{"id":"https://openalex.org/W2040412635","doi":"https://doi.org/10.1073/pnas.1422872112","title":"MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo","display_name":"MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo","publication_year":2015,"publication_date":"2015-04-14","ids":{"openalex":"https://openalex.org/W2040412635","doi":"https://doi.org/10.1073/pnas.1422872112","mag":"2040412635","pmid":"https://pubmed.ncbi.nlm.nih.gov/25922517","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4418851"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1422872112","doi":"https://doi.org/10.1073/pnas.1422872112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1422872112","pdf_url":"https://www.pnas.org/content/pnas/112/17/5437.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/112/17/5437.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057242288","display_name":"Bilal N. Sheikh","orcid":"https://orcid.org/0000-0002-1970-6236","observed_orcids":["https://orcid.org/0000-0002-1970-6236"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bilal N. Sheikh","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023141316","display_name":"Natalie L. Downer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Natalie L. Downer","raw_affiliation_strings":["Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027183726","display_name":"Belinda Phipson","orcid":"https://orcid.org/0000-0002-1711-7454","observed_orcids":["https://orcid.org/0000-0002-1711-7454"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Belinda Phipson","raw_affiliation_strings":["Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070688637","display_name":"Hannah Kate Vanyai","orcid":"https://orcid.org/0000-0001-7761-0606","observed_orcids":["https://orcid.org/0000-0001-7761-0606"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hannah K. Vanyai","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","bDepartment of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"bDepartment of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046701980","display_name":"Andrew J. Kueh","orcid":"https://orcid.org/0009-0005-9596-1422","observed_orcids":["https://orcid.org/0009-0005-9596-1422"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew J. Kueh","raw_affiliation_strings":["Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034469657","display_name":"Davis James McCarthy","orcid":"https://orcid.org/0000-0002-2218-6833","observed_orcids":["https://orcid.org/0000-0002-2218-6833"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Davis J. McCarthy","raw_affiliation_strings":["Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and","cBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"cBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054704071","display_name":"Gordon K. Smyth","orcid":"https://orcid.org/0000-0001-9221-2892","observed_orcids":["https://orcid.org/0000-0001-9221-2892"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gordon K. Smyth","raw_affiliation_strings":["Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and","Department of Mathematics and Statistics, University of Melbourne, Melbourne, VIC 3052, Australia","Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and Department of Mathematics and Statistics, University of Melbourne, Melbourne, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Melbourne, Melbourne, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; and Department of Mathematics and Statistics, University of Melbourne, Melbourne, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078083260","display_name":"Tim Thomas","orcid":"https://orcid.org/0000-0002-7623-8344","observed_orcids":["https://orcid.org/0000-0002-7623-8344"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tim Thomas","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","bDepartment of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"bDepartment of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050532805","display_name":"Anne Kathrin Voss","orcid":"https://orcid.org/0000-0002-3853-9381","observed_orcids":["https://orcid.org/0000-0002-3853-9381"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anne K. Voss","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","bDepartment of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"aDevelopment and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"bDepartment of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia;","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4458,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.80988549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"112","issue":"17","first_page":"5437","last_page":"5442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moz","display_name":"MOZ","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bmi1","display_name":"BMI1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hox-genes","display_name":"Hox genes","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/chromatin-modifying-complexes","display_name":"chromatin-modifying complexes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/homeotic-transformation","display_name":"homeotic transformation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/anteroposterior-axis","display_name":"anterior-posterior axis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.5009999871253967},{"id":"https://openalex.org/keywords/double-knockout-mice","display_name":"double knockout mice","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.9800375699996948},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7088630795478821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.672549307346344},{"id":"https://openalex.org/C46751350","wikidata":"https://www.wikidata.org/wiki/Q1939530","display_name":"Homeotic gene","level":4,"score":0.6011632680892944},{"id":"https://openalex.org/C2778987575","wikidata":"https://www.wikidata.org/wiki/Q21145992","display_name":"BMI1","level":3,"score":0.5309181809425354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4485170841217041},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44775786995887756},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4131251871585846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39039209485054016},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3186836838722229}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1422872112","doi":"https://doi.org/10.1073/pnas.1422872112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1422872112","pdf_url":"https://www.pnas.org/content/pnas/112/17/5437.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4418851","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4418851","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:25922517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25922517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/116037","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/116037","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1422872112","doi":"https://doi.org/10.1073/pnas.1422872112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1422872112","pdf_url":"https://www.pnas.org/content/pnas/112/17/5437.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G126943299","display_name":"Effects of MOZ on chromatin and transcription of genes regulating palate development","funder_award_id":"1051078","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1828502848","display_name":"How DNA controls the embryonic development of humans and mice","funder_award_id":"1003435","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1883785566","display_name":"Interaction between Moz and Bmi1 in defining epigenetic states and gene expression patterns","funder_award_id":"1008699","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2260313631","display_name":null,"funder_award_id":"1051078","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G2459224897","display_name":"Statistical bioinformatics for genomic research","funder_award_id":"1058892","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2532479927","display_name":null,"funder_award_id":"1081421","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G2589971633","display_name":"The Role of Moz in Cancer","funder_award_id":"1030704","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2632642442","display_name":null,"funder_award_id":"1008699","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G3212871698","display_name":null,"funder_award_id":"1003435","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G3269073167","display_name":null,"funder_award_id":"1030704","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G421962803","display_name":null,"funder_award_id":"1010851","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G4711354754","display_name":null,"funder_award_id":"1058892","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G553948410","display_name":null,"funder_award_id":"575512","funder_id":"https://openalex.org/F4320322220","funder_display_name":"Department of Health and Aged Care, Australian Government"},{"id":"https://openalex.org/G5686300559","display_name":"Uncoupled Research Fellowship","funder_award_id":"575512","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7374130541","display_name":"Effects of histone acetyltransferases on chromatin modifications","funder_award_id":"1010851","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7581438427","display_name":"NHMRC Research Fellowship","funder_award_id":"1081421","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320322220","display_name":"Department of Health and Aged Care, Australian Government","ror":"https://ror.org/02swcnz29"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040412635.pdf","grobid_xml":"https://content.openalex.org/works/W2040412635.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W96037378","https://openalex.org/W174481975","https://openalex.org/W1560744534","https://openalex.org/W1597195398","https://openalex.org/W1768482373","https://openalex.org/W1946881562","https://openalex.org/W1963601589","https://openalex.org/W1967269362","https://openalex.org/W1968931043","https://openalex.org/W1974484497","https://openalex.org/W1975702835","https://openalex.org/W1975805528","https://openalex.org/W1978896959","https://openalex.org/W1979013477","https://openalex.org/W1982166080","https://openalex.org/W1985348819","https://openalex.org/W1992182462","https://openalex.org/W1993950966","https://openalex.org/W2006788765","https://openalex.org/W2008668462","https://openalex.org/W2011180717","https://openalex.org/W2011753829","https://openalex.org/W2017840637","https://openalex.org/W2023003508","https://openalex.org/W2035299191","https://openalex.org/W2041791362","https://openalex.org/W2053626988","https://openalex.org/W2055013769","https://openalex.org/W2062640733","https://openalex.org/W2068288447","https://openalex.org/W2071789449","https://openalex.org/W2082959814","https://openalex.org/W2091151146","https://openalex.org/W2091611885","https://openalex.org/W2097706279","https://openalex.org/W2100147083","https://openalex.org/W2117138389","https://openalex.org/W2118603578","https://openalex.org/W2122468638","https://openalex.org/W2123791127","https://openalex.org/W2126334907","https://openalex.org/W2146497742","https://openalex.org/W2161313400","https://openalex.org/W2169236261","https://openalex.org/W2172280531"],"related_works":["https://openalex.org/W2736159798","https://openalex.org/W1974484497","https://openalex.org/W2090108799","https://openalex.org/W3212371533","https://openalex.org/W1979013477","https://openalex.org/W1886115146","https://openalex.org/W7057096853","https://openalex.org/W2005523409","https://openalex.org/W6996057951","https://openalex.org/W2613966178"],"abstract_inverted_index":{"Hox":[0,67,95,118,142,162,201,232],"genes":[1,96,143],"underlie":[2],"the":[3,10,41,49,56,61,76,81,98,101,105,122,128,156,198,205,228,239],"specification":[4,214,241],"of":[5,44,63,130,200,231,242],"body":[6,145,211,243],"segment":[7,146,212,244],"identity":[8,147,180,213],"in":[9,32,134,140,161,167,181,204,215],"anterior-posterior":[11],"axis.":[12],"They":[13],"are":[14],"activated":[15],"during":[16,48,66,97,197,210,227],"gastrulation":[17],"and":[18,80,89,93,132,144,159,170,192,209],"undergo":[19],"a":[20,24,33,177,223],"dynamic":[21],"shift":[22,99],"from":[23,100],"transcriptionally":[25,102],"repressed":[26,94,103],"to":[27,104,116,176],"an":[28],"active":[29,106],"chromatin":[30,45,64],"state":[31],"sequence":[34],"that":[35,87,155,190,219],"reflects":[36],"their":[37,138],"chromosomal":[38],"location.":[39],"Nevertheless,":[40],"precise":[42],"role":[43,62,139,226],"modifying":[46],"complexes":[47,221],"initial":[50,123],"activation":[51,124],"phase":[52,230],"remains":[53],"unclear.":[54],"In":[55],"current":[57],"study,":[58],"we":[59,85,136],"examined":[60],"regulators":[65],"gene":[68,163,202,233],"activation.":[69],"Using":[70],"embryonic":[71],"stem":[72],"cell":[73,207],"lines":[74],"lacking":[75],"transcriptional":[77],"activator":[78],"MOZ":[79,88,110,131,191],"polycomb-family":[82],"repressor":[83],"BMI1,":[84,90],"showed":[86],"respectively,":[91],"promoted":[92],"state.":[107],"Strikingly":[108],"however,":[109],"but":[111],"not":[112],"BMI1":[113,133,193],"was":[114],"required":[115],"regulate":[117],"mRNA":[119],"levels":[120],"after":[121],"phase.":[125],"To":[126],"determine":[127],"interaction":[129],"vivo,":[135],"interrogated":[137],"regulating":[141],"using":[148],"Moz;Bmi1":[149,182],"double":[150,183],"deficient":[151],"mice.":[152],"We":[153,217],"found":[154],"homeotic":[157],"transformations":[158],"shifts":[160],"expression":[164,203],"boundaries":[165],"observed":[166],"single":[168],"Moz":[169],"Bmi1":[171],"mutant":[172],"mice":[173],"were":[174],"rescued":[175],"wild":[178],"type":[179],"knockout":[184],"animals.":[185],"Together,":[186],"our":[187],"findings":[188],"establish":[189],"play":[194],"opposing":[195],"roles":[196],"onset":[199],"ES":[206],"model":[208],"vivo.":[216],"propose":[218],"chromatin-modifying":[220],"have":[222],"previously":[224],"unappreciated":[225],"initiation":[229],"expression,":[234],"which":[235],"is":[236],"critical":[237],"for":[238],"correct":[240],"identity.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
