{"id":"https://openalex.org/W2040079565","doi":"https://doi.org/10.1016/j.cbpa.2009.06.013","title":"Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes","display_name":"Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes","publication_year":2009,"publication_date":"2009-07-20","ids":{"openalex":"https://openalex.org/W2040079565","doi":"https://doi.org/10.1016/j.cbpa.2009.06.013","mag":"2040079565","pmid":"https://pubmed.ncbi.nlm.nih.gov/19620019"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbpa.2009.06.013","doi":"https://doi.org/10.1016/j.cbpa.2009.06.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2009.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000149019","display_name":"Heather A. Cooke","orcid":"https://orcid.org/0000-0001-9742-5993","observed_orcids":["https://orcid.org/0000-0001-9742-5993"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A Cooke","raw_affiliation_strings":["Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, USA","Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, USA","institution_ids":["https://openalex.org/I103531236"]},{"raw_affiliation_string":"Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, United States","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017347423","display_name":"Carl V. Christianson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl V Christianson","raw_affiliation_strings":["Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, United States","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070268234","display_name":"Steven D. Bruner","orcid":"https://orcid.org/0000-0002-0522-480X","observed_orcids":["https://orcid.org/0000-0002-0522-480X"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven D Bruner","raw_affiliation_strings":["Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, MA 02467, United States","institution_ids":["https://openalex.org/I103531236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070268234"],"corresponding_institution_ids":["https://openalex.org/I103531236"],"apc_list":{"value":4510,"currency":"USD","value_usd":4510},"apc_paid":null,"fwci":0.2088,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.29004329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"4","first_page":"460","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.33009999990463257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ammonia-lyase","display_name":"ammonia-lyase","score":0.7129999995231628},{"id":"https://openalex.org/keywords/prosthetic-groups","display_name":"prosthetic groups","score":0.6710000038146973},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.6729999780654907},{"id":"https://openalex.org/keywords/electrophilic-catalysis","display_name":"electrophilic catalysis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/substrate-recognition","display_name":"substrate recognition","score":0.8080000281333923},{"id":"https://openalex.org/keywords/x-ray-crystal-structure","display_name":"X-ray crystal structure","score":0.8899999856948853},{"id":"https://openalex.org/keywords/natural-product-biosynthesis","display_name":"natural product biosynthesis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chemoenzymatic-synthesis","display_name":"chemoenzymatic synthesis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rational-enzyme-design","display_name":"rational enzyme design","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6986788511276245},{"id":"https://openalex.org/C2777269803","wikidata":"https://www.wikidata.org/wiki/Q407727","display_name":"Lyase","level":3,"score":0.6553136110305786},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.621540904045105},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5915170311927795},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5031117796897888},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4362286925315857},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.422995001077652},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.4135211110115051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3865443170070648}],"mesh":[{"descriptor_ui":"D000642","descriptor_name":"Ammonia-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000642","descriptor_name":"Ammonia-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbpa.2009.06.013","doi":"https://doi.org/10.1016/j.cbpa.2009.06.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2009.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},{"id":"pmid:19620019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19620019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in chemical biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W65912396","https://openalex.org/W1538363759","https://openalex.org/W1572965758","https://openalex.org/W1581285304","https://openalex.org/W1653566113","https://openalex.org/W1809209698","https://openalex.org/W1966250107","https://openalex.org/W1967936283","https://openalex.org/W1970945409","https://openalex.org/W1971187624","https://openalex.org/W1971283485","https://openalex.org/W1980879856","https://openalex.org/W1981369922","https://openalex.org/W1986197387","https://openalex.org/W1987170844","https://openalex.org/W1998631453","https://openalex.org/W2001189466","https://openalex.org/W2002515555","https://openalex.org/W2004025737","https://openalex.org/W2010302211","https://openalex.org/W2013828974","https://openalex.org/W2018165864","https://openalex.org/W2023144470","https://openalex.org/W2027826166","https://openalex.org/W2030361186","https://openalex.org/W2062579366","https://openalex.org/W2068902221","https://openalex.org/W2071223302","https://openalex.org/W2077390442","https://openalex.org/W2078143828","https://openalex.org/W2079236526","https://openalex.org/W2082529739","https://openalex.org/W2083393849","https://openalex.org/W2089671644","https://openalex.org/W2091255112","https://openalex.org/W2092292013","https://openalex.org/W2107167014","https://openalex.org/W2108119743","https://openalex.org/W2125087385","https://openalex.org/W2128323040","https://openalex.org/W2139620042","https://openalex.org/W2154031992","https://openalex.org/W2154094001","https://openalex.org/W2161996750"],"related_works":["https://openalex.org/W1681767500","https://openalex.org/W1981369922","https://openalex.org/W2413524338","https://openalex.org/W1980879856","https://openalex.org/W3202076440","https://openalex.org/W4391614385","https://openalex.org/W1984198081","https://openalex.org/W1985300431","https://openalex.org/W2049834621","https://openalex.org/W1927930699"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
