{"id":"https://openalex.org/W2040270754","doi":"https://doi.org/10.1002/mrd.10067","title":"Pyruvate utilization by mouse oocytes is influenced by meiotic status and the cumulus oophorus","display_name":"Pyruvate utilization by mouse oocytes is influenced by meiotic status and the cumulus oophorus","publication_year":2002,"publication_date":"2002-03-18","ids":{"openalex":"https://openalex.org/W2040270754","doi":"https://doi.org/10.1002/mrd.10067","mag":"2040270754","pmid":"https://pubmed.ncbi.nlm.nih.gov/11933168"},"language":"en","primary_location":{"id":"doi:10.1002/mrd.10067","doi":"https://doi.org/10.1002/mrd.10067","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.10067","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen M. Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen M. Downs","raw_affiliation_strings":["Biology Department, Marquette University, 530 N 15 Street, Milwaukee, WI 53233, USA. stephen.downs@marquette.edu","Biology Department, Marquette University, 530 N 15 Street, Milwaukee, WI 53233, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Marquette University, 530 N 15 Street, Milwaukee, WI 53233, USA. stephen.downs@marquette.edu","institution_ids":["https://openalex.org/I102461120"]},{"raw_affiliation_string":"Biology Department, Marquette University, 530 N 15 Street, Milwaukee, WI 53233, USA","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020278379","display_name":"Peter G. Humpherson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter G. Humpherson","raw_affiliation_strings":["Biology Department, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057703824","display_name":"Henry J. Leese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henry J. Leese","raw_affiliation_strings":["Biology Department, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102461120"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":4.2425,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.93776662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"1","first_page":"113","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyruvate-utilization","display_name":"pyruvate utilization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/oocyte-energy-metabolism","display_name":"oocyte energy metabolism","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cumulus-oophorus","display_name":"cumulus oophorus","score":0.8799999952316284},{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.6809999942779541},{"id":"https://openalex.org/keywords/pyruvate-oxidation","display_name":"pyruvate oxidation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.8209999799728394},{"id":"https://openalex.org/keywords/3-isobutyl-1-methylxanthine","display_name":"3-isobutyl-1-methylxanthine","score":0.7440000176429749},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.9879999756813049},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.8330000042915344},{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mouse-oocytes","display_name":"mouse oocytes","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2994119143","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Germinal vesicle","level":4,"score":0.8331900835037231},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.6765074133872986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5881542563438416},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.5863903164863586},{"id":"https://openalex.org/C2778928357","wikidata":"https://www.wikidata.org/wiki/Q5194195","display_name":"Cumulus oophorus","level":4,"score":0.5054285526275635},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.48672130703926086},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4227224588394165},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32487642765045166},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31669506430625916},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3084784746170044},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30787375569343567},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2015945315361023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrd.10067","doi":"https://doi.org/10.1002/mrd.10067","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.10067","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:11933168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11933168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6055639802","display_name":"MEIOTIC REGULATION IN MAMMALIAN OOCYTES","funder_award_id":"R15HD039172","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1819194792","https://openalex.org/W1964499723","https://openalex.org/W1976069063","https://openalex.org/W1976129687","https://openalex.org/W1981516020","https://openalex.org/W1981794598","https://openalex.org/W1982451630","https://openalex.org/W1986520935","https://openalex.org/W1987462487","https://openalex.org/W1990255218","https://openalex.org/W1991432068","https://openalex.org/W1997800433","https://openalex.org/W2011269438","https://openalex.org/W2016979866","https://openalex.org/W2018211192","https://openalex.org/W2023921091","https://openalex.org/W2034763955","https://openalex.org/W2049693640","https://openalex.org/W2051250694","https://openalex.org/W2051755508","https://openalex.org/W2053470850","https://openalex.org/W2055883961","https://openalex.org/W2056522699","https://openalex.org/W2057370040","https://openalex.org/W2068510828","https://openalex.org/W2083291133","https://openalex.org/W2090276649","https://openalex.org/W2091042682","https://openalex.org/W2094202638","https://openalex.org/W2100475231","https://openalex.org/W2138773618","https://openalex.org/W2140503635","https://openalex.org/W2149021404","https://openalex.org/W2149745618","https://openalex.org/W2164223710","https://openalex.org/W2181917632","https://openalex.org/W2405821189","https://openalex.org/W2409576416"],"related_works":["https://openalex.org/W2140503635","https://openalex.org/W2049693640","https://openalex.org/W2138773618","https://openalex.org/W2056522699","https://openalex.org/W2160819114","https://openalex.org/W1987040958","https://openalex.org/W2230648386","https://openalex.org/W2083291133","https://openalex.org/W2022094375","https://openalex.org/W2116853358"],"abstract_inverted_index":{"In":[0,26,151],"this":[1,274],"study,":[2],"the":[3,9,27,52,79,89,124,164,174,181,189,193,209,239,258,266,308,317],"effects":[4],"of":[5,13,30,49,123,136,173,236,260,269,273,312,316],"meiotic":[6,65,103,171,194,224,304],"status":[7,172,305],"on":[8],"energy":[10,165],"substrate":[11,166,275],"dynamics":[12,167],"mouse":[14],"oocyte-cumulus":[15],"cell":[16],"complexes":[17],"(OCCs)":[18],"and":[19,51,54,60,63,78,129,131,148,160,233,302],"denuded":[20],"oocytes":[21,55,125,187,220,288,301],"(DOs)":[22],"have":[23,289],"been":[24],"examined.":[25],"first":[28],"series":[29],"experiments,":[31],"OCCs":[32,80,253,279],"from":[33],"PMSG-primed,":[34],"immature":[35],"mice":[36],"were":[37,56,168],"cultured":[38],"in":[39,43,68,85,115,188,223,242,257],"minimum":[40],"essential":[41],"medium":[42,53,70,143],"8-microl":[44],"microdrops":[45],"under":[46],"a":[47,82,153,290],"variety":[48],"conditions,":[50],"sampled":[57],"for":[58,64,293],"pyruvate":[59,86,106,130,149,161,176,200,218,230,249,294],"glucose":[61,90,111,132,146,159,237],"concentration":[62,91],"status.":[66],"Oocytes":[67],"control":[69,137],"underwent":[71],"germinal":[72,190],"vesicle":[73,191],"breakdown":[74],"within":[75],"3":[76],"hr":[77],"displayed":[81],"time-dependent":[83],"increase":[84],"consumption,":[87,107],"but":[88,108,314],"changed":[92],"very":[93],"little.":[94],"Treatment":[95],"with":[96,170,180],"IBMX":[97],"or":[98,212,298],"dbcAMP,":[99],"which":[100],"maintained":[101,186],"complete":[102],"arrest,":[104],"suppressed":[105],"slightly":[109],"more":[110,229,248],"was":[112,156,178,196,250,276],"consumed":[113,216,251],"than":[114,219,231,254,280,295],"controls.":[116],"Hypoxanthine":[117],"(HX)":[118],"allowed":[119],"up":[120],"to":[121,126,141],"10%":[122],"resume":[127],"maturation,":[128],"consumption":[133,147,177],"resembled":[134],"that":[135,205,285,303],"OCCs.":[138,243,318],"FSH":[139],"added":[140],"HX-containing":[142],"stimulated":[144],"significant":[145],"production.":[150],"general,":[152],"reciprocal":[154],"relationship":[155],"observed":[157],"between":[158],"consumption.":[162,201],"When":[163],"compared":[169],"oocytes,":[175,313],"associated":[179],"maturation":[182],"process.":[183],"Although":[184],"HX":[185],"stage,":[192],"arrest":[195],"\"leaky,\"":[197],"allowing":[198],"increased":[199],"Additional":[202],"experiments":[203],"showed":[204],"DOs":[206,226,256],"at":[207],"either":[208],"prophase":[210,296],"I":[211],"metaphase":[213,299],"II":[214],"stages":[215],"less":[217,272],"actively":[221],"engaged":[222],"maturation.":[225],"oxidized":[227,277],"significantly":[228],"OCCs,":[232],"glycolytic":[234],"metabolism":[235,309],"lowered":[238],"oxidation":[240,262],"rate":[241],"Furthermore,":[244],"while":[245],"5-6.2":[246],"times":[247],"by":[252,255,278,281],"absence":[259],"glucose,":[261],"did":[263],"not":[264,310],"mediate":[265],"meiosis-inducing":[267],"effect":[268],"pyruvate,":[270],"since":[271],"DOs.":[282],"We":[283],"conclude":[284],"meiotically":[286],"active":[287],"greater":[291],"requirement":[292],"I-":[297],"II-arrested":[300],"can":[306],"influence":[307],"only":[311],"also":[315]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
