{"id":"https://openalex.org/W2040447333","doi":"https://doi.org/10.1136/annrheumdis-2012-eular.1969","title":"THU0004 Camp responsive element modulator (CREM) alpha contributes to decreased NOTCH-1 expression in T cells from patients with systemic lupus erythematosus (SLE)","display_name":"THU0004 Camp responsive element modulator (CREM) alpha contributes to decreased NOTCH-1 expression in T cells from patients with systemic lupus erythematosus (SLE)","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2040447333","doi":"https://doi.org/10.1136/annrheumdis-2012-eular.1969","mag":"2040447333"},"language":"en","primary_location":{"id":"doi:10.1136/annrheumdis-2012-eular.1969","doi":"https://doi.org/10.1136/annrheumdis-2012-eular.1969","is_oa":false,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2012-eular.1969","pdf_url":null,"source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101624076","display_name":"Thomas Rauen","orcid":"https://orcid.org/0000-0002-6544-8901","observed_orcids":["https://orcid.org/0000-0002-6544-8901"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Rauen","raw_affiliation_strings":["Department of Nephrology and Clinical Immunology, Rwth Aachen University, Aachen, Germany","1Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Clinical Immunology, Rwth Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"1Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034672759","display_name":"Alexandros P. Grammatikos","orcid":"https://orcid.org/0000-0001-6544-8218","observed_orcids":["https://orcid.org/0000-0001-6544-8218"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Grammatikos","raw_affiliation_strings":["Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010338029","display_name":"Christian Michael Hedrich","orcid":"https://orcid.org/0000-0002-1295-6179","observed_orcids":["https://orcid.org/0000-0002-1295-6179"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.M. Hedrich","raw_affiliation_strings":["Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048559252","display_name":"Vasileios C. Kyttaris","orcid":"https://orcid.org/0000-0001-7652-3826","observed_orcids":["https://orcid.org/0000-0001-7652-3826"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V.C. Kyttaris","raw_affiliation_strings":["Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086854418","display_name":"Klaus Tenbrock","orcid":"https://orcid.org/0000-0002-3566-227X","observed_orcids":["https://orcid.org/0000-0002-3566-227X"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Tenbrock","raw_affiliation_strings":["Department of Pediatrics, Rwth Aachen University, Aachen, Germany","3Department of Pediatrics, Rwth Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Rwth Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"3Department of Pediatrics, Rwth Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062225576","display_name":"Ute Raffetseder","orcid":"https://orcid.org/0000-0002-7236-9793","observed_orcids":["https://orcid.org/0000-0002-7236-9793"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Raffetseder","raw_affiliation_strings":["Department of Nephrology and Clinical Immunology, Rwth Aachen University, Aachen, Germany","1Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Clinical Immunology, Rwth Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"1Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107960647","display_name":"J\u00fcrgen Floege","orcid":"https://orcid.org/0000-0001-7102-6150","observed_orcids":["https://orcid.org/0000-0001-7102-6150"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Floege","raw_affiliation_strings":["Department of Nephrology and Clinical Immunology, Rwth Aachen University, Aachen, Germany","1Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Clinical Immunology, Rwth Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"1Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027542245","display_name":"George C. Tsokos","orcid":"https://orcid.org/0000-0001-9589-2360","observed_orcids":["https://orcid.org/0000-0001-9589-2360"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.C. Tsokos","raw_affiliation_strings":["Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Division of Rheumatology, Bidmc, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":null,"first_page":"155","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9120000004768372},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.46700000762939453},{"id":"https://openalex.org/keywords/histone-h3","display_name":"histone H3","score":0.9610000252723694},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.7329999804496765},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.6129999756813049},{"id":"https://openalex.org/keywords/immunopathogenesis","display_name":"immunopathogenesis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5730000138282776},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.42899999022483826},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9959999918937683},{"id":"https://openalex.org/keywords/camp-response-element","display_name":"cAMP response element","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8150713443756104},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.5520845651626587},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5136998891830444},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5123573541641235},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47932279109954834},{"id":"https://openalex.org/C202769670","wikidata":"https://www.wikidata.org/wiki/Q4045508","display_name":"Notch proteins","level":4,"score":0.423134446144104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4182770848274231},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4133821129798889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41197603940963745},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3341918885707855},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33029818534851074},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.326480895280838},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24097341299057007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19247353076934814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12618014216423035},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/annrheumdis-2012-eular.1969","doi":"https://doi.org/10.1136/annrheumdis-2012-eular.1969","is_oa":false,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2012-eular.1969","pdf_url":null,"source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2143973426","https://openalex.org/W2071700011","https://openalex.org/W4408874030","https://openalex.org/W3086093197","https://openalex.org/W4293770183","https://openalex.org/W4395022786","https://openalex.org/W2071947503","https://openalex.org/W2347934620","https://openalex.org/W1972784203","https://openalex.org/W2052803753"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}