{"id":"https://openalex.org/W2040025366","doi":"https://doi.org/10.1016/0009-8981(96)06397-8","title":"CYP2E1, ALDH2 and ADH2 genotypes and blood ethanol elimination kinetics","display_name":"CYP2E1, ALDH2 and ADH2 genotypes and blood ethanol elimination kinetics","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2040025366","doi":"https://doi.org/10.1016/0009-8981(96)06397-8","mag":"2040025366","pmid":"https://pubmed.ncbi.nlm.nih.gov/8930415"},"language":"en","primary_location":{"id":"doi:10.1016/0009-8981(96)06397-8","doi":"https://doi.org/10.1016/0009-8981(96)06397-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0009-8981(96)06397-8","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112261588","display_name":"Kazuhiko Iwahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]},{"id":"https://openalex.org/I4210135297","display_name":"Kagawa University Hospital","ror":"https://ror.org/033sspj46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiko Iwahashi","raw_affiliation_strings":["Department of Neuropsychiatry, Kagawa Medical School, Japan","Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Kagawa Medical School, Japan","institution_ids":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]},{"raw_affiliation_string":"Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004943055","display_name":"Kiyoshi Ameno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Ameno","raw_affiliation_strings":["Department of Forensic Medicine, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Medicine, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101483872","display_name":"Hiroshi Kinoshita","orcid":"https://orcid.org/0000-0002-5872-0719","observed_orcids":["https://orcid.org/0000-0002-5872-0719"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kinoshita","raw_affiliation_strings":["Department of Forensic Medicine, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Medicine, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007692515","display_name":"Kazuhiko Nakamura","orcid":"https://orcid.org/0000-0001-7375-5867","observed_orcids":["https://orcid.org/0000-0001-7375-5867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhiko Nakamura","raw_affiliation_strings":["Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113590265","display_name":"Ryosuke Miyatake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryosuke Miyatake","raw_affiliation_strings":["Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100831560","display_name":"Hiroshi Suwaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Suwaki","raw_affiliation_strings":["Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031759706","display_name":"Yoshiyuki Ichikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiyuki Ichikawa","raw_affiliation_strings":["Department of Biochemistry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014706648","display_name":"Iwao Ijiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iwao Ijiri","raw_affiliation_strings":["Department of Forensic Medicine, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Medicine, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-1, Japan","institution_ids":["https://openalex.org/I201933988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112261588"],"corresponding_institution_ids":["https://openalex.org/I201933988","https://openalex.org/I4210135297"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.7671,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66107635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"255","issue":"1","first_page":"85","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isopropanol","display_name":"isopropanol","score":0.796999990940094},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acetone","display_name":"acetone","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.718999981880188},{"id":"https://openalex.org/keywords/aldh2","display_name":"ALDH2","score":0.9440000057220459},{"id":"https://openalex.org/keywords/adh2","display_name":"ADH2","score":0.9470000267028809},{"id":"https://openalex.org/keywords/alcohol-dehydrogenase","display_name":"alcohol dehydrogenase","score":0.7889999747276306},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6119999885559082},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.8100000023841858},{"id":"https://openalex.org/keywords/clearance","display_name":"clearance","score":0.40400001406669617},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.6610000133514404},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.5820000171661377},{"id":"https://openalex.org/keywords/chlorzoxazone","display_name":"chlorzoxazone","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.7039860486984253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6657249331474304},{"id":"https://openalex.org/C2776378800","wikidata":"https://www.wikidata.org/wiki/Q2259181","display_name":"Carboxyhemoglobin","level":4,"score":0.4531179368495941},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.45279088616371155},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4389965832233429},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40685901045799255},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36427322030067444},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.36228856444358826},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.34005317091941833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2669023871421814},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.23592111468315125},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.22945228219032288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14891743659973145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.139104425907135},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071396","descriptor_name":"Aldehyde Dehydrogenase, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019392","descriptor_name":"Cytochrome P-450 CYP2E1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019392","descriptor_name":"Cytochrome P-450 CYP2E1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0009-8981(96)06397-8","doi":"https://doi.org/10.1016/0009-8981(96)06397-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0009-8981(96)06397-8","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},{"id":"pmid:8930415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8930415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica chimica acta; international journal of clinical chemistry","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1914476337","https://openalex.org/W2034562813","https://openalex.org/W2275258586","https://openalex.org/W2276081664","https://openalex.org/W2397218143","https://openalex.org/W2417591862","https://openalex.org/W4301041382","https://openalex.org/W6694735702"],"related_works":["https://openalex.org/W1971617741","https://openalex.org/W2143498897","https://openalex.org/W2075272989","https://openalex.org/W2412081071","https://openalex.org/W1774024886","https://openalex.org/W2082869892","https://openalex.org/W2139369713","https://openalex.org/W2417537731","https://openalex.org/W1972861393","https://openalex.org/W586753342"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}