{"id":"https://openalex.org/W2040050602","doi":"https://doi.org/10.1111/j.1600-0757.1994.tb00023.x","title":"Early\u2010onset periodontitis: systemic aspects of etiology and pathogenesis","display_name":"Early\u2010onset periodontitis: systemic aspects of etiology and pathogenesis","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2040050602","doi":"https://doi.org/10.1111/j.1600-0757.1994.tb00023.x","mag":"2040050602","pmid":"https://pubmed.ncbi.nlm.nih.gov/9673167"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0757.1994.tb00023.x","doi":"https://doi.org/10.1111/j.1600-0757.1994.tb00023.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0757.1994.tb00023.x","pdf_url":null,"source":{"id":"https://openalex.org/S43912546","display_name":"Periodontology 2000","issn_l":"0906-6713","issn":["0906-6713","1600-0757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Periodontology 2000","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076712549","display_name":"Harvey A. Schenkein","orcid":"https://orcid.org/0000-0002-7397-643X","observed_orcids":["https://orcid.org/0000-0002-7397-643X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey A. Schenkein","raw_affiliation_strings":["Periodontology Research Center, School of Dentistry, Virginia Commonwealth University, Richmond, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Periodontology Research Center, School of Dentistry, Virginia Commonwealth University, Richmond, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014230085","display_name":"Thomas E. Van Dyke","orcid":"https://orcid.org/0000-0003-0568-124X","observed_orcids":["https://orcid.org/0000-0003-0568-124X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas E. Van Dyke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.646,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.81967213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"7","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-periodontitis","display_name":"early-onset periodontitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/systemic-factors","display_name":"systemic factors","score":0.6650000214576721},{"id":"https://openalex.org/keywords/etiology","display_name":"etiology","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6805459260940552},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.6443848609924316},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.6125813126564026},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6093527674674988},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.25035738945007324},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17443689703941345},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.15394064784049988},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0970015823841095}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012744","descriptor_name":"Sex Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016976","descriptor_name":"Aggregatibacter actinomycetemcomitans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016976","descriptor_name":"Aggregatibacter actinomycetemcomitans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0757.1994.tb00023.x","doi":"https://doi.org/10.1111/j.1600-0757.1994.tb00023.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0757.1994.tb00023.x","pdf_url":null,"source":{"id":"https://openalex.org/S43912546","display_name":"Periodontology 2000","issn_l":"0906-6713","issn":["0906-6713","1600-0757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Periodontology 2000","raw_type":"journal-article"},{"id":"pmid:9673167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9673167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Periodontology 2000","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1427425506","display_name":"PERIODONTOSIS--CHARACTERIZATION OF THE NEUTROPHIL DEFECT","funder_award_id":"R01DE006436","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3091950350","display_name":"RESEARCH CENTER FOR PERIODONTAL DISEASES","funder_award_id":"P50DE010703","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7141978583","display_name":"PERIODONTAL DISEASE RESEARCH PROGRAM PROJECT GRANT                               ","funder_award_id":"P01DE008972","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":174,"referenced_works":["https://openalex.org/W149933857","https://openalex.org/W159821038","https://openalex.org/W162831375","https://openalex.org/W1482504710","https://openalex.org/W1488320419","https://openalex.org/W1506896023","https://openalex.org/W1536850607","https://openalex.org/W1789931699","https://openalex.org/W1824740895","https://openalex.org/W1851444268","https://openalex.org/W1852860123","https://openalex.org/W1853221362","https://openalex.org/W1912302551","https://openalex.org/W1924670752","https://openalex.org/W1925952218","https://openalex.org/W1932191072","https://openalex.org/W1963583786","https://openalex.org/W1966119483","https://openalex.org/W1967704097","https://openalex.org/W1969036692","https://openalex.org/W1969752885","https://openalex.org/W1969818302","https://openalex.org/W1969852564","https://openalex.org/W1970195989","https://openalex.org/W1971218913","https://openalex.org/W1972163629","https://openalex.org/W1975162762","https://openalex.org/W1975681884","https://openalex.org/W1976539849","https://openalex.org/W1977589098","https://openalex.org/W1979187396","https://openalex.org/W1979641057","https://openalex.org/W1979886876","https://openalex.org/W1980567712","https://openalex.org/W1983325416","https://openalex.org/W1986237424","https://openalex.org/W1986365415","https://openalex.org/W1987506532","https://openalex.org/W1988908900","https://openalex.org/W1989393818","https://openalex.org/W1989757358","https://openalex.org/W1991303831","https://openalex.org/W1992974353","https://openalex.org/W1994441639","https://openalex.org/W1997293768","https://openalex.org/W1997386790","https://openalex.org/W1997680014","https://openalex.org/W1997728507","https://openalex.org/W1998026456","https://openalex.org/W1998545564","https://openalex.org/W1998610176","https://openalex.org/W1998865886","https://openalex.org/W1999222340","https://openalex.org/W1999901693","https://openalex.org/W2002401227","https://openalex.org/W2004562173","https://openalex.org/W2005620780","https://openalex.org/W2008918605","https://openalex.org/W2010000368","https://openalex.org/W2010595043","https://openalex.org/W2012962189","https://openalex.org/W2013694258","https://openalex.org/W2014723101","https://openalex.org/W2017047568","https://openalex.org/W2020016710","https://openalex.org/W2020551797","https://openalex.org/W2021198897","https://openalex.org/W2021216312","https://openalex.org/W2025461206","https://openalex.org/W2025911626","https://openalex.org/W2027729467","https://openalex.org/W2030711174","https://openalex.org/W2031394055","https://openalex.org/W2032668368","https://openalex.org/W2035445594","https://openalex.org/W2036158298","https://openalex.org/W2038995875","https://openalex.org/W2039212055","https://openalex.org/W2042853194","https://openalex.org/W2043656402","https://openalex.org/W2045701014","https://openalex.org/W2045712801","https://openalex.org/W2046326422","https://openalex.org/W2048209944","https://openalex.org/W2048537780","https://openalex.org/W2049992378","https://openalex.org/W2055372140","https://openalex.org/W2057264967","https://openalex.org/W2058331077","https://openalex.org/W2058430210","https://openalex.org/W2058451482","https://openalex.org/W2058712377","https://openalex.org/W2058779497","https://openalex.org/W2059023865","https://openalex.org/W2060744568","https://openalex.org/W2060908324","https://openalex.org/W2062371993","https://openalex.org/W2063592779","https://openalex.org/W2063959484","https://openalex.org/W2066369692","https://openalex.org/W2066721646","https://openalex.org/W2073158725","https://openalex.org/W2075188186","https://openalex.org/W2078245219","https://openalex.org/W2078569884","https://openalex.org/W2084070945","https://openalex.org/W2084173849","https://openalex.org/W2086972104","https://openalex.org/W2090435421","https://openalex.org/W2091507184","https://openalex.org/W2091930819","https://openalex.org/W2092229218","https://openalex.org/W2095932979","https://openalex.org/W2097217138","https://openalex.org/W2098033313","https://openalex.org/W2100134709","https://openalex.org/W2101164928","https://openalex.org/W2107866776","https://openalex.org/W2108297040","https://openalex.org/W2110320635","https://openalex.org/W2114643962","https://openalex.org/W2114929203","https://openalex.org/W2119090133","https://openalex.org/W2121480605","https://openalex.org/W2123416282","https://openalex.org/W2123557285","https://openalex.org/W2127646823","https://openalex.org/W2128408192","https://openalex.org/W2128575095","https://openalex.org/W2129571298","https://openalex.org/W2130430665","https://openalex.org/W2131787275","https://openalex.org/W2132614349","https://openalex.org/W2133667912","https://openalex.org/W2134236748","https://openalex.org/W2135327859","https://openalex.org/W2136034608","https://openalex.org/W2136929229","https://openalex.org/W2140846725","https://openalex.org/W2141025965","https://openalex.org/W2141203380","https://openalex.org/W2147110523","https://openalex.org/W2153565559","https://openalex.org/W2155057861","https://openalex.org/W2160534201","https://openalex.org/W2160809158","https://openalex.org/W2163706886","https://openalex.org/W2165202574","https://openalex.org/W2167072452","https://openalex.org/W2168740226","https://openalex.org/W2169497440","https://openalex.org/W2172030218","https://openalex.org/W2178098775","https://openalex.org/W2180410382","https://openalex.org/W2186643230","https://openalex.org/W2187167166","https://openalex.org/W2195310592","https://openalex.org/W2215175305","https://openalex.org/W2218732524","https://openalex.org/W2260732597","https://openalex.org/W2291951258","https://openalex.org/W2326265645","https://openalex.org/W2374269147","https://openalex.org/W2397988067","https://openalex.org/W2401781882","https://openalex.org/W2408782028","https://openalex.org/W2410324534","https://openalex.org/W2410570150","https://openalex.org/W2414814381","https://openalex.org/W2416186311","https://openalex.org/W2427802884","https://openalex.org/W2584191795","https://openalex.org/W2606131090","https://openalex.org/W3211446668"],"related_works":["https://openalex.org/W2106671334","https://openalex.org/W2992104573","https://openalex.org/W2423455445","https://openalex.org/W1993940688","https://openalex.org/W2062125780","https://openalex.org/W2040041887","https://openalex.org/W2395590055","https://openalex.org/W1985114409","https://openalex.org/W2035219417","https://openalex.org/W2019322525"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}