{"id":"https://openalex.org/W2040147710","doi":"https://doi.org/10.1902/jop.2004.75.1.91","title":"Vascular Endothelial Growth Factor in Gingival Tissues and Crevicular Fluids of Diabetic and Healthy Periodontal Patients","display_name":"Vascular Endothelial Growth Factor in Gingival Tissues and Crevicular Fluids of Diabetic and Healthy Periodontal Patients","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2040147710","doi":"https://doi.org/10.1902/jop.2004.75.1.91","mag":"2040147710","pmid":"https://pubmed.ncbi.nlm.nih.gov/15025220"},"language":"en","primary_location":{"id":"doi:10.1902/jop.2004.75.1.91","doi":"https://doi.org/10.1902/jop.2004.75.1.91","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2004.75.1.91","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009719341","display_name":"Pelin G\u00fcneri","orcid":"https://orcid.org/0000-0001-9423-9191","observed_orcids":["https://orcid.org/0000-0001-9423-9191"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Pelin G\u00fcneri","raw_affiliation_strings":["Department of Oral Diagnosis & Radiology, Ege University School of Dentistry, Bornova, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Diagnosis & Radiology, Ege University School of Dentistry, Bornova, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019431679","display_name":"F\u00fcsun \u00dcnl\u00fc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"F\u00fcsun \u00dcnl\u00fc","raw_affiliation_strings":["Department of Periodontology, Ege University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Ege University","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065349110","display_name":"Banu Ye\u015filbek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Banu Ye\u015filbek","raw_affiliation_strings":["Department of Periodontology, Ege University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Ege University","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037250165","display_name":"F\u0131rat Bayraktar","orcid":"https://orcid.org/0000-0001-7800-2530","observed_orcids":["https://orcid.org/0000-0001-7800-2530"]},"institutions":[{"id":"https://openalex.org/I193615760","display_name":"Dokuz Eyl\u00fcl University","ror":"https://ror.org/00dbd8b73","country_code":"TR","type":"education","lineage":["https://openalex.org/I193615760"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Firat Bayraktar","raw_affiliation_strings":["Division of Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey","institution_ids":["https://openalex.org/I193615760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035239280","display_name":"Ali Kokuluda\u011f","orcid":"https://orcid.org/0000-0002-6266-6532","observed_orcids":["https://orcid.org/0000-0002-6266-6532"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali Kokuludag","raw_affiliation_strings":["Division of Immunology, Ege University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Ege University Faculty of Medicine","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041184758","display_name":"Mine Hekimgil","orcid":"https://orcid.org/0000-0002-9454-4521","observed_orcids":["https://orcid.org/0000-0002-9454-4521"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mine Hekimgil","raw_affiliation_strings":["Department of Pathology, Ege University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ege University Faculty of Medicine","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081564924","display_name":"Hayal Boyac\u0131o\u011flu","orcid":"https://orcid.org/0000-0003-0887-0302","observed_orcids":["https://orcid.org/0000-0003-0887-0302"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hayal Boyaciolu","raw_affiliation_strings":["Department of Statistics, Ege University Faculty of Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Ege University Faculty of Science","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009719341"],"corresponding_institution_ids":["https://openalex.org/I41641357"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.4156,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.90193603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"75","issue":"1","first_page":"91","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8960000276565552},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/gingival-crevicular-fluid","display_name":"gingival crevicular fluid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gingiva","display_name":"gingiva","score":0.9210000038146973},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.9649999737739563},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8529043197631836},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.7761563658714294},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.6979407072067261},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6658465266227722},{"id":"https://openalex.org/C58747440","wikidata":"https://www.wikidata.org/wiki/Q1059860","display_name":"Gingival and periodontal pocket","level":3,"score":0.47478243708610535},{"id":"https://openalex.org/C2778380114","wikidata":"https://www.wikidata.org/wiki/Q143652","display_name":"Periodontium","level":2,"score":0.4407757818698883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4382343292236328},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.41540202498435974},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.4020291268825531},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3683096170425415},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3637029528617859},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.32548075914382935},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.25900956988334656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18898358941078186}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1902/jop.2004.75.1.91","doi":"https://doi.org/10.1902/jop.2004.75.1.91","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2004.75.1.91","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},{"id":"pmid:15025220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15025220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W32167704","https://openalex.org/W73620502","https://openalex.org/W157350335","https://openalex.org/W191115448","https://openalex.org/W1613798522","https://openalex.org/W1693988505","https://openalex.org/W1772825397","https://openalex.org/W1966596942","https://openalex.org/W1969733740","https://openalex.org/W1970190437","https://openalex.org/W1973444933","https://openalex.org/W1973447263","https://openalex.org/W1978397664","https://openalex.org/W1980755389","https://openalex.org/W1982060502","https://openalex.org/W1991958278","https://openalex.org/W2000227520","https://openalex.org/W2004643661","https://openalex.org/W2007576281","https://openalex.org/W2009025335","https://openalex.org/W2009872653","https://openalex.org/W2014907034","https://openalex.org/W2021792184","https://openalex.org/W2026530967","https://openalex.org/W2026892520","https://openalex.org/W2026959779","https://openalex.org/W2030948097","https://openalex.org/W2031858216","https://openalex.org/W2032193873","https://openalex.org/W2034657988","https://openalex.org/W2038734816","https://openalex.org/W2052200585","https://openalex.org/W2053441140","https://openalex.org/W2056817640","https://openalex.org/W2058656019","https://openalex.org/W2060698866","https://openalex.org/W2063578228","https://openalex.org/W2070603415","https://openalex.org/W2073119994","https://openalex.org/W2074185541","https://openalex.org/W2083586774","https://openalex.org/W2089327677","https://openalex.org/W2093541784","https://openalex.org/W2100741462","https://openalex.org/W2101417448","https://openalex.org/W2109118973","https://openalex.org/W2122276925","https://openalex.org/W2122766759","https://openalex.org/W2130488639","https://openalex.org/W2138173853","https://openalex.org/W2140564799","https://openalex.org/W2141731877","https://openalex.org/W2142932515","https://openalex.org/W2161808245","https://openalex.org/W2169977161","https://openalex.org/W2182428270","https://openalex.org/W2410285866","https://openalex.org/W2429759174"],"related_works":["https://openalex.org/W2056817640","https://openalex.org/W3016449060","https://openalex.org/W208610671","https://openalex.org/W1988721617","https://openalex.org/W3215757793","https://openalex.org/W4408010860","https://openalex.org/W1980734686","https://openalex.org/W2010884904","https://openalex.org/W2373424970","https://openalex.org/W2038734816"],"abstract_inverted_index":{"BACKGROUND:":[0],"Periodontal":[1],"disease":[2],"is":[3,83,260],"one":[4],"of":[5,58,73,80,99,115,132,165,197,214,217,225,254,266,274,285],"the":[6,35,56,61,67,71,130,136,181,187,226,271],"major":[7],"oral":[8],"problems":[9],"encountered":[10],"in":[11,28,39,75,88,117,122,180,186,210,222,241,248,262,270,282],"patients":[12,41,199,228],"with":[13,94],"diabetes":[14],"mellitus":[15],"(DM).":[16],"Vascular":[17],"changes,":[18],"neutrophil":[19],"dysfunction,":[20],"altered":[21],"collagen":[22],"synthesis,":[23],"and":[24,34,60,70,90,102,108,121,128,168,221,269],"genetic":[25],"predisposition":[26],"observed":[27,38,179],"DM":[29],"may":[30,42],"contribute":[31,65],"to":[32,66,84],"periodontitis;":[33],"vascular":[36,45],"alterations":[37],"such":[40],"depend":[43],"on":[44],"endothelial":[46],"growth":[47],"factor":[48],"(VEGF)":[49],"actions.":[50],"Few":[51],"reports":[52],"are":[53],"available":[54],"about":[55],"mechanism":[57],"neovascularization":[59],"angiogenic":[62],"factors":[63],"that":[64,258],"periodontal":[68,76,153,215,242,264,283],"pathology":[69],"role":[72],"VEGF":[74,86,176,207,237,259,279],"diseases.":[77],"The":[78,252],"aim":[79],"this":[81,255],"study":[82,256],"compare":[85],"expression":[87],"healthy":[89,100,119,133,189,191,219,249,272],"periodontally":[91],"diseased":[92],"tissues":[93,265],"gingival":[95],"crevice":[96],"fluid":[97],"(GCF)":[98],"persons":[101],"diabetic":[103,126,198,227,275],"patients.":[104,276],"METHODS:":[105],"Gingival":[106],"tissue":[107,167,192,212],"GCF":[109,170,236,278],"samples":[110,171,196,213,224],"were":[111,155,172,239],"collected":[112],"from":[113,129],"sites":[114,131,216,243,273,284],"periodontitis":[116],"10":[118,123,147],"subjects":[120],"type":[124],"2":[125],"patients,":[127],"gingiva":[134],"within":[135],"same":[137],"groups.":[138,288],"Therefore,":[139],"each":[140],"patient":[141],"became":[142],"his/her":[143],"own":[144],"control.":[145],"Additionally,":[146,277],"people":[148,220],"without":[149],"any":[150],"systemic":[151],"or":[152,185],"diseases":[154],"enrolled,":[156],"forming":[157],"a":[158,163],"negative":[159,182],"control":[160,183],"group.":[161],"Thus,":[162],"total":[164],"50":[166,169],"provided.":[173],"RESULTS:":[174],"No":[175],"staining":[177,202],"was":[178,208],"group":[184],"systemically":[188,218],"people's":[190],"samples,":[193],"whereas":[194],"four":[195],"showed":[200,257],"positive":[201],"(P":[203,229,244],"<":[204,245],"0.05).":[205,231],"However,":[206],"revealed":[209],"two":[211],"six":[223],">":[230],"In":[232],"all":[233,263,286],"test":[234,287],"groups,":[235],"levels":[238],"higher":[240],"0.05)":[246],"than":[247],"sites.":[250],"CONCLUSION:":[251],"results":[253],"increased":[261,281],"both":[267],"groups":[268],"values":[280]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
