{"id":"https://openalex.org/W2040454459","doi":"https://doi.org/10.1371/journal.pgen.1001026","title":"Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo","display_name":"Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo","publication_year":2010,"publication_date":"2010-07-15","ids":{"openalex":"https://openalex.org/W2040454459","doi":"https://doi.org/10.1371/journal.pgen.1001026","mag":"2040454459","pmid":"https://pubmed.ncbi.nlm.nih.gov/20664788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904797"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1001026","doi":"https://doi.org/10.1371/journal.pgen.1001026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1001026","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001026&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001026&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055136563","display_name":"Vikram Khurana","orcid":"https://orcid.org/0000-0002-4018-5527","observed_orcids":["https://orcid.org/0000-0002-4018-5527"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Khurana","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016946786","display_name":"Ilan Elson\u2010Schwab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilan Elson-Schwab","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081272972","display_name":"Tudor A. Fulga","orcid":"https://orcid.org/0000-0002-1056-0082","observed_orcids":["https://orcid.org/0000-0002-1056-0082"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tudor A. Fulga","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America","Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102889603","display_name":"Katherine A. Sharp","orcid":"https://orcid.org/0000-0002-7574-7331","observed_orcids":["https://orcid.org/0000-0002-7574-7331"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. Sharp","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007366570","display_name":"Carin A. Loewen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carin A. Loewen","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028862628","display_name":"Erin E. Mulkearns-Hubert","orcid":"https://orcid.org/0000-0002-9310-2094","observed_orcids":["https://orcid.org/0000-0002-9310-2094"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Mulkearns","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068241218","display_name":"Jaana Tyynel\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jaana Tyynel\u00e4","raw_affiliation_strings":["Institute of Biomedicine/Medical Biochemistry and Developmental Biology, Helsinki University, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine/Medical Biochemistry and Developmental Biology, Helsinki University, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008377476","display_name":"Clemens R. Scherzer","orcid":"https://orcid.org/0000-0002-0567-9193","observed_orcids":["https://orcid.org/0000-0002-0567-9193"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clemens R. Scherzer","raw_affiliation_strings":["Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002571663","display_name":"Mel \u0392. Feany","orcid":"https://orcid.org/0000-0003-0315-7970","observed_orcids":["https://orcid.org/0000-0003-0315-7970"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mel B. Feany","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002571663"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.9,"has_fulltext":true,"cited_by_count":152,"citation_normalized_percentile":{"value":0.9115766,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"6","issue":"7","first_page":"e1001026","last_page":"e1001026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6779999732971191},{"id":"https://openalex.org/keywords/c-terminal-truncation","display_name":"C-terminal truncation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tau-cleavage","display_name":"tau cleavage","score":0.7990000247955322},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/drosophila-model","display_name":"Drosophila model","score":0.8489999771118164},{"id":"https://openalex.org/keywords/postmitotic-neurons","display_name":"postmitotic neurons","score":0.7829999923706055},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6995316743850708},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6542258262634277},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.640662431716919},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6090803146362305},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.600498378276825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5970835089683533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4877477288246155},{"id":"https://openalex.org/C56928146","wikidata":"https://www.wikidata.org/wiki/Q2934402","display_name":"Calpain","level":3,"score":0.4824538826942444},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.4814950227737427},{"id":"https://openalex.org/C78553746","wikidata":"https://www.wikidata.org/wiki/Q423561","display_name":"Cathepsin A","level":4,"score":0.45833614468574524},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.445883184671402},{"id":"https://openalex.org/C2780034444","wikidata":"https://www.wikidata.org/wiki/Q5052485","display_name":"Cathepsin L","level":4,"score":0.4448431432247162},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4216713607311249},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3572530150413513},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31333136558532715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21657750010490417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20880040526390076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18123701214790344},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.13404199481010437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12339910864830017},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08195558190345764},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05713838338851929},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0504206120967865}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pgen.1001026","doi":"https://doi.org/10.1371/journal.pgen.1001026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1001026","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001026&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2904797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904797","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:20664788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20664788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.227","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.227","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e0/23/PLoS_Genet_2010_Jul_15_6(7)_e1001026.tar.gz","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/8160859","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160859","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aac121ca1623427eb049dd57cbdfc71c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aac121ca1623427eb049dd57cbdfc71c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 6, Iss 7, p e1001026 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/142631","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Lysosomal_Dysfunction_Promotes_Cleavage_and_Neurotoxicity_of_Tau_In_Vivo_/142631","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:helda.helsinki.fi:10138/162573","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/162573","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:fde2cac9-cdfc-40d0-a2d9-4e3e43bfc968","doi":null,"is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:fde2cac9-cdfc-40d0-a2d9-4e3e43bfc968","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1001026","doi":"https://doi.org/10.1371/journal.pgen.1001026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1001026","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001026&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1185609304","display_name":null,"funder_award_id":"P50 AG005134","funder_id":"https://openalex.org/F4320308349","funder_display_name":"Massachusetts General Hospital"},{"id":"https://openalex.org/G1715636844","display_name":"Risk Marker for Parkinson's Disease: Enabling Novel Therapies","funder_award_id":"R01NS064155","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6781161026","display_name":null,"funder_award_id":"NIH P50","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7637191593","display_name":"Massachusetts Alzheimer's Disease Research Center","funder_award_id":"P50AG005134","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8937461195","display_name":"Genetic Dissection of Neurodegenerative Dementias","funder_award_id":"R01AG019790","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320309257","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040454459.pdf","grobid_xml":"https://content.openalex.org/works/W2040454459.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W18034176","https://openalex.org/W32417562","https://openalex.org/W125508901","https://openalex.org/W1511517753","https://openalex.org/W1564587827","https://openalex.org/W1641175229","https://openalex.org/W1675881254","https://openalex.org/W1968937229","https://openalex.org/W1970673364","https://openalex.org/W1973573196","https://openalex.org/W1974760231","https://openalex.org/W1980323811","https://openalex.org/W1981253832","https://openalex.org/W1985351513","https://openalex.org/W1986628169","https://openalex.org/W1988022242","https://openalex.org/W1989856924","https://openalex.org/W1994263020","https://openalex.org/W1997198091","https://openalex.org/W1998276610","https://openalex.org/W1999153033","https://openalex.org/W2004879508","https://openalex.org/W2004977000","https://openalex.org/W2012666269","https://openalex.org/W2016758992","https://openalex.org/W2019336333","https://openalex.org/W2024869398","https://openalex.org/W2038120434","https://openalex.org/W2040107841","https://openalex.org/W2045509178","https://openalex.org/W2046930479","https://openalex.org/W2060441085","https://openalex.org/W2062100528","https://openalex.org/W2063720739","https://openalex.org/W2064587868","https://openalex.org/W2067042124","https://openalex.org/W2068011527","https://openalex.org/W2068826499","https://openalex.org/W2069159417","https://openalex.org/W2075106837","https://openalex.org/W2076107153","https://openalex.org/W2080878773","https://openalex.org/W2084835703","https://openalex.org/W2085661569","https://openalex.org/W2090817340","https://openalex.org/W2092607846","https://openalex.org/W2093822807","https://openalex.org/W2096410114","https://openalex.org/W2105704879","https://openalex.org/W2110888808","https://openalex.org/W2112110295","https://openalex.org/W2112874709","https://openalex.org/W2125005234","https://openalex.org/W2125172225","https://openalex.org/W2133548029","https://openalex.org/W2135124405","https://openalex.org/W2145396101","https://openalex.org/W2148526984","https://openalex.org/W2152119060","https://openalex.org/W2165049228","https://openalex.org/W2169831780","https://openalex.org/W2172007938","https://openalex.org/W2185805123","https://openalex.org/W3214092816","https://openalex.org/W4230565756"],"related_works":["https://openalex.org/W7097275642","https://openalex.org/W4393933784","https://openalex.org/W3134183645","https://openalex.org/W2011457307","https://openalex.org/W6902023251","https://openalex.org/W2084219778","https://openalex.org/W6958389328","https://openalex.org/W2005069707","https://openalex.org/W3175180296","https://openalex.org/W1988022242"],"abstract_inverted_index":{"Expansion":[0],"of":[1,67,86,95,100,113,127,135,143,151,161,189,208,217],"the":[2,28,47,111,133],"lysosomal":[3,29,176,226],"system,":[4],"including":[5,34],"cathepsin":[6,77,87,114,144,154,167,196,201],"D":[7,58,78,88,155,168,197],"upregulation,":[8],"is":[9,59,107,130,138,156],"an":[10],"early":[11],"and":[12,37,44,70,178,200,210,228],"prominent":[13],"finding":[14],"in":[15,49,51,63,103,110,169,181,233],"Alzheimer's":[16,32,68,104,234],"disease":[17,69,105],"brain.":[18],"Cell":[19],"culture":[20],"studies,":[21],"however,":[22],"have":[23],"provided":[24],"differing":[25],"perspectives":[26],"on":[27],"connection":[30,48],"to":[31,42,174],"disease,":[33],"both":[35,195],"protective":[36],"detrimental":[38],"influences.":[39],"We":[40,116,163,191],"sought":[41],"clarify":[43],"molecularly":[45],"define":[46],"vivo":[50],"a":[52,64,80,96,184,221],"genetically":[53],"tractable":[54],"model":[55,66],"organism.":[56],"Cathepsin":[57],"upregulated":[60],"with":[61],"age":[62],"Drosophila":[65],"related":[71],"tauopathies.":[72],"Genetic":[73],"analysis":[74],"reveals":[75],"that":[76,118,149,165,194],"plays":[79],"neuroprotective":[81],"role":[82],"because":[83],"genetic":[84,147],"ablation":[85],"markedly":[89,122],"potentiates":[90],"tau-induced":[91],"neurotoxicity.":[92],"Further,":[93],"generation":[94],"C-terminally":[97],"truncated":[98,119,128,136],"form":[99],"tau":[101,120,129,137,209,218],"found":[102],"patients":[106],"significantly":[108],"increased":[109,123],"absence":[112],"D.":[115],"show":[117,204],"has":[121],"neurotoxicity,":[124],"while":[125],"solubility":[126],"decreased.":[131],"Importantly,":[132],"toxicity":[134],"not":[139],"affected":[140],"by":[141,153],"removal":[142],"D,":[145],"providing":[146],"evidence":[148],"modulation":[150],"neurotoxicity":[152],"mediated":[157],"through":[158,224],"C-terminal":[159,187,206],"cleavage":[160,216],"tau.":[162,190],"demonstrate":[164,193],"removing":[166],"adult":[170],"postmitotic":[171],"neurons":[172],"leads":[173],"aberrant":[175],"expansion":[177],"caspase":[179,212,215],"activation":[180],"vivo,":[182],"suggesting":[183],"mechanism":[185,223],"for":[186],"truncation":[188,207],"also":[192],"knockout":[198],"mice":[199],"D-deficient":[202],"sheep":[203],"abnormal":[205],"accompanying":[211],"activation.":[213],"Thus,":[214],"may":[219],"be":[220],"molecular":[222],"which":[225],"dysfunction":[227],"neurodegeneration":[229],"are":[230],"causally":[231],"linked":[232],"disease.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
