{"id":"https://openalex.org/W2039971323","doi":"https://doi.org/10.1182/blood.v99.7.2369","title":"Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome","display_name":"Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2039971323","doi":"https://doi.org/10.1182/blood.v99.7.2369","mag":"2039971323","pmid":"https://pubmed.ncbi.nlm.nih.gov/11895769"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v99.7.2369","doi":"https://doi.org/10.1182/blood.v99.7.2369","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v99.7.2369","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109092459","display_name":"Sebastian Stier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Stier","raw_affiliation_strings":["From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060867127","display_name":"Tao Cheng","orcid":"https://orcid.org/0000-0002-5925-2769","observed_orcids":["https://orcid.org/0000-0002-5925-2769","https://orcid.org/0000-0003-1095-6439","https://orcid.org/0000-0003-4395-1095"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Cheng","raw_affiliation_strings":["From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046310316","display_name":"David Dombkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Dombkowski","raw_affiliation_strings":["From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079013323","display_name":"Nadia Carlesso","orcid":"https://orcid.org/0000-0002-5131-9885","observed_orcids":["https://orcid.org/0000-0002-5131-9885"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadia Carlesso","raw_affiliation_strings":["From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083648953","display_name":"David T. Scadden","orcid":"https://orcid.org/0000-0001-9821-7133","observed_orcids":["https://orcid.org/0000-0001-9821-7133"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Scadden","raw_affiliation_strings":["From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Partners AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":12.4889,"has_fulltext":false,"cited_by_count":414,"citation_normalized_percentile":{"value":0.99124385,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"99","issue":"7","first_page":"2369","last_page":"2378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lineage-commitment","display_name":"lineage commitment","score":0.781000018119812},{"id":"https://openalex.org/keywords/lymphoid-differentiation","display_name":"lymphoid differentiation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/myeloid-differentiation","display_name":"myeloid differentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rag1-knockout-mice","display_name":"Rag1 knockout mice","score":0.7570000290870667},{"id":"https://openalex.org/keywords/stem-cell-kinetics","display_name":"stem cell kinetics","score":0.753000020980835},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.8700000047683716},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8310891389846802},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.7244590520858765},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7219595313072205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7149414420127869},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5665064454078674},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.5030750632286072},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5026247501373291},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4696713387966156},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.4690820276737213},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4682871699333191},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.45203155279159546},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.42835530638694763},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39767250418663025},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.26949137449264526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15238866209983826},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016654","descriptor_name":"Genes, RAG-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v99.7.2369","doi":"https://doi.org/10.1182/blood.v99.7.2369","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v99.7.2369","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:11895769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11895769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1033944488","display_name":"CDK INHIBITORS AND STEM CELL REGULATION","funder_award_id":"K08DK002761","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1875122671","display_name":"PATHOBIOLOGY OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA","funder_award_id":"R01HL045851","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G708834083","display_name":"Dynamic interactions between stem cell and their niche","funder_award_id":"R01DK050234","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W8143991","https://openalex.org/W64429679","https://openalex.org/W78011824","https://openalex.org/W1553072335","https://openalex.org/W1555225591","https://openalex.org/W1587502583","https://openalex.org/W1660631781","https://openalex.org/W1816761971","https://openalex.org/W1902852561","https://openalex.org/W1920902362","https://openalex.org/W1973035870","https://openalex.org/W1975730939","https://openalex.org/W1975771868","https://openalex.org/W1975870825","https://openalex.org/W1980212327","https://openalex.org/W1981780292","https://openalex.org/W1986447155","https://openalex.org/W1995286997","https://openalex.org/W1995900441","https://openalex.org/W2000550532","https://openalex.org/W2015010345","https://openalex.org/W2015377623","https://openalex.org/W2018527149","https://openalex.org/W2022989605","https://openalex.org/W2025748388","https://openalex.org/W2031018864","https://openalex.org/W2046928493","https://openalex.org/W2065510014","https://openalex.org/W2067131315","https://openalex.org/W2068903461","https://openalex.org/W2069501059","https://openalex.org/W2076229495","https://openalex.org/W2083847717","https://openalex.org/W2093958228","https://openalex.org/W2099770647","https://openalex.org/W2108491220","https://openalex.org/W2118623951","https://openalex.org/W2133440148","https://openalex.org/W2137263623","https://openalex.org/W2140489687","https://openalex.org/W2145185496","https://openalex.org/W2146399729","https://openalex.org/W2146660065","https://openalex.org/W2152414109","https://openalex.org/W2154861644","https://openalex.org/W2160082285","https://openalex.org/W2165918134","https://openalex.org/W2301310480","https://openalex.org/W2404234352","https://openalex.org/W2411802233","https://openalex.org/W2751246398","https://openalex.org/W4210958860","https://openalex.org/W4230605418","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1816761971","https://openalex.org/W1521353146","https://openalex.org/W1521747274","https://openalex.org/W2017625115","https://openalex.org/W2560088165","https://openalex.org/W2783147546","https://openalex.org/W2000878423","https://openalex.org/W2121501665","https://openalex.org/W2036357799","https://openalex.org/W2067065681"],"abstract_inverted_index":{"Hematopoietic":[0],"stem":[1,36,47,56,81,100],"cells":[2],"sequentially":[3],"pass":[4],"through":[5],"a":[6,19],"series":[7],"of":[8,22,33,108],"decision":[9,78],"points":[10,79],"affecting":[11],"self-renewal":[12,58,85],"or":[13],"lineage-specific":[14,23],"differentiation.":[15],"Notch1":[16,75,94],"receptor":[17],"is":[18],"known":[20],"modulator":[21],"events":[24],"in":[25,30,34,80,105],"hematopoiesis":[26],"that":[27],"we":[28,44],"assessed":[29],"the":[31,106],"context":[32,107],"vivo":[35],"cell":[37,48,57,82,101],"kinetics.":[38],"Using":[39],"RAG-1(-/-)":[40],"mouse":[41],"stems":[42],"cells,":[43],"documented":[45],"increased":[46],"numbers":[49],"due":[50],"to":[51],"decreased":[52],"differentiation":[53,72,87],"and":[54,88,110],"enhanced":[55],"induced":[59],"by":[60],"Notch1.":[61],"Unexpectedly,":[62],"preferential":[63],"lymphoid":[64,89],"over":[65,86,90],"myeloid":[66,91],"lineage":[67,92],"commitment":[68],"was":[69],"noted":[70],"when":[71],"occurred.":[73],"Therefore,":[74],"affects":[76],"2":[77],"regulation,":[83],"favoring":[84],"outcome.":[93],"offers":[95],"an":[96],"attractive":[97],"target":[98],"for":[99],"manipulation":[102],"strategies,":[103],"particularly":[104],"immunodeficiency":[109,112],"acquired":[111],"syndrome.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}