{"id":"https://openalex.org/W2040156598","doi":"https://doi.org/10.1158/0008-5472.can-11-3213","title":"Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate","display_name":"Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate","publication_year":2012,"publication_date":"2012-03-14","ids":{"openalex":"https://openalex.org/W2040156598","doi":"https://doi.org/10.1158/0008-5472.can-11-3213","mag":"2040156598","pmid":"https://pubmed.ncbi.nlm.nih.gov/22422988","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3313080"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-11-3213","doi":"https://doi.org/10.1158/0008-5472.can-11-3213","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-3213","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3313080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011322600","display_name":"Robert C. Clarke","orcid":"https://orcid.org/0000-0002-9278-0854","observed_orcids":["https://orcid.org/0000-0002-9278-0854","https://orcid.org/0000-0002-9802-8241"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Clarke","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025967603","display_name":"Katherine Loree Cook","orcid":"https://orcid.org/0000-0001-6241-0214","observed_orcids":["https://orcid.org/0000-0001-6241-0214"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine L. Cook","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107559782","display_name":"Rong Hu","orcid":"https://orcid.org/0009-0001-8198-9185","observed_orcids":["https://orcid.org/0009-0001-8198-9185"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Hu","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004975206","display_name":"Caroline O. B. Facey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline O.B. Facey","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018700398","display_name":"Iman Tavassoly","orcid":"https://orcid.org/0000-0002-2258-1091","observed_orcids":["https://orcid.org/0000-0002-2258-1091"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iman Tavassoly","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045569688","display_name":"Jessica L. Schwartz","orcid":"https://orcid.org/0000-0003-3326-8989","observed_orcids":["https://orcid.org/0000-0003-3326-8989"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica L. Schwartz","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041169644","display_name":"William T. Baumann","orcid":"https://orcid.org/0000-0001-9723-2307","observed_orcids":["https://orcid.org/0000-0001-9723-2307"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T. Baumann","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028908910","display_name":"John J. Tyson","orcid":"https://orcid.org/0000-0001-7560-6013","observed_orcids":["https://orcid.org/0000-0001-7560-6013"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Tyson","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101536121","display_name":"Jianhua Xuan","orcid":"https://orcid.org/0000-0001-7256-1374","observed_orcids":["https://orcid.org/0000-0001-7256-1374"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Xuan","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112684346","display_name":"Yue Wang","orcid":"https://orcid.org/0009-0003-5310-2713","observed_orcids":["https://orcid.org/0009-0003-5310-2713"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063869345","display_name":"Anni M. W\u00e4rri","orcid":"https://orcid.org/0000-0002-0535-847X","observed_orcids":["https://orcid.org/0000-0002-0535-847X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anni W\u00e4rri","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001200228","display_name":"Ayesha N. Shajahan\u2010Haq","orcid":"https://orcid.org/0000-0001-7616-320X","observed_orcids":["https://orcid.org/0000-0001-7616-320X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayesha N. Shajahan","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC; 3Department of Biological Sciences and 4Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011322600"],"corresponding_institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356","https://openalex.org/I859038795"],"apc_list":null,"apc_paid":null,"fwci":1.8397,"has_fulltext":false,"cited_by_count":218,"citation_normalized_percentile":{"value":0.87995198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"72","issue":"6","first_page":"1321","last_page":"1331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9929999709129333},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8119999766349792},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.6330000162124634},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.9095656871795654},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8278012275695801},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7612649202346802},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.6628126502037048},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6206265687942505},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5249536037445068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5210270881652832},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5041848421096802},{"id":"https://openalex.org/C2781331208","wikidata":"https://www.wikidata.org/wiki/Q18032378","display_name":"XBP1","level":5,"score":0.4897210896015167},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4520948529243469},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.4338228702545166},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.41424521803855896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3938209116458893},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3707258403301239},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32691681385040283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14046862721443176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12370234727859497},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11967802047729492},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-11-3213","doi":"https://doi.org/10.1158/0008-5472.can-11-3213","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-3213","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:22422988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22422988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2594678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3313080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3313080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3313080","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2594678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3313080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1120715699","display_name":"Endocrine resistance in breast cancer","funder_award_id":"5r01ca131465-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2248540122","display_name":"Integration of ER-related signaling in breast cancer","funder_award_id":"U54CA149147","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2766688800","display_name":null,"funder_award_id":"R01-GM078989","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5193547763","display_name":"Georgetown-Howard Universities Center for Clinical and Translational Science (GHU","funder_award_id":"UL1TR000101","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5593705226","display_name":"Stochastic models of cell cycle regulation in eukaryotes","funder_award_id":"5r01gm078989-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6224354128","display_name":null,"funder_award_id":"R01-CA131465","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6409748060","display_name":"Uncovering Estrogen Receptor-Signaling Networks to Overcome Endocrine Resistance","funder_award_id":"R01CA149653","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000895459","display_name":"Training Grant In Tumor Biology","funder_award_id":"T32CA009686","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W150569175","https://openalex.org/W846918294","https://openalex.org/W1507812324","https://openalex.org/W1520983351","https://openalex.org/W1523693806","https://openalex.org/W1534980720","https://openalex.org/W1558526836","https://openalex.org/W1595815978","https://openalex.org/W1605507149","https://openalex.org/W1863580086","https://openalex.org/W1869069324","https://openalex.org/W1956944003","https://openalex.org/W1964050579","https://openalex.org/W1965531523","https://openalex.org/W1965727325","https://openalex.org/W1966134982","https://openalex.org/W1970090817","https://openalex.org/W1970609612","https://openalex.org/W1970637701","https://openalex.org/W1971614113","https://openalex.org/W1972482541","https://openalex.org/W1972582451","https://openalex.org/W1975280295","https://openalex.org/W1976531450","https://openalex.org/W1977868384","https://openalex.org/W1981551685","https://openalex.org/W1982047494","https://openalex.org/W1983137299","https://openalex.org/W1986843840","https://openalex.org/W1988482079","https://openalex.org/W1994239968","https://openalex.org/W2001568034","https://openalex.org/W2003380425","https://openalex.org/W2003724895","https://openalex.org/W2005129842","https://openalex.org/W2005727437","https://openalex.org/W2006625458","https://openalex.org/W2010211837","https://openalex.org/W2012040176","https://openalex.org/W2013145602","https://openalex.org/W2013947447","https://openalex.org/W2013956549","https://openalex.org/W2014734622","https://openalex.org/W2016599680","https://openalex.org/W2019424220","https://openalex.org/W2020124645","https://openalex.org/W2020145209","https://openalex.org/W2020921095","https://openalex.org/W2025511820","https://openalex.org/W2028453264","https://openalex.org/W2031169909","https://openalex.org/W2035059302","https://openalex.org/W2036677133","https://openalex.org/W2037386621","https://openalex.org/W2037657846","https://openalex.org/W2037908592","https://openalex.org/W2038481055","https://openalex.org/W2038763220","https://openalex.org/W2041115282","https://openalex.org/W2041749209","https://openalex.org/W2044702943","https://openalex.org/W2045373134","https://openalex.org/W2046770259","https://openalex.org/W2053908396","https://openalex.org/W2055793916","https://openalex.org/W2058906289","https://openalex.org/W2060123522","https://openalex.org/W2062515127","https://openalex.org/W2063953032","https://openalex.org/W2064783114","https://openalex.org/W2065031087","https://openalex.org/W2069924169","https://openalex.org/W2072714194","https://openalex.org/W2076812391","https://openalex.org/W2079282879","https://openalex.org/W2079791855","https://openalex.org/W2081731224","https://openalex.org/W2081857846","https://openalex.org/W2084537120","https://openalex.org/W2086541892","https://openalex.org/W2086939601","https://openalex.org/W2089762734","https://openalex.org/W2092295090","https://openalex.org/W2095833325","https://openalex.org/W2097066287","https://openalex.org/W2097255042","https://openalex.org/W2099254673","https://openalex.org/W2100948166","https://openalex.org/W2102025854","https://openalex.org/W2102217018","https://openalex.org/W2106314483","https://openalex.org/W2110212786","https://openalex.org/W2114360920","https://openalex.org/W2115205812","https://openalex.org/W2115772647","https://openalex.org/W2119239003","https://openalex.org/W2119488140","https://openalex.org/W2122408366","https://openalex.org/W2124344762","https://openalex.org/W2126783165","https://openalex.org/W2127639686","https://openalex.org/W2127684300","https://openalex.org/W2127906377","https://openalex.org/W2129585918","https://openalex.org/W2131606388","https://openalex.org/W2134435289","https://openalex.org/W2135574023","https://openalex.org/W2137073563","https://openalex.org/W2137368432","https://openalex.org/W2137392137","https://openalex.org/W2138509357","https://openalex.org/W2139226937","https://openalex.org/W2141426082","https://openalex.org/W2145108300","https://openalex.org/W2146906901","https://openalex.org/W2147862373","https://openalex.org/W2149786785","https://openalex.org/W2152398979","https://openalex.org/W2152604814","https://openalex.org/W2156394189","https://openalex.org/W2157766835","https://openalex.org/W2159466552","https://openalex.org/W2160063599","https://openalex.org/W2160281718","https://openalex.org/W2162076197","https://openalex.org/W2162424825","https://openalex.org/W2163285372","https://openalex.org/W2163776632","https://openalex.org/W2164778558","https://openalex.org/W2165725885","https://openalex.org/W2166280494","https://openalex.org/W2168215039","https://openalex.org/W2170939329","https://openalex.org/W2172114433","https://openalex.org/W2259802687","https://openalex.org/W2620241325","https://openalex.org/W4296231862","https://openalex.org/W6632190732","https://openalex.org/W6675152483","https://openalex.org/W6684012855"],"related_works":["https://openalex.org/W2914672066","https://openalex.org/W2058906289","https://openalex.org/W1515059831","https://openalex.org/W2008696134","https://openalex.org/W1560822815","https://openalex.org/W2084537120","https://openalex.org/W2918234068","https://openalex.org/W3208116624","https://openalex.org/W2608026191","https://openalex.org/W2593649021"],"abstract_inverted_index":{"How":[0,39],"breast":[1],"cancer":[2],"cells":[3],"respond":[4],"to":[5,61,91,115,122,153],"the":[6,51,62,69,78,83,89,97,147,158,167,178],"stress":[7,81,92,135],"of":[8,80,88,99,139,146,169,177],"endocrine":[9],"therapies":[10],"determines":[11],"whether":[12,35],"they":[13],"will":[14],"acquire":[15],"a":[16,21,25,31],"resistant":[17],"phenotype":[18],"or":[19],"execute":[20],"cell-death":[22],"pathway.":[23],"After":[24],"survival":[26],"signal":[27],"is":[28,45,66,93,149,172],"successfully":[29],"executed,":[30],"cell":[32],"must":[33],"decide":[34],"it":[36],"should":[37],"replicate.":[38],"these":[40,55,170],"cell-fate":[41,64,183],"decisions":[42],"are":[43,57,136,188],"regulated":[44],"unclear,":[46],"but":[47],"evidence":[48],"suggests":[49],"that":[50,53,181],"signals":[52,113],"determine":[54],"outcomes":[56],"highly":[58],"integrated.":[59,173],"Central":[60,174],"final":[63],"decision":[65,186],"signaling":[67,179],"from":[68,106],"unfolded":[70,159],"protein":[71,109,160],"response,":[72,161],"which":[73],"can":[74],"be":[75],"activated":[76],"following":[77,103],"sensing":[79],"within":[82],"endoplasmic":[84],"reticulum.":[85],"The":[86,111],"duration":[87,98],"response":[90,152],"partly":[94],"mediated":[95],"by":[96,133],"inositol-requiring":[100],"enzyme-1":[101],"activation":[102],"its":[104],"release":[105],"heat":[107],"shock":[108],"A5.":[110],"resulting":[112],"appear":[114],"use":[116],"several":[117],"B-cell":[118],"lymphoma-2":[119],"family":[120],"members":[121],"both":[123],"suppress":[124],"apoptosis":[125],"and":[126,143,163,165,185],"activate":[127],"autophagy.":[128],"Changes":[129],"in":[130,151],"metabolism":[131],"induced":[132],"cellular":[134],"key":[137],"components":[138],"this":[140],"regulatory":[141],"system,":[142],"further":[144],"adaptation":[145],"metabolome":[148],"affected":[150],"stress.":[154],"Here":[155],"we":[156],"describe":[157],"autophagy,":[162],"apoptosis,":[164],"how":[166],"regulation":[168,184],"processes":[171],"topologic":[175],"features":[176],"network":[180],"integrate":[182],"execution":[187],"discussed.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}