{"id":"https://openalex.org/W2040280429","doi":"https://doi.org/10.1016/0304-3835(88)90103-6","title":"DNA methylation levels in acute human leukemia","display_name":"DNA methylation levels in acute human leukemia","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W2040280429","doi":"https://doi.org/10.1016/0304-3835(88)90103-6","mag":"2040280429","pmid":"https://pubmed.ncbi.nlm.nih.gov/3359414"},"language":"en","primary_location":{"id":"doi:10.1016/0304-3835(88)90103-6","doi":"https://doi.org/10.1016/0304-3835(88)90103-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3835(88)90103-6","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048312997","display_name":"Gerd P. Pfeifer","orcid":"https://orcid.org/0000-0002-5080-9604","observed_orcids":["https://orcid.org/0000-0002-5080-9604"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gerd P. Pfeifer","raw_affiliation_strings":["Zentrum der Biologischen Chemie, Universit\u00e4t Frankfurt, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Biologischen Chemie, Universit\u00e4t Frankfurt, F.R.G","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035280987","display_name":"Sabine D. Steigerwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Steigerwald","raw_affiliation_strings":["Zentrum der Biologischen Chemie der Universit\u00e4t Frankfurt, D-6000 Frankfurt a.M. 70 F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Biologischen Chemie der Universit\u00e4t Frankfurt, D-6000 Frankfurt a.M. 70 F.R.G","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072586004","display_name":"Thomas L. J. Boehm","orcid":"https://orcid.org/0000-0001-5172-7478","observed_orcids":["https://orcid.org/0000-0001-5172-7478"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas L.J. Boehm","raw_affiliation_strings":["Zentrum der Biologischen Chemie der Universit\u00e4t Frankfurt, D-6000 Frankfurt a.M. 70 F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Biologischen Chemie der Universit\u00e4t Frankfurt, D-6000 Frankfurt a.M. 70 F.R.G","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088537388","display_name":"Du\u0161an Drahovsk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dusan Drahovsky","raw_affiliation_strings":["Zentrum der Biologischen Chemie der Universit\u00e4t Frankfurt, D-6000 Frankfurt a.M. 70 F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Biologischen Chemie der Universit\u00e4t Frankfurt, D-6000 Frankfurt a.M. 70 F.R.G","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048312997"],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":0.128,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.391398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"39","issue":"2","first_page":"185","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cpg-dinucleotides","display_name":"CpG","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dna-hypomethylation","display_name":"DNA hypomethylation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/leukemic-transformation","display_name":"leukemic transformation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/leukocyte-subpopulations","display_name":"leukocyte subpopulations","score":0.7839999794960022},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7994405031204224},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7484422922134399},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7328036427497864},{"id":"https://openalex.org/C202199734","wikidata":"https://www.wikidata.org/wiki/Q900386","display_name":"Demethylation","level":5,"score":0.6683930158615112},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6618095636367798},{"id":"https://openalex.org/C16824249","wikidata":"https://www.wikidata.org/wiki/Q5205753","display_name":"DNA demethylation","level":5,"score":0.6387333869934082},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6275855302810669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5769314765930176},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.5753175020217896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5167617201805115},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.5045849084854126},{"id":"https://openalex.org/C2775926025","wikidata":"https://www.wikidata.org/wiki/Q238563","display_name":"5-Methylcytosine","level":5,"score":0.4922138750553131},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4143410325050354},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.4135490953922272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2760598063468933},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2564297616481781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20164549350738525},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12275788187980652}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0304-3835(88)90103-6","doi":"https://doi.org/10.1016/0304-3835(88)90103-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3835(88)90103-6","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:3359414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3359414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W285568945","https://openalex.org/W1580225213","https://openalex.org/W1598605388","https://openalex.org/W1771276563","https://openalex.org/W1969883059","https://openalex.org/W1973319885","https://openalex.org/W1974359182","https://openalex.org/W1974747095","https://openalex.org/W1978419388","https://openalex.org/W1992952780","https://openalex.org/W1996782393","https://openalex.org/W2016659849","https://openalex.org/W2020824064","https://openalex.org/W2021115739","https://openalex.org/W2021644415","https://openalex.org/W2028235686","https://openalex.org/W2029874395","https://openalex.org/W2070945812","https://openalex.org/W2074508501","https://openalex.org/W2077529094","https://openalex.org/W2129754994","https://openalex.org/W2143498507","https://openalex.org/W2277711025","https://openalex.org/W2427608276","https://openalex.org/W2531464287","https://openalex.org/W2883573165","https://openalex.org/W4299397353","https://openalex.org/W6635593028","https://openalex.org/W6638658445","https://openalex.org/W6655933438","https://openalex.org/W6681123238"],"related_works":["https://openalex.org/W2044465868","https://openalex.org/W2278024908","https://openalex.org/W115186932","https://openalex.org/W2326400034","https://openalex.org/W1966330708","https://openalex.org/W2473283396","https://openalex.org/W4280602103","https://openalex.org/W2979700576","https://openalex.org/W2054984477","https://openalex.org/W2975944215"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}