{"id":"https://openalex.org/W2040468963","doi":"https://doi.org/10.1002/jcb.10541","title":"Effect of glucose concentration on activation of the ASK1\u2013SEK1\u2013JNK1 signal transduction pathway","display_name":"Effect of glucose concentration on activation of the ASK1\u2013SEK1\u2013JNK1 signal transduction pathway","publication_year":2003,"publication_date":"2003-06-16","ids":{"openalex":"https://openalex.org/W2040468963","doi":"https://doi.org/10.1002/jcb.10541","mag":"2040468963","pmid":"https://pubmed.ncbi.nlm.nih.gov/12858332"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.10541","doi":"https://doi.org/10.1002/jcb.10541","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.10541","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://onlinelibrary.wiley.com/doi/10.1002/jcb.10541/abstract","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100439345","display_name":"Jae Jin Song","orcid":"https://orcid.org/0000-0001-8183-9550","observed_orcids":["https://orcid.org/0000-0001-8183-9550"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae J. Song","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, The Hillman Cancer Center G.5a, 5117 Centre Ave., Pittsburgh, PA 15213, USA. leeyj@msx.upmc.edu","Department of Surgery, University of Pittsburgh, The Hillman Cancer Center G.5a, 5117 Centre Ave., Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, The Hillman Cancer Center G.5a, 5117 Centre Ave., Pittsburgh, PA 15213, USA. leeyj@msx.upmc.edu","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, The Hillman Cancer Center G.5a, 5117 Centre Ave., Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040610316","display_name":"Yong Jun Lee","orcid":"https://orcid.org/0000-0001-5914-8489","observed_orcids":["https://orcid.org/0000-0001-5914-8489"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong J. Lee","raw_affiliation_strings":["Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania","Department of Surgery, University of Pittsburgh, The Hillman Cancer Center G.5a, 5117 Centre Ave., Pittsburgh, PA 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, The Hillman Cancer Center G.5a, 5117 Centre Ave., Pittsburgh, PA 15213","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040610316"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.5772,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.62042999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"89","issue":"4","first_page":"653","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.6150000095367432},{"id":"https://openalex.org/keywords/ask1","display_name":"ASK1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/jnk1","display_name":"JNK1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/sek1","display_name":"SEK1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glutaredoxin","display_name":"glutaredoxin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/thioredoxin","display_name":"thioredoxin","score":0.996999979019165},{"id":"https://openalex.org/keywords/daxx","display_name":"DAXX","score":0.9259999990463257},{"id":"https://openalex.org/keywords/traf2","display_name":"TRAF2","score":1.0},{"id":"https://openalex.org/keywords/low-glucose","display_name":"low glucose","score":0.5709999799728394},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.5180000066757202},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.7815356254577637},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.5860176086425781},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.578394889831543},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.5450693368911743},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5427695512771606},{"id":"https://openalex.org/C89380225","wikidata":"https://www.wikidata.org/wiki/Q14908178","display_name":"Death-associated protein 6","level":5,"score":0.5040270686149597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43649959564208984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.431729257106781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.304829478263855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3009311258792877},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.27496373653411865},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2232097089290619},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.15292298793792725},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12509289383888245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06739407777786255},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047992","descriptor_name":"TNF Receptor-Associated Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047992","descriptor_name":"TNF Receptor-Associated Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047992","descriptor_name":"TNF Receptor-Associated Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048055","descriptor_name":"Mitogen-Activated Protein Kinase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048055","descriptor_name":"Mitogen-Activated Protein Kinase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048055","descriptor_name":"Mitogen-Activated Protein Kinase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054477","descriptor_name":"Glutaredoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054477","descriptor_name":"Glutaredoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054477","descriptor_name":"Glutaredoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcb.10541","doi":"https://doi.org/10.1002/jcb.10541","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.10541","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:12858332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12858332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/114623","doi":null,"is_oa":true,"landing_page_url":"http://onlinelibrary.wiley.com/doi/10.1002/jcb.10541/abstract","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/114623","doi":null,"is_oa":true,"landing_page_url":"http://onlinelibrary.wiley.com/doi/10.1002/jcb.10541/abstract","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1531546675","display_name":null,"funder_award_id":"CA 48000","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5758740798","display_name":"STRESS RESPONSES IN MAMMALIAN CELLS","funder_award_id":"5r01ca048000-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W33354229","https://openalex.org/W43791475","https://openalex.org/W1582456049","https://openalex.org/W1754823593","https://openalex.org/W1956944003","https://openalex.org/W1968160256","https://openalex.org/W1969268163","https://openalex.org/W1982233032","https://openalex.org/W1987351682","https://openalex.org/W2005341765","https://openalex.org/W2009619113","https://openalex.org/W2011862846","https://openalex.org/W2012357103","https://openalex.org/W2015805559","https://openalex.org/W2016127055","https://openalex.org/W2034580062","https://openalex.org/W2045764707","https://openalex.org/W2064122617","https://openalex.org/W2085569151","https://openalex.org/W2090193716","https://openalex.org/W2102955022","https://openalex.org/W2116938728","https://openalex.org/W2130191536","https://openalex.org/W2139466117","https://openalex.org/W2144714494","https://openalex.org/W2148209200","https://openalex.org/W2165884308","https://openalex.org/W2166731734","https://openalex.org/W2490919379","https://openalex.org/W2969240875","https://openalex.org/W4241091303"],"related_works":["https://openalex.org/W2158825501","https://openalex.org/W1972163091","https://openalex.org/W2076732948","https://openalex.org/W2116777960","https://openalex.org/W2378184336","https://openalex.org/W2337255290","https://openalex.org/W2019776436","https://openalex.org/W2014139218","https://openalex.org/W2042144127","https://openalex.org/W2151404901"],"abstract_inverted_index":{"Recently,":[0],"acute":[1],"total":[2],"glucose":[3,38,53,97],"deprivation":[4],"has":[5],"been":[6],"shown":[7],"to":[8,59,63,103],"cause":[9],"activation":[10,47],"of":[11,17,37,48,75,83,87],"ASK1-MEK-MAPK":[12],"signal":[13],"transduction":[14],"and":[15,77,85,89],"dissociation":[16,74],"glutaredoxin":[18],"(GRX)":[19],"from":[20,80],"apoptosis":[21],"signal-regulating":[22],"kinase":[23],"1":[24],"(ASK1).":[25],"In":[26],"this":[27],"study,":[28],"we":[29,66],"investigated":[30],"whether":[31],"clinically":[32],"relevant":[33],"concentrations":[34],"(0.01-0.1":[35],"mM)":[36],"promote":[39],"ASK1":[40,72,92],"activation.":[41],"We":[42],"observed":[43,68],"that":[44,69],"a":[45,52,96],"prominent":[46],"JNK1":[49,64],"occurred":[50,94],"at":[51,95],"concentration":[54,98],"less":[55,99],"than":[56,100],"or":[57,101],"equal":[58,102],"0.01":[60,104],"mM.":[61,105],"Similar":[62],"activation,":[65,73],"also":[67],"low":[70],"glucose-induced":[71],"GRX":[76],"thioredoxin":[78],"(TRX)":[79],"ASK1,":[81,84],"dimerization":[82],"association":[86],"Daxx":[88],"TRAF2":[90],"with":[91],"significantly":[93]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}