{"id":"https://openalex.org/W204046905","doi":null,"title":"Synthesis and biodistribution of (C-11) labeled irreversible inhibitors of MAO A and B","display_name":"Synthesis and biodistribution of (C-11) labeled irreversible inhibitors of MAO A and B","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W204046905","mag":"204046905"},"language":"en","primary_location":{"id":"mag:204046905","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6856685-synthesis-biodistribution-labeled-irreversible-inhibitors-mao","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111835572","display_name":"Robert R MacGregor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert MacGregor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111871534","display_name":"Christer Halldin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Halldin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112477718","display_name":"Joanna S. Fowler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna S. Fowler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113629856","display_name":"A. P. Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. P. Wolf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025961784","display_name":"David Alexoff","orcid":"https://orcid.org/0000-0002-0612-1239","observed_orcids":["https://orcid.org/0000-0002-0612-1239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Alexoff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0612-1239","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112359118","display_name":"Carroll D. Arnett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carroll D. Arnett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030695945","display_name":"Bengt L\u00e5ngstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bengt L\u00e5ngstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03013575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-oxidase","display_name":"monoamine oxidase","score":0.8610000014305115},{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.8690000176429749},{"id":"https://openalex.org/keywords/monoamine-oxidase-b","display_name":"monoamine oxidase B","score":1.0},{"id":"https://openalex.org/keywords/irreversible-enzyme-inhibitors","display_name":"irreversible enzyme inhibitors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/clorgyline","display_name":"clorgyline","score":0.8130000233650208},{"id":"https://openalex.org/keywords/selegiline","display_name":"selegiline","score":0.9190000295639038},{"id":"https://openalex.org/keywords/propargylamines","display_name":"propargylamines","score":0.7279999852180481},{"id":"https://openalex.org/keywords/carbon-11-radiolabeling","display_name":"carbon-11 radiolabeling","score":0.8109999895095825},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7609999775886536},{"id":"https://openalex.org/keywords/enzyme-localization","display_name":"enzyme localization","score":0.31700000166893005},{"id":"https://openalex.org/keywords/brain-enzyme-activity","display_name":"brain enzyme activity","score":0.40799999237060547},{"id":"https://openalex.org/keywords/radiosynthesis","display_name":"radiotracer synthesis","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7850109338760376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7550365328788757},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.7374991178512573},{"id":"https://openalex.org/C2910293678","wikidata":"https://www.wikidata.org/wiki/Q2889652","display_name":"Clorgyline","level":4,"score":0.7199946641921997},{"id":"https://openalex.org/C39398028","wikidata":"https://www.wikidata.org/wiki/Q18028862","display_name":"Monoamine oxidase B","level":4,"score":0.6807001829147339},{"id":"https://openalex.org/C198684833","wikidata":"https://www.wikidata.org/wiki/Q2823748","display_name":"Specific activity","level":3,"score":0.5709813833236694},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5666689872741699},{"id":"https://openalex.org/C114461151","wikidata":"https://www.wikidata.org/wiki/Q14888415","display_name":"Monoamine oxidase A","level":4,"score":0.5503588914871216},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.5408371686935425},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.5328750014305115},{"id":"https://openalex.org/C2781450507","wikidata":"https://www.wikidata.org/wiki/Q128381","display_name":"Harmine","level":2,"score":0.48739415407180786},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43072134256362915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42395448684692383},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3244001269340515},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11584010720252991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08665093779563904},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0862971842288971},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:204046905","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6856685-synthesis-biodistribution-labeled-irreversible-inhibitors-mao","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009077522","https://openalex.org/W2005656534","https://openalex.org/W2314185396","https://openalex.org/W2333962735","https://openalex.org/W210003554","https://openalex.org/W2025109436","https://openalex.org/W2142456895","https://openalex.org/W1963782667","https://openalex.org/W2021051139","https://openalex.org/W139133722"],"abstract_inverted_index":{"Alterations":[0],"in":[1,10,83,119,128,174,200],"the":[2,36,56,146,168,189],"enzyme":[3,57,198],"monoamine":[4],"oxidase":[5],"(MAO)":[6],"have":[7,22,91],"been":[8,23,92],"implicated":[9],"a":[11,71,100,109],"number":[12],"of":[13,17,104,112,136,138,151,157,170,176,191],"diseases.":[14],"Two":[15],"types":[16],"MAO":[18,50,79,148,186],"(A":[19],"and":[20,41,52,66,81,89,108,124,126,134,181,187],"B)":[21],"identified":[24],"by":[25,35,58],"their":[26,32],"substrate":[27],"selectivity":[28],"as":[29,31],"well":[30],"selective":[33,76,155],"inhibition":[34],"propargyl":[37],"amines":[38],"clorgyline":[39],"(la)":[40],"L-deprenyl":[42],"(lb).":[43],"These":[44],"inhibitors,":[45],"which":[46],"are":[47],"substrates":[48],"for":[49,78,195],"A":[51,180],"B":[53,185],"respectively,":[54],"deactivate":[55],"becoming":[59],"covalently":[60],"or":[61],"irreversibly":[62],"attached":[63],"to":[64,141,144,159,178,183],"it,":[65],"so,":[67],"if":[68],"labeled":[69],"with":[70,99],"positron":[72],"emitter":[73],"may":[74],"provide":[75],"probes":[77],"localization":[80],"reactivity":[82],"vivo":[84,175,201],"using":[85,192,202],"PET.":[86],"N-(C-11)methyl":[87],"1a":[88,125,177],"1b":[90,127,182],"synthesized.":[93],"Synthesis":[94],"time":[95],"was":[96],"40":[97],"min":[98],"radiochemical":[101],"yield":[102],"(EOB)":[103],"approx.":[105,113],"=":[106,114],"20%":[107],"specific":[110,132,147,171],"activity":[111,158],"200":[115],"mCi/..mu..mole":[116],"(EOB).":[117],"Differences":[118],"tissue":[120],"distribution":[121],"between":[122],"control":[123],"pretreated":[129],"mice":[130],"demonstrated":[131],"uptake":[133],"retention":[135],"each":[137],"these":[139],"tracers":[140],"organs":[142],"known":[143],"contain":[145],"subtype.":[149],"Centrifugation":[150],"brain":[152],"homogenates":[153],"showed":[154],"binding":[156,173],"particulate":[160],"material":[161],"following":[162],"protein":[163],"precipitation.":[164],"The":[165],"results":[166],"support":[167],"premise":[169],"irreversible":[172],"type":[179,184],"demonstrate":[188],"feasibility":[190],"this":[193],"approach":[194],"probing":[196],"functional":[197],"activitymore\u00a0\u00bb":[199],"PET.\u00ab\u00a0less":[203]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
