{"id":"https://openalex.org/W204030352","doi":null,"title":"[An experimental study on destruction of K562 and HL60 induced by 5-aminolaevulinic acid-based photodynamic therapy].","display_name":"[An experimental study on destruction of K562 and HL60 induced by 5-aminolaevulinic acid-based photodynamic therapy].","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W204030352","mag":"204030352","pmid":"https://pubmed.ncbi.nlm.nih.gov/16013252"},"language":"zh","primary_location":{"id":"pmid:16013252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16013252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017040783","display_name":"\u5f20\u5b9d\u7434","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoqin Zhang","raw_affiliation_strings":["The Key laboratory of Biomedical Information Engineering of Ministry of Education, Pediatrics Department, First Hospital of Medical College Xi'an Jiaotong University, Xi'an 710061, China. zhangbq@mail.xjtu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key laboratory of Biomedical Information Engineering of Ministry of Education, Pediatrics Department, First Hospital of Medical College Xi'an Jiaotong University, Xi'an 710061, China. zhangbq@mail.xjtu.edu.cn","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042871410","display_name":"\u82d7\u4e3d\u971e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lixia Miao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101672678","display_name":"Zhen-xi Zhang","orcid":"https://orcid.org/0000-0001-7343-510X","observed_orcids":["https://orcid.org/0000-0001-7343-510X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhenxi Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mi Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mi Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031077848","display_name":"\u9648\u7f8e\u84dd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meilan Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1158,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48337903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"3","first_page":"525","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.6840000152587891},{"id":"https://openalex.org/keywords/n-acetylornithine","display_name":"N-acetylornithine","score":0.6840000152587891},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.6539999842643738},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8550000190734863},{"id":"https://openalex.org/keywords/s-phase-arrest","display_name":"S phase arrest","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cell-death-mode","display_name":"cell death mode","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4063716530799866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3360707759857178}],"mesh":[{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16013252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16013252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi","raw_type":"Journal Article"},{"id":"mag:204030352","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/90574X/200503/20330469.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555123","display_name":"\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u6742\u5fd7","issn_l":"1001-5515","issn":["1001-5515"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u6742\u5fd7","raw_type":null},{"id":"mag:2468906502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16013252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1009203884","https://openalex.org/W2341293018","https://openalex.org/W2468906502","https://openalex.org/W2342198032","https://openalex.org/W2516930451","https://openalex.org/W971101447","https://openalex.org/W2378450509","https://openalex.org/W2352740489","https://openalex.org/W2299815860","https://openalex.org/W2001222190"],"abstract_inverted_index":{"This":[0],"experiment":[1,217],"was":[2,56,77,101,177,195,233,239],"designed":[3],"to":[4,58,79,103,278],"explore":[5],"the":[6,15,22,36,60,81,84,105,108,124,129,144,148,170,188,206,215,219,223,236,256,259,262,273],"pattern":[7,61,221,238],"of":[8,43,62,128,147,172,175,190,193,205,222,246,258],"K562":[9,63,176,208,224,279],"and":[10,21,64,90,156,165,182,187,199,209,225,235,280],"HL60":[11,65,194,210,226,281],"leukemia":[12,44,227,260],"cells":[13,125,130,247],"death,":[14],"effects":[16],"on":[17],"their":[18],"cell":[19,85],"cycle":[20,86],"cytoplasmic":[23,109],"free":[24,110,266],"calcium":[25,98,111,267],"concentration":[26,112,268],"([Ca2+]i)":[27],"induced":[28,68,87,230,276],"by":[29,69,88,231,253],"5-aminolaevulinic":[30],"acid-based":[31],"photodynamic":[32],"therapy":[33],"(ALA-PDT).":[34],"Under":[35],"transmission":[37],"electron":[38],"microscope":[39],"(TEM),":[40],"two":[41,244],"kinds":[42,245],"cells'":[45,66,149,228],"ultrastructure":[46],"were":[47,121,132,151,211,248],"observed.":[48],"Flow":[49,71,139],"cytometry":[50,72,140],"combined":[51,73],"with":[52,74,97],"Annexin":[53],"V-FITC/PI":[54],"labeling":[55,76],"used":[57,78,102],"detect":[59,104],"death":[67,150,229,257],"ALA-PDT.":[70,254],"PI":[75],"analyze":[80],"change":[82,106],"in":[83,107,123,264],"ALA-PDT,":[89],"confocal":[91],"laser":[92],"scanning":[93],"microscopy":[94],"(CLSM)":[95],"combining":[96],"fluorescence":[99],"probe":[100],"([Ca2+]i).":[113],"Immediately":[114,164],"after":[115,154,168],"irradiation,":[116,169],"many":[117],"typical":[118],"apoptotic":[119],"bodies":[120],"seen":[122],"treated.":[126],"Most":[127],"treated":[131,207],"necrotic":[133],"at":[134,159,250],"24":[135,160,166],"hours":[136,161,167],"following":[137],"irradiation.":[138,163],"analysis":[141],"suggested":[142],"that":[143],"main":[145,237],"patterns":[146],"apoptosis":[152,234],"immediately":[153],"irradiation":[155],"necrosis":[157,240],"post-apoptosis":[158],"post":[162,241],"proportion":[171,189],"S":[173,191,251],"phase":[174,192,252],"57.":[178],"67%":[179],"+/-":[180,184,197],"1.13%":[181],"84.77%":[183],"6.20%":[185],"respectively,":[186],"74.60%":[196],"7.27%":[198],"84.60%":[200],"1.74%":[201],"respectively.":[202],"Both":[203],"[Ca+]i":[204],"increased":[212],"obviously.":[213],"In":[214],"best":[216],"condition,":[218],"initial":[220],"PDT":[232],"apoptosis.":[242],"The":[243],"arrested":[249],"During":[255],"cells,":[261],"increase":[263],"intracellular":[265],"could":[269],"be":[270],"responsible":[271],"for":[272],"ALA":[274],"photodynamically":[275],"damage":[277],"cells.":[282]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}