{"id":"https://openalex.org/W2040436346","doi":"https://doi.org/10.1017/s003118200100720x","title":"Characterization of a putative nitric oxide synthase in the neuromuscular system of the parasitic nematode, Ascaris suum","display_name":"Characterization of a putative nitric oxide synthase in the neuromuscular system of the parasitic nematode, Ascaris suum","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2040436346","doi":"https://doi.org/10.1017/s003118200100720x","mag":"2040436346","pmid":"https://pubmed.ncbi.nlm.nih.gov/11272653"},"language":"en","primary_location":{"id":"doi:10.1017/s003118200100720x","doi":"https://doi.org/10.1017/s003118200100720x","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s003118200100720x","pdf_url":null,"source":{"id":"https://openalex.org/S161475033","display_name":"Parasitology","issn_l":"0031-1820","issn":["0031-1820","1469-8161"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069823596","display_name":"Zainab A. Bascal","orcid":"https://orcid.org/0000-0001-8468-8890","observed_orcids":["https://orcid.org/0000-0001-8468-8890"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Z.A. BASCAL","raw_affiliation_strings":["Division of Cell Sciences, School of Biological Sciences, University of Southampton, UK","Division of Cell Sciences, School of Biological Sciences, University of Southampton SO16 7PX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Sciences, School of Biological Sciences, University of Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Division of Cell Sciences, School of Biological Sciences, University of Southampton SO16 7PX","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J.M. CUNNINGHAM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]},{"id":"https://openalex.org/I71637028","display_name":"University of Brighton","ror":"https://ror.org/04kp2b655","country_code":"GB","type":"education","lineage":["https://openalex.org/I71637028"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.M. CUNNINGHAM","raw_affiliation_strings":["Present address: School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 49J","Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton BN1 9QG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address: School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 49J","institution_ids":["https://openalex.org/I71637028"]},{"raw_affiliation_string":"Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton BN1 9QG","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072230113","display_name":"Lindy M. Holden-Dye","orcid":"https://orcid.org/0000-0002-9704-1217","observed_orcids":["https://orcid.org/0000-0002-9704-1217"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. HOLDEN-DYE","raw_affiliation_strings":["Division of Cell Sciences, School of Biological Sciences, University of Southampton SO16 7PX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Sciences, School of Biological Sciences, University of Southampton SO16 7PX","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009214454","display_name":"Michael O\u2019Shea","orcid":"https://orcid.org/0000-0002-1694-4714","observed_orcids":["https://orcid.org/0000-0002-1694-4714"]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. O'SHEA","raw_affiliation_strings":["Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton BN1 9QG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton BN1 9QG","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031692281","display_name":"Robert James Walker","orcid":"https://orcid.org/0000-0003-3366-0956","observed_orcids":["https://orcid.org/0000-0003-3366-0956"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R.J. WALKER","raw_affiliation_strings":["Division of Cell Sciences, School of Biological Sciences, University of Southampton SO16 7PX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Sciences, School of Biological Sciences, University of Southampton SO16 7PX","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":2.1686,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85418542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"122","issue":"2","first_page":"219","last_page":"231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.10949999839067459,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/ascaris-suum","display_name":"Ascaris suum","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuromuscular-system","display_name":"neuromuscular system","score":0.8040000200271606},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/citrulline-formation","display_name":"citrulline formation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/nadph-diaphorase","display_name":"NADPH-diaphorase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/parasitic-nematodes","display_name":"parasitic nematodes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.46700000762939453},{"id":"https://openalex.org/keywords/enzyme-cofactors","display_name":"enzyme cofactors","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2779845534","wikidata":"https://www.wikidata.org/wiki/Q2062253","display_name":"Ascaris suum","level":3,"score":0.9970378875732422},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.9379373788833618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7147136330604553},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7122529149055481},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6336644291877747},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5563659071922302},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5043636560440063},{"id":"https://openalex.org/C2778830712","wikidata":"https://www.wikidata.org/wiki/Q5185","display_name":"Nematode","level":2,"score":0.42468899488449097},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.42181161046028137},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.41166695952415466},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32592377066612244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16866165399551392},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16607901453971863},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0633542537689209},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.051437437534332275},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001196","descriptor_name":"Ascariasis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001196","descriptor_name":"Ascariasis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002956","descriptor_name":"Citrulline","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D017165","descriptor_name":"Ascaris suum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1017/s003118200100720x","doi":"https://doi.org/10.1017/s003118200100720x","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s003118200100720x","pdf_url":null,"source":{"id":"https://openalex.org/S161475033","display_name":"Parasitology","issn_l":"0031-1820","issn":["0031-1820","1469-8161"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"journal-article"},{"id":"pmid:11272653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11272653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:56296","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/56296/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:publications/1cf24ff2-9723-430a-a56e-f44c0803657f","doi":null,"is_oa":false,"landing_page_url":"https://research.brighton.ac.uk/en/publications/1cf24ff2-9723-430a-a56e-f44c0803657f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401758","display_name":"University of Brighton Repository (University of Brighton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71637028","host_organization_name":"University of Brighton","host_organization_lineage":["https://openalex.org/I71637028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bascal, Z A, Cunningham, J, Holden-Dye, L, O'Shea, M & Walker, R J 2001, 'Characterization of a putative nitric oxide synthase in the neuromuscular system of the parasitic nematode, Ascaris suum', Parasitology, vol. 122, no. 2, pp. 219-232. https://doi.org/10.1017/S003118200100720X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W34237247","https://openalex.org/W1481105441","https://openalex.org/W1602985420","https://openalex.org/W1834041853","https://openalex.org/W1965154887","https://openalex.org/W1978934213","https://openalex.org/W1992049177","https://openalex.org/W1994745653","https://openalex.org/W1995064239","https://openalex.org/W2000894085","https://openalex.org/W2001541852","https://openalex.org/W2010469212","https://openalex.org/W2010711283","https://openalex.org/W2034769077","https://openalex.org/W2035464530","https://openalex.org/W2036993395","https://openalex.org/W2040877063","https://openalex.org/W2041412673","https://openalex.org/W2042917077","https://openalex.org/W2049311375","https://openalex.org/W2058695135","https://openalex.org/W2059379142","https://openalex.org/W2063503589","https://openalex.org/W2067778134","https://openalex.org/W2074082812","https://openalex.org/W2079236431","https://openalex.org/W2086871241","https://openalex.org/W2089796673","https://openalex.org/W2090611949","https://openalex.org/W2092459487","https://openalex.org/W2092826613","https://openalex.org/W2120533372","https://openalex.org/W2162143859","https://openalex.org/W2165128240","https://openalex.org/W2165338417","https://openalex.org/W2173112447","https://openalex.org/W2182737880"],"related_works":["https://openalex.org/W2162143859","https://openalex.org/W2076469882","https://openalex.org/W2972871641","https://openalex.org/W2507659567","https://openalex.org/W4229441357","https://openalex.org/W1979923782","https://openalex.org/W2303801449","https://openalex.org/W2069922346","https://openalex.org/W1988806198","https://openalex.org/W2133023223"],"abstract_inverted_index":{"In":[0],"this":[1],"paper":[2],"we":[3],"report":[4],"on":[5,27],"the":[6,21,39,49,96,111,115,143,150],"biochemical":[7,112],"presence":[8,116],"of":[9,24,41,80,98,110,117,121,133,145,153],"nitric":[10],"oxide":[11],"synthase":[12],"(NOS)-like":[13],"activity":[14,34,68,92],"in":[15,75,149],"Ascaris":[16],"suum":[17,29,56,105],"tissue":[18,53],"and":[19,45,83,101,124],"examine":[20],"pharmacological":[22],"effect":[23],"NO":[25,46,102,123,146],"donors":[26],"A.":[28,55,104,154],"muscle":[30],"strip":[31],"preparation.":[32],"NOS":[33,64,67,91],"was":[35,73],"determined":[36],"by":[37,103],"monitoring":[38],"formation":[40,47,97],"[3H]citrulline":[42],"from":[43,54,131],"[3H]L-arginine":[44],"via":[48],"oxyhaemoglobin":[50],"assay.":[51],"Neuromuscular":[52],"which":[57],"stained":[58],"positively":[59],"for":[60,88,142],"NADPH":[61,70,82],"diaphorase,":[62],"contained":[63],"activity.":[65],"Neither":[66],"nor":[69],"diaphorase":[71],"staining":[72],"detected":[74],"intestinal":[76],"tissue.":[77],"The":[78,108],"absence":[79],"Ca2+,":[81],"other":[84],"co-factors":[85],"normally":[86],"required":[87],"mammalian":[89],"neuronal":[90,135],"only":[93],"partially":[94],"reduced":[95],"both":[99],"citrulline":[100],"neuromuscular":[106,151],"homogenate.":[107],"results":[109],"assays":[113],"indicate":[114],"an":[118],"enzyme":[119],"capable":[120],"producing":[122],"citrulline,":[125],"but":[126],"with":[127],"a":[128],"different":[129],"profile":[130],"that":[132],"rat":[134],"NOS.":[136],"We":[137],"also":[138],"present":[139],"preliminary":[140],"evidence":[141],"action":[144],"(NO":[147],"donors)":[148],"system":[152],"suum.":[155]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}