{"id":"https://openalex.org/W2040177546","doi":"https://doi.org/10.1016/j.immuni.2014.04.019","title":"Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions","display_name":"Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2040177546","doi":"https://doi.org/10.1016/j.immuni.2014.04.019","mag":"2040177546","pmid":"https://pubmed.ncbi.nlm.nih.gov/24909886","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4067745"},"language":"en","primary_location":{"id":"doi:10.1016/j.immuni.2014.04.019","doi":"https://doi.org/10.1016/j.immuni.2014.04.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.immuni.2014.04.019","pdf_url":"http://www.cell.com/article/S1074761314001836/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1074761314001836/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032504865","display_name":"Paola Di Meglio","orcid":"https://orcid.org/0000-0002-2066-7780","observed_orcids":["https://orcid.org/0000-0002-2066-7780"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paola Di\u00a0Meglio","raw_affiliation_strings":["Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022483837","display_name":"Jo\u00e3o H. Duarte","orcid":"https://orcid.org/0000-0001-7186-4947","observed_orcids":["https://orcid.org/0000-0001-7186-4947"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o\u00a0H. Duarte","raw_affiliation_strings":["Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056961888","display_name":"Helena Ahlfors","orcid":"https://orcid.org/0000-0002-8183-0895","observed_orcids":["https://orcid.org/0000-0002-8183-0895"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helena Ahlfors","raw_affiliation_strings":["Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060587596","display_name":"Nick D. L. Owens","orcid":"https://orcid.org/0000-0002-2151-9923","observed_orcids":["https://orcid.org/0000-0002-2151-9923"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick\u00a0D.L. Owens","raw_affiliation_strings":["Division of Systems Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057356289","display_name":"Ying Li","orcid":"https://orcid.org/0000-0002-4041-2646","observed_orcids":["https://orcid.org/0000-0002-4041-2646"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063199921","display_name":"Federica Villanova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Federica Villanova","raw_affiliation_strings":["St. John's Institute of Dermatology, King's College London and NIHR Biomedical Research Centre, London SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. John's Institute of Dermatology, King's College London and NIHR Biomedical Research Centre, London SE1 9RT, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081480794","display_name":"Isabella Tosi","orcid":"https://orcid.org/0000-0002-2638-8539","observed_orcids":["https://orcid.org/0000-0002-2638-8539"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Isabella Tosi","raw_affiliation_strings":["St. John's Institute of Dermatology, King's College London and NIHR Biomedical Research Centre, London SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. John's Institute of Dermatology, King's College London and NIHR Biomedical Research Centre, London SE1 9RT, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022366571","display_name":"Keiji Hirota","orcid":"https://orcid.org/0000-0002-4737-0661","observed_orcids":["https://orcid.org/0000-0002-4737-0661"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keiji Hirota","raw_affiliation_strings":["Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034983939","display_name":"Frank Oliver Nestle","orcid":"https://orcid.org/0000-0003-1033-5309","observed_orcids":["https://orcid.org/0000-0003-1033-5309"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frank\u00a0O. Nestle","raw_affiliation_strings":["St. John's Institute of Dermatology, King's College London and NIHR Biomedical Research Centre, London SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. John's Institute of Dermatology, King's College London and NIHR Biomedical Research Centre, London SE1 9RT, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006740586","display_name":"Ulrich Mrowietz","orcid":"https://orcid.org/0000-0002-9539-0712","observed_orcids":["https://orcid.org/0000-0002-9539-0712"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Mrowietz","raw_affiliation_strings":["Psoriasis Center, Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psoriasis Center, Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057532738","display_name":"Michael J. Gilchrist","orcid":"https://orcid.org/0000-0001-9762-1951","observed_orcids":["https://orcid.org/0000-0001-9762-1951"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael\u00a0J. Gilchrist","raw_affiliation_strings":["Division of Systems Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059045389","display_name":"Brigitta Stockinger","orcid":"https://orcid.org/0000-0001-8781-336X","observed_orcids":["https://orcid.org/0000-0001-8781-336X"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Brigitta Stockinger","raw_affiliation_strings":["Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. Electronic address: bstocki@nimr.mrc.ac.uk","Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. Electronic address: bstocki@nimr.mrc.ac.uk","institution_ids":["https://openalex.org/I4405285715"]},{"raw_affiliation_string":"Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059045389"],"corresponding_institution_ids":["https://openalex.org/I4405285715"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":{"value":10400,"currency":"USD","value_usd":10400},"fwci":13.5935,"has_fulltext":true,"cited_by_count":377,"citation_normalized_percentile":{"value":0.99323284,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"40","issue":"6","first_page":"989","last_page":"1001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":1.0},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ficz","display_name":"FICZ","score":0.906000018119812},{"id":"https://openalex.org/keywords/imiquimod-induced-skin-inflammation","display_name":"imiquimod-induced skin inflammation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ahr-agonists","display_name":"AhR agonists","score":0.6399999856948853},{"id":"https://openalex.org/keywords/ahr-antagonists","display_name":"AhR antagonists","score":0.953000009059906},{"id":"https://openalex.org/keywords/environmental-stimuli","display_name":"environmental stimuli","score":0.5669999718666077},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.9828655123710632},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.769305408000946},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.743631899356842},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6531740427017212},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5990724563598633},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5738290548324585},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5534706115722656},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5322434902191162},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48294347524642944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40140020847320557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08623811602592468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077271","descriptor_name":"Imiquimod","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D065633","descriptor_name":"Cytochrome P-450 CYP1B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.immuni.2014.04.019","doi":"https://doi.org/10.1016/j.immuni.2014.04.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.immuni.2014.04.019","pdf_url":"http://www.cell.com/article/S1074761314001836/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4067745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4067745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Text"},{"id":"pmid:24909886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24909886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/709f7c51-cb1f-4582-9b4e-b85c17fabb0c","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/files/139957928/Activation_of_the_Aryl_DIMEGLIO_Publishedonline05June2014_GOLD_VoR_CC_BY_.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Di Meglio, P, Duarte, J H, Ahlfors, H, Owens, N D L, Li, Y, Villanova, F, Tosi, I, Hirota, K, Nestle, F O, Mrowietz, U, Gilchrist, M J & Stockinger, B 2014, 'Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions', Immunity, vol. 40, no. 6, pp. 989-1001. https://doi.org/10.1016/j.immuni.2014.04.019","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.immuni.2014.04.019","doi":"https://doi.org/10.1016/j.immuni.2014.04.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.immuni.2014.04.019","pdf_url":"http://www.cell.com/article/S1074761314001836/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2944643838","display_name":"The influence of Aryl hydrocarbon receptor ligands on protective and pathological immune responses","funder_award_id":"232782","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G4053289341","display_name":"Physiological functions of the aryl hydrocarbon receptor in innate and adaptive immune responses.","funder_award_id":"100910","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2040177546.pdf","grobid_xml":"https://content.openalex.org/works/W2040177546.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1486724483","https://openalex.org/W1537074337","https://openalex.org/W1573967258","https://openalex.org/W1939997832","https://openalex.org/W1968797543","https://openalex.org/W1971708477","https://openalex.org/W1976544953","https://openalex.org/W1981177186","https://openalex.org/W1981177225","https://openalex.org/W1990531488","https://openalex.org/W1993003564","https://openalex.org/W1994576750","https://openalex.org/W1997382475","https://openalex.org/W2000477360","https://openalex.org/W2001020866","https://openalex.org/W2004671403","https://openalex.org/W2005585150","https://openalex.org/W2011427930","https://openalex.org/W2014913358","https://openalex.org/W2021068763","https://openalex.org/W2034654881","https://openalex.org/W2036224418","https://openalex.org/W2037482981","https://openalex.org/W2041635511","https://openalex.org/W2042118950","https://openalex.org/W2043527671","https://openalex.org/W2047893094","https://openalex.org/W2057448387","https://openalex.org/W2068162195","https://openalex.org/W2068912461","https://openalex.org/W2069677284","https://openalex.org/W2071813734","https://openalex.org/W2082280403","https://openalex.org/W2086210534","https://openalex.org/W2092118888","https://openalex.org/W2100193266","https://openalex.org/W2102889851","https://openalex.org/W2104152486","https://openalex.org/W2113315025","https://openalex.org/W2113817581","https://openalex.org/W2123342417","https://openalex.org/W2129726409","https://openalex.org/W2145634436","https://openalex.org/W2151197941","https://openalex.org/W2155528979","https://openalex.org/W2155582127","https://openalex.org/W2169758620","https://openalex.org/W2170270785","https://openalex.org/W2419540374","https://openalex.org/W2561759163","https://openalex.org/W4247778217"],"related_works":["https://openalex.org/W4200140926","https://openalex.org/W4229332392","https://openalex.org/W4412517327","https://openalex.org/W4366190816","https://openalex.org/W4400826832","https://openalex.org/W3012657936","https://openalex.org/W4392916051","https://openalex.org/W2071964058","https://openalex.org/W4417300233","https://openalex.org/W3180911120"],"abstract_inverted_index":{"Environmental":[0],"stimuli":[1],"are":[2,18],"known":[3],"to":[4,6,87],"contribute":[5],"psoriasis":[7,50],"pathogenesis":[8],"and":[9,76,126],"that":[10,24,33],"of":[11,49,73,83,104,108,123],"other":[12],"autoimmune":[13],"diseases,":[14],"but":[15],"the":[16,25,46,61,66,70,84,121,128],"mechanisms":[17],"largely":[19],"unknown.":[20],"Here":[21],"we":[22],"show":[23],"aryl":[26],"hydrocarbon":[27],"receptor":[28],"(AhR),":[29],"a":[30,80,115],"transcription":[31,109],"factor":[32],"senses":[34],"environmental":[35],"stimuli,":[36],"modulates":[37],"pathology":[38],"in":[39,45,69,92,120,134],"psoriasis.":[40],"AhR-activating":[41],"ligands":[42],"reduced":[43,65],"inflammation":[44,75],"lesional":[47],"skin":[48,74],"patients,":[51],"whereas":[52],"AhR":[53,58,119],"antagonists":[54],"increased":[55],"inflammation.":[56],"Similarly,":[57],"signaling":[59],"via":[60],"endogenous":[62],"ligand":[63],"FICZ":[64],"inflammatory":[67,124,136],"response":[68],"imiquimod-induced":[71],"model":[72],"AhR-deficient":[77],"mice":[78],"exhibited":[79],"substantial":[81],"exacerbation":[82],"disease,":[85],"compared":[86],"AhR-sufficient":[88],"controls.":[89],"Nonhematopoietic":[90],"cells,":[91],"particular":[93],"keratinocytes,":[94],"were":[95],"responsible":[96],"for":[97,118,130],"this":[98],"hyperinflammatory":[99],"response,":[100],"which":[101],"involved":[102],"upregulation":[103],"AP-1":[105],"family":[106],"members":[107],"factors.":[110],"Thus,":[111],"our":[112],"data":[113],"suggest":[114],"critical":[116],"role":[117],"regulation":[122],"responses":[125],"open":[127],"possibility":[129],"novel":[131],"therapeutic":[132],"strategies":[133],"chronic":[135],"disorders.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":30},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":34},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}