{"id":"https://openalex.org/W2040328743","doi":"https://doi.org/10.1016/j.chembiol.2007.04.005","title":"Identification of a Type III Thioesterase Reveals the Function of an Operon Crucial for Mtb Virulence","display_name":"Identification of a Type III Thioesterase Reveals the Function of an Operon Crucial for Mtb Virulence","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2040328743","doi":"https://doi.org/10.1016/j.chembiol.2007.04.005","mag":"2040328743","pmid":"https://pubmed.ncbi.nlm.nih.gov/17524985"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2007.04.005","doi":"https://doi.org/10.1016/j.chembiol.2007.04.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2007.04.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S107455210700141X/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S107455210700141X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023583451","display_name":"Feng Wang","orcid":"https://orcid.org/0000-0003-2980-4646","observed_orcids":["https://orcid.org/0000-0003-2980-4646"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Wang","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044063629","display_name":"Robert Langley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Langley","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037429579","display_name":"G\u00fcl\u00e7in G\u00fclten","orcid":"https://orcid.org/0000-0002-9393-881X","observed_orcids":["https://orcid.org/0000-0002-9393-881X"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gulcin Gulten","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037068649","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0002-0118-2294","observed_orcids":["https://orcid.org/0000-0002-0118-2294"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103456216","display_name":"James C. Sacchettini","orcid":"https://orcid.org/0000-0001-5767-2367","observed_orcids":["https://orcid.org/0000-0001-5767-2367"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James C. Sacchettini","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103456216"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":2.1643,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.86392244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"5","first_page":"543","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/acyl-carrier-protein","display_name":"acyl carrier protein","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nonribosomal-peptide-synthetase","display_name":"nonribosomal peptide synthetase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/active-site-structure","display_name":"active site structure","score":0.5910000205039978},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.9829999804496765},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.628000020980835},{"id":"https://openalex.org/keywords/mouse-macrophages","display_name":"mouse macrophages","score":0.7139999866485596},{"id":"https://openalex.org/keywords/bacterial-pathogenesis","display_name":"bacterial pathogenesis","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.866254985332489},{"id":"https://openalex.org/C2780622759","wikidata":"https://www.wikidata.org/wiki/Q76818446","display_name":"Thioesterase","level":4,"score":0.8077657222747803},{"id":"https://openalex.org/C2777379556","wikidata":"https://www.wikidata.org/wiki/Q1443801","display_name":"Nonribosomal peptide","level":4,"score":0.7552879452705383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6980955004692078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5207321643829346},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5030731558799744},{"id":"https://openalex.org/C69953675","wikidata":"https://www.wikidata.org/wiki/Q310284","display_name":"L-arabinose operon","level":5,"score":0.4416544437408447},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3677752614021301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3563663959503174},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.21745792031288147},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.2040068805217743}],"mesh":[{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010170","descriptor_name":"Palmitoyl-CoA Hydrolase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010170","descriptor_name":"Palmitoyl-CoA Hydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010170","descriptor_name":"Palmitoyl-CoA Hydrolase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.chembiol.2007.04.005","doi":"https://doi.org/10.1016/j.chembiol.2007.04.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2007.04.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S107455210700141X/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},{"id":"pmid:17524985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17524985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2007.04.005","doi":"https://doi.org/10.1016/j.chembiol.2007.04.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2007.04.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S107455210700141X/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3284805785","display_name":"Structural Genomics of Persistence Targets from M. tuberculosis","funder_award_id":"P01AI068135","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040328743.pdf","grobid_xml":"https://content.openalex.org/works/W2040328743.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1581414347","https://openalex.org/W1581518593","https://openalex.org/W1592296453","https://openalex.org/W1593630258","https://openalex.org/W1839417013","https://openalex.org/W1855537617","https://openalex.org/W1935793071","https://openalex.org/W1980530950","https://openalex.org/W2001641653","https://openalex.org/W2008867070","https://openalex.org/W2015642465","https://openalex.org/W2017723161","https://openalex.org/W2017727500","https://openalex.org/W2020490055","https://openalex.org/W2020848561","https://openalex.org/W2022103709","https://openalex.org/W2033777683","https://openalex.org/W2040067533","https://openalex.org/W2061361921","https://openalex.org/W2067887310","https://openalex.org/W2095717895","https://openalex.org/W2098442675","https://openalex.org/W2098504064","https://openalex.org/W2109817270","https://openalex.org/W2124254997","https://openalex.org/W2128482141","https://openalex.org/W2132169354","https://openalex.org/W2135839939","https://openalex.org/W2140354550","https://openalex.org/W2144794307","https://openalex.org/W2149122112","https://openalex.org/W2149419665","https://openalex.org/W2164718888","https://openalex.org/W2172354041","https://openalex.org/W2735246829"],"related_works":["https://openalex.org/W2802801467","https://openalex.org/W2585434061","https://openalex.org/W7095974828","https://openalex.org/W2041723357","https://openalex.org/W2034329420","https://openalex.org/W2047510552","https://openalex.org/W3157162775","https://openalex.org/W2048556830","https://openalex.org/W2181733037","https://openalex.org/W1595451534"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}