{"id":"https://openalex.org/W2040322783","doi":"https://doi.org/10.1523/jneurosci.0234-09.2009","title":"Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation","display_name":"Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation","publication_year":2009,"publication_date":"2009-05-13","ids":{"openalex":"https://openalex.org/W2040322783","doi":"https://doi.org/10.1523/jneurosci.0234-09.2009","mag":"2040322783","pmid":"https://pubmed.ncbi.nlm.nih.gov/19439614","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2827328"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0234-09.2009","doi":"https://doi.org/10.1523/jneurosci.0234-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0234-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/19/6367.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/19/6367.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007846044","display_name":"William A. Tyler","orcid":"https://orcid.org/0000-0002-5423-289X","observed_orcids":["https://orcid.org/0000-0002-5423-289X"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Tyler","raw_affiliation_strings":["Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, USA","institution_ids":["https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068525650","display_name":"Nitish Gangoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitish Gangoli","raw_affiliation_strings":["Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and","institution_ids":["https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077493890","display_name":"Pradeepa Gokina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeepa Gokina","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015671396","display_name":"Haesun A. Kim","orcid":"https://orcid.org/0000-0003-0282-2553","observed_orcids":["https://orcid.org/0000-0003-0282-2553"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haesun A. Kim","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029038731","display_name":"Matthew V. Covey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Covey","raw_affiliation_strings":["Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and","institution_ids":["https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005833478","display_name":"Steven W. Levison","orcid":"https://orcid.org/0000-0002-1264-7309","observed_orcids":["https://orcid.org/0000-0002-1264-7309"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven W. Levison","raw_affiliation_strings":["Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and","institution_ids":["https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026427036","display_name":"Teresa L. Wood","orcid":"https://orcid.org/0000-0002-4480-660X","observed_orcids":["https://orcid.org/0000-0002-4480-660X"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Teresa L. Wood","raw_affiliation_strings":["Department of Neurology & Neuroscience, New Jersey Medical School, UMDNJ, Newark, NJ","Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Neuroscience, New Jersey Medical School, UMDNJ, Newark, NJ","institution_ids":["https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Department of Neurology & Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101-1709, and","institution_ids":["https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026427036"],"corresponding_institution_ids":["https://openalex.org/I4402554120","https://openalex.org/I4405286694"],"apc_list":null,"apc_paid":null,"fwci":4.6815,"has_fulltext":true,"cited_by_count":268,"citation_normalized_percentile":{"value":0.95836576,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"29","issue":"19","first_page":"6367","last_page":"6378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9330000281333923},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mtorc2","display_name":"mTORC2","score":1.0},{"id":"https://openalex.org/keywords/raptors","display_name":"raptors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rictor","display_name":"Rictor","score":1.0},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.9660000205039978},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.9430000185966492},{"id":"https://openalex.org/keywords/plasmalogens","display_name":"plasmalogens","score":0.718999981880188},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/white-matter-development","display_name":"white matter development","score":0.75},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.574999988079071},{"id":"https://openalex.org/keywords/myelin-gene-expression","display_name":"myelin gene expression","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.824573278427124},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.7840595245361328},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7436478734016418},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.7105837464332581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.692453145980835},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5958173274993896},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.503696858882904},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4599205255508423},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.4480132758617401},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.4385729134082794},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37656649947166443},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3167220950126648},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09655287861824036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09035423398017883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08088445663452148}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009185","descriptor_name":"Myelin Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.0234-09.2009","doi":"https://doi.org/10.1523/jneurosci.0234-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0234-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/19/6367.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:19439614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19439614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2827328","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2827328/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.378.6214","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.378.6214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://njms.rutgers.edu/proweb/documents/ActivationoftheMammalianTargetofRapamycin.pdf","raw_type":"text"},{"id":"mag:2186364706","doi":null,"is_oa":false,"landing_page_url":"https://www.jneurosci.org/content/29/19/6367.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0234-09.2009","doi":"https://doi.org/10.1523/jneurosci.0234-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0234-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/19/6367.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G253156660","display_name":"Rutgers Mass Spectrometry Center for Integrative Neuroscience Research","funder_award_id":"P30NS046593","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5495868414","display_name":"Oligodendrocyte Generation--A Multifactorial Approach","funder_award_id":"R01NS037560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7676090874","display_name":"Functional analysis of erbB2 signaling in myelin-forming glial cells","funder_award_id":"R01NS056135","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8918733155","display_name":"Neural Stem Cell Responses to Perinatal Brain Damage","funder_award_id":"R01MH059950","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040322783.pdf","grobid_xml":"https://content.openalex.org/works/W2040322783.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1589421810","https://openalex.org/W1758833828","https://openalex.org/W1977100089","https://openalex.org/W1983698019","https://openalex.org/W1986420581","https://openalex.org/W1989453114","https://openalex.org/W1993589868","https://openalex.org/W2006559495","https://openalex.org/W2014547350","https://openalex.org/W2021012077","https://openalex.org/W2027260046","https://openalex.org/W2031052253","https://openalex.org/W2032313226","https://openalex.org/W2036518710","https://openalex.org/W2037908014","https://openalex.org/W2039383073","https://openalex.org/W2042528531","https://openalex.org/W2052583546","https://openalex.org/W2059665233","https://openalex.org/W2059994807","https://openalex.org/W2060525739","https://openalex.org/W2061556393","https://openalex.org/W2065887259","https://openalex.org/W2077044475","https://openalex.org/W2077339168","https://openalex.org/W2077492083","https://openalex.org/W2078630298","https://openalex.org/W2095192176","https://openalex.org/W2102118606","https://openalex.org/W2103612830","https://openalex.org/W2119151792","https://openalex.org/W2120316837","https://openalex.org/W2129585918","https://openalex.org/W2140884992","https://openalex.org/W2165626417","https://openalex.org/W2166744602","https://openalex.org/W2391415472","https://openalex.org/W3140459896","https://openalex.org/W4238567307","https://openalex.org/W6675488394"],"related_works":["https://openalex.org/W7098869186","https://openalex.org/W2059813092","https://openalex.org/W2999517433","https://openalex.org/W2163087082","https://openalex.org/W1996798743","https://openalex.org/W3010218740","https://openalex.org/W2119940382","https://openalex.org/W2091174313","https://openalex.org/W2077239398","https://openalex.org/W1569826023"],"abstract_inverted_index":{"Although":[0],"both":[1],"extrinsic":[2],"and":[3,13,72,77,114,125,172,190],"intrinsic":[4],"factors":[5],"have":[6],"been":[7],"identified":[8],"that":[9,25,36,100,201],"orchestrate":[10],"the":[11,21,27,39,56,66,90,95,118,121,155,199],"differentiation":[12,54,107,189,207],"maturation":[14],"of":[15,38,42,68,81,94,120,136,170,193],"oligodendrocytes,":[16],"less":[17],"is":[18,45],"known":[19],"about":[20],"intracellular":[22],"signaling":[23,111],"pathways":[24],"control":[26],"overall":[28],"commitment":[29,204],"to":[30,59,205],"differentiate.":[31],"Here,":[32],"we":[33],"provide":[34],"evidence":[35],"activation":[37],"mammalian":[40],"target":[41],"rapamycin":[43],"(mTOR)":[44],"essential":[46],"for":[47],"oligodendrocyte":[48,53,61,106,179,188,206],"differentiation.":[49,180],"Specifically,":[50],"mTOR":[51,82,101,129,185,202],"regulates":[52,203],"at":[55,154],"late":[57],"progenitor":[58],"immature":[60],"transition":[62],"as":[63],"assessed":[64],"by":[65,117],"expression":[67,144,153,162],"stage":[69],"specific":[70],"antigens":[71],"myelin":[73,142,151,194],"proteins":[74,123],"including":[75],"MBP":[76,161],"PLP.":[78],"Furthermore,":[79],"phosphorylation":[80,177],"on":[83,105],"Ser":[84],"2448":[85],"correlates":[86],"with":[87],"myelination":[88],"in":[89,145],"subcortical":[91],"white":[92],"matter":[93],"developing":[96],"brain.":[97],"We":[98],"demonstrate":[99],"exerts":[102],"its":[103],"effects":[104],"through":[108],"two":[109],"distinct":[110],"complexes,":[112],"mTORC1":[113,159,171],"mTORC2,":[115],"defined":[116],"presence":[119],"adaptor":[122],"raptor":[124,137],"rictor,":[126],"respectively.":[127],"Disrupting":[128],"complex":[130],"formation":[131],"via":[132,163],"siRNA":[133],"mediated":[134],"knockdown":[135],"or":[138],"rictor":[139],"significantly":[140],"reduced":[141,191],"protein":[143],"vitro.":[146],"However,":[147],"mTORC2":[148,173],"alone":[149],"controlled":[150],"gene":[152],"mRNA":[156],"level,":[157],"whereas":[158],"influenced":[160],"an":[164],"alternative":[165],"mechanism.":[166],"In":[167,181],"addition,":[168],"investigation":[169],"targets":[174],"revealed":[175],"differential":[176],"during":[178],"OPC-DRG":[182],"cocultures,":[183],"inhibiting":[184],"potently":[186],"abrogated":[187],"numbers":[192],"segments.":[195],"These":[196],"data":[197],"support":[198],"hypothesis":[200],"before":[208],"myelination.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}