":[196],"different":[201,251],"subcellular":[202],"locations":[203],"2006).":[207],"The":[208,460,478],"proportion":[209],"immobile":[211],"greater":[215],"for":[216,535],"those":[217],"containing":[218],"NR2A":[220],"2006),":[225],"although":[226],"mechanisms":[229],"underlying":[230],"this":[231,248,517,554,645,674],"behaviour":[232,622,748],"remain":[233],"matter":[235],"current":[237],"investigation.":[238],"It":[239,628,691],"remains":[241,555],"be":[243,693],"established":[244],"what":[246],"extent":[247],"correlates":[249],"geometries":[252],"spine":[254],"heads":[255],"necks":[257],"or":[258,386,406],"developmental":[260],"changes":[261],"properties":[264],"between":[269,590],"proteins.":[274],"Since":[275],"needs":[277],"breeze,":[279],"something":[280],"over":[281],"membrane":[284,570,600],"has":[285,362,722,758],"aid":[287],"receptor":[290,304,427,511,611,658,699,756],"boat.":[291],"Indeed,":[292],"extracellular":[296],"matrix,":[297],"like":[298],"reelin,":[299],"appear":[300],"favour":[302],"navigation":[305],"2007).\r\n\r\nIf":[309],"move,":[313],"there":[314],"little":[316],"reason,":[317],"least":[319],"principle,":[321],"why":[322],"should":[324,650],"so":[327,789],"even":[328],"sites.":[331],"cortex,":[334,452],"proposed":[340],"exist":[342],"specific":[344],"layers":[345],"entorhinal,":[348],"visual":[349],"somatosensory":[351],"region":[352],"(Woodhall":[353],"2001;":[356],"Brasier":[357],"Feldman,":[359],"2008).":[360],"generally":[364],"inferred":[365],"electrophysiological":[367,528],"recordings":[368],"pharmacological":[370],"block":[371,507],"associated":[376],"increase":[378,726],"paired-pulse":[381],"ratio":[382],"evoked":[384,495],"EPSCs":[385,496,501],"decrease":[387],"miniature":[389],"EPSC":[390],"frequency.":[391],"Whether":[392],"effects":[394],"directly":[396],"consequent":[397],"prevention":[399],"Ca2+":[401,417,709],"influx":[402,710],"indirectly":[407],"inhibition":[410],"depolarization-induced":[413],"recruitment":[414],"voltage-gated":[416],"channels,":[418],"indicate":[421],"certain":[424],"synapses":[425],"activation":[428,700],"enhances":[429],"probability":[431],"neurotransmitter":[433,594],"release.":[434],"By":[435],"using":[436],"similar":[438],"approach":[439],"acute":[441],"slices":[442],"adult":[444],"rats,":[445],"layer":[447],"V":[448],"entorhinal":[451],"Yang":[453],"(2008)":[456],"(this":[457],"issue":[458],"Journal":[461],"Physiology)":[463],"caught":[466],"sight":[467],"cruising":[471],"amidst":[472],"waves":[474],"terminals.":[477],"conclusion":[479],"based":[481],"on":[482,615],"observation":[484],"if":[486],"blocked,":[491],"frequency-dependent":[492],"facilitation":[493],"frequency":[498],"spontaneous":[500],"recover":[502],"irreversible,":[505],"use-dependent":[506],"by":[508],"antagonist":[512],"MK-801.\r\n\r\nA":[513],"definitive":[514],"proof":[515],"interpretation":[518],"would":[519,582,618,692,743],"inevitably":[520],"require":[521],"multidisciplinary":[523],"effort,":[524],"functional":[527],"approaches":[529],"combined":[531],"anatomical":[533],"evidence":[534],"live":[540],"imaging":[541],"trajectories.":[544],"But":[545],"absence":[548],"yet-unidentified":[550],"anchoring":[552],"proteins,":[553],"feasible":[557],"hypothesis":[558],"provided":[559],"inside":[565],"underneath":[567],"strong":[573],"enough":[574],"constantly":[576],"drive":[577],"aground.":[580],"One":[581],"then":[583],"speculate":[584],"takes":[588],"place":[589],"zones,":[592],"vesicles":[595],"fusing":[596],"continuously":[601],"push":[602],"away,":[604],"sites":[607],"exo-endocytosis,":[609],"trafficking":[612],"occurs.\r\n\r\nWhat":[613],"implications":[614],"transmission":[617],"such":[619],"dynamic":[621,747],"have?":[627],"could":[629,680,714],"work":[630],"as":[631],"homeostatic":[633],"mechanism":[634],"maintain":[636],"constant":[637],"baseline":[639],"level":[640],"release":[642],"probability.":[643],"For":[644],"happen,":[647],"occur":[651],"within":[652],"time":[654],"frame":[655],"deactivation":[659],"(\u223c100":[660],"ms)":[661],"more":[664],"quantitative":[665],"analysis":[666],"future":[669],"will":[670,774],"help":[671],"elucidate":[673],"scenario.":[675],"general":[677],"though,":[678],"provide":[681],"neurons":[682],"an":[684],"additional":[685],"tool":[686],"regulate":[688],"strength.":[690],"interesting":[694],"know":[696],"whether":[697,737],"per":[701],"se":[702],"alters":[703],"mobility":[705,729,757],"nearby:":[708],"lead":[715,776],"protein":[717],"kinase":[718],"C":[719],"activation,":[720],"shown":[724],"own":[728],"Finally,":[734],"I":[735],"wonder":[736],"glutamate":[738],"escape":[739],"terminals":[742],"alter":[745],"adjacent":[752],"synapses.\r\n\r\nThe":[753],"notion":[754],"definitely":[759],"changed":[760],"our":[761],"understanding":[762],"function.":[765],"No":[766],"doubt":[767],"extraordinary":[769],"adventures":[770],"soon":[775],"us":[777],"better":[779],"shores,":[780],"clearer":[782],"views":[783],"physiological":[786],"processes":[787],"studied":[788],"far.":[790]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}