{"id":"https://openalex.org/W2040416929","doi":"https://doi.org/10.1186/1756-0500-5-283","title":"Long-term safety and tolerability of donepezil 23 mg in patients with moderate to severe Alzheimer\u2019s disease","display_name":"Long-term safety and tolerability of donepezil 23 mg in patients with moderate to severe Alzheimer\u2019s disease","publication_year":2012,"publication_date":"2012-06-08","ids":{"openalex":"https://openalex.org/W2040416929","doi":"https://doi.org/10.1186/1756-0500-5-283","mag":"2040416929","pmid":"https://pubmed.ncbi.nlm.nih.gov/22681723","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493328"},"language":"en","primary_location":{"id":"doi:10.1186/1756-0500-5-283","doi":"https://doi.org/10.1186/1756-0500-5-283","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-5-283","pdf_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-5-283","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-5-283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002451678","display_name":"Pierre N. Tariot","orcid":"https://orcid.org/0000-0002-6058-8032","observed_orcids":["https://orcid.org/0000-0002-6058-8032"]},"institutions":[{"id":"https://openalex.org/I4387152203","display_name":"Banner Alzheimer\u2019s Institute","ror":"https://ror.org/023jwkg52","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4387152203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre Tariot","raw_affiliation_strings":["Banner Alzheimer's Institute, 901 E. Willetta Street, Third Floor, Phoenix, AZ 85006, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Alzheimer's Institute, 901 E. Willetta Street, Third Floor, Phoenix, AZ 85006, USA","institution_ids":["https://openalex.org/I4387152203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002183686","display_name":"Stephen Salloway","orcid":"https://orcid.org/0000-0002-2631-0942","observed_orcids":["https://orcid.org/0000-0002-2631-0942"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Salloway","raw_affiliation_strings":["Brown Alpert Medical School, 345 Blackstone Boulevard, Providence, RI, 02906, USA","Brown Alpert Medical School, Providence, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Alpert Medical School, 345 Blackstone Boulevard, Providence, RI, 02906, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Brown Alpert Medical School, Providence, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007647619","display_name":"Jane Yardley","orcid":"https://orcid.org/0000-0001-8198-4328","observed_orcids":["https://orcid.org/0000-0001-8198-4328"]},"institutions":[{"id":"https://openalex.org/I4210148122","display_name":"Eisai (United Kingdom)","ror":"https://ror.org/054j7wb83","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210148122","https://openalex.org/I55881946"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jane Yardley","raw_affiliation_strings":["Neuroscience Product Creation Unit, Eisai Ltd, European Knowledge Centre, Mosquito Way, Hatfield, Hertfordshire, AL10 9SN, UK","Neuroscience Product Creation Unit, Eisai Ltd, European Knowledge Centre, Mosquito Way, Hatfield, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Product Creation Unit, Eisai Ltd, European Knowledge Centre, Mosquito Way, Hatfield, Hertfordshire, AL10 9SN, UK","institution_ids":["https://openalex.org/I4210148122"]},{"raw_affiliation_string":"Neuroscience Product Creation Unit, Eisai Ltd, European Knowledge Centre, Mosquito Way, Hatfield, Hertfordshire, UK","institution_ids":["https://openalex.org/I4210148122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013384258","display_name":"Joan A. Mackell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Mackell","raw_affiliation_strings":["Pfizer, Inc, 235 E 42nd St 235/9/11, New York, NY, 10017, USA","Pfizer Inc, New York, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, Inc, 235 E 42nd St 235/9/11, New York, NY, 10017, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Inc, New York, USA,","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078195357","display_name":"Margaret L. Moline","orcid":"https://orcid.org/0000-0003-0807-2167","observed_orcids":["https://orcid.org/0000-0003-0807-2167"]},"institutions":[{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Moline","raw_affiliation_strings":["Eisai Medical Research, Eisai Inc, 55 Challenger Road, Ridgefield Park, NJ, 07660, USA","Eisai Medical Research, Eisai Inc, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Medical Research, Eisai Inc, 55 Challenger Road, Ridgefield Park, NJ, 07660, USA","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Eisai Medical Research, Eisai Inc, NJ, USA","institution_ids":["https://openalex.org/I4210151718"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007647619"],"corresponding_institution_ids":["https://openalex.org/I4210148122"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":1.7241,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.81977647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"1","first_page":"283","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.22349999845027924,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/long-term-safety","display_name":"long-term safety","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7110000252723694},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.7639999985694885},{"id":"https://openalex.org/keywords/weight-change","display_name":"weight change","score":0.37599998712539673},{"id":"https://openalex.org/keywords/electrocardiographic-changes","display_name":"electrocardiographic changes","score":0.7609999775886536},{"id":"https://openalex.org/keywords/laboratory-parameters","display_name":"laboratory parameters","score":0.8830000162124634},{"id":"https://openalex.org/keywords/vital-signs","display_name":"vital signs","score":0.7039999961853027},{"id":"https://openalex.org/keywords/safety-signals","display_name":"safety signals","score":0.5090000033378601},{"id":"https://openalex.org/keywords/dose-limiting-adverse-events","display_name":"dose-limiting adverse events","score":0.4429999887943268},{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.9385136365890503},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.9070488214492798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8883874416351318},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8481419086456299},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.650974452495575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5540640354156494},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48631104826927185},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.43342775106430054},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.34567150473594666},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3348502516746521},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31918439269065857},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000553","descriptor_name":"Ambulatory Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D054316","descriptor_name":"Biomarkers, Pharmacological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1756-0500-5-283","doi":"https://doi.org/10.1186/1756-0500-5-283","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-5-283","pdf_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-5-283","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3493328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493328","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Res Notes","raw_type":"Text"},{"id":"pmid:22681723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22681723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC research notes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.6274","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.6274","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/fc/f1/1756-0500-5-283.PMC3493328.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6f07624f29f04534ac2934a401407e95","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6f07624f29f04534ac2934a401407e95","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Research Notes, Vol 5, Iss 1, p 283 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1756-0500-5-283","doi":"https://doi.org/10.1186/1756-0500-5-283","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-5-283","pdf_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-5-283","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040416929.pdf","grobid_xml":"https://content.openalex.org/works/W2040416929.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W153536053","https://openalex.org/W1596784741","https://openalex.org/W1967451438","https://openalex.org/W1984261359","https://openalex.org/W1985528178","https://openalex.org/W1991517279","https://openalex.org/W2007472466","https://openalex.org/W2030079540","https://openalex.org/W2033774309","https://openalex.org/W2036996542","https://openalex.org/W2037650041","https://openalex.org/W2045923955","https://openalex.org/W2051118933","https://openalex.org/W2064887457","https://openalex.org/W2101807135","https://openalex.org/W2112522119","https://openalex.org/W2124862277","https://openalex.org/W2126510379","https://openalex.org/W2127482098","https://openalex.org/W2141158065","https://openalex.org/W2156220037","https://openalex.org/W2159011576","https://openalex.org/W2775750683","https://openalex.org/W3150026755","https://openalex.org/W4248856529"],"related_works":["https://openalex.org/W2033774309","https://openalex.org/W2059514646","https://openalex.org/W7096377545","https://openalex.org/W2018309238","https://openalex.org/W7095647503","https://openalex.org/W2200011476","https://openalex.org/W2101265858","https://openalex.org/W2001340967","https://openalex.org/W2016958718","https://openalex.org/W2141158065"],"abstract_inverted_index":{"BACKGROUND:":[0],"Donepezil":[1],"(23":[2],"mg/day)":[3],"is":[4,314],"approved":[5],"by":[6],"the":[7,14,70,90,128,160,167,248,255,290,298,301,329,342,346],"US":[8],"Food":[9],"and":[10,45,73,93,115,121,131,144,147,164,264,275,279,294],"Drug":[11],"Administration":[12],"for":[13],"treatment":[15,171,309],"of":[16,36,64,75,103,127,133,193,213,220,233,262,284,300,324,331,345],"patients":[17,37,80,184,195,214,228,267,327],"with":[18,81,310,316],"moderate":[19,82,223],"to":[20,48,54,68,83,150,203,239,251,336,341],"severe":[21,84],"Alzheimer's":[22],"disease":[23],"(AD).":[24],"Approval":[25],"was":[26,67,176,201,339],"based":[27],"on":[28,41],"results":[29],"from":[30,244,333],"a":[31,99],"24-week,":[32],"randomized,":[33],"double-blind":[34,91,154,249],"study":[35,66,92,102,155,163,175,208,250,257,305],"who":[38,88,230,268],"were":[39,94,157,226,237,269],"stable":[40],"donepezil":[42,52,76,105,242,311,332],"10":[43,60,245,334],"mg/day":[44,56,78,246,253,313,335,338],"randomized":[46],"2:1":[47],"either":[49],"increase":[50],"their":[51],"dose":[53,243,330],"23":[55,77,106,252,272,312,337],"or":[57,206,222],"continue":[58],"taking":[59],"mg/day.":[61,107],"The":[62,211,282,321],"objective":[63],"this":[65,174],"assess":[69],"long-term":[71,308],"safety":[72,168,319],"tolerability":[74],"in":[79,139,159,173,191,247,254,326],"AD.":[85],"METHODS:":[86],"Patients":[87],"completed":[89],"eligible":[95],"could":[96],"enroll":[97],"into":[98],"12-month":[100],"extension":[101,162,256],"open-label":[104,113,161],"Clinic":[108],"visits":[109],"took":[110],"place":[111],"at":[112,116,187,197],"baseline":[114],"months":[117],"3,":[118],"6,":[119],"9,":[120],"12.":[122],"Safety":[123],"analyses":[124],"comprised":[125,166],"examination":[126],"incidence,":[129],"severity,":[130],"timing":[132],"treatment-emergent":[134],"adverse":[135],"events":[136],"(AEs);":[137],"changes":[138],"weight,":[140],"electrocardiogram,":[141],"vital":[142],"signs,":[143],"laboratory":[145],"parameters;":[146],"discontinuation":[148],"due":[149,238],"AEs.":[151],"RESULTS:":[152],"915":[153],"completers":[156],"enrolled":[158],"902":[165],"population.":[169],"Mean":[170],"duration":[172,299],"10.3":[177],"\u00b1":[178],"3.5":[179],"months.":[180],"In":[181],"total,":[182],"674":[183],"(74.7%)":[185],"reported":[186],"least":[188,198],"one":[189,199],"AE;":[190],"320":[192],"these":[194],"(47.5%)":[196],"AE":[200],"considered":[202],"be":[204],"possibly":[205],"probably":[207],"drug":[209],"related.":[210],"majority":[212],"reporting":[215],"AEs":[216,219,263,286,325],"(81.9%)":[217],"had":[218,258],"mild":[221],"severity.":[224],"There":[225],"268":[227],"(29.7%)":[229],"discontinued":[231],"early,":[232],"which":[234],"123":[235],"(13.6%)":[236],"AEs.Patients":[240],"increasing":[241,328],"slightly":[259],"higher":[260],"rates":[261],"SAEs":[265],"than":[266],"already":[270],"receiving":[271],"mg":[273],"(78.0%":[274],"16.9%":[276],"vs":[277],"72.8%":[278],"14.0%,":[280],"respectively).":[281],"incidence":[283,323],"new":[285,318],"declined":[287],"rapidly":[288],"after":[289],"first":[291],"2":[292],"weeks":[293,344],"remained":[295],"low":[296],"throughout":[297],"study.":[302,347],"CONCLUSION:":[303],"This":[304],"shows":[306],"that":[307],"associated":[315],"no":[317],"signals.":[320],"elevated":[322],"limited":[340],"initial":[343]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}