{"id":"https://openalex.org/W2040430740","doi":"https://doi.org/10.1371/journal.pone.0075730","title":"Alternative mRNA Splicing Generates Two Distinct ADAM12 Prodomain Variants","display_name":"Alternative mRNA Splicing Generates Two Distinct ADAM12 Prodomain Variants","publication_year":2013,"publication_date":"2013-10-07","ids":{"openalex":"https://openalex.org/W2040430740","doi":"https://doi.org/10.1371/journal.pone.0075730","mag":"2040430740","pmid":"https://pubmed.ncbi.nlm.nih.gov/24116070","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792144"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0075730","doi":"https://doi.org/10.1371/journal.pone.0075730","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075730","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075730&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075730&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086854401","display_name":"Sara Duhachek-Muggy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Duhachek-Muggy","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423886","display_name":"Hui zi Li","orcid":"https://orcid.org/0000-0002-4114-8349","observed_orcids":["https://orcid.org/0000-0002-4114-8349"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101614003","display_name":"Yue Qi","orcid":"https://orcid.org/0009-0008-8151-6231","observed_orcids":["https://orcid.org/0009-0008-8151-6231","https://orcid.org/0000-0003-0007-2373"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Qi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001440213","display_name":"Anna \u017b\u00f3\u0142kiewska","orcid":"https://orcid.org/0000-0003-3632-9337","observed_orcids":["https://orcid.org/0000-0003-3632-9337"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna Zolkiewska","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, United States of America","institution_ids":["https://openalex.org/I189590672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001440213"],"corresponding_institution_ids":["https://openalex.org/I189590672"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.5038,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.63527208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"10","first_page":"e75730","last_page":"e75730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5029000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5029000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.3978999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adam12","display_name":"ADAM12","score":1.0},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8560000061988831},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.7689999938011169},{"id":"https://openalex.org/keywords/propeptide","display_name":"propeptide","score":0.7950000166893005},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.8389999866485596},{"id":"https://openalex.org/keywords/er-retention","display_name":"endoplasmic reticulum retention","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intracellular-trafficking","display_name":"intracellular trafficking","score":0.8109999895095825},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.516005277633667},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5156577825546265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4876009523868561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48729407787323},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44655460119247437},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.44339942932128906},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42794108390808105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39615166187286377},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3349551558494568},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2675720453262329}],"mesh":[{"descriptor_ui":"D000072199","descriptor_name":"ADAM12 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0075730","doi":"https://doi.org/10.1371/journal.pone.0075730","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075730","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075730&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2785993","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792144","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3792144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792144","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24116070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24116070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.777.2225","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.777.2225","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a8/be/pone.0075730.PMC3792144.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:608a1338f4134510bfa7973a00a73766","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/608a1338f4134510bfa7973a00a73766","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 10, p e75730 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0075730","doi":"https://doi.org/10.1371/journal.pone.0075730","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075730","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075730&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4249347040","display_name":"ADAM12 in Breast Tumor Initiating Cells","funder_award_id":"R01CA172222","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6954944049","display_name":"Structure-Function Analysis of Breast Cancer-Associated Mutations in ADAM12","funder_award_id":"R15CA151065","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333823","display_name":"Johnson Cancer Research Center, Kansas State University","ror":"https://ror.org/00nffqq91"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040430740.pdf","grobid_xml":"https://content.openalex.org/works/W2040430740.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W106435946","https://openalex.org/W1489859181","https://openalex.org/W1560997129","https://openalex.org/W1756962622","https://openalex.org/W1968429206","https://openalex.org/W1970353663","https://openalex.org/W1975459968","https://openalex.org/W1976460160","https://openalex.org/W1977343146","https://openalex.org/W1978607785","https://openalex.org/W1982092344","https://openalex.org/W1985267095","https://openalex.org/W1992929086","https://openalex.org/W1999902365","https://openalex.org/W2000417926","https://openalex.org/W2006044964","https://openalex.org/W2017075758","https://openalex.org/W2017695022","https://openalex.org/W2020016375","https://openalex.org/W2027643232","https://openalex.org/W2028395883","https://openalex.org/W2032576495","https://openalex.org/W2032969516","https://openalex.org/W2033678360","https://openalex.org/W2035927236","https://openalex.org/W2040012541","https://openalex.org/W2043794272","https://openalex.org/W2048356493","https://openalex.org/W2050049526","https://openalex.org/W2051692904","https://openalex.org/W2053588758","https://openalex.org/W2058451898","https://openalex.org/W2063972138","https://openalex.org/W2065073025","https://openalex.org/W2066090767","https://openalex.org/W2067192296","https://openalex.org/W2078269233","https://openalex.org/W2081934244","https://openalex.org/W2086773479","https://openalex.org/W2095998476","https://openalex.org/W2097432825","https://openalex.org/W2097817417","https://openalex.org/W2101017424","https://openalex.org/W2102397474","https://openalex.org/W2106292881","https://openalex.org/W2114853101","https://openalex.org/W2116495755","https://openalex.org/W2116502202","https://openalex.org/W2118600301","https://openalex.org/W2125754655","https://openalex.org/W2129033989","https://openalex.org/W2132346087","https://openalex.org/W2133011337","https://openalex.org/W2134533989","https://openalex.org/W2136267882","https://openalex.org/W2137438871","https://openalex.org/W2138193564","https://openalex.org/W2143813439","https://openalex.org/W2147808314","https://openalex.org/W2153149701","https://openalex.org/W2160366016","https://openalex.org/W2162839806","https://openalex.org/W2167709602","https://openalex.org/W2169389096","https://openalex.org/W4251174927"],"related_works":["https://openalex.org/W7097601422","https://openalex.org/W2081452057","https://openalex.org/W2082375367","https://openalex.org/W2800890007","https://openalex.org/W4410875986","https://openalex.org/W3121740907","https://openalex.org/W7097259779","https://openalex.org/W7095298335","https://openalex.org/W6907883151","https://openalex.org/W2050959416"],"abstract_inverted_index":{"Human":[0],"ADAM12,":[1],"transcript":[2],"variant":[3],"1":[4],"(later":[5],"on":[6],"referred":[7],"to":[8,137,145],"as":[9],"Var-1b),":[10],"present":[11,66],"in":[12,50,58,67,92,141,147,153,171,197],"publicly":[13],"available":[14],"databases":[15],"contains":[16],"the":[17,21,26,30,44,51,82,86,116,123,138,154,162,182],"sequence":[18,199],"5'-GTAATTCTG-3'":[19],"at":[20,29],"nucleotide":[22],"positions":[23],"340-348":[24],"of":[25,33,39,122,165,185],"coding":[27],"region,":[28],"3'":[31],"end":[32],"exon":[34],"4.":[35],"The":[36],"translation":[37],"product":[38],"this":[40,95],"variant,":[41,79],"ADAM12-Lb,":[42],"includes":[43],"three":[45],"amino":[46],"acid":[47],"motif":[48,54],"(114)VIL(116)":[49,87],"prodomain.":[52],"This":[53],"is":[55,64,73,90,133,151,157,188],"not":[56,65,74,158],"conserved":[57],"ADAM12":[59,146,187],"from":[60],"different":[61],"species":[62],"and":[63,105,112,119,126,135,156,167],"other":[68,148],"human":[69,101],"ADAMs.":[70],"Currently,":[71],"it":[72],"clear":[75],"whether":[76],"a":[77,142],"shorter":[78],"Var-1a,":[80],"encoding":[81],"protein":[83],"version":[84],"without":[85],"motif,":[88],"ADAM12-La,":[89],"expressed":[91],"human.":[93],"In":[94],"work,":[96],"we":[97],"have":[98],"established":[99],"that":[100,181],"mammary":[102],"epithelial":[103],"cells":[104,108],"breast":[106,173],"cancer":[107,174],"express":[109],"both":[110],"Var-1a":[111],"Var-1b":[113],"transcripts.":[114],"Importantly,":[115],"proteolytic":[117],"processing":[118],"intracellular":[120],"trafficking":[121],"corresponding":[124],"ADAM12-La":[125,132,166],"ADAM12-Lb":[127,150,168],"proteins":[128,169],"are":[129],"different.":[130],"While":[131],"cleaved":[134],"trafficked":[136],"cell":[139,175],"surface":[140],"manner":[143],"similar":[144],"species,":[149],"retained":[152],"ER":[155],"proteolytically":[159],"processed.":[160],"Furthermore,":[161],"relative":[163],"abundance":[164],"detected":[170],"several":[172],"lines":[176],"varies":[177],"significantly.":[178],"We":[179],"conclude":[180],"canonical":[183],"form":[184],"transmembrane":[186],"represented":[189],"by":[190],"Var-1a/ADAM12-La,":[191],"rather":[192],"than":[193],"Var-1b/ADAM12-Lb":[194],"currently":[195],"featured":[196],"major":[198],"databases.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}