{"id":"https://openalex.org/W2040447293","doi":null,"title":"Peptide-based approaches to treat asthma, arthritis, other autoimmune diseases and pathologies of the central nervous system.","display_name":"Peptide-based approaches to treat asthma, arthritis, other autoimmune diseases and pathologies of the central nervous system.","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2040447293","mag":"2040447293","pmid":"https://pubmed.ncbi.nlm.nih.gov/16088315"},"language":"en","primary_location":{"id":"pmid:16088315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16088315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86999","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013173450","display_name":"Kristin D. Hauff","orcid":"https://orcid.org/0000-0001-6533-7040","observed_orcids":["https://orcid.org/0000-0001-6533-7040"]},"institutions":[{"id":"https://openalex.org/I4210088414","display_name":"CancerCare Manitoba","ror":"https://ror.org/005cmms77","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210088414"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kristin Hauff","raw_affiliation_strings":["Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I4210088414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051193640","display_name":"Christina R. Zamzow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Zamzow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055464700","display_name":"Warren J Law","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Warren J Law","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084837609","display_name":"Jimmy de Melo","orcid":"https://orcid.org/0000-0001-9393-9217","observed_orcids":["https://orcid.org/0000-0001-9393-9217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jimmy De Melo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086623251","display_name":"Kieron Kennedy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kieron Kennedy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015174059","display_name":"Marek \u0141o\u015b","orcid":"https://orcid.org/0000-0001-9518-1411","observed_orcids":["https://orcid.org/0000-0001-9518-1411"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Los","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6684,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.89267097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"53","issue":"4","first_page":"308","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-peptides","display_name":"peptide therapeutics","score":0.7170000076293945},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7329999804496765},{"id":"https://openalex.org/keywords/central-nervous-system-pathology","display_name":"central nervous system pathology","score":0.8360000252723694},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.6389999985694885},{"id":"https://openalex.org/keywords/receptor-mediated-transport","display_name":"receptor-mediated transport","score":0.5730000138282776},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.8460000157356262},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cytokine-receptor-antagonists","display_name":"cytokine receptor antagonists","score":0.6620000004768372},{"id":"https://openalex.org/keywords/rhein","display_name":"rhein","score":0.8339999914169312},{"id":"https://openalex.org/keywords/anakinra","display_name":"anakinra","score":0.9929999709129333},{"id":"https://openalex.org/keywords/omalizumab","display_name":"omalizumab","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.6335738897323608},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6017882823944092},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5794029235839844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5541123151779175},{"id":"https://openalex.org/C2781228260","wikidata":"https://www.wikidata.org/wiki/Q415411","display_name":"Anakinra","level":3,"score":0.536146879196167},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5350142121315002},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47643929719924927},{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.4524648189544678},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4416532516479492},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.43111610412597656},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4308064579963684},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.379401296377182},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.3739805519580841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2200152575969696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09227776527404785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16088315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16088315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:liu-86999","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86999","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2040447293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16088315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-86999","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86999","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W14759517","https://openalex.org/W65126790","https://openalex.org/W102850330","https://openalex.org/W128151115","https://openalex.org/W177850641","https://openalex.org/W186008867","https://openalex.org/W271228137","https://openalex.org/W605428254","https://openalex.org/W1484493305","https://openalex.org/W1504210864","https://openalex.org/W1510613202","https://openalex.org/W1552426876","https://openalex.org/W1562521125","https://openalex.org/W1571910978","https://openalex.org/W1576189384","https://openalex.org/W1584683177","https://openalex.org/W1590085201","https://openalex.org/W1595158048","https://openalex.org/W1815831370","https://openalex.org/W1876982538","https://openalex.org/W1894866967","https://openalex.org/W1950962680","https://openalex.org/W1963764148","https://openalex.org/W1967658373","https://openalex.org/W1967886362","https://openalex.org/W1968485009","https://openalex.org/W1970808851","https://openalex.org/W1971065666","https://openalex.org/W1971529317","https://openalex.org/W1973755752","https://openalex.org/W1974129665","https://openalex.org/W1976822357","https://openalex.org/W1977727810","https://openalex.org/W1981689714","https://openalex.org/W1981956388","https://openalex.org/W1982301681","https://openalex.org/W1982597486","https://openalex.org/W1983069749","https://openalex.org/W1984397793","https://openalex.org/W1989323902","https://openalex.org/W1990437207","https://openalex.org/W1991243909","https://openalex.org/W1992495029","https://openalex.org/W1992721705","https://openalex.org/W1993824920","https://openalex.org/W2000317966","https://openalex.org/W2001867528","https://openalex.org/W2003107854","https://openalex.org/W2004739654","https://openalex.org/W2006346685","https://openalex.org/W2007252822","https://openalex.org/W2007301712","https://openalex.org/W2008337882","https://openalex.org/W2011171873","https://openalex.org/W2013702629","https://openalex.org/W2014587146","https://openalex.org/W2015051992","https://openalex.org/W2016698723","https://openalex.org/W2019189895","https://openalex.org/W2021126994","https://openalex.org/W2022126065","https://openalex.org/W2025742193","https://openalex.org/W2029251290","https://openalex.org/W2031753589","https://openalex.org/W2036523089","https://openalex.org/W2039344241","https://openalex.org/W2042143995","https://openalex.org/W2043513023","https://openalex.org/W2044164984","https://openalex.org/W2046818609","https://openalex.org/W2054889018","https://openalex.org/W2055296721","https://openalex.org/W2056589112","https://openalex.org/W2057069458","https://openalex.org/W2060560910","https://openalex.org/W2063939984","https://openalex.org/W2065663262","https://openalex.org/W2065997245","https://openalex.org/W2066378061","https://openalex.org/W2068282797","https://openalex.org/W2070060348","https://openalex.org/W2072721016","https://openalex.org/W2072755638","https://openalex.org/W2072841722","https://openalex.org/W2074919840","https://openalex.org/W2076524675","https://openalex.org/W2076859770","https://openalex.org/W2076987224","https://openalex.org/W2079335891","https://openalex.org/W2080544464","https://openalex.org/W2082516120","https://openalex.org/W2084195145","https://openalex.org/W2085855286","https://openalex.org/W2087035014","https://openalex.org/W2095574154","https://openalex.org/W2097317917","https://openalex.org/W2100022378","https://openalex.org/W2100042048","https://openalex.org/W2102055860","https://openalex.org/W2102546508","https://openalex.org/W2107588151","https://openalex.org/W2110052844","https://openalex.org/W2110366466","https://openalex.org/W2112003099","https://openalex.org/W2112649783","https://openalex.org/W2113690827","https://openalex.org/W2116473511","https://openalex.org/W2124596356","https://openalex.org/W2125121937","https://openalex.org/W2129068079","https://openalex.org/W2130614990","https://openalex.org/W2130679860","https://openalex.org/W2134437167","https://openalex.org/W2135605030","https://openalex.org/W2143168912","https://openalex.org/W2149598176","https://openalex.org/W2150294606","https://openalex.org/W2152578953","https://openalex.org/W2155039139","https://openalex.org/W2155878006","https://openalex.org/W2157359173","https://openalex.org/W2157571916","https://openalex.org/W2157852649","https://openalex.org/W2160006107","https://openalex.org/W2168015727","https://openalex.org/W2168912192","https://openalex.org/W2169367420","https://openalex.org/W2178219419","https://openalex.org/W2253882122","https://openalex.org/W2340697304","https://openalex.org/W2394898865","https://openalex.org/W2412337393","https://openalex.org/W2415863387","https://openalex.org/W2417202386","https://openalex.org/W2440676177","https://openalex.org/W2586910755","https://openalex.org/W2925184086","https://openalex.org/W3148913165","https://openalex.org/W6893691362"],"related_works":["https://openalex.org/W3040742359","https://openalex.org/W2511306377","https://openalex.org/W4251260029","https://openalex.org/W2154957550","https://openalex.org/W2890366782","https://openalex.org/W7169860806","https://openalex.org/W1570227300","https://openalex.org/W4386514647","https://openalex.org/W4405405128","https://openalex.org/W3209322240"],"abstract_inverted_index":{"In":[0,133],"this":[1],"review":[2,86],"we":[3,142,178],"focus":[4],"on":[5],"peptide-":[6],"and":[7,14,31,51,98],"peptidomimetic-based":[8],"approaches":[9],"that":[10,174],"target":[11,79],"autoimmune":[12],"diseases":[13],"some":[15],"pathologies":[16,37],"of":[17,68,84,92,151,163,182,191],"the":[18,65,85,96,113,123,140,149,152,161,180],"central":[19],"nervous":[20],"system.":[21],"Special":[22],"attention":[23],"is":[24,157],"given":[25],"to":[26,42,78,90,108,135,159],"asthma,":[27],"allergic":[28],"rhinitis,":[29],"osteoarthritis,":[30],"Alzheimer's":[32],"disease,":[33],"but":[34],"other":[35,100,172],"related":[36],"are":[38,71,87],"also":[39,88,143],"reviewed,":[40],"although":[41],"a":[43],"lesser":[44],"degree.":[45],"Among":[46],"others,":[47],"drugs":[48],"like":[49],"Diacerhein":[50],"its":[52],"active":[53],"form":[54],"Rhein,":[55],"Pralnacasan,":[56],"Anakinra":[57],"(Kineret),":[58],"Omalizumab,":[59],"an":[60,192],"antibody":[61],"\"BION-1\",":[62],"directed":[63],"against":[64],"common":[66],"beta-chain":[67],"cytokine":[69],"receptors,":[70],"described":[72],"below":[73],"as":[74,76,104,106,128,169,171],"well":[75,105,170],"attempts":[77],"beta-amyloid":[80],"peptide":[81],"aggregation.":[82],"Parts":[83],"dedicated":[89],"targeting":[91,183],"pathologic":[93],"conditions":[94],"in":[95,99,122,139],"brain":[97],"tissues":[101],"with":[102],"peptides":[103,127],"methods":[107],"deliver":[109],"larger":[110],"molecules":[111],"through":[112,130],"\"blood--brain":[114],"barrier\"":[115],"by":[116,125],"exploring":[117],"receptor-mediated":[118],"transport,":[119],"or":[120,188],"elsewhere":[121],"body":[124],"using":[126],"carriers":[129],"cellular":[131],"membranes.":[132],"addition":[134],"highlighting":[136],"current":[137],"developments":[138],"field,":[141],"propose,":[144],"for":[145,186],"future":[146],"drug":[147],"targets,":[148],"components":[150,185],"inflammasome":[153,184],"protein":[154],"complex,":[155],"which":[156],"believed":[158],"initiate":[160],"activation":[162],"caspase-":[164],"1":[165],"dependent":[166],"signaling":[167],"events,":[168],"pathways":[173],"signal":[175],"inflammation.":[176],"Thus":[177],"discuss":[179],"possibility":[181],"negative":[187],"positive":[189],"modulation":[190],"inflammatory":[193],"response.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}